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11. 发明授权

US08672472B2 Means for controlling the progression of myopia 有权
标题翻译：用于控制近视进展的手段
公开(公告)号：US08672472B2
公开(公告)日：2014-03-18
申请号：US13548018
申请日：2012-07-12
申请人： Brien Anthony Holden , Arthur Ho , Padmaja Rajagopal Sankaridurg , Thomas Arthur Aller , Earl Leo Smith, III
发明人： Brien Anthony Holden , Arthur Ho , Padmaja Rajagopal Sankaridurg , Thomas Arthur Aller , Earl Leo Smith, III
IPC分类号： G02C7/04
CPC分类号： G02C7/044 , G02C7/04 , G02C7/042 , G02C7/061 , G02C2202/24
摘要： A contact lens (10) for use in controlling or retarding the progression of myopia in an eye has a central optical zone (20) approximating the normal diameter of the pupil of the eye (22) that gives clear central vision at distance for the wearer. An annular peripheral optical zone 24 that is substantially outside the diameter of the pupil is formed around the central optical zone (20) with greater refractive power than that of the central zone (22) so that oblique rays entering the eye through the peripheral optical zone (24) will be brought to focus at a focal plane that is substantially on or anterior to the peripheral region of the retina. Preferably, the rear surface (16) of the lens is shaped to conform to the cornea of the eye and the front surface (18) of the lens (10) is shaped to provide—in conjunction with the rear surface (16)—the desired optical properties of the central and peripheral optical zones. The front surface (18) is also preferably contoured to form a smooth transition (30) between the junction of the central optical zone (20) and the peripheral optical zone (24), with or without designed optical properties such as progressive power.
摘要翻译：用于控制或延缓眼睛近视进展的隐形眼镜（10）具有近似于眼睛（22）的瞳孔的正常直径的中心光学区域（20），其为佩戴者提供远距离的清晰的中心视觉。基本上位于瞳孔直径外侧的环形周边光学区域24围绕中心光学区域（20）以比中心区域（22）更大的折光力形成，使得通过外围光学区域进入眼睛的斜射线（24）将被聚焦在基本上在视网膜周边区域的前方或前方的焦平面上。优选地，透镜的后表面（16）成形为符合眼睛的角膜，并且透镜（10）的前表面（18）成形为与后表面（16）一起提供 - 中心和周边光学区域的所需光学特性。前表面（18）还优选成形为在中心光学区（20）和周边光学区（24）的接合处之间形成平滑过渡（30），具有或不具有设计的光学特性（例如渐进屈光力）。

12. 发明授权

US08240847B2 Means for controlling the progression of myopia 有权
标题翻译：控制近视进展的手段
公开(公告)号：US08240847B2
公开(公告)日：2012-08-14
申请号：US11758441
申请日：2007-06-05
申请人： Brien Anthony Holden , Arthur Ho , Padmaja Rajagopal Sankaridurg , Thomas Arthur Aller , Earl Leo Smith, III
发明人： Brien Anthony Holden , Arthur Ho , Padmaja Rajagopal Sankaridurg , Thomas Arthur Aller , Earl Leo Smith, III
IPC分类号： G02C7/04
CPC分类号： G02C7/044 , G02C7/04 , G02C7/042 , G02C7/061 , G02C2202/24
摘要： A contact lens (10) for use in controlling or retarding the progression of myopia in an eye has a central optical zone (20) approximating the normal diameter of the pupil of the eye (22) that gives clear central vision at distance for the wearer. An annular peripheral optical zone 24 that is substantially outside the diameter of the pupil is formed around the central optical zone (20) with greater refractive power than that of the central zone (22) so that oblique rays entering the eye through the peripheral optical zone (24) will be brought to focus at a focal plane that is substantially on or anterior to the peripheral region of the retina. Preferably, the rear surface (16) of the lens is shaped to conform to the cornea of the eye and the front surface (18) of the lens (10) is shaped to provide—in conjunction with the rear surface (16)—the desired optical properties of the central and peripheral optical zones. The front surface (18) is also preferably contoured to form a smooth transition (30) between the junction of the central optical zone (20) and the peripheral optical zone (24), with or without designed optical properties such as progressive power.
摘要翻译：用于控制或延缓眼睛近视进展的隐形眼镜（10）具有近似于眼睛（22）的瞳孔的正常直径的中心光学区域（20），其为佩戴者提供距离的清晰的中心视觉。基本上位于瞳孔直径外侧的环形周边光学区域24围绕中心光学区域（20）以比中心区域（22）更大的折光力形成，使得通过外围光学区域进入眼睛的斜射线（24）将被聚焦在基本上在视网膜周边区域的前方或前方的焦平面上。优选地，透镜的后表面（16）成形为符合眼睛的角膜，并且透镜（10）的前表面（18）成形为与后表面（16）一起提供 - 中心和周边光学区域的所需光学特性。前表面（18）还优选成形为在中心光学区（20）和周边光学区（24）的接合处之间形成平滑过渡（30），具有或不具有设计的光学特性（例如渐进屈光力）。

