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11. 发明授权

US07490646B2 Vehicle pneumatic tire with transverse grooves defining flank segments having different angles 有权
标题翻译：具有限定具有不同角度的侧翼段的横向槽的车辆充气轮胎
公开(公告)号：US07490646B2
公开(公告)日：2009-02-17
申请号：US11088848
申请日：2005-03-25
申请人： Peter Bogenschuetz , Markus Metz , Frank Walloch
发明人： Peter Bogenschuetz , Markus Metz , Frank Walloch
IPC分类号： B60C11/11 , B60C11/13
CPC分类号： B60C11/13 , B60C11/1315 , Y10S152/902
摘要： Vehicle pneumatic tire with a rubber tread profile having blocks formed by circumferential grooves and transverse grooves. At least some of the transverse grooves are defined by first and second flank segments. The first and second flank segments have different angles with respect to a radial direction. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.
摘要翻译：具有橡胶胎面轮胎的车辆充气轮胎具有由圆周槽和横向槽形成的块。至少一些横向槽由第一和第二侧面段限定。第一和第二侧面区段相对于径向具有不同的角度。本摘要不旨在限定说明书中公开的发明，也不旨在以任何方式限制本发明的范围。

12. 发明申请

US20050277670A1 Chemokine receptor binding compounds 失效
公开(公告)号：US20050277670A1
公开(公告)日：2005-12-15
申请号：US11012002
申请日：2004-12-13
申请人： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
发明人： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
IPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D43/02
CPC分类号： C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

13. 发明申请

US20050211355A1 Vehicle pneumatic tire 有权
标题翻译：汽车充气轮胎
公开(公告)号：US20050211355A1
公开(公告)日：2005-09-29
申请号：US11088760
申请日：2005-03-25
申请人： Markus Metz
发明人： Markus Metz
IPC分类号： B60C11/03 , B60C11/04 , B60C11/12 , B60C11/13
CPC分类号： B60C11/042 , B60C11/0309 , B60C11/125 , B60C11/13 , B60C11/1315 , B60C2011/0381 , Y10S152/03 , Y10S152/901 , Y10S152/902
摘要： A tire including a tread rubber having at least one positive profile. Wherein the positive profile is formed by at least one circumferential groove. Further, the tire includes at least one truncated groove extending into the positive profile from the circumferential groove, such that the truncated groove includes at least one flank surface. Further still, the tire includes the truncated groove being inclined at an acute angle to a direction of rotation of the tire. The tire includes a pitch of the flank surface that continuously changes with respect to the radial direction over a length of the truncated groove. The tire being a vehicle pneumatic tire. The instant abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.
摘要翻译：一种轮胎，其包括具有至少一个正轮廓的胎面橡胶。其中正轮廓由至少一个周向槽形成。此外，轮胎包括从周向槽延伸到正型轮廓中的至少一个截头槽，使得截头槽包括至少一个侧面。此外，轮胎包括与轮胎的旋转方向成锐角倾斜的截头槽。轮胎包括在截头槽的长度上相对于径向方向连续变化的侧面的间距。轮胎是车辆充气轮胎。本摘要既不旨在限定本说明书中公开的发明，也不旨在以任何方式限制本发明的范围。

14. 发明授权

US07503361B2 Tire with tread having transverse grooves forming block flank surfaces 有权
标题翻译：具有胎面的轮胎具有形成块侧面的横向槽
公开(公告)号：US07503361B2
公开(公告)日：2009-03-17
申请号：US11088751
申请日：2005-03-25
申请人： Markus Metz
发明人： Markus Metz
IPC分类号： B60C11/13
CPC分类号： B60C11/13 , B60C11/11 , B60C11/1323
摘要： A tire includes a tread rubber having a positive profile formed by at least one circumferential groove. Wherein the transverse grooves extends into the positive profile from the circumferential groove to form block flank surfaces. Further, the transverse grooves have bending points at which a change of direction takes place at an obtuse angle. Further still, at least one block flank has at least three flank surfaces, wherein at least one of the flank surfaces is inclined and connected to an upper surface of the positive profile. The tire is a vehicle pneumatic tire. The instant abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.
摘要翻译：轮胎包括具有由至少一个周向槽形成的正轮廓的胎面橡胶。其中横向槽从周向槽延伸到正轮廓以形成块侧面。此外，横向槽具有以钝角发生方向变化的弯曲点。此外，至少一个块侧面具有至少三个侧面，其中，所述侧面中的至少一个倾斜并连接到所述正轮廓的上表面。轮胎是车辆充气轮胎。本摘要既不旨在限定本说明书中公开的发明，也不旨在以任何方式限制本发明的范围。

