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11. 发明专利

EA028968B1 ГЕТЕРОЦИКЛИЧЕСКИЕ АЦЕТАМИДНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРА D1 ДОФАМИНА (D1 PAM) 未知
公开(公告)号：EA028968B1
公开(公告)日：2018-01-31
申请号：EA201591988
申请日：2014-04-18
申请人： ASTELLAS PHARMA INC
发明人： SHIRAKI RYOTA , TOBE TAKAHIKO , KAWAKAMI SHIMPEI , MORITOMO HIROYUKI , OHMIYA MAKOTO
IPC分类号： C07D413/12 , A61K31/423 , A61K31/428 , A61K31/498 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/36 , C07D403/12 , C07D417/12
摘要： Гетероциклическиеацетамидныесоединениясогласнонастоящемуизобретениюобладаютположительнойаллостерическоймодулирующейактивностьюпоотношениюк рецептору D1 дофаминаи могутбытьиспользованыв качествеагентадляпредупрежденияи/илилечениякогнитивногоухудшения, негативныхсимптомовшизофрении, болезниПаркинсона, болезниАльцгеймера, болезниХантингтона, зависимостиотлекарственныхсредствилит.п.

12. 发明专利

SG11201508448RA HETEROCYCLIC ACETAMIDE COMPOUND 未知
公开(公告)号：SG11201508448RA
公开(公告)日：2015-11-27
申请号：SG11201508448R
申请日：2014-04-18
申请人： ASTELLAS PHARMA INC
发明人： SHIRAKI RYOTA , TOBE TAKAHIKO , KAWAKAMI SHIMPEI , MORITOMO HIROYUKI , OHMIYA MAKOTO
IPC分类号： C07D413/12 , A61K31/423 , A61K31/428 , A61K31/498 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/36 , C07D403/12 , C07D417/12
摘要： [Problem] A compound which is useful as a dopamine D1 receptor positive allosteric modulator (D1 PAM) is provided. [Means for Solution] The present inventors have studied a compound which has a dopamine D1 receptor positive allosteric modulating activity and is useful as an active ingredient of a pharmaceutical composition for preventing and/or treating cognitive impairment, negative symptoms of schizophrenia, Parkinson's disease, Alzheimer's disease, Huntington's disease, drug addictions, or the like, and they have thus found that a heterocyclic acetamide compound has a dopamine D1 receptor positive allosteric modulating activity, thereby completing the present invention. The heterocyclic acetamide compound of the present invention has a dopamine D1 receptor positive allosteric modulating activity and can be used as an agent for preventing and/or treating cognitive impairment, negative symptoms of schizophrenia, Parkinson's disease, Alzheimer's disease, Huntington's disease, drug addictions, or the like.

13. 发明专利

CA2706171C FUSED INDANE COMPOUND 未知
公开(公告)号：CA2706171C
公开(公告)日：2013-10-08
申请号：CA2706171
申请日：2008-11-26
申请人： ASTELLAS PHARMA INC
发明人： HAYASHIBE SATOSHI , YAMASAKI SHINGO , SHIRAISHI NOBUYUKI , HOSHII HIROAKI , TOBE TAKAHIKO
IPC分类号： C07D221/16 , A61K31/403 , A61K31/435 , A61K31/438 , A61K31/538 , A61K31/55 , A61P25/00 , C07D209/70 , C07D223/32 , C07D265/34 , C07D491/048 , C07D495/04
摘要： [Problems] To provide a compound which is useful as an NMDA receptor antagonist. [Means for solution] The present inventors have studied a compound having an NMDA receptor antagonistic action, and confirmed that the fused indane compound of the present invention has an excellent NMDA receptor antagonistic action, thereby completed the present invention. The fused indane compound of the present invention has an excellent NMDA receptor antagonistic action and can be used as a prophylactic and/or therapeutic agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, intractable depression, attention deficit hyperactivity disorder, migraines, or the like. [Selected Figure] None

14. 发明专利

DK2221296T3 KONDENSEREDE INDANFORBINDELSER 未知
公开(公告)号：DK2221296T3
公开(公告)日：2012-09-24
申请号：DK08853617
申请日：2008-11-26
申请人： ASTELLAS PHARMA INC
发明人： HAYASHIBE SATOSHI , YAMASAKI SHINGO , SHIRAISHI NOBUYUKI , HOSHII HIROAKI , TOBE TAKAHIKO
IPC分类号： C07D209/94 , A61K31/403 , A61K31/435 , A61K31/4365 , A61K31/538 , A61K31/55 , A61P9/10 , A61P25/04 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/36 , A61P43/00 , C07D221/16 , C07D223/32 , C07D265/34 , C07D491/048 , C07D495/04