13. 发明授权

US09423633B2 Treating ocular refractive error 有权
$Treating ocular refractive error$
标题翻译：治疗眼屈光不正
公开(公告)号：US09423633B2
公开(公告)日：2016-08-23
申请号：US13812480
申请日：2011-07-26
申请人： Arthur Ho , Padmaja Rajagopal Sankaridurg , Earl Leo Smith, III , Brien Anthony Holden
发明人： Arthur Ho , Padmaja Rajagopal Sankaridurg , Earl Leo Smith, III , Brien Anthony Holden
IPC分类号： G02C7/06 , G02C7/04 , G02C7/02 , A61F2/14
CPC分类号： G02C7/042 , A61F2/142 , A61F2/1451 , G02C7/02 , G02C7/04 , G02C7/041 , G02C7/045 , G02C7/047 , G02C7/048 , G02C7/06 , G02C2202/24
摘要： A lens for an eye that includes a zone with a first power profile for images received by the retina on the fovea, a zone with a second power profile for images received by the peripheral retina on the nasal side and a zone with a third power profile for images received by the peripheral retina on the temporal side. The first power profile is selected to provide clear or acceptable vision and the second and third power profiles are selected to affect the peripheral image position.
摘要翻译：一种用于眼睛的透镜，其包括具有用于由中央凹上的视网膜接收的图像的第一功率分布的区域，具有由鼻侧的外周视网膜接收的图像的第二功率分布的区域和具有第三功率分布的区域对于外周视网膜在时间侧接收的图像。选择第一功率分布以提供清晰或可接受的视觉，并且选择第二和第三功率分布以影响周边图像位置。

14. 发明申请

US20120320334A1 CORNEAL REMODELLING CONTACT LENSES AND METHODS OF TREATING REFRACTIVE ERROR USING CORNEAL REMODELLING 有权
标题翻译：角膜重构接触镜和使用角膜重构处理反射误差的方法
公开(公告)号：US20120320334A1
公开(公告)日：2012-12-20
申请号：US13581949
申请日：2011-03-03
申请人： Arthur Ho , Padmaja Rajagopal Sankaridurg , Brien Anthony Holden , Percy Fabian Lazon , Xiang Chen , Fabian Conrad , Earl Leo Smith III
发明人： Arthur Ho , Padmaja Rajagopal Sankaridurg , Brien Anthony Holden , Percy Fabian Lazon , Xiang Chen , Fabian Conrad , Earl Leo Smith III
IPC分类号： G02C7/04
CPC分类号： G02C7/047 , G02C7/04 , G02C7/044 , G02C2202/24
摘要： Contact lenses are described with a corneal remodelling effect. This corneal remodelling effect is one or both of broad-area corneal remodelling and localised remodelling. The contact lenses may also have a refractive power. The refractive power may vary across the lens and for myopia may have increased power centrally. The increased power may be provided over a lens area that has increased thickness due to localised remodelling.
摘要翻译：描述隐形眼镜具有角膜重塑作用。这种角膜重塑效应是广域角膜重塑和局部重塑中的一种或两种。隐形眼镜也可以具有屈光力。透镜的屈光度可能有所不同，近视可能会集中增加功率。可以在由于局部重塑而具有增加的厚度的透镜区域上提供增加的功率。

