专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明专利

ZA201006694B MODULATORS OF THE PROSTACYCLIN (PG12) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 未知
公开(公告)号：ZA201006694B
公开(公告)日：2012-03-28
申请号：ZA201006694
申请日：2010-09-17
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , CHEN WEICHAO , KRAMER BRYAN A , SADEQUE ABU JM , SHYFRYNA HANNA L , SHIN YOUNG-JUN , VALLAR PUREZA , ZOU NING
IPC分类号： A61P20060101 , A61K20060101 , C07C20060101
摘要： The present invention relates to amide derivatives of Formula (Xllla) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor.Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).

12. 发明专利

CY1115776T1 ΤΡΟΠΟΠΟΙΗΤΕΣ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΠΡΟΣΤΑΚΥΚΛΙΝΗ (PG12) ΧΡΗΣΙΜΟΙ ΓΙΑ ΤΗ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΔΙΑΤΑΡΑΧΩΝ ΠΟΥ ΣΧΕΤΙΖΟΝΤΑΙ ΜΕ ΑΥΤΟΝ 未知
公开(公告)号：CY1115776T1
公开(公告)日：2017-01-25
申请号：CY141100986
申请日：2014-11-26
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , CHEN WEICHAO , KRAMER BRYAN A , SADEQUE ABU JM , SHYFRYNA HANNA L , SHIN YOUNG-JUN , VALLAR PUREZA , ZOU NING
IPC分类号： A61K31/17 , A61K31/27 , A61P43/00 , C07C271/08 , C07C275/18
摘要： ΗπαρούσαεφεύρεσηαναφέρεταισεπαράγωγααμιδίουτουΤύπου (XIIIa) καισεφαρμακευτικέςσυνθέσειςαυτώνπουτροποποιούντηδραστικότητατουυποδοχέα PG12. Οιενώσειςτηςπαρούσαςεφεύρεσηςκαιφαρμακευτικέςσυνθέσειςαυτώνστρέφονταισεμεθόδουςχρήσιμεςστηθεραπευτικήαγωγή: πνευμονικήςαρτηριακήςυπέρτασης (ΡΑΗ)· ιδιοπαθούςΡΑΗ· οικογενούςΡΑΗ· ΡΑΗσυνδεόμενηςμεμιααγγειακήνόσοτουκολλαγόνου, μιασυγγενήκαρδιοπάθεια, πυλαίαυπέρταση, μόλυνσηαπό HIV, λήψηενόςφαρμάκουή τοξίνης, κληρονομικήαιμορραγικήτηλαγγειεκτασία, σπληνεκτομή, πνευμονικήφλεβο-αποφρακτικήνόσο (PVOD) ήπνευμονικήτριχοειδικήαιμαγγειωμάτωση (PCH)- ΡΑΗμεσημαντικήφλεβικήή τριχοειδικήσυμμετοχή· συσσώρευσηςαιμοπεταλίων· πάθησηςστεφανιαίαςαρτηρίας· εμφράγματοςτουμυοκαρδίου· παροδικήςισχαιμικήςπροσβολής· στηθάγχης· αποπληξίας· βλάβηςισχαιμίας-επαναιμάτωσης· επαναστένωσης· κολπικήςμαρμαρυγής· σχηματισμούθρόμβουαίματοςσεέναάτομουποβληθένσεαγγειοπλαστικήή χειρουργικήπαράκαμψηςτωνστεφανιαίωναγγείωνή σεέναάτομοπουπάσχειαπόκολπικήμαρμαρυγή· αρτηριοσκλήρυνσης· αθηροθρόμβωσης· άσθματοςή ενόςσυμπτώματοςαυτού· μιαςσχετιζόμενηςμεδιαβήτηδιαταραχήςόπωςδιαβητικήπεριφερικήνευροπάθεια, διαβητικήνεφροπάθειαή διαβητικήαμφιβληστροειδοπάθεια· γλαυκώματοςή άλληςπάθησηςτουοφθαλμούμεμηφυσιολογικήενδοφθάλμιαπίεση· υπέρτασης· φλεγμονής· ψωρίασης· ψωριασικήςαρθρίτιδας· ρευματοειδούςαρθρίτιδας· νόσουτου Crohn-απόρριψηςμοσχεύματος- πολλαπλήςσκλήρυνσης· συστημικούερυθηματώδουςλύκου (SLE)- ελκωτικήςκολίτιδας- βλάβηςισχαιμίας-επαναιμάτωσης- επαναστένωσης- αρτηριοσκλήρυνσης· ακμής· διαβήτητύπουΙ· διαβήτητύπου 2· σήψης· και

13. 发明专利

AU2011305525B2 Modulators of the GPR119 receptor and the treatment of disorders related thereto 未知
公开(公告)号：AU2011305525B2
公开(公告)日：2016-08-18
申请号：AU2011305525
申请日：2011-09-21
申请人： ARENA PHARM INC
发明人： JONES ROBERT M , LEHMANN JUERG , CHEN WEICHAO , EDWARDS JEFFREY , MARQUEZ GLEN , MORGAN MICHAEL E , SADEQUE ABU J M , KIM SUN HEE
IPC分类号： C07D413/14 , A61K31/506 , A61P3/00
摘要： The present invention relates to the GPR119 receptor agonists:3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-