15. 发明专利

ZA201003112B FUSED INDANE COMPOUND 未知
公开(公告)号：ZA201003112B
公开(公告)日：2011-07-27
申请号：ZA201003112
申请日：2010-05-04
申请人： ASTELLAS PHARMA INC
发明人： HOSHII HIROAKI , YAMASAKI SHINGO , SHIRAISHI NOBUYUKI , TOBE TAKAHIKO , HAYASHIBE SATOSHI
摘要： [Problems] To provide a compound which is useful as an NMDA receptor antagonist. [Means for solution] The present inventors have studied a compound having an NMDA receptor antagonistic action, and confirmed that the fused indane compound of the present invention has an excellent NMDA receptor antagonistic action, thereby completed the present invention. The fused indane compound of the present invention has an excellent NMDA receptor antagonistic action and can be used as a prophylactic and/or therapeutic agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, intractable depression, attention deficit hyperactivity disorder, migraines, or the like.

16. 发明专利

CA2580980C CYCLIC AMINE DERIVATIVE OR SALT THEREOF 未知
公开(公告)号：CA2580980C
公开(公告)日：2011-05-03
申请号：CA2580980
申请日：2005-09-20
申请人： ASTELLAS PHARMA INC
发明人： HAYASHIBE SATOSHI , KANAYAMA TAKATOSHI , OHMORI JUNYA , TOBE TAKAHIKO , MAENO KYOICHI , SHITAKA YOSHITSUGU , SUZUKI JOTAROU , KAWABATA SHIGEKI , SHIRAISHI NOBUYUKI , YAMASAKI SHINGO , SUZUKI DAISUKE , HOSHII HIROAKI
IPC分类号： C07C217/54
摘要： Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its salt characterized in that the amine-containing structure A therein bonds to a 2- or 3-cyclic condensed ring (e.g., indane, tetralone,4,5,6,7--tetrahydrobenzothiophene, 4,5,6,7-tetrahydrobenzofuran, 7,8-dihydro-6H-indeno[4,5--b]furan,2,3-dihydro-1H-cyclopenta[1]naphthalene) via X1(bond or lower alkylene); and an NMDA antagonist containing it as an active ingredient thereof.

17. 发明专利

NO20072036A 未知
公开(公告)号：NO20072036A
公开(公告)日：2007-05-23
申请号：NO20072036
申请日：2007-04-20
申请人： ASTELLAS PHARMA INC
发明人： HAYASHIBE SATOSHI , KANAYAMA TAKATOSHI , OHMORI JUNYA , TOBE TAKAHIKO , MAENO KYOICHI , SHITAKA YOSHITSUGU , SUZUKI JOTAROU , KAWABATA SHIGEKI , SHIRAISHI NOBUYUKI , YAMASAKI SHINGO , SUZUKI DAISUKE , HOSHII HIROAKI
IPC分类号： C07D211/04
CPC分类号： C07C217/74 , C07C215/42 , C07C2601/08 , C07D211/22 , C07D295/088 , C07D307/94 , C07D319/14 , C07D401/06 , C07D405/04 , C07D409/04 , C07D409/10 , C07D413/04 , C07D453/02

