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11. 发明申请

WO2012109158A3 AUTOMATIC CALIBRATION FOR DEVICE WITH CONTROLLED MOTION RANGE AND VARIABLE APERTURE COLLIMATOR 审中-公开
公开(公告)号：WO2012109158A3
公开(公告)日：2012-08-16
申请号：PCT/US2012/024016
申请日：2012-02-06
申请人： ACCURAY INCORPORATED , SAYEH, Sohail , ASMEROM, George , RAMRAJ, Sankaralingam , GAO, Jian , KUDUVALLI, Gopinath
发明人： SAYEH, Sohail , ASMEROM, George , RAMRAJ, Sankaralingam , GAO, Jian , KUDUVALLI, Gopinath
IPC分类号： G21K1/04 , G01D5/244 , G05B19/401 , A61N5/10
摘要： An apparatus includes a portion that moves along a guided path and a displacement gauge that outputs readings based on the portion's position on the guided path. The apparatus additionally includes an intermediate limit switch that is activated in response to the portion being moved to an intermediate position on the guided path. The apparatus also includes a processing device configured to calibrate the apparatus based on a first reading corresponding to a first position on the guided path and a second reading corresponding to a second position on the guided path. The processing device verifies the calibration based on a third reading corresponding to the intermediate position. The apparatus may be a variable aperture collimator.

12. 发明申请

WO2010039404A1 SUBTRACTION OF A SEGMENTED ANATOMICAL FEATURE FROM AN ACQUIRED IMAGE 审中-公开
标题翻译：从获取的图像中分离出分离的解剖特征
公开(公告)号：WO2010039404A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/056526
申请日：2009-09-10
申请人： ACCURAY INCORPORATED , FU, Dongshan , KUDUVALLI, Gopinath , ZHANG, Hui
发明人： FU, Dongshan , KUDUVALLI, Gopinath , ZHANG, Hui
IPC分类号： G06K9/18
CPC分类号： A61N5/1049 , A61N2005/1062 , G06T5/50 , G06T2207/20224
摘要： A system, method and apparatus for subtracting a synthetically- generated image, including a segmented anatomical feature, from an acquired image.
摘要翻译：一种用于从所获取的图像中减去合成生成的图像（包括分割的解剖特征）的系统，方法和装置。

13. 发明申请

WO2009091382A1 USE OF A SINGLE X-RAY IMAGE IN A STEREO IMAGING PAIR FOR QUALITY ASSURANCE OF TRACKING 审中-公开
标题翻译：在立体成像对中使用单个X射线图像用于追踪的质量保证
公开(公告)号：WO2009091382A1
公开(公告)日：2009-07-23
申请号：PCT/US2008/013644
申请日：2008-12-11
申请人： ACCURAY INCORPORATED , KUDUVALLI, Gopinath , FU, Dongshan , MAURER JR., Calvin, R., Jr.
发明人： KUDUVALLI, Gopinath , FU, Dongshan , MAURER JR., Calvin, R., Jr.
IPC分类号： G06K9/00
CPC分类号： G06T7/33 , A61B6/4014 , A61B6/4452 , A61B6/588 , A61N5/1049 , A61N5/1075 , A61N2005/1061 , G06T2207/10072 , G06T2207/10124 , G06T2207/30004
摘要： A method and system for aligning a volume of interest in a three- dimensional treatment coordinate system with a reference position using stereoscopic imaging data and for monitoring and correcting alignment of the volume of interest in the three-dimensional treatment coordinate system using monoscopic imaging data.
摘要翻译：一种用于使用立体成像数据将三维治疗坐标系中的感兴趣体积与参考位置对准并且用于监测和校正三维中感兴趣体积的对准的方法和系统治疗坐标系使用单像成像数据。

