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11. 发明授权

US07645752B2 Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors 失效
标题翻译：磺酰基取代的1H-吲哚作为5-羟色胺受体的配体
公开(公告)号：US07645752B2
公开(公告)日：2010-01-12
申请号：US11622649
申请日：2007-01-12
申请人： Robert E. McDevitt , Yanfang Li , Albert J. Robichaud , Gavin D. Heffernan , Richard D. Coghlan , Ronald C. Bernotas
发明人： Robert E. McDevitt , Yanfang Li , Albert J. Robichaud , Gavin D. Heffernan , Richard D. Coghlan , Ronald C. Bernotas
IPC分类号： A61K31/404 , A61K31/454 , A61K31/55 , A61K31/10 , C07D403/02 , C07D209/30 , C07C317/32
CPC分类号： C07D209/30 , C07D405/12
摘要： The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment of disorders related to or associated with the 5-hydroxytryptamine-6 and 5-hydroxtryptamine-2A receptors or with norepinephrine reuptake inhibition.
摘要翻译：本发明涉及式I化合物：其是5-羟色胺-6和5-羟色胺-2A受体的调节剂，它们是去甲肾上腺素再摄取的抑制剂。本发明的化合物及其药物组合物可用于治疗与5-羟色胺-6和5-羟色胺-2A受体相关或与其相关的病症或去甲肾上腺素再摄取抑制。

12. 发明申请

US20100004599A1 ONE-WAY VALVE FOR TROCAR 审中-公开
标题翻译：单向阀
公开(公告)号：US20100004599A1
公开(公告)日：2010-01-07
申请号：US12309655
申请日：2007-06-14
申请人： Taili Zhou , Yanfang Li
发明人： Taili Zhou , Yanfang Li
IPC分类号： A61B17/34
CPC分类号： A61B17/3498 , A61B17/3421 , A61B17/3462 , A61B17/3474 , A61M39/06 , A61M2039/0633 , A61M2039/064 , A61M2039/0646 , A61M2039/0666
摘要： An one-way valve for trocar is provided, which is mounted in the cavity of the end portion of the trocar sheath tube (2), and includes a V-shaped funnel construction (11) acted as the upper portion of the one-way valve (1), a slit (12) provided on the bottom surface of the V-shaped funnel construction (11), and a supporting body (13) acted as the lower portion of the one-way valve (1) and providing the sealing pressure to the slit (12). The supporting body (13) is connected to the outside of the inclined plane of the V-shaped funnel construction (11). Because the supporting body (13) which can provide the sealing pressure to the slit (12) is provided, when the one-way valve (1) is longitudinally compressed, the unique design of the supporting body (13) will provide sealing pressure on the slit (12). This is due to the spring back force formed when the valve is compressed.
摘要翻译：提供一种用于套针针的单向阀，其安装在套管针管（2）的端部的空腔中，并且包括用作单向上部的V形漏斗结构（11）阀（1），设置在V形漏斗结构（11）的底面上的狭缝（12）和作为单向阀（1）的下部的支撑体（13）密封到狭缝（12）的压力。支撑体（13）连接到V形漏斗结构（11）的倾斜平面的外侧。由于能够对狭缝（12）提供密封压力的支撑体（13），所以当单向阀（1）被纵向压缩时，支撑体（13）的独特设计将提供密封压力狭缝（12）。这是由于当阀被压缩时形成的弹回力。

13. 发明申请

US20070203120A1 Sulfonyl Substituted 1H-Indoles as Ligands for the 5-Hydroxytryptamine Receptors 失效
标题翻译：磺酰取代的1H-吲哚作为5-羟基色胺受体的配体
公开(公告)号：US20070203120A1
公开(公告)日：2007-08-30
申请号：US11622649
申请日：2007-01-12
申请人： Robert E. McDevitt , Yanfang Li , Albert J. Robichaud , Gavin D. Heffernan , Richard D. Coghlan , Ronald C. Bernotas
发明人： Robert E. McDevitt , Yanfang Li , Albert J. Robichaud , Gavin D. Heffernan , Richard D. Coghlan , Ronald C. Bernotas
IPC分类号： A61K31/55 , A61K31/454 , A61K31/404 , C07D403/02
CPC分类号： C07D209/30 , C07D405/12
摘要： The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the invention, and pharmaceutical composition thereof, are useful in the treatment of disorders related to or associated with the 5-hydroxytryptamine-6 and 5-hydroxtryptamine-2A receptors or with norepinephrine reuptake inhibition.
摘要翻译：本发明涉及式I化合物：其是5-羟色胺-6和5-羟色胺-2A受体的调节剂，它们是去甲肾上腺素再摄取的抑制剂。本发明的化合物及其药物组合物可用于治疗与5-羟色胺-6和5-羟色胺-2A受体相关或与其相关的病症或去甲肾上腺素再摄取抑制。

