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11. 发明申请

US20100221191A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：US20100221191A1
公开(公告)日：2010-09-02
申请号：US12682063
申请日：2008-10-10
申请人： Duncan George Wynn , Ian Martin Newington , Hanno Priebe
发明人： Duncan George Wynn , Ian Martin Newington , Hanno Priebe
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula wherein each R1 independently are the same or different and denotes a hydrogen atom or a C1 to C4 straight of branched alkyl group; each R2 independently are the same or different and denotes a hydrogen atom or a C1 to C4 straight of branched alkyl group; and each R3, R4 and R5 independently are the same or different and denote C1 to C6 straight of branched alkyl moieties substituted by 1 to 6 —OH groups. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有两个具有通式的连接的碘化苯基的化合物，其中每个R 1独立地相同或不同，表示氢原子或支链烷基的C1至C4直链; 每个R 2独立地相同或不同，表示氢原子或支链烷基的C1〜C4直链; 并且每个R 3，R 4和R 5各自独立地相同或不同，并且表示被1至6个-OH基取代的支链烷基部分的C1至C6直链。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

12. 发明申请

US20100209356A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：US20100209356A1
公开(公告)日：2010-08-19
申请号：US12682066
申请日：2008-10-10
申请人： Duncan George Wynn , Lars-Goran Wistrand
发明人： Duncan George Wynn , Lars-Goran Wistrand
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： C07C237/46 , A61K49/0433
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula (I) and salts or optical active isomers thereof, wherein each of R1, R2 and R3 independently are the same or different and denote a hydrogen atom or a C1 to C4 straight of branched alkyl group; each R4 independently are the same or different and denote C1 to C6 straight of branched alkyl moieties substituted by up to 6 —OH groups; and each R5 independently are the same or different and denote C1 to C6 straight of branched alkyl moieties substituted by up to 6 —OH groups provided that at least one alkyl group is substituted with at least 2 hydroxy groups. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式（I）的两个连接的碘化苯基及其盐或光学活性异构体的化合物，其中R1，R2和R3各自独立地相同或不同，表示氢原子或支链烷基的C1〜C4直链; 每个R 4独立地相同或不同，并且表示被至多6个-OH基团取代的支链烷基部分的C1至C6直链; 并且每个R 5独立地相同或不同，并且表示被至多6个-OH基团取代的支链烷基部分的C1至C6直链，条件是至少一个烷基被至少2个羟基取代。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

13. 发明申请

US20100189656A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：US20100189656A1
公开(公告)日：2010-07-29
申请号：US12664905
申请日：2008-06-27
申请人： Lars-Goran Wistrand , Duncan George Wynn , Ian Martin Newington , Veronique Morisson-Iveson
发明人： Lars-Goran Wistrand , Duncan George Wynn , Ian Martin Newington , Veronique Morisson-Iveson
IPC分类号： A61K49/04 , C07C233/77 , A61P43/00
CPC分类号： A61K49/0433 , C07C237/42 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a triamine alkyl central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地，含碘化合物是含有三胺烷基中心部分的化合物，允许与其结合的三个碘化苯基的排列。本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。

14. 发明申请

US20100183522A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：US20100183522A1
公开(公告)日：2010-07-22
申请号：US12664892
申请日：2008-06-27
申请人： Lars-Goran Wistrand , Duncan George Wynn , Ian Martin Newington
发明人： Lars-Goran Wistrand , Duncan George Wynn , Ian Martin Newington
IPC分类号： A61K49/04 , C07C235/46
CPC分类号： A61K49/0433 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a tris(aminoalkyl)amine group allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有三（氨基烷基）胺基团的化合物，允许与其结合的三个碘化苯基的排列。本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。

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