14. 发明申请

WO2008121276A1 DETERMINING AN OPTIMIZED PATH TRAVERSAL FOR RADIATION TREATMENT DELIVERY SYSTEM 审中-公开
标题翻译：确定用于辐射治疗传送系统的优化路径
公开(公告)号：WO2008121276A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/003896
申请日：2008-03-24
申请人： ACCURAY INCORPORATED , SAYEH, Sohail , KUDUVALLI, Gopinath , BROWN, Daniel
发明人： SAYEH, Sohail , KUDUVALLI, Gopinath , BROWN, Daniel
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61B5/055 , A61B6/032 , A61B6/4014 , A61B6/466 , A61B6/563 , A61B8/13 , A61B8/565
摘要： An apparatus and method for determining optimized path traversal in a radiation delivery system is described. In one embodiment, determining an optimized path traversal in a radiation delivery system involves providing a plurality of spatial nodes used in a treatment plan, where each of the plurality of spatial nodes represents a position of a radiation source made available to the treatment plan for delivering radiation to a target, identifying a number of unused spatial nodes, from among the plurality of spatial nodes, at which radiation is not delivered according to the treatment plan, and skipping travel to one or more of the unused nodes by the radiation source when administering the treatment plan. Other embodiments are also described.
摘要翻译：描述了用于确定辐射递送系统中的优化路径遍历的装置和方法。在一个实施例中，确定辐射递送系统中的优化的路径遍历包括提供在治疗计划中使用的多个空间节点，其中多个空间节点中的每一个代表可用于治疗计划的辐射源的位置，用于递送从多个空间节点中识别多个未使用空间节点的辐射，根据治疗计划不辐射辐射，并且当管理时由辐射源跳过到一个或多个未使用的节点治疗计划。还描述了其它实施例。

15. 发明申请

WO2007038062A2 WORKSPACE OPTIMIZATION FOR RADIATION TREATMENT DELIVERY SYSTEM 审中-公开
标题翻译：辐射处理交付系统的工作空间优化
公开(公告)号：WO2007038062A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/036373
申请日：2006-09-18
申请人： ACCURAY INCORPORATED , ALLISON, John , DOOLEY, John, R. , WEST, Jay, B. , KUDUVALLI, Gopinath , WANG, Jin-Wu, J. , KILBY, Warren , OLENDER, Derek , SARACEN, Michael
发明人： ALLISON, John , DOOLEY, John, R. , WEST, Jay, B. , KUDUVALLI, Gopinath , WANG, Jin-Wu, J. , KILBY, Warren , OLENDER, Derek , SARACEN, Michael
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1083
摘要： An apparatus and method for optimizing a workspace of a radiation treatment delivery system. An optimized treatment plan is generated for delivering a dose of radiation to a volume of interest (“VOI”) in a patient using fewer changes to a treatment plan parameter during delivery of the dose of radiation then available to a radiation treatment delivery system. The optimized treatment plan limits a number of adjustments to the treatment plan parameter during delivery of the dose of radiation. Prior to delivery, the optimized treatment plan is analyzed to determine whether a quality of the optimized treatment plan is acceptable.
摘要翻译：一种用于优化放射治疗递送系统的工作空间的装置和方法。产生优化的治疗计划，用于在辐射剂量的辐射剂量期间使用较少的治疗计划参数的变化，将辐射量提供给感兴趣体积（“VOI”），然后可用于辐射治疗递送系统。优化的治疗计划在辐射剂量的传递期间限制对治疗计划参数的一些调整。在交付之前，分析优化的治疗计划，以确定优化治疗计划的质量是否可以接受。

16. 发明申请

WO2007002927A2 IMAGING GEOMETRY 审中-公开
标题翻译：成像几何
公开(公告)号：WO2007002927A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/025794
申请日：2006-06-29
申请人： ACCURAY INCORPORATED , CARRANO, Aaron, W. , KUDUVALLI, Gopinath , SARACEN, Michael, J. , BODDULURI, Mohan
发明人： CARRANO, Aaron, W. , KUDUVALLI, Gopinath , SARACEN, Michael, J. , BODDULURI, Mohan
IPC分类号： A61B6/02 , G21K4/00 , G03C9/00
CPC分类号： A61B6/022 , A61B6/4458 , A61N5/1049 , A61N2005/1061
摘要： A system and method for stereoscopically imaging a patient at multiple locations in a radiation treatment system to enable the delivery of radiation treatments from multiple ranges of treatment angles without obstructing the imaging system or the radiation treatment.
摘要翻译：一种用于在放射治疗系统中的多个位置处对患者进行立体成像的系统和方法，以使得能够从多个治疗角度范围递送辐射治疗，而不会阻碍成像系统或放射治疗。