14. 发明专利

HRP20141209T2 MODULATORI RECEPTORA PROSTACIKLINA (PGI2) KORISNI ZA LIJEČENJE POREMEĆAJA POVEZANIH S TIME 未知
公开(公告)号：HRP20141209T2
公开(公告)日：2016-05-06
申请号：HRP20141209
申请日：2014-12-15
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , CHEN WEICHAO , KRAMER BRYAN A , SADEQUE ABU J M , SHYFRYNA HANNA L , SHIN YOUNG-JUN , VALLAR PUREZA , ZOU NING
IPC分类号： A61K31/17 , A61K31/27 , A61P43/00 , C07C271/08 , C07C275/18

15. 发明专利

HK1204278A1 MODULATORS OF THE PROSTACYCLIN (PG12) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO (PGI2) PGI2 未知
公开(公告)号：HK1204278A1
公开(公告)日：2015-11-13
申请号：HK15104855
申请日：2015-05-21
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , CHEN WEICHAO , KRAMER BRYAN A A , SADEQUE ABU J M J M , SHIFRINA HANNA L L , SHIN YOUNG JUN , VALLAR PUREZA , ZOU NING
IPC分类号： A61P20060101 , A61K20060101 , C07C20060101
摘要： The present invention relates to amide derivatives of Formula (Xllla) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor.Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).

16. 发明专利

RS53684B1 MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 未知
公开(公告)号：RS53684B1
公开(公告)日：2015-04-30
申请号：RSP20140679
申请日：2009-03-17
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , CHEN WEICHAO , KRAMER BRYAN A , SADEQUE ABU J M , SHYFRYNA HANNA L , SHIN YOUNG-JUN , VALLAR PUREZA , ZOU NING
IPC分类号： A61K31/17 , A61K31/27 , A61P43/00 , C07C271/08 , C07C275/18
摘要： The present invention relates to amide derivatives of Formula (Xllla) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor.Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).

17. 发明专利

CR20130145A MODULADORES DEL RECEPTOR GPR119 Y EL TRATAMIETO DE TRASTORNOS RELACIONADOS CON ESTE 未知
公开(公告)号：CR20130145A
公开(公告)日：2013-07-09
申请号：CR20130145
申请日：2013-03-22
申请人： ARENA PHARM INC
发明人： JONES ROBERT M , LEHMANN JUERG , CHEN WEICHAO , EDWARDS JEFFREY , MARQUEZ GLEN , MORGAN MICHAEL E , SADEQUE ABU J M , KIM SUN HEE
IPC分类号： C07D413/14 , A61K31/506 , A61P3/00
摘要： La presente invención se refiere a los agonistas del receptor 5 GPR119:3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-il)-1,2,4-oxadiazol-5-il)piperidin-1- il)pirimidin-4-ilamino)-N,N-dimetilbenzamida; 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-il)-1,2,4-oxadiazol-5- il)piperidin-1-il)pirimidin-4-ilamino)-N-metilbenzamida; y10 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-il)-1,2,4-oxadiazol-5-il)piperidin-1-il)pirimidin-4- ilamino)benzamida, y a sales, solvatos e hidratos farmacéuticamente aceptables de estos

18. 发明专利

AU2011305525A8 Modulators of the GPR119 receptor and the treatment of disorders related thereto 未知
公开(公告)号：AU2011305525A8
公开(公告)日：2013-05-23
申请号：AU2011305525
申请日：2011-09-21
申请人： ARENA PHARM INC
发明人： JONES ROBERT M , LEHMANN JUERG , CHEN WEICHAO , EDWARDS JEFFREY , MARQUEZ GLEN , MORGAN MICHAEL E , SADEQUE ABU J M , KIM SUN HEE
IPC分类号： C07D413/14 , A61K31/506 , A61P3/00
摘要： The present invention relates to the GPR119 receptor agonists:3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-

19. 发明专利

AU2011305525A1 Modulators of the GPR119 receptor and the treatment of disorders related thereto 未知
公开(公告)号：AU2011305525A1
公开(公告)日：2013-05-09
申请号：AU2011305525
申请日：2011-09-21
申请人： ARENA PHARM INC
发明人： JONES ROBERT M , LEHMANN JUERG , CHEN WEICHAO , EDWARDS JEFFREY , MARQUEZ GLEN , MORGAN MICHAEL E , SADEQUE ABU J M
IPC分类号： C07D413/14 , A61K31/506 , A61P3/00
摘要： The present invention relates to the GPR119 receptor agonists:3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)-

20. 发明专利

NZ587693A Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto 未知
公开(公告)号：NZ587693A
公开(公告)日：2012-07-27
申请号：NZ58769309
申请日：2009-03-17
申请人： ARENA PHARM INC
发明人： TRAN THUY-ANH , CHEN WEICHAO , KRAMER BRYAN A , SADEQUE ABU J
IPC分类号： A61K31/17 , A61K31/27 , A61P43/00 , C07C271/08 , C07C275/18
摘要： The disclosure relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. These compounds are useful in the treatment of: pulmonary arterial hypertension (PAH); idiopathic PAH; familial PAH; PAH associated with a collagen vascular disease, a congenital heart disease, portal hypertension, HIV infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH); PAH with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式