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11. 发明专利

BR9812727A 未知
公开(公告)号：BR9812727A
公开(公告)日：2000-08-22
申请号：BR9812727
申请日：1998-04-14
申请人： AMERICAN CYANAMID CO
发明人： LEVIN JEREMY IAN , ZASK ARIE , GU YANSONG , ALBRIGHT JAY DONALD , DU XUEMEI
IPC分类号： A61K31/437 , A61K31/4375 , A61K31/4427 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/519 , A61K31/63 , A61K31/635 , A61K31/66 , A61P1/00 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/04 , A61P43/00 , C07D213/00 , C07D215/54 , C07D231/00 , C07D233/00 , C07D239/00 , C07D261/00 , C07D275/00 , C07D333/00 , C07D401/12 , C07D409/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07F9/547 , A61K31/44
摘要： This invention provides, low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF- alpha converting enzyme (TACE, tumor necrosis factor- alpha converting enzyme) of formula (B) wherein (B) is (1), (2), or (3); P and Q are (4) or (5), provided that when P is (4), Q is (5), and vice versa; T, U, W, and X are each, independently, carbon or nitrogen, provided that when T or U is carbon, either may be optionally substituted with R ; Y is carbon, nitrogen, oxygen or sulfur, provided that at least one of T, U, W, X, and Y is not carbon, and further provided that no more than 2 of T, U, W, and X are nitrogen; (6) is a phenyl ring or is a heteroaryl ring of ring 5-6 atoms which may contain 0-2 heteroatoms selected from nitrogen, oxygen, and sulfur, in addition to any heteroatoms defined by W or X; wherein the phenyl or heteroaryl ring may be optionally mono-, di-, or tri- substituted with R ; Z is a phenyl, naphthyl, heteroaryl, or heteroaryl fused to phenyl, wherein the heteroaryl moiety contains of 5-6 ring atoms and 1-3 heteroatoms selected from nitrogen, oxygen, or sulfur; wherein the phenyl, naphthyl, heteroaryl, or phenyl fused heteroaryl moieties may be optionally mono-, di-, or tri-substituted with R ; R is hydrogen, halogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cyclocalkyl of 3-6 carbon atoms, -(CH2)nZ, -OR , -CN, -COR , perfluoroalkyl of 1-4 carbon atoms, -CONR R , -S(O)xR -OPO(OR )OR , -PO(OR )R , -OC(O)NR R3, -COOR , -CONR R , -SO3H, -NR R , -NR COR , -NR COOR , -SO2NR R , -NR CONR R , -NR C(=NR )NR R , -SO2NHCOR , -CONHSO2R , -tetrazol-5-yl, -SO2NHCN, -SO2NHCONR R , or Z; V is a saturated or partially unsaturated heterocycloalkyl ring of 5-7 ring atoms having 1-3 heteroatoms selected from N, O, or S, which may be optionally mono-, or di-substituted with R ; R and R are each, independently, hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms; perfluoroalkyl of 1-4 carbon atoms, Z or V; R is alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, cycloalkyl of 3-6 carbon atoms; perfluoroalkyl of 1-4 carbon atoms, Z or V; R is hydrogen, alkyl of 1-8 carbon atoms, alkenyl of 2-6 carbon atoms, alkynyl of 2-6 carbon atoms, Z, or V; n = 1-6; x = 0-2 or a pharmaceutically acceptable salt thereof.

12. 发明专利

AU1941300A Tricyclic benzazepine vasopressin antagonists 未知
公开(公告)号：AU1941300A
公开(公告)日：2000-06-01
申请号：AU1941300
申请日：2000-02-23
申请人： AMERICAN CYANAMID CO
发明人： ALBRIGHT JAY DONALD , SANTOS EFREN GUILLERMO DELOS , DU XUEMEI , REICH MARVIN FRED , VENKATESAN ARANAPAKAM
IPC分类号： A61K31/4162 , C07D471/14 , C07D495/14

13. 发明专利

HU9702219A2 6-[4-(ACYLAMINO)BENZOYL]-PYRAZOLO[3,4-D]THIENO[3,2-B]AZEPINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：HU9702219A2
公开(公告)日：1998-07-28
申请号：HU9702219
申请日：1996-01-16
申请人： AMERICAN CYANAMID CO
发明人： ALBRIGHT JAY DONALD , DELOS SANTOS EFREN GUILLERMO , DU XUEMEI , REICH MARVIN FRED , VENKATESAN ARANAPAKAM MUDUMBAI
IPC分类号： A61K31/55 , A61P1/16 , A61P7/10 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , C07D471/14 , C07D491/147 , C07D495/14 , C07D498/14
摘要： Tricyclic compound of the general Formula I: I as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.

14. 发明专利

CZ224897A3 TRICYCLIC DIAZEPINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF 未知
公开(公告)号：CZ224897A3
公开(公告)日：1998-04-15
申请号：CZ224897
申请日：1996-01-16
申请人： AMERICAN CYANAMID CO
发明人： ALBRIGHT JAY DONALD , DELOS SANTOS EFREN GUILLERMO , DU XUEMEI , REICH MARVIN FRED , VENKATESAN ARANAPAKAM MUDUMBAI
IPC分类号： A61K31/55 , A61P1/16 , A61P7/10 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , C07D471/14 , C07D491/147 , C07D495/14 , C07D498/14
摘要： Tricyclic compound of the general Formula I: I as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.