14. 发明申请

US20070099912A1 Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands 审中-公开
标题翻译：吡咯并[2,3-F]和[3,2-F]异喹啉酮衍生物，为5-羟色胺-6配体
公开(公告)号：US20070099912A1
公开(公告)日：2007-05-03
申请号：US11588610
申请日：2006-10-27
申请人： Ping Zhou , Yanfang Li
发明人： Ping Zhou , Yanfang Li
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D209/08 , C07D471/04
摘要： The present invention provides a compound of formula I or II and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I或II化合物及其在治疗性治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病中的用途。

15. 发明申请

US20150236699A1 INPUT BUFFER CIRCUIT, METHOD, AND INTEGRATED CIRCUIT 审中-公开
标题翻译：输入缓存器电路，方法和集成电路
公开(公告)号：US20150236699A1
公开(公告)日：2015-08-20
申请号：US14622616
申请日：2015-02-13
申请人： Yanfang Li , Lei Huang , Zhaohong Li
发明人： Yanfang Li , Lei Huang , Zhaohong Li
IPC分类号： H03K19/0175 , H03K19/094
CPC分类号： H03K19/017509 , H03K19/09407
摘要： This document discusses, among other things, an input buffer circuit, an input buffer method, and an integrated circuit, the input buffer circuit raising, using a potential raising device, a potential of a first reference ground to a potential of a second reference ground of an input stage, and improving a trigger voltage of the input stage. After the input stage is triggered and outputs a first buffer signal, an output stage transforms the potential of the second reference ground of the first buffer signal back to the potential of the first reference ground, and outputs a second buffer signal.
摘要翻译：该文件尤其讨论了输入缓冲电路，输入缓冲方法和集成电路，输入缓冲电路使用电位提升装置将第一参考电位的电位提升到第二参考地的电位的输入级，并提高输入级的触发电压。在触发输入级并输出第一缓冲器信号之后，输出级将第一缓冲器信号的第二参考地的电位转换回第一参考地的电位，并输出第二缓冲信号。

16. 发明授权

US07723329B2 Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands 有权
标题翻译：取代的3-磺基吲唑衍生物作为5-羟色胺-6配体
公开(公告)号：US07723329B2
公开(公告)日：2010-05-25
申请号：US11504350
申请日：2006-08-14
申请人： Hassan Mahmoud Elokdah , Alexander Alexei Greenfield , Kevin Liu , Robert Emmett McDevitt , Geraldine Ruth McFarlane , Cristina Grosanu , Jennifer Rebecca Lo , Yanfang Li , Albert Jean Robichaud , Ronald Charles Bernotas
发明人： Hassan Mahmoud Elokdah , Alexander Alexei Greenfield , Kevin Liu , Robert Emmett McDevitt , Geraldine Ruth McFarlane , Cristina Grosanu , Jennifer Rebecca Lo , Yanfang Li , Albert Jean Robichaud , Ronald Charles Bernotas
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/416 , C07D413/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12
摘要： The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式I化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

17. 发明申请

US20100040196A1 X-RAY GENERATOR FOR ACHIEVING STEREOSCOPIC IMAGING EFFECT AND MEDICAL X-RAY DEVICE USING THE X-RAY GENERATOR 审中-公开
标题翻译：用于实现立体成像效果的X射线发生器和使用X射线发生器的医疗X射线装置
公开(公告)号：US20100040196A1
公开(公告)日：2010-02-18
申请号：US12531072
申请日：2008-04-02
申请人： Yingguang Zhang , Yanfang Li , Taili Zhou
发明人： Yingguang Zhang , Yanfang Li , Taili Zhou
IPC分类号： A61B6/02
CPC分类号： G03B42/026 , A61B6/022 , A61B6/4028 , A61B6/504 , G03B35/04
摘要： The present invention provides an X-ray generator for achieving stereoscopic imaging effect and an X-ray device using the X-ray generator (101) as the X-ray source. The X-ray generator (101) can emit X-rays alternately from two positions the space of which conforms to the requirement for achieving stereoscopic imaging effect of the human beings.
摘要翻译：本发明提供一种用于实现立体成像效果的X射线发生器和使用该X射线发生器（101）作为X射线源的X射线装置。 X射线发生器（101）可以从两个位置交替地发射X射线，其中空间符合实现人的立体成像效果的要求。

