专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明专利

HU0002843A2 NEW BETHA-CARBOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：HU0002843A2
公开(公告)日：2001-04-28
申请号：HU0002843
申请日：2000-07-21
申请人： ADIR
发明人： BOUTIN JEAN , BRION JEAN-DANIEL , DEKEYNE ANNE , GOLDSTEIN SOLO , MILLAN MARK , PARMENTIER JEAN-GILES , POISSONNET GUILLAUME
IPC分类号： A61K31/437 , A61P1/00 , A61P15/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07B61/00 , C07D471/04
摘要： 1-( beta -Carbolin-1-yl)-cycloalkanecarboxylic acid derivatives (I) are new. beta -Carboline derivatives of formula (I), and their isomers and acid or base addition salts, are new. dotted lines = optional bonds; R1 = H, alkyl, -R6-Q, -COOR7, -COR8 or -CONHR8; or is absent if the N of NR1 carries an intracyclic double bond; R6 = 1-6C alkylene; Q = cycloalkyl, aryl or heterocyclyl; R7 = alkyl, Q or -R6-Q; R8 = H or as R7; R2 = CN, COOR8, CONHR8, mono- or dialkylaminoalkylaminocarbonyl, NR8R9, NHCOOR7 or COR6; R9 = as R8; R3 + R4 = group completing 3-10C cycloalkyl; R5 = H, alkyl or arylalkyl; Ra-Rd = H, halo, alkyl, OH, alkoxy, trihaloalkyl, trihaloalkoxy, NO2, CN, NH2, mono- or dialkylamino, aryl, arylalkyl, alkoxycarbonyl, 1-6C acyl, aryloxy or arylalkoxy; cycloalkyl moiety = 3-10C mono- or bicyclic, saturated or mono- or polyunsaturated (but not aromatic) group (optionally substituted by one or more of halo, OH, alkyl and alkoxy); aryl moiety = phenyl, naphthyl, tetrahydronaphthyl, dihydronaphthyl, indenyl or indanyl group (optionally substituted by one or more of halo, OH, CN, NO2, alkyl, alkoxy, NH2, mono- or dialkylamino, aryloxy, arylalkoxy, trihaloalkyl, 1-6C acyl, alkoxycarbonyl, alkylaminocarbonyl and oxo); heterocyclyl moiety = 5-12 membered mono- or bicyclic, saturated or unsaturated, aromatic or non-aromatic group containing 1-3 of N, O and S as heteroatom(s) (optionally substituted by one or more of halo, OH, alkyl, alkoxy, NO2, oxo, NH2, and mono- or dialkylamino); alkyl moieties have 1-6C. An Independent claim is included for the preparation of (I).

12. 发明专利

BR0003105A 未知
公开(公告)号：BR0003105A
公开(公告)日：2001-03-13
申请号：BR0003105
申请日：2000-07-24
申请人： ADIR
发明人： GOLDSTEIN SOLO , BOUTIN JEAN , POISSONNET GUILLAUME , PARMENTIER JEAN-GILLES , BRION JEAN-DANIEL , MILLAN MARK , DEKEYNE ANNE
IPC分类号： A61K31/437 , A61P1/00 , A61P15/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07B61/00 , C07D471/04 , A61K31/4375
摘要： 1-( beta -Carbolin-1-yl)-cycloalkanecarboxylic acid derivatives (I) are new. beta -Carboline derivatives of formula (I), and their isomers and acid or base addition salts, are new. dotted lines = optional bonds; R1 = H, alkyl, -R6-Q, -COOR7, -COR8 or -CONHR8; or is absent if the N of NR1 carries an intracyclic double bond; R6 = 1-6C alkylene; Q = cycloalkyl, aryl or heterocyclyl; R7 = alkyl, Q or -R6-Q; R8 = H or as R7; R2 = CN, COOR8, CONHR8, mono- or dialkylaminoalkylaminocarbonyl, NR8R9, NHCOOR7 or COR6; R9 = as R8; R3 + R4 = group completing 3-10C cycloalkyl; R5 = H, alkyl or arylalkyl; Ra-Rd = H, halo, alkyl, OH, alkoxy, trihaloalkyl, trihaloalkoxy, NO2, CN, NH2, mono- or dialkylamino, aryl, arylalkyl, alkoxycarbonyl, 1-6C acyl, aryloxy or arylalkoxy; cycloalkyl moiety = 3-10C mono- or bicyclic, saturated or mono- or polyunsaturated (but not aromatic) group (optionally substituted by one or more of halo, OH, alkyl and alkoxy); aryl moiety = phenyl, naphthyl, tetrahydronaphthyl, dihydronaphthyl, indenyl or indanyl group (optionally substituted by one or more of halo, OH, CN, NO2, alkyl, alkoxy, NH2, mono- or dialkylamino, aryloxy, arylalkoxy, trihaloalkyl, 1-6C acyl, alkoxycarbonyl, alkylaminocarbonyl and oxo); heterocyclyl moiety = 5-12 membered mono- or bicyclic, saturated or unsaturated, aromatic or non-aromatic group containing 1-3 of N, O and S as heteroatom(s) (optionally substituted by one or more of halo, OH, alkyl, alkoxy, NO2, oxo, NH2, and mono- or dialkylamino); alkyl moieties have 1-6C. An Independent claim is included for the preparation of (I).