18. 发明专利

MX2007003337A DERIVADO DE AMINA CICLICA O SAL DEL MISMO. 未知
公开(公告)号：MX2007003337A
公开(公告)日：2007-05-21
申请号：MX2007003337
申请日：2005-09-20
申请人： ASTELLAS PHARMA INC
发明人： OHMORI JUNYA , KANAYAMA TAKATOSHI , HAYASHIBE SATOSHI , TOBE TAKAHIKO , MAENO KYOICHI , SHITAKA YOSHITSUGU , SUZUKI JOTAROU , KAWABATA SHIGEKI , SHIRAISHI NOBUYUKI , YAMASAKI SHINGO , HOSHII HIROAKI , SUZUKI DAISUKE
IPC分类号： C07C217/54
摘要： Un compuesto util como un antagonista de NMDA teniendo una amplia region de seguridad que es un agente terapeutico para enfermedad de Alzheimer, demencia vascular (agnosis vascular), enfermedad de Parkinson, apoplejia isquemica, y dolores o un agente de prevencion para estos. El compuesto es un derivado de amina o sal del mismos carcterizado por comprender una estructura que contiene amina (A) y un amplio fusionado di-o triciclico (indano, tetralona, 4,5,6,7-tetrahidrobenzotiofeno, 4,5,,6,7- tetrahidrobenzofuran, 7,8-dihidro6H-indeno [4,5-b]furan, 2,3-dihidro1h-ciclopenta [a]naftaleno, etc) unido a la estructura (A) a traves de X1 (un enlace, alquileno inferior, etc). El antagonista de NMDA contiene el derivado o sal como un ingrediente activo.

19. 发明专利

CY1119754T1 ΕΤΕΡΟΚΥΚΛΙΚΗ ΕΝΩΣΗ ΑΜΙΔΙΟΥ ΟΞΙΚΟΥ ΟΞΕΟΣ 未知
公开(公告)号：CY1119754T1
公开(公告)日：2018-06-27
申请号：CY171101288
申请日：2017-12-06
申请人： ASTELLAS PHARMA INC
发明人： SHIRAKI RYOTA , TOBE TAKAHIKO , KAWAKAMI SHIMPEI , MORITOMO HIROYUKI , OHMIYA MAKOTO
IPC分类号： C07D413/12 , A61K31/423 , A61K31/428 , A61K31/498 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/36 , C07D403/12 , C07D417/12
摘要： [Πρόβλημα] ΘαπαρασχεθείμιαένωσητουΧημικούΤύπου (I) πουναείναιχρήσιμηωςέναςθετικόςαλλοστερικόςδιαμορφωτήςυποδοχέαδοπαμίνης D1 (D1 ΡΑΜ). [Λύση] Οιεφευρέτεςμελέτησανμιαένωσηπουέχειμίαδράσηθετικήςαλλοστερικήςδιαμόρφωσηςυποδοχέαδοπαμίνης D1 καιπουείναιχρήσιμηωςέναενεργόσυστατικόμίγματοςγιαμιαφαρμακευτικήσύνθεσηγιαπρόληψηκαι/ήαγωγήγνωσιακήςδυσλειτουργίας, αρνητικώνσυμπτωμάτωνσχιζοφρένειας, νόσοτουΠάρκινσον, νόσοτουΑλτσχάϊμερ, νόσοτουΧάντινγκτον, εξάρτησηςφαρμάκωνκλπ, έχουνεπιβεβαιώσειότιμίαετεροκυκλικήένωσηαμιδίουοξικούοξέοςέχειμιαδράσηθετικήςαλλοστερικήςδιαμόρφωσηςυποδοχέαδοπαμίνης D1, καιέχουνσυμπληρώσειτηνπαρούσαεφεύρεση. Αυτήη ετεροκυκλικήένωσηαμιδίουοξικούοξέοςέχειμιαδράσηθετικήςαλλοστερικήςδιαμόρφωσηςυποδοχέαδοπαμίνης D1 καιμπορείναχρησιμοποιηθείωςέναςπροληπτικόςκαι/ήθεραπευτικόςπαράγωνγιαγνωσιακήδυσλειτουργία, αρνητικάσυμπτώματασχιζοφρένειας, νόσοτουΠάρκινσον, νόσοτουΑλτσχάϊμερ, νόσοτουΧάντινγκτον, εξάρτησηςφαρμάκων, κλπ.

20. 发明专利

RS56865B1 HETEROCIKLIČNO AMIDNO JEDINJENJE SIRĆETNE KISELINE 未知
公开(公告)号：RS56865B1
公开(公告)日：2018-04-30
申请号：RSP20171324
申请日：2014-04-18
申请人： ASTELLAS PHARMA INC
发明人： SHIRAKI RYOTA , TOBE TAKAHIKO , KAWAKAMI SHIMPEI , MORITOMO HIROYUKI , OHMIYA MAKOTO
IPC分类号： C07D413/12 , A61K31/423 , A61K31/428 , A61K31/498 , A61P25/14 , A61P25/16 , A61P25/28 , A61P25/36 , C07D403/12 , C07D417/12

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