15. 发明授权

US07491735B2 Chemokine receptor binding compounds 失效
公开(公告)号：US07491735B2
公开(公告)日：2009-02-17
申请号：US11012002
申请日：2004-12-13
申请人： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
发明人： Yuanxi Zhou , Gary J. Bridger , Renato T. Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria R. Di Fluri , Siqiao Nan
IPC分类号： A61K31/4468
CPC分类号： C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

16. 发明申请

US20080066846A1 Motor Vehicle Pneumatic Tire 审中-公开
标题翻译：汽车气动轮胎
公开(公告)号：US20080066846A1
公开(公告)日：2008-03-20
申请号：US11573247
申请日：2005-07-05
申请人： Markus Metz
发明人： Markus Metz
IPC分类号： B60C13/02
CPC分类号： B60C13/001
摘要： Vehicle pneumatic tire with a carcass, in particular of radial construction, with sidewalls and with a tread rubber (1), whereby a moiré-free pattern is arranged in a first surface area of a sidewall rubber strip (7), which pattern is formed by one or more linear families of curves, and a moiré pattern is arranged in a second surface area connecting to the first surface area in the circumferential direction of the vehicle pneumatic tire, which pattern is formed embodied from the superimposition of at least two linear non-identical families of curves. Sidewall rubber strip (7) is embodied free from markings to provide information, whereby a moiré pattern is arranged on the surface of the sidewall rubber strip (7), which pattern is formed embodied from the superimposition of at least two linear non-identical families of curves, characterized in that in the second surface area on the sidewall rubber strip (7).
摘要翻译：具有胎体（特别是径向构造）的车辆充气轮胎具有侧壁和胎面橡胶（1），由此在侧壁橡胶条（7）的第一表面区域中布置无莫纹图案，所述胎纹橡胶条（7）形成，通过一个或多个线性曲线族，并且在连接到车辆充气轮胎的圆周方向上的第一表面区域的第二表面区域中布置有莫尔图案，该图案形成为由至少两个线性非线性相同的曲线族。侧壁橡胶条（7）被实施为没有标记以提供信息，由此在侧壁橡胶条（7）的表面上布置有莫尔图案，所述图案形成由至少两个线性不相同的族的曲线，其特征在于在侧壁橡胶条（7）上的第二表面区域。

17. 发明申请

US20070066624A1 Chemokine receptor binding compounds 审中-公开
标题翻译：趋化因子受体结合化合物
公开(公告)号：US20070066624A1
公开(公告)日：2007-03-22
申请号：US11505669
申请日：2006-08-16
申请人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Ernest McEachern , Curtis Harwig , Renato Skerlj , Gary Bridger , Tong-Shuang Li , Markus Metz
发明人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Ernest McEachern , Curtis Harwig , Renato Skerlj , Gary Bridger , Tong-Shuang Li , Markus Metz
IPC分类号： A61K31/496 , A61K31/454 , C07D403/14 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/08
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译：本发明涉及趋化因子受体结合化合物，药物组合物及其用途。更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR4或CCR5的调节剂。一方面，这些化合物表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。

18. 发明申请

US20050059702A1 Chemokine receptor binding heterocyclic compounds with enhanced efficacy 有权
标题翻译：趋化因子受体结合杂环化合物具有增强的疗效
公开(公告)号：US20050059702A1
公开(公告)日：2005-03-17
申请号：US10831098
申请日：2004-04-22
申请人： Gary Bridger , Ernest Mceachern , Renato Skerlj , Dominique Schols , Ian Baird , Ai Kaller , Curtis Harwig , Yongbao Zhu , Gang Chen , Krystyna Skupinska , Markus Metz
发明人： Gary Bridger , Ernest Mceachern , Renato Skerlj , Dominique Schols , Ian Baird , Ai Kaller , Curtis Harwig , Yongbao Zhu , Gang Chen , Krystyna Skupinska , Markus Metz
IPC分类号： A61K20060101 , A61K31/40 , A61K31/444 , A61K31/445 , A61K31/495 , A61K31/54 , A61K31/55 , C07D223/02 , C07D227/00 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D41/14
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Compounds that interact with the CXCR4 receptor are described. These compounds are useful in treating, for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well as asthma or cancer, and are useful in methods to elevate progenitor and stem cell counts as well as methods to elevate white blood cell counts.
摘要翻译：描述了与CXCR4受体相互作用的化合物。这些化合物可用于治疗例如HIV感染和炎性病症如类风湿性关节炎以及哮喘或癌症，并且可用于提高祖细胞和干细胞计数的方法以及升高白细胞计数的方法。