13. 发明专利

NO20003764D0 未知
公开(公告)号：NO20003764D0
公开(公告)日：2000-07-21
申请号：NO20003764
申请日：2000-07-21
申请人： ADIR
发明人： GOLDSTEIN SOLO , POISSONNET GUILLAUME , PARMENTIER JEAN-GILLES , BRION JEAN-DANIEL , MILLAN MARK , DEKEYNE ANNE , BOUTIN JEAN
IPC分类号： A61K31/437 , A61P1/00 , A61P15/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07B61/00 , C07D471/04 , C07D
摘要： 1-( beta -Carbolin-1-yl)-cycloalkanecarboxylic acid derivatives (I) are new. beta -Carboline derivatives of formula (I), and their isomers and acid or base addition salts, are new. dotted lines = optional bonds; R1 = H, alkyl, -R6-Q, -COOR7, -COR8 or -CONHR8; or is absent if the N of NR1 carries an intracyclic double bond; R6 = 1-6C alkylene; Q = cycloalkyl, aryl or heterocyclyl; R7 = alkyl, Q or -R6-Q; R8 = H or as R7; R2 = CN, COOR8, CONHR8, mono- or dialkylaminoalkylaminocarbonyl, NR8R9, NHCOOR7 or COR6; R9 = as R8; R3 + R4 = group completing 3-10C cycloalkyl; R5 = H, alkyl or arylalkyl; Ra-Rd = H, halo, alkyl, OH, alkoxy, trihaloalkyl, trihaloalkoxy, NO2, CN, NH2, mono- or dialkylamino, aryl, arylalkyl, alkoxycarbonyl, 1-6C acyl, aryloxy or arylalkoxy; cycloalkyl moiety = 3-10C mono- or bicyclic, saturated or mono- or polyunsaturated (but not aromatic) group (optionally substituted by one or more of halo, OH, alkyl and alkoxy); aryl moiety = phenyl, naphthyl, tetrahydronaphthyl, dihydronaphthyl, indenyl or indanyl group (optionally substituted by one or more of halo, OH, CN, NO2, alkyl, alkoxy, NH2, mono- or dialkylamino, aryloxy, arylalkoxy, trihaloalkyl, 1-6C acyl, alkoxycarbonyl, alkylaminocarbonyl and oxo); heterocyclyl moiety = 5-12 membered mono- or bicyclic, saturated or unsaturated, aromatic or non-aromatic group containing 1-3 of N, O and S as heteroatom(s) (optionally substituted by one or more of halo, OH, alkyl, alkoxy, NO2, oxo, NH2, and mono- or dialkylamino); alkyl moieties have 1-6C. An Independent claim is included for the preparation of (I).

