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11. 发明授权

US07171983B2 Multi-reservoir pressure control system 有权
标题翻译：多层压力控制系统
公开(公告)号：US07171983B2
公开(公告)日：2007-02-06
申请号：US10916270
申请日：2004-08-11
申请人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
发明人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
IPC分类号： F15C1/04 , F04B41/06
CPC分类号： B01L9/527 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/025 , B01L2200/027 , B01L2200/146 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/082 , G01N11/08 , G01N27/44791 , G01N2035/1044 , G05D7/0694 , Y10T137/2076 , Y10T137/218 , Y10T137/86131
摘要： Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.
摘要翻译：改进的微流体装置，系统和方法允许通过在多个储存器处施加，控制和改变压力来选择性地输送微流体网络的微流体通道内的流体。将微流体网络建模为通过通道段连接在一起的一系列节点并且确定通道段的流动阻力特性可以允许计算通过在储存器处的给定压力构造导致的通道段的流体流动。为了在特定通道或一系列通道内实现期望的流量，可以使用网络模型来识别储层压力。粘度计或其他流量传感器可以测量通道内的流量特性，并且可以使用测量的流量特性来计算产生期望流量的压力。多储层压力调节器和压力控制器系统可以可选地与电动或其它流体输送机构结合使用。

12. 发明申请

US20050241941A1 High throughput screening assay systems in microscale fluidic devices 审中-公开
标题翻译：微量流体装置中的高通量筛选测定系统
公开(公告)号：US20050241941A1
公开(公告)日：2005-11-03
申请号：US11176805
申请日：2005-07-06
申请人： J. Parce , Anne Kopf-Sill , Luc Bousse
发明人： J. Parce , Anne Kopf-Sill , Luc Bousse
IPC分类号： G01N31/20 , B01J19/00 , B01L3/00 , C12Q1/04 , C12Q1/25 , G01N27/26 , G01N27/27 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/574 , G01N35/08 , G01N37/00
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
摘要翻译：本发明提供了可用于进行高通量筛选测定的新型微流体装置和方法。特别地，本发明的装置和方法可用于筛选大量不同的化合物，因为它们对多种化学品，优选生物化学体系的影响。

13. 发明授权

US06915679B2 Multi-reservoir pressure control system 有权
公开(公告)号：US06915679B2
公开(公告)日：2005-07-12
申请号：US09792435
申请日：2001-02-23
申请人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
发明人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
IPC分类号： G01N11/04 , B01L3/00 , B01L9/00 , G01N11/08 , G01N27/06 , G01N27/447 , G01N35/08 , G01N35/10 , G01N37/00 , G05D7/06 , G01N11/00
CPC分类号： B01L9/527 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/025 , B01L2200/027 , B01L2200/146 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/082 , G01N11/08 , G01N27/44791 , G01N2035/1044 , G05D7/0694 , Y10T137/2076 , Y10T137/218 , Y10T137/86131
摘要： Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.

14. 发明申请

US20060000722A1 High throughput screening assay systems in microscale fluidic devices 审中-公开
公开(公告)号：US20060000722A1
公开(公告)日：2006-01-05
申请号：US11050900
申请日：2005-02-03
申请人： J. Parce , Anne Kopf-Sill , Luc Bousse
发明人： J. Parce , Anne Kopf-Sill , Luc Bousse
IPC分类号： G01N27/26
CPC分类号： C12Q1/00 , B01J19/0093 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00837 , B01J2219/00853 , B01L3/50273 , B01L3/502784 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.

15. 发明授权

US06429025B1 High-throughput screening assay systems in microscale fluidic devices 有权
标题翻译：微量流体装置中的高通量筛选测定系统
公开(公告)号：US06429025B1
公开(公告)日：2002-08-06
申请号：US09214035
申请日：1998-12-22
申请人： John Wallace Parce , Anne Kopf-Sill , Luc J. Bousse
发明人： John Wallace Parce , Anne Kopf-Sill , Luc J. Bousse
IPC分类号： G01N33558
CPC分类号： G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
摘要翻译：本发明提供了可用于进行高通量筛选测定的新型微流体装置和方法。特别地，本发明的装置和方法可用于筛选大量不同的化合物，因为它们对多种化学品，优选生物化学体系的影响。

16. 发明授权

US5053060A Device and method for degassing, gassing and debubbling liquids 失效
标题翻译：脱气，放气和脱泡液体的装置和方法
公开(公告)号：US5053060A
公开(公告)日：1991-10-01
申请号：US546094
申请日：1990-06-29
申请人： Anne Kopf-Sill , Henry L. Schwartz
发明人： Anne Kopf-Sill , Henry L. Schwartz
IPC分类号： B01D19/00 , C02F3/20
CPC分类号： B01D19/0031 , C02F3/208 , Y02W10/15
摘要： This invention is a debubbler, degasser or gasser device used to remove gas bubbles and/or dissolved gasses from a liquid stream or to add gasses to a liquid stream. The device consists of a first block, a hydrophobic membrane, and a second block. The first block has a channel for carrying liquids which is grooved into its lower surface. The end of the channel is connected to an inlet and outlet. The second block has venting holes. When the hydrophobic membrane is pressed between the first and second block liquid can flow through the channel and bubbles or dissolved gasses in the liquid stream pass through the hydrophobic membrane. Alternatively, or in combination with degassing or debubbling, the device may be employed to introduce into the liquid stream gasses provided on the opposing side of the hydrophobic membrane.
摘要翻译：本发明是用于从液体流中除去气泡和/或溶解气体或将气体添加到液体流中的脱泡器，脱气器或放气装置。该装置由第一块，疏水膜和第二块构成。第一块具有用于承载在其下表面开槽的液体的通道。通道的末端连接到入口和出口。第二块有排气孔。当疏水膜在第一和第二阻塞液体之间被挤压时，可以流过该通道，并且液体流中的气泡或溶解的气体通过疏水膜。或者，或者与脱气或脱泡相结合，可以将该装置引入设置在疏水膜的相对侧上的液体气体中。

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