15. 发明授权

US08201941B2 Corneal and epithelial remodelling 有权
标题翻译：角膜和上皮重塑
公开(公告)号：US08201941B2
公开(公告)日：2012-06-19
申请号：US12309841
申请日：2007-07-31
申请人： Jennifer Denise Choo , Arthur Ho , William E. Meyers , Fabian Conrad , Brien Anthony Holden
发明人： Jennifer Denise Choo , Arthur Ho , William E. Meyers , Fabian Conrad , Brien Anthony Holden
IPC分类号： G02C7/04
CPC分类号： G02C7/047 , A61B3/107 , A61F9/007 , G02C2202/24
摘要： This invention relates to methods of shaping the anterior surface of the eye for controlling the progression of refractive error of the eye, in particular, myopia. The method employs the fitting of orthokeratology lenses having a precisely shaped posterior surface adapted to accurately shape the peripheral region of the eye. The method includes the steps of assessing central and peripheral refractive error parameters for the eye, determining the optimal anterior surface profile for the eye, including at both the optical centre of the cornea and at a selected optical periphery of the cornea, which would result in a desired refractive correction to achieve good vision for the eye and the desired peripheral refraction (curvature of field) for the eye for controlling progression of myopia. Accurate measurement of the shape of the pre-treated eye is important, thereby enabling a corresponding lens profile to be designed or selected so that the treatment process achieves a post-treatment peripheral profile which optimally focuses peripheral rays anteriorly of the retina, thereby controlling the progression of myopia. The invention extends to a lens manufactured so as to optimally treat the peripheral region of the eye.
摘要翻译：本发明涉及使眼睛的前表面成形以控制眼睛的屈光不正的进展，特别是近视的方法。该方法采用具有精确成形后表面的角膜矫形镜片的装配，以适当地使眼睛周边区域成形。该方法包括以下步骤：评估眼睛的中心和周边屈光不正参数，确定眼睛的最佳前表面轮廓，包括在角膜的光学中心和角膜的选定的光学周边，这将导致期望的屈光矫正以实现眼睛的良好视力和用于眼睛控制近视进展的期望的周边折射（曲率））。预处理眼睛的形状的准确测量是重要的，从而使得能够设计或选择相应的透镜轮廓，使得治疗过程实现后处理的外围轮廓，其最佳地聚焦视网膜前方的外周射线，从而控制近视进展。本发明延伸到制造以最佳地治疗眼睛周边区域的镜片。

16. 发明授权

US07665842B2 Method and apparatus for controlling peripheral image position for reducing progression of myopia 有权
标题翻译：控制周边图像位置以减少近视进展的方法和装置
公开(公告)号：US07665842B2
公开(公告)日：2010-02-23
申请号：US11622246
申请日：2007-01-11
申请人： Arthur Ho , Earl Leo Smith, III , Padmaja Sankaridurg , Brien Anthony Holden
发明人： Arthur Ho , Earl Leo Smith, III , Padmaja Sankaridurg , Brien Anthony Holden
IPC分类号： G02C7/02 , A61B3/10
CPC分类号： G02C7/02 , A61F9/008 , A61F2009/00872 , G02C7/047 , G02C2202/24
摘要： A method and apparatus are disclosed for controlling optical aberrations to alter relative curvature of field by providing optical devices and methods comprising the repositioning of peripheral off-axis focal points relative to the retina to produce stimulus for influencing the progression of refractive error while simultaneously controlling the position of the central focal point near to the retina to provide clear central vision and simultaneously providing zones of controlled peripheral defocus and other optical aberrations to improve peripheral vision for select directions of gaze.
摘要翻译：公开了一种通过提供光学装置和方法来控制光学像差以改变相对曲率的方法和装置，所述光学装置和方法包括相对于视网膜重新定位外围离轴焦点，以产生用于影响屈光不正的进展的刺激，同时控制中心焦点靠近视网膜的位置，以提供清晰的中央视觉，同时提供受控外围散焦和其他光学像差的区域，以改善注视方向的周边视力。