17. 发明申请

WO2006006966A2 DRR GENERATION USING A NON-LINEAR ATTENUATION MODEL 审中-公开
标题翻译：使用非线性衰减模型的DRR生成
公开(公告)号：WO2006006966A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/011200
申请日：2005-04-01
申请人： ACCURAY, INC. , FU, Dongshan , KUDUVALLI, Gopinath
发明人： FU, Dongshan , KUDUVALLI, Gopinath
IPC分类号： G06K9/00
CPC分类号： G06T11/008
摘要： A method and system are presented for generating a DRR of an anatomical region so that the visibility within the DRR of one or more skeletal reference structures is enhanced. 3D scan data, which have been obtained from a 3D scan of the object conducted at a 3D scan energy level, are provided. The 3D scan data are modified to compensated for a difference between the ratio of bone-to-tissue attenuation at the 3D scan energy level, and the ratio of bone-to-tissue attenuation at the intensity of the imaging beam which the DRR emulates. The modified 3D scan data are related to the raw 3D scan data by a non-linear, exponential relationship. A plurality of hypothetical rays are cast through the modified 3D scan data, from the known geometry of the imaging beam. The 3D scan data are integrated along each hypothetical ray, and the integrated values are projected onto an imaging plane.
摘要翻译：提出了一种用于生成解剖区域的DRR的方法和系统，使得增强了一个或多个骨骼参考结构的DRR内的可视性。提供了从3D扫描能级进行的对象的3D扫描获得的3D扫描数据。 3D扫描数据被修改以补偿3D扫描能量级别的骨组织衰减比率与DRR模拟的成像束强度之间的骨组织衰减比。经修改的3D扫描数据通过非线性指数关系与原始3D扫描数据相关。通过成像光束的已知几何形状，通过修改的3D扫描数据投射多个假想射线。 3D扫描数据沿着每个假想射线进行积分，并将积分值投影到成像平面上。

18. 发明申请

WO2011156526A2 IMAGING METHODS AND TARGET TRACKING FOR IMAGE-GUIDED RADIATION TREATMENT 审中-公开
标题翻译：用于图像导向辐射治疗的成像方法和目标跟踪
公开(公告)号：WO2011156526A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039678
申请日：2011-06-08
申请人： ACCURAY, INC. , THOMSON, Euan, S. , MAURER, Calvin, R., Jr. , LEE, Mu, Young , KUDUVALLI, Gopinath , JORDAN, Petr , CHOPRA, Prashant
发明人： THOMSON, Euan, S. , MAURER, Calvin, R., Jr. , LEE, Mu, Young , KUDUVALLI, Gopinath , JORDAN, Petr , CHOPRA, Prashant
IPC分类号： G06T7/00 , A61N5/10
CPC分类号： A61N5/1067 , A61B6/025 , A61B6/032 , A61B6/4014 , A61B6/4071 , A61B6/4085 , A61B6/4458 , A61B6/482 , A61B6/488 , A61N5/1049 , A61N5/1083 , A61N2005/1061 , G06T7/0014 , G06T7/70 , G06T2200/04 , G06T2207/10112 , G06T2207/30004
摘要： Systems, methods, and related computer program products for medical imaging and image-guided radiation treatment (IGRT) are described. In one preferred embodiment, an IGRT system provides intrafraction target tracking based on a comparison of intrafraction x-ray tomosynthesis image data with initial x-ray tomosynthesis image data acquired with the patient in an initial treatment position, the initial x-ray tomosynthesis image data having an inherent registration with co-acquired image data from a setup imaging system integral with, or having known geometry relative to, the tomosynthesis imaging system. Repeated registration of intrafraction x-ray tomosynthesis image data with pre-acquired reference image data from a different frame of reference is not required during intrafraction radiation delivery. Selective integration therewith of x-ray source arrays, dual-energy imaging, stereoscopic imaging, static and dynamic source collimation, and/or inverse geometry tomosynthesis imaging are also described. Advantages include streamlined intrafraction computation, reduced patient x-ray dose, and/or reduced treatment delivery margins.
摘要翻译：描述了用于医学成像和图像引导辐射治疗（IGRT）的系统，方法和相关的计算机程序产品。在一个优选实施例中，IGRT系统基于将分数内x射线断层合成图像数据与在初始治疗位置中与患者获取的初始x射线断层合成图像数据的比较，初始x射线断层合成图像数据具有与来自与所述断层摄影成像系统成一体或具有已知几何形状的建立成像系统的共同获取的图像数据的固有配准。在分组内辐射传递期间，不需要从不同的参照系参考图像数据重新注册分组内x射线断层合成图像数据。还描述了与x射线源阵列，双能量成像，立体成像，静态和动态源准直以及/或反向几何断层合成成像的选择性整合。优点包括流线型内分泌计算，减少患者x射线剂量和/或减少治疗输送余量。