15. 发明专利

ZA9600299B Tricyclic benzazepine vasopressin antagonists 未知
公开(公告)号：ZA9600299B
公开(公告)日：1997-07-15
申请号：ZA9600299
申请日：1996-01-15
申请人： AMERICAN CYANAMID CO
发明人： ALBRIGHT JAY D , DU XUEMEI , VENKATESAN ARANAPAKAM M , DELOS SANTOS EFREN G , REICH MARVIN F
IPC分类号： A61K31/55 , A61P1/16 , A61P7/10 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , C07D471/14 , C07D491/147 , C07D495/14 , C07D498/14 , C07D , A61K , C07F
CPC分类号： C07D471/14 , C07D495/14

16. 发明专利

AU4775596A Tricyclic benzazepine vasopressin antagonists 未知
公开(公告)号：AU4775596A
公开(公告)日：1996-08-07
申请号：AU4775596
申请日：1996-01-16
申请人： AMERICAN CYANAMID CO
发明人： ALBRIGHT JAY DONALD , SANTOS EFREN GUILLERMO DELOS , DU XUEMEI , REICH MARVIN FRED , VENKATESAN ARANAPAKAM MUDUMBAI
IPC分类号： A61K31/55 , A61P1/16 , A61P7/10 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , C07D471/14 , C07D491/147 , C07D495/14 , C07D498/14
摘要： Tricyclic compound of the general Formula I: I as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.

17. 发明专利

ECSP941135A ANTAGONISTAS TRICICLICOS DE VASOPRESINA DE BENZACEPINA 未知
公开(公告)号：ECSP941135A
公开(公告)日：1995-02-27
申请号：ECSP941135
申请日：1994-07-27
申请人： AMERICAN CYANAMID CO
发明人： SUM FUK-WAH , DU XUEMEI , ALBRIGHT JAY DONALD , REICH MARVIN FRED
IPC分类号： A61K31/395 , A61K31/435 , A61K31/473 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P1/16 , A61P9/04 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P43/00 , C07D221/12 , C07D221/18 , C07D223/18 , C07D223/20 , C07D223/22 , C07D223/28 , C07D225/00 , C07D225/08 , C07D243/18 , C07D243/38 , C07D245/04 , C07D267/16 , C07D267/18 , C07D267/20 , C07D279/30 , C07D281/00 , C07D281/14 , C07D281/16 , C07D285/00 , C07D285/38 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： Compuestos tricíclicos no peptídicos de vasopresina, que tienen la fórmula general: que exhiben actividad antagonista en los receptores V1 y/o V2 y exhiben actividad antagonista de vasopresina in vivo, métodos para emplear dichos compuestos en el tratamiento de enfermedades caracterizadas por un exceso de reabsorción renal de agua, el procedimiento es para preparar dichos compuestos.

18. 发明专利

CA2128955A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS 未知
公开(公告)号：CA2128955A1
公开(公告)日：1995-01-30
申请号：CA2128955
申请日：1994-07-27
申请人： AMERICAN CYANAMID CO
发明人： ALBRIGHT JAY D , REICH MARVIN F , SUM FUK-WAH , DU XUEMEI
IPC分类号： A61K31/395 , A61K31/435 , A61K31/473 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P1/16 , A61P9/04 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P43/00 , C07D221/12 , C07D221/18 , C07D223/18 , C07D223/20 , C07D223/22 , C07D223/28 , C07D225/00 , C07D225/08 , C07D243/18 , C07D243/38 , C07D245/04 , C07D267/16 , C07D267/18 , C07D267/20 , C07D279/30 , C07D281/00 , C07D281/14 , C07D281/16 , C07D285/00 , C07D285/38 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： Title: TRICYCLIC BENZAPINE VASOPRESSIN ANTAGONISTS Tricyclic compounds of the general Formula I: F o r m u l a I as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.

19. 发明专利

FI111077B 未知
公开(公告)号：FI111077B
公开(公告)日：2003-05-30
申请号：FI20011100
申请日：2001-05-25
申请人： AMERICAN CYANAMID CO
发明人： ALBRIGHT JAY D , REICH MARVIN F , SUM FUK-WAH , DU XUEMEI
IPC分类号： A61K31/395 , A61K31/435 , A61K31/473 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P1/16 , A61P9/04 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P43/00 , C07D221/12 , C07D221/18 , C07D223/18 , C07D223/20 , C07D223/22 , C07D223/28 , C07D225/00 , C07D225/08 , C07D243/18 , C07D243/38 , C07D245/04 , C07D267/16 , C07D267/18 , C07D267/20 , C07D279/30 , C07D281/00 , C07D281/14 , C07D281/16 , C07D285/00 , C07D285/38 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： Tricyclic compounds of the general Formula I: as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.

20. 发明专利

FI108433B 未知
公开(公告)号：FI108433B
公开(公告)日：2002-01-31
申请号：FI943542
申请日：1994-07-28
申请人： AMERICAN CYANAMID CO
发明人： ALBRIGHT JAY D , REICH MARVIN F , SUM FUK-WAH , DU XUEMEI
IPC分类号： A61K31/395 , A61K31/435 , A61K31/473 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P1/16 , A61P9/04 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P43/00 , C07D221/12 , C07D221/18 , C07D223/18 , C07D223/20 , C07D223/22 , C07D223/28 , C07D225/00 , C07D225/08 , C07D243/18 , C07D243/38 , C07D245/04 , C07D267/16 , C07D267/18 , C07D267/20 , C07D279/30 , C07D281/00 , C07D281/14 , C07D281/16 , C07D285/00 , C07D285/38 , C07D401/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D493/04
摘要： Tricyclic compounds of the general Formula I: as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.

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