19. 发明授权

US06691753B2 Pneumatic tire including circumferential grooves and slanting grooves 有权
标题翻译：气动轮胎，包括周向槽和倾斜槽
公开(公告)号：US06691753B2
公开(公告)日：2004-02-17
申请号：US10090003
申请日：2002-03-05
申请人： Katja Hanebuth , Markus Metz , Frank Jenne , Tanja Wackerhage , Thomas Sych
发明人： Katja Hanebuth , Markus Metz , Frank Jenne , Tanja Wackerhage , Thomas Sych
IPC分类号： B60C1103
CPC分类号： B60C13/04 , B60C9/2009 , B60C11/0302 , B60C11/125 , B60C11/13 , B60C2011/0374 , Y10S152/03
摘要： A pneumatic tire for motor vehicles has a running surface profile designed in the direction of rotation, with two shoulder regions (S1, S2) each being a constituent of a row of shoulder blocks, and with a middle region (C) separated from them by circumferential grooves (2) running in the circumferential direction; this middle region encompasses the width of the circumferential grooves (2) and covers a minimum width of 60% of the width of the running surface (B), is free from circumferential grooves running in the circumferential direction and is equipped with a number of V-shaped running rills (1), which open into the circumferential grooves (2) and whose V-peaks rest at least essentially on the equator line (M—M). In the two partial regions of the middle region (C) running to the side of the equator line (M—M) there are a number of slanting grooves (4) which are oriented in the same direction to the course of the V-shaped rills (1), crossing at least three V-shaped rills (1) following each other in the circumferential direction and being at least essentially of a straight design, wherein these slanting grooves (4) run at an incline at a much smaller angle (&bgr;, &bgr;′) to the equator line (M—M) than the V-shaped rills (1) and which are the widest of all grooves or rills of the profile, wherein the slanting grooves (4) of the one partial region of the middle region (C) are offset in the circumferential direction with respect to those of the other partial region.
摘要翻译：一种用于机动车辆的充气轮胎具有沿旋转方向设计的行进表面轮廓，两个肩部区域（S1，S2）各自是一排肩胛骨块的构成部分，并且其中间区域（C）与它们分开，周向槽（2）沿圆周方向延伸; 该中间区域包围周向槽（2）的宽度并且覆盖行进面（B）的宽度的最小宽度的60％，没有在圆周方向上延伸的周向槽，并且配备有多个V （1），其开口到圆周凹槽（2）中，其V峰至少基本上搁置在赤道线（MM）上。在运行到赤道线（MM）侧的中间区域（C）的两个部分区域中，存在多个倾斜槽（4），其相对于V形轨道的路线在圆周方向上交叉至少三个V形的轨道（1），并且至少基本上是直的设计，其中这些倾斜槽（4）以较小的角度（β， β'）到V形斜面（1）的赤道线（MM），并且是轮廓的所有凹槽或斜面中最宽的，其中中间区域的一个局部区域的倾斜槽（4） C）相对于另一部分区域的圆周方向偏移。

20. 发明授权

US07790747B2 Chemokine receptor binding compounds 失效
标题翻译：趋化因子受体结合化合物
公开(公告)号：US07790747B2
公开(公告)日：2010-09-07
申请号：US11453221
申请日：2006-06-14
申请人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
发明人： Yuanxi Zhou , Elyse Bourque , Yongbao Zhu , Jonathan Langille , Markus Metz , Wen Yang , Ernest J. McEachern , Curtis Harwig , Ian R. Baird , Tong-Shuang Li , Renato T. Skerlj
IPC分类号： A61K31/4545 , C07D409/14
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
摘要翻译：本发明涉及趋化因子受体结合化合物，药物组合物及其用途。更具体地，本发明涉及趋化因子受体活性的调节剂，优选CCR5的调节剂。这些化合物表现出对人体免疫缺陷病毒（HIV）感染靶细胞的保护作用。

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