专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明专利

CA2873075A1 NAMPT INHIBITORS 未知
公开(公告)号：CA2873075A1
公开(公告)日：2013-07-14
申请号：CA2873075
申请日：2013-05-10
申请人： ABBVIE INC
发明人： CURTIN MICHAEL L , LONGENECKER KENTON , HANSEN TODD M , CLARK RICHARD F , SORENSEN BRYAN , HEYMAN HOWARD R , JI ZHIQIN
IPC分类号： C07D401/14 , A61K31/4406 , A61K31/445 , A61P29/00 , A61P35/00 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

12. 发明专利

AU4178097A 6-o-substituted ketolides having antibacterial activity 未知
公开(公告)号：AU4178097A
公开(公告)日：1998-03-26
申请号：AU4178097
申请日：1997-09-02
申请人： ABBVIE INC
发明人： OR YAT SUN , MA ZHENKUN , CLARK RICHARD F , CHU DANIEL T , PLATTNER JACOB J
IPC分类号： A61K31/70 , A61K31/7048 , A61P31/04 , C07H17/00 , C07H17/08
摘要： 6-Substituted ketolides of e.g. formula (II) or (III), and their salts, esters and prodrugs are new: Y + Z = X; X = OH, =NOR1 or =NOC(R5)(R6)OR1; or one of Y and Z = H; and the other = H, OH, protected OH or NR7R8; R1 = 1-12C alkyl (optionally substituted), 3-12C cycloalkyl or SiR2R3R4; R2-R4 = 1-12C alkyl or aryl; R5, R6 = H or 1-12C alkyl (optionally substituted), or R5 + R6 = 3-12C cycloalkyl; R7, R8 = H or 1-6C alkyl; or NR7R8 = 3-7 membered ring which, when the ring is 5-7 membered may optionally contain O, NH, N(1-6C alkyl), N(aryl), N(aryl-1-6C alkyl), N (substituted aryl-1-6C alkyl), N(heteroaryl), N(heteroaryl-1-6C alkyl), N(substituted heteroaryl-1-6C alkyl), S or S(O)n; n = 1 or 2; Ra = H or OH; Rc = H or hydroxy protecting group; R9 = 1-6C alkyl (optionally substituted), 3-7C cycloalkyl or optionally substituted aryl or heteroaryl; M = CONH, NHCO, NH, N=, NMe, NHCOO, NHCONH, OCONHY, OCOO, O, S(O)n, COO, OCO or CO; R = methyl (substituted by CN, F, CO2R10, S(O)nR10, NHCOR10, NHCONR11R12, aryl, substituted aryl, heteroaryl or substituted heteroaryl); 2-10C alkyl (optionally substituted), 3C alkenyl (substituted by halo, CHO, CO2R10, COR9, CONR11R12, CN, optionally substituted aryl or heteroaryl, 3-7C cycloalkyl or 1-12C alkyl substituted by heteroaryl); 4-10C alkenyl (optionally substituted), or 3-10C alkynyl optionally substituted); R10 = 1-3C alkyl (optionally aryl substituted), or heteroaryl substituted 1-3C alkyl; R11, R12 = H or 1-3C alkyl (optionally substituted); A, B, D, E = H, 1-6C alkyl (optionally substituted by optionally substituted), 3-7C cycloalkyl, optionally substituted aryl or heteroaryl, heterocycloalkyl or 1-6C alkyl substituted by MR9; provided that \- 2 of A, B, D and E = H; or any one pair of substituents, consisting of AB, AD, AE, BD, BE or DE taken with the atoms to which they are attached, form a 3- to 7-membered ring optionally containing O, NH, N(1-6C alkyl), N(aryl-1-6C alkyl), N(substituted aryl-1-6C alkyl), N(heteroaryl-1-6C alkyl), N(substituted heteroaryl-1-6C alkyl), S, S(O)n, CONH, CONR12, NHCO, NR12CO or C(=NH)NH.

13. 发明专利

SG10201602857UA NAMPT And Rock Inhibitors 未知
公开(公告)号：SG10201602857UA
公开(公告)日：2016-05-30
申请号：SG10201602857U
申请日：2011-11-11
申请人： ABBVIE INC , ABBVIE DEUTSCHLAND
发明人： CURTIN MICHAEL L , SORENSEN BRYAN K , HEYMAN HOWARD R , CLARK RICHARD F , WOLLER KEVIN R , SHAH OMAR J , MICHAELIDES MICHAEL , TSE CHRIS , VASUDEVAN ANIL , MACK HELMUT , HANSEN TODD M , SWEIS RAMZI , PLIUSHCHEV MARINA A
摘要： Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.