17. 发明申请

US20090303442A1 CORNEAL AND EPITHELIAL REMODELLING 有权
标题翻译：角膜和上皮重塑
公开(公告)号：US20090303442A1
公开(公告)日：2009-12-10
申请号：US12309841
申请日：2007-07-31
申请人： Jennifer Denise Choo , Arthur Ho , William E. Meyers , Fabian Conrad , Brien Anthony Holden
发明人： Jennifer Denise Choo , Arthur Ho , William E. Meyers , Fabian Conrad , Brien Anthony Holden
IPC分类号： G02C7/04 , A61B3/10
CPC分类号： G02C7/047 , A61B3/107 , A61F9/007 , G02C2202/24
摘要： This invention relates to methods of shaping the anterior surface of the eye for controlling the progression of refractive error of the eye, in particular, myopia. The method employs the fitting of orthokeratology lenses having a precisely shaped posterior surface adapted to accurately shape the peripheral region of the eye. The method includes the steps of assessing central and peripheral refractive error parameters for the eye, determining the optimal anterior surface profile for the eye, including at both the optical centre of the cornea and at a selected optical periphery of the cornea, which would result in a desired refractive correction to achieve good vision for the eye and the desired peripheral refraction (curvature of field) for the eye for controlling progression of myopia. Accurate measurement of the shape of the pre-treated eye is important, thereby enabling a corresponding lens profile to be designed or selected so that the treatment process achieves a post-treatment peripheral profile which optimally focuses peripheral rays anteriorly of the retina, thereby controlling the progression of myopia. The invention extends to a lens manufactured so as to optimally treat the peripheral region of the eye.
摘要翻译：本发明涉及使眼睛的前表面成形以控制眼睛的屈光不正的进展，特别是近视的方法。该方法采用具有精确成形后表面的角膜矫形镜片的装配，以适当地使眼睛周边区域成形。该方法包括以下步骤：评估眼睛的中心和周边屈光不正参数，确定眼睛的最佳前表面轮廓，包括在角膜的光学中心和角膜的选定的光学周边，这将导致期望的屈光矫正以实现眼睛的良好视力和用于眼睛控制近视进展的期望的周边折射（曲率））。预处理眼睛的形状的准确测量是重要的，从而使得能够设计或选择相应的透镜轮廓，使得治疗过程实现后处理的外围轮廓，其最佳地聚焦视网膜前方的外周射线，从而控制近视进展。本发明延伸到制造以最佳地治疗眼睛周边区域的镜片。

18. 发明申请

US20130010255A1 Means for Controlling the Progression of Myopia 有权
标题翻译：控制近视进展的手段
公开(公告)号：US20130010255A1
公开(公告)日：2013-01-10
申请号：US13548018
申请日：2012-07-12
申请人： Brien Anthony Holden , Arthur Ho , Padmaja Rajagopal Sankaridurg , Thomas Arthur Aller , Earl Leo Smith, III
发明人： Brien Anthony Holden , Arthur Ho , Padmaja Rajagopal Sankaridurg , Thomas Arthur Aller , Earl Leo Smith, III
IPC分类号： G02C7/04
CPC分类号： G02C7/044 , G02C7/04 , G02C7/042 , G02C7/061 , G02C2202/24
摘要： A contact lens (10) for use in controlling or retarding the progression of myopia in an eye has a central optical zone (20) approximating the normal diameter of the pupil of the eye (22) that gives clear central vision at distance for the wearer. An annular peripheral optical zone 24 that is substantially outside the diameter of the pupil is formed around the central optical zone (20) with greater refractive power than that of the central zone (22) so that oblique rays entering the eye through the peripheral optical zone (24) will be brought to focus at a focal plane that is substantially on or anterior to the peripheral region of the retina. Preferably, the rear surface (16) of the lens is shaped to conform to the cornea of the eye and the front surface (18) of the lens (10) is shaped to provide—in conjunction with the rear surface (16)—the desired optical properties of the central and peripheral optical zones. The front surface (18) is also preferably contoured to form a smooth transition (30) between the junction of the central optical zone (20) and the peripheral optical zone (24), with or without designed optical properties such as progressive power.
摘要翻译：用于控制或延缓眼睛近视进展的隐形眼镜（10）具有近似于眼睛（22）的瞳孔的正常直径的中心光学区域（20），其为佩戴者提供距离的清晰的中心视觉。基本上位于瞳孔直径外侧的环形周边光学区域24围绕中心光学区域（20）以比中心区域（22）更大的折光力形成，使得通过外围光学区域进入眼睛的斜射线（24）将被聚焦在基本上在视网膜周边区域的前方或前方的焦平面上。优选地，透镜的后表面（16）成形为符合眼睛的角膜，并且透镜（10）的前表面（18）成形为与后表面（16）一起提供 - 中心和周边光学区域的所需光学特性。前表面（18）还优选成形为在中心光学区（20）和周边光学区（24）的接合处之间形成平滑过渡（30），具有或不具有设计的光学特性（例如渐进屈光力）。