19. 发明申请

WO2006011935A2 ROI SELECTION IN IMAGE REGISTRATION 审中-公开
标题翻译：投资选择图像注册
公开(公告)号：WO2006011935A2
公开(公告)日：2006-02-02
申请号：PCT/US2005/010754
申请日：2005-03-30
申请人： ACCURAY, INC. , FU, Dongshan , KUDUVALLI, Gopinath
发明人： FU, Dongshan , KUDUVALLI, Gopinath
IPC分类号： G06K9/32 , G06K9/34 , G06K9/00
CPC分类号： G06K9/3233 , G06T7/238 , G06T7/32 , G06T2207/10116 , G06T2207/10124 , G06T2207/20016 , G06T2207/20021 , G06T2207/20132 , G06T2207/30004
摘要： A method and system is presented for automatically selecting a region of interest (ROI) within an image of an object, for example when performing non-rigid image registration between the image and another image of the object. In this way, the need for user interaction can be minimized or eliminated during image registration. The ROI is determined by defining an entropy measure H of the image, and selecting the region within the image in which the entropy measure is maximized, In this way, the ROI is optimized to contain as much information as possible. In one embodiment, the entropy measure H is a modified Shannon entropy, defined by H = - Σ I P(I) log P(I), where I is the value of the image intensity level, and P(I) is the probability of an image intensity value I occurring within the ROI.
摘要翻译：提出了一种方法和系统，用于在对象的图像内自动选择感兴趣区域（ROI），例如当在图像与对象的另一图像之间执行非刚性图像配准时。以这种方式，可以在图像配准期间最小化或消除用户交互的需要。通过定义图像的熵测量H并选择熵测量最大化的图像内的区域来确定ROI。这样，ROI被优化以包含尽可能多的信息。在一个实施例中，熵测量H是由H = -SIP（I）log P（I）定义的修改的香农熵，其中I是图像强度水平的值，并且P（I）是图像强度值I发生在ROI内。

20. 发明申请

WO2005024721A2 2D/3D IMAGE REGISTRATION IN IMAGE-GUIDED RADIOSURGERY 审中-公开
标题翻译：图像导向放射治疗中的2D / 3D图像注册
公开(公告)号：WO2005024721A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/027158
申请日：2004-08-20
申请人： ACCURAY, INC. , KUDUVALLI, Gopinath , FU, Dongshan , QURESHI, Shehrzad
发明人： KUDUVALLI, Gopinath , FU, Dongshan , QURESHI, Shehrzad
IPC分类号： G06T
CPC分类号： A61N5/1049 , A61N5/1067 , A61N5/107 , A61N2005/1061 , A61N2005/1062 , G01N23/04 , G06T7/254 , G06T7/32 , G06T7/38 , G06T2207/10124 , G06T2207/30004
摘要： An image-guided radiosurgery method and system are presented that use 2D/3D image registration to keep the radiosurgical beams properly focused onto a treatment target. A pre-treatment 3D scan of the target is generated at or near treatment planning time. A set of 2D DRRs are generated, based on the pretreatment 3D scan. At least one 2D x-ray image of the target is generated in near real time during treatment. The DRRs are registered with the x-ray images, by computing a set of 3D transformation parameters that represent the change in target position between the 3D scan and the x-ray images. The relative position of the radiosurgical beams and the target is continuously adjusted in near real time in accordance with the 3D transformation parameters. A hierarchical and iterative 2D/3D registration algorithm is used, in which the transformation parameters that are in-plane with respect to the image plane of the x-ray images are computed separately from the out-of-plane transformation parameters.
摘要翻译：提出了一种使用2D / 3D图像配准的图像引导放射外科手术方法和系统，将放射外科手术束适当地聚焦到治疗目标上。在治疗计划时间或附近产生目标的预处理3D扫描。基于预处理3D扫描生成一组2D DRR。在治疗期间，近乎实时地产生目标的至少一个2D X射线图像。通过计算表示3D扫描和X射线图像之间的目标位置的变化的一组3D变换参数，向X射线图像登记DRR。根据3D变换参数，放射外科手术束和目标物的相对位置以近实时的方式连续调整。使用分层和迭代的2D / 3D注册算法，其中相对于x射线图像的像面在平面内的变换参数与面外变换参数分开计算。

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