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11. 发明申请

WO2006020005A3 SALIVARY TRANSCRIPTOME DIAGNOSTICS 审中-公开
公开(公告)号：WO2006020005A3
公开(公告)日：2006-02-23
申请号：PCT/US2005/025138
申请日：2005-07-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WONG, David
发明人： WONG, David
IPC分类号： C12Q1/68
摘要： The present invention concerns probes and methods useful in diagnosing, identifying and monitoring the progression of disease states through measurements of gene products in saliva.

12. 发明申请

WO2013109815A1 INTERFACE DEVICES, SYSTEMS, AND METHODS FOR USE WITH INTRAVASCULAR PRESSURE MONITORING DEVICES 审中-公开
标题翻译：用于血管内压力监测装置的界面装置，系统和方法
公开(公告)号：WO2013109815A1
公开(公告)日：2013-07-25
申请号：PCT/US2013/022041
申请日：2013-01-18
申请人： VOLCANO CORPORATION , DORANDO, Dale Gene , WONG, David , ALPERT, Howard David
发明人： DORANDO, Dale Gene , WONG, David , ALPERT, Howard David
IPC分类号： A61B5/0215
CPC分类号： A61B5/02158 , A61B5/02007 , A61B5/6851 , A61B5/6852 , A61B5/7278 , A61B5/742 , A61B5/7475 , A61B2560/0443 , A61B2562/0247 , A61B2562/085
摘要： Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to provide FFR measurements in a small, compact device that integrates with existing proximal and distal pressure measurement systems and does not require a separate power source.
摘要翻译：本公开的实施例被配置为评估血管中的阻塞的严重性，特别是血管中的狭窄。在一些特定实施例中，本公开的装置，系统和方法被配置为在与现有的近端和远端压力测量系统集成并且不需要单独的电源的小型紧凑装置中提供FFR测量。

13. 发明申请

WO2008039615A2 CONTROLLED RELEASE HYDROGEL FORMULATION 审中-公开
标题翻译：控制释放水凝胶配方
公开(公告)号：WO2008039615A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/076551
申请日：2007-08-22
申请人： BIOKEY, INC. , CHOW, San-laung , WONG, David , GARCIA, Damian
发明人： CHOW, San-laung , WONG, David , GARCIA, Damian
IPC分类号： A61K31/47 , A61K31/496 , A61K9/14 , A61P43/00
CPC分类号： A61K9/2054 , A61K9/2027 , A61K9/2095 , A61K31/47 , A61K31/496
摘要： Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as controlled release dosage compositions for hydrophobic active ingredients. In one aspect, the invention provides a pharmaceutical formulation comprising a therapeutically effective amount of a hydrophobic drug, an adjustable ratio of a non-cross linked hydrogel polymer and a non-gelling insoluble polymer. One example is a controlled release pharmaceutical composition which includes 1% to 80% of a therapeutically amount of cilostazol, 4% to 80% of a water-swelling hydrogel polymer, and 4% to 80% of a non-gelling insoluble polymer. In another aspect, a constant release profile of the pharmaceutical formulation is obtained. In another aspect, a zero degree release profile of the pharmaceutical formulation is obtained. Further, a method for treating intermittent claudication using the pharmaceutical formulation is provided.
摘要翻译：本发明的实施方案通常提供药物组合物，制备口服药物组合物的方法，例如用于疏水性活性成分的控释剂型组合物。一方面，本发明提供了一种药物制剂，其包含治疗有效量的疏水性药物，可调节比例的非交联水凝胶聚合物和非凝胶不溶性聚合物。一个实例是控释药物组合物，其包含1％至80％的治疗量的西洛他唑，4％至80％的水溶胀水凝胶聚合物和4％至80％的非胶凝不溶性聚合物。另一方面，获得药物制剂的恒定释放曲线。另一方面，获得药物制剂的零度释放曲线。此外，提供了使用该药物制剂治疗间歇性跛行的方法。

14. 发明申请

WO2005012574A2 BIOLOGICAL BAR-CODE 审中-公开
标题翻译：生物条码
公开(公告)号：WO2005012574A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/013545
申请日：2004-04-29
申请人： GENVAULT CORPORATION , DAVIS, James, C. , EGGERS, Mitchell, E. , IBARRA, Rafael , SADLER, John , WONG, David , JAFFE, Syrus, Merrill
发明人： DAVIS, James, C. , EGGERS, Mitchell, E. , IBARRA, Rafael , SADLER, John , WONG, David , JAFFE, Syrus, Merrill
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12Q2531/113 , C12Q2563/185
摘要： The invention provides compositions and methods useful for identifying, verifying or authenticating any type of sample, whether the sample is biological or non-biological.
摘要翻译：本发明提供了用于鉴定，验证或鉴定任何类型的样品的组合物和方法，无论样品是生物还是非生物的。

15. 发明申请

WO2003000239A1 STABLE PHARMACEUTICAL COMPOSITIONS CONTAINING PRAVASTATIN 审中-公开
标题翻译：含有PRAVASTATIN的稳定的药物组合物
公开(公告)号：WO2003000239A1
公开(公告)日：2003-01-03
申请号：PCT/US2002/017713
申请日：2002-06-05
申请人： ANDRX PHARMACEUTICALS, INC. , LI, Boyong , NANGIA, Avinash , DELY, Aaron , WONG, David
发明人： LI, Boyong , NANGIA, Avinash , DELY, Aaron , WONG, David
IPC分类号： A61K9/20
CPC分类号： A61K31/22 , A61K9/0004 , A61K9/1617 , A61K9/1623 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2077 , A61K31/235
摘要： Stabilized pharmaceutical preparations containing a drug which is sensitive to a low pH environment, such as pravastatin are disclosed in which pravastatin degradations is prevented with a buffering agent. The basic excipient enhances storage stability.
摘要翻译：公开了含有对低pH环境敏感的药物如普伐他汀的稳定药物制剂，其中用缓冲剂防止普伐他汀降解。碱性赋形剂提高了储存稳定性。