19. 发明授权

US07997727B2 Method and apparatus for controlling peripheral image position for reducing progression of myopia 有权
标题翻译：控制周边图像位置以减少近视进展的方法和装置
公开(公告)号：US07997727B2
公开(公告)日：2011-08-16
申请号：US12685083
申请日：2010-01-11
申请人： Arthur Ho , Earl Leo Smith, III , Padmaja Sankaridurg , Brien Anthony Holden
发明人： Arthur Ho , Earl Leo Smith, III , Padmaja Sankaridurg , Brien Anthony Holden
IPC分类号： G02C7/02 , A61B3/10
CPC分类号： G02C7/02 , A61F9/008 , A61F2009/00872 , G02C7/047 , G02C2202/24
摘要： A method and apparatus are disclosed for controlling optical aberrations to alter relative curvature of field by providing optical devices and methods comprising the repositioning of peripheral off-axis focal points relative to the retina to produce stimulus for influencing the progression of refractive error while simultaneously controlling the position of the central focal point near to the retina to provide clear central vision and simultaneously providing zones of controlled peripheral defocus and other optical aberrations to improve peripheral vision for select directions of gaze.
摘要翻译：公开了一种通过提供光学装置和方法来控制光学像差以改变相对曲率的方法和装置，所述光学装置和方法包括相对于视网膜重新定位外围离轴焦点，以产生用于影响屈光不正的进展的刺激，同时控制中心焦点靠近视网膜的位置，以提供清晰的中央视觉，同时提供受控外围散焦和其他光学像差的区域，以改善注视方向的周边视力。

20. 发明申请

US20090076602A1 EYE TREATMENT 失效
标题翻译：眼睛治疗
公开(公告)号：US20090076602A1
公开(公告)日：2009-03-19
申请号：US12299239
申请日：2007-05-03
申请人： Arthur Ho , Brien Anthony Holden , Fabrice Manns , Jean-Marie Arthur Parel
发明人： Arthur Ho , Brien Anthony Holden , Fabrice Manns , Jean-Marie Arthur Parel
IPC分类号： A61F2/16 , A61B19/00
CPC分类号： A61F2/16 , A61F2/1624 , A61F2240/002 , A61L27/18 , A61L27/50 , A61L2430/16 , C08L83/04
摘要： The present invention relates to a method of determining the IOL refractive index for an ocular replacement material for replacing tissue in the capsular bag comprising combining a neutral (non-correcting) reference refractive index (“NRRI”) of between 1.421 and 1.450 with a refractive index correction factor (“RICF”) ascertained by reference to the refractive power required to correct the patient's refractive error. The present invention also relates to methods of treating presbyopia, myopia and hyperopia using the above method.
摘要翻译：本发明涉及一种确定用于更换囊袋中的组织的眼睛替代材料的IOL折射率的方法，包括将1.421和1.450之间的中性（非校正）参考折射率（“NRRI”）与折射率通过参考校正患者的屈光不正所需的屈光力确定的指数校正因子（“RICF”）。本发明还涉及使用上述方法治疗老花眼，近视和远视的方法。

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