14. 发明专利

HK1208221A1 NAMPT INHIBITORS NAMPT 未知
公开(公告)号：HK1208221A1
公开(公告)日：2016-02-26
申请号：HK15108839
申请日：2015-09-10
申请人： ABBVIE INC
发明人： CLARK RICHARD F , SORENSEN BRYAN , OSUMA AUGUSTINE T , FREY ROBIN , LONGENECKER KENTON , DOHERTY GEORGE , CURTIN MICHAEL L , MICHAELIDES MICHAEL R , SWEIS RAMZI F , PLIUSHCHEV MARINA A , JUDD ANDY , HANSEN TODD M , HEYMAN HOWARD R
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101

15. 发明专利

HU230166B1 未知
公开(公告)号：HU230166B1
公开(公告)日：2015-09-28
申请号：HU9902869
申请日：1997-09-02
申请人： ABBVIE INC
发明人： CHU DANIEL T , CLARK RICHARD F , MA ZHENKUN , OR YAT SUN , PLATTNER JACOB J
IPC分类号： C07H17/08 , A61K31/70 , A61K31/7048 , A61P31/04 , C07H17/00

16. 发明专利

MX2014013734A INHIBIDORES DE NAMPT. 未知
公开(公告)号：MX2014013734A
公开(公告)日：2015-06-10
申请号：MX2014013734
申请日：2013-05-10
申请人： ABBVIE INC
发明人： PLIUSHCHEV MARINA A , FREY ROBIN , HANSEN TODD M , CURTIN MICHAEL L , CLARK RICHARD F , SORENSEN BRYAN , OSUMA AUGUSTINE T , LONGENECKER KENTON , SWEIS RAMZI F , JUDD ANDY , HEYMAN HOWARD R , MICHAELIDES MICHAEL R , DOHERTY GEORGE
IPC分类号： C07D471/04 , A61K31/407 , A61P29/00 , A61P35/00
摘要： Se describen compuestos que inhiben la actividad de NAMPT, composiciones que contiene los compuestos y métodos para tratar de enfermedades durante las cuales se expresa NAMPT.

17. 发明专利

CO7151512A2 Inhibidores del nampt 未知
公开(公告)号：CO7151512A2
公开(公告)日：2014-12-29
申请号：CO14266532
申请日：2014-12-03
申请人： ABBVIE INC
发明人： CLARK RICHARD F , SORENSEN BRYAN , OSUMA AUGUSTINE T , FREY ROBIN , LONGENECKER KENTON , DOHERTY GEORGE , CURTIN MICHAEL L , MICHAELIDES MICHAEL R , SWEIS RAMZI F , PLIUSHCHEV MARINA A , JUDD ANDY , HANSEN TODD M , HEYMAN HOWARD R
IPC分类号： A61K31/407 , A61P29/00 , A61P35/00 , C07D471/14
摘要： VER ANEXOS

18. 发明专利

PH12014502513A1 NAMPT INHIBITORS 未知
公开(公告)号：PH12014502513A1
公开(公告)日：2014-12-15
申请号：PH12014502513
申请日：2014-11-11
申请人： ABBVIE INC
发明人： CLARK RICHARD F , BRYAN SORENSEN , OSUMA AUGUSTINE T , ROBIN FREY , KENTON LONGENECKER , GEORGE DOHERTY , CURTIN MICHAEL L , MICHAELIDES MICHAEL R , SWEIS RAMZI F , PLIUSHCHEV MARINA A , ANDY JUDD , HANSEN TODD M , HEYMAN HOWARD R
IPC分类号： A61K31/407 , A61P29/00 , A61P35/00 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

19. 发明专利

MX2014013752A INHIBIDORES DE NAMPT. 未知
公开(公告)号：MX2014013752A
公开(公告)日：2014-12-08
申请号：MX2014013752
申请日：2013-05-10
申请人： ABBVIE INC
发明人： HANSEN TODD M , CURTIN MICHAEL L , CLARK RICHARD F , SORENSEN BRYAN , LONGENECKER KENTON , HEYMAN HOWARD R , JI ZHIQIN
IPC分类号： C07D401/14 , A61K31/4406 , A61K31/445 , A61P29/00 , A61P35/00 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Se describen compuestos que inhiben la actividad de NAMPT, composiciones que contiene los compuestos y métodos para tratar enfermedades durante las cuales se expresa NAMPT.

20. 发明专利

UY34804A INHIBIDORES DEL NAMPT 未知
公开(公告)号：UY34804A
公开(公告)日：2013-12-31
申请号：UY34804
申请日：2013-05-10
申请人： ABBVIE INC
发明人： HEYMAN HOWARD R , HANSEN TODD M , KENTON LONGENECKER , CURTIN MICHAEL L , CLARK RICHARD F , BRYAN SORENSEN , ZHIQIN JI , KEVIN WOLLER , GEORGE DOHERTY , ROBIN FREY
IPC分类号： A61P19/02 , A61K31/35 , A61K31/397 , A61P25/00 , A61P25/28 , A61P31/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Compuestos que inhiben la actividad del NAMPT, composiciones que contienen dichos compuestos y métodos para tratar enfermedades en las que se expresa el NAMPT.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式