14. 发明专利

ZA9409973B Eburnane analogues a process for the preparation thereof and pharmaceutical compositions containing them 未知
公开(公告)号：ZA9409973B
公开(公告)日：1995-08-22
申请号：ZA9409973
申请日：1994-12-14
申请人： ADIR
发明人： BRION JEAN-DANIEL , THAL CLAUDE , DEMUYNCK LUC , PARMENTIER JEAN-GILLES , LEPAGNOL JEAN , LESTAGE PIERRE , PUJOL JEAN-FRANCOIS , SCHMITT PASCAL , POTIER PIERRE
IPC分类号： C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , A61K , C07D
CPC分类号： C07D461/00

15. 发明专利

IE64180B1 New triene derivatives having a chromene structure processes for preparing them and pharmaceutical compositions containing them 未知
公开(公告)号：IE64180B1
公开(公告)日：1995-07-12
申请号：IE116289
申请日：1989-04-12
申请人： ADIR
发明人： BRION JEAN-DANIEL , BAUT GUILLAUME LE , DUCREY PATRICK , PIESSARD-ROBERT SYLVIE , CUDENNEC CLAUDE , SEURRE GENEVIEVE
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58
摘要： Compounds of general formula (I): in which: R1, R2, R3 and R4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms, R5 denotes a carboxyl, (lower alkyloxy)carbonyl, (lower alkenyloxy)carbonyl or (lower alkynyloxy)-carbonyl, their isomers, stereoisomers and diastereoisomers, and also their addition salts with a pharmaceutically acceptable base. Medicinal products.

16. 发明专利

PT90261B 未知
公开(公告)号：PT90261B
公开(公告)日：1994-07-29
申请号：PT9026189
申请日：1989-04-12
申请人： ADIR
发明人： BRION JEAN-DANIEL , BAUT GUILLAUME LE , DUCREY PATRICK , PIESSARD-ROBERT SYLVIE , CUDENNEC CLAUDE , SEURRE GENEVIEVE
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58
摘要： Compounds of general formula (I): in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group, R1, R2, R3 and R4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms, their isomers, enantiomers, diastereoisomers and also, when R denotes a carboxyl, their addition salts with a pharmaceutically acceptable base and, when R contains a basic group, their addition salts with a pharmaceutically acceptable acid.

18. 发明专利

AU610379B2 BENZOPYRAN DERIVATIVES 未知
公开(公告)号：AU610379B2
公开(公告)日：1991-05-16
申请号：AU3265989
申请日：1989-04-12
申请人： ADIR
发明人： BRION JEAN-DANIEL , BAUT GUILLAUME LE , DUCREY PATRICK , PIESSARD-ROBERT SYLVIE , CUDENNEC CLAUDE , SEURRE GENEVIEVE
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58 , A61K31/38 , A61K31/40 , A61K31/445 , A61K31/475 , A61K31/44 , A61K31/505 , A61K31/535 , A61K31/54
摘要： Compounds of general formula (I): in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group, R1, R2, R3 and R4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms, their isomers, enantiomers, diastereoisomers and also, when R denotes a carboxyl, their addition salts with a pharmaceutically acceptable base and, when R contains a basic group, their addition salts with a pharmaceutically acceptable acid.

19. 发明专利

FR2630110B1 未知
公开(公告)号：FR2630110B1
公开(公告)日：1990-07-27
申请号：FR8804870
申请日：1988-04-13
申请人： ADIR
发明人： BRION JEAN-DANIEL , BAUT GUILLAUME LE , DUCREY PATRICK , PIESSARD-ROBERT SYLVIE , CUDENNEC CLAUDE , SEURRE GENEVIEVE
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58
摘要： Compounds of general formula (I): in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group, R1, R2, R3 and R4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms, their isomers, enantiomers, diastereoisomers and also, when R denotes a carboxyl, their addition salts with a pharmaceutically acceptable base and, when R contains a basic group, their addition salts with a pharmaceutically acceptable acid.

20. 发明专利

AU3265989A BENZOPYRAN DERIVATIVES 未知
公开(公告)号：AU3265989A
公开(公告)日：1989-12-21
申请号：AU3265989
申请日：1989-04-12
申请人： ADIR
发明人： BRION JEAN-DANIEL , PIESSARD-ROBERT SYLVIE , CUDENNEC CLAUDE , SEURRE GENEVIEVE , BAUT GUILLAUME LE , DUCREY PATRICK
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58 , A61K31/38 , A61K31/40 , A61K31/445 , A61K31/475 , A61K31/44 , A61K31/505 , A61K31/535 , A61K31/54
摘要： Compounds of general formula (I): in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group, R1, R2, R3 and R4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms, their isomers, enantiomers, diastereoisomers and also, when R denotes a carboxyl, their addition salts with a pharmaceutically acceptable base and, when R contains a basic group, their addition salts with a pharmaceutically acceptable acid.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式