18. 发明申请

US20100021550A1 RADIOPAQUE BIODEGRADABLE VASCULAR EMBOLIC MICROSPHERES 审中-公开
标题翻译：放射性生物可降解血管微生物微球
公开(公告)号：US20100021550A1
公开(公告)日：2010-01-28
申请号：US12523046
申请日：2008-01-14
申请人： Yanfang Li , Taili Zhou
发明人： Yanfang Li , Taili Zhou
IPC分类号： A61K9/16
CPC分类号： A61L24/0042 , A61L24/001 , A61L2430/36
摘要： A radiopaque biodegradable vascular embolic microsphere comprises of a biodegradable material and a radiopaque material which can be both delivered to the vascular system, in which, the biodegradable material incorporates the radiopaque material to form granule structure. The embolic microsphere, readily visible under X-ray, can be delivered or drift with blood flow to a peripheral vessel or site, and can be manufactured using a simple process. A radiopaque biodegradable vascular embolic microsphere incorporating therapeutic agent(s) comprises of a biodegradable material, a radiopaque material, and therapeutic agent(s), which can be all delivered to the vascular system, in which, the biodegradable material incorporates the radiopaque material and the therapeutic agent to form granule structure. This embolic microsphere can be delivered to the targeted site under X-ray guidance, and then embolize the site, and release the therapeutic agent directly at the targeted site while degrading in vivo.
摘要翻译：不透射线的可生物降解的血管栓塞微球包括可生物降解材料和不透射线的材料，其可以被递送到血管系统，其中生物可降解材料包含不透射线材料以形成颗粒结构。在X射线下容易看到的栓塞微球可以通过血流传送或漂移到外周血管或部位，并且可以使用简单的方法制造。包含治疗剂的不透射线的可生物降解的血管栓塞微球包括可生物降解材料，不透射线材料和治疗剂，其可以全部递送到血管系统，其中生物可降解材料包含不透射线材料和治疗剂形成颗粒结构。该栓塞微球可以在X射线引导下输送到目标部位，然后栓塞部位，并在靶向部位直接释放治疗剂，同时降解体内。

19. 发明授权

US07452885B2 Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation 失效
标题翻译：氨基-5-（6元）杂芳基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US07452885B2
公开(公告)日：2008-11-18
申请号：US11478098
申请日：2006-06-29
申请人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
发明人： Ping Zhou , Michael Sotirios Malamas , Yanfang Li , Albert Jean Robichaud , Dominick Anthony Quagliato
IPC分类号： C07D403/04 , A61K31/4439
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的2-氨基-5-杂芳基-5-苯基咪唑酮化合物本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

20. 发明申请

US20070191431A1 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation 审中-公开
标题翻译： 2-氨基-5-哌啶基咪唑酮化合物及其用于β-分泌酶调节的用途
公开(公告)号：US20070191431A1
公开(公告)日：2007-08-16
申请号：US11640751
申请日：2006-12-18
申请人： Ping Zhou , Ronald Bernotas , Yanfang Li , Pawel Nowak , Derek Cole , Eric Manas , Yi Fan , Yinfa Yan
发明人： Ping Zhou , Ronald Bernotas , Yanfang Li , Pawel Nowak , Derek Cole , Eric Manas , Yi Fan , Yinfa Yan
IPC分类号： A61K31/454 , C07D403/02 , C07D405/14
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14
摘要： The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula I The present invention also provides methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.
摘要翻译：本发明提供式I的2-氨基-5-哌啶基咪唑酮化合物本发明还提供了抑制β-分泌酶（BACE）和β-淀粉样蛋白沉积物和神经原纤维缠结的治疗的方法和组合物。

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