16. 发明申请

WO2010135705A2 BIOLOGICAL BAR CODE 审中-公开
标题翻译：生物条码
公开(公告)号：WO2010135705A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035856
申请日：2010-05-21
申请人： GENVAULT CORPORATION , DAVIS, James C. , EGGERS, Mitchell D. , IBARRA, Rafael , SADLER, John , WONG, David , JAFFE, Syrus M. , SAGHBINI, Michael , HOGAN, Michael
发明人： DAVIS, James C. , EGGERS, Mitchell D. , IBARRA, Rafael , SADLER, John , WONG, David , JAFFE, Syrus M. , SAGHBINI, Michael , HOGAN, Michael
CPC分类号： C12Q1/6813 , C12Q2565/514 , C12Q2563/185
摘要： The invention provides coding compositions comprising mixtures of coding oligonucleotides and methods of using such compositions to code samples. The compositions and methods are useful for identifying, verifying, or authenticating any type of sample, whether the sample is biological or non-biological.
摘要翻译：本发明提供包含编码寡核苷酸的混合物的编码组合物和使用这些组合物编码样品的方法。组合物和方法可用于鉴定，验证或认证任何类型的样品，无论样品是生物还是非生物样品。

17. 发明申请

WO2010108077A3 CONTROLLED RELEASE PARTICULATES CONTAINING WATER-INSOLUBLE DRUG 审中-公开
公开(公告)号：WO2010108077A3
公开(公告)日：2010-09-23
申请号：PCT/US2010/027935
申请日：2010-03-19
申请人： BIOKEY, INC. , WONG, David , CHENG, Xiufang , CHOW, San-Laung
发明人： WONG, David , CHENG, Xiufang , CHOW, San-Laung
IPC分类号： A61K9/22 , A61K9/20 , A61K47/30 , A61K31/05
摘要： A pharmaceutical composition. The composition has a plurality of controlled release particulates. Each particulate includes a coating layer and a core partially coated with the coating layer, in which the core contains a water-insoluble drug 5-80 wt.% and a first polymer 0.2-80 wt.% and the coating layer contains the water-insoluble drug 0-50 wt.% and a second polymer 0.2-50 wt.%. Each of the first and second polymers, independently, is a water-insoluble polymer, an enteric polymer, or a combination thereof. A method of making the composition is also disclosed herein.

18. 发明申请

WO2007117314A2 METHODS AND FORMULATIONS FOR MAKING CONTROLLED RELEASE ORAL DOSAGE FORM 审中-公开
标题翻译：制备控制释放口服剂型的方法和制剂
公开(公告)号：WO2007117314A2
公开(公告)日：2007-10-18
申请号：PCT/US2006/061625
申请日：2006-12-05
申请人： BIOKEY, INC. , CHOW, San-laung , WONG, David , GARCIA, Damian
发明人： CHOW, San-laung , WONG, David , GARCIA, Damian
IPC分类号： A61K9/24
CPC分类号： A61K9/2886 , A61K9/284 , A61K9/2846
摘要： Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating antidepressant or smoking cessation. In one aspect, the invention provides a pharmaceutical formulation comprising a core, including bupropion and its salt derivatives, and a coating. The coating may include one or more surfactants and aqueous dispersions of one or more insoluble pharmaceutical acceptable polymers. The core may also include aqueous dispersions of one or more insoluble pharmaceutical acceptable polymers. In another aspect, the invention provides methods for preparing and administering a pharmaceutical composition in oral dosage form, such as a tablet.
摘要翻译：本发明的实施方案通常提供药物组合物，制备口服药物组合物的方法，例如延长释放剂量组合物，以及治疗抗抑郁药或戒烟的方法。一方面，本发明提供了包含核心的药物制剂，包括安非他酮及其盐衍生物和涂层。涂层可以包括一种或多种不溶性药学上可接受的聚合物的表面活性剂和水分散体。核心还可以包括一种或多种不溶性药学上可接受的聚合物的水分散体。另一方面，本发明提供了制备和施用口服剂型（例如片剂）的药物组合物的方法。

19. 发明申请

WO2003000177A3 STABLE CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS CONTAINING PRAVASTATIN 审中-公开
公开(公告)号：WO2003000177A3
公开(公告)日：2003-01-03
申请号：PCT/US2002/017589
申请日：2002-06-05
申请人： ANDRX PHARMACEUTICALS, INC. , LI, Boyong , DELY, Aaron , WONG, David
发明人： LI, Boyong , DELY, Aaron , WONG, David
IPC分类号： A61K9/16
摘要： Stabilized sustained release pharmaceutical preparations containing a drug which is sensitive to a low pH environment, such as pravastatin are disclosed in which pravastatin degradation is prevented with a buffering agent. The basic excipient enhances storage stability.

20. 发明申请

WO2021237057A1 SARS-COV-2 (COVID-19) ANTIBODY TEST ON SALIVA AND BLOOD USING EFIRM TECHNOLOGY 审中-公开
公开(公告)号：WO2021237057A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/033601
申请日：2021-05-21
申请人： WONG, David , STROM, Charles
发明人： WONG, David , STROM, Charles
IPC分类号： G01N27/28 , G01N27/30 , G01N33/569 , G01N33/53
摘要： A liquid biopsy system and method for the detection of SARS-CoV-2 antibodies in bodily fluids is described. In particular, the system is suitable for detecting SARS-CoV-2 antibodies in a saliva sample of a subject.

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