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11. 发明申请

WO0240997A3 PRODUCTION AND USE OF PROTEINS PRODUCING AN ALTERED IMMUNOGENIC RESPONSE 审中-公开
标题翻译：生产和使用产生改变的免疫应答的蛋白质
公开(公告)号：WO0240997A3
公开(公告)日：2004-08-12
申请号：PCT/US0130062
申请日：2001-09-26
申请人： GENENCOR INT , ESTELL DAVID A , HARDING FIONA A
发明人： ESTELL DAVID A , HARDING FIONA A
IPC分类号： G01N33/53 , C12N9/56 , C12N9/64 , G01N33/50 , G01N33/68 , A01K67/027
CPC分类号： G01N33/6854 , G01N33/505
摘要： The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions.
摘要翻译：本发明涉及一种用于生产超低和过敏组合物的新方法和组合物。具体地，本发明包括中和或降低T细胞识别表位的能力，从而防止个体对蛋白质的致敏。或者，T细胞表位突变以产生增加的免疫原性反应。

12. 发明申请

WO02077187A2 PROTEINS PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：产生改变的免疫应答的蛋白质及其制备和使用方法
公开(公告)号：WO02077187A2
公开(公告)日：2002-10-03
申请号：PCT/US0209205
申请日：2002-03-22
申请人： GENENCOR INT , PROCTER & GAMBLE , ESTELL DAVID A , GANSHAW GRANT C , HARDING FIONA A , LARENAS EDMUND A , POULOSE AYROOKARAN J , SIKORSKI ELIZABETH ELLEN , ELLIOTT RUSSEL PHILIP
发明人： ESTELL DAVID A , GANSHAW GRANT C , HARDING FIONA A , LARENAS EDMUND A , POULOSE AYROOKARAN J , SIKORSKI ELIZABETH ELLEN , ELLIOTT RUSSEL PHILIP
IPC分类号： C07H21/04 , A61K8/64 , A61K8/67 , A61K38/00 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C12N9/54 , C12N
CPC分类号： C12N9/54 , A61K8/64 , A61K8/671 , A61K8/676 , A61K8/678 , A61K38/00 , A61K2800/72 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10
摘要： The present invention relates to novel protein variants that exhibit reduced allergenicity when compared to the parental proteins. Also included are DNA molecules that encode the novel variants, host cells comprising the DNA and methods of making proteins less allergenic.
摘要翻译：本发明涉及与亲本蛋白质相比显示出降低的变应原性的新型蛋白质变体。还包括编码新变体的DNA分子，包含DNA的宿主细胞和使蛋白质变得不敏感的方法。

13. 发明申请

WO2007067473A3 PERHYDROLASE EPITOPES 审中-公开
公开(公告)号：WO2007067473A3
公开(公告)日：2007-09-07
申请号：PCT/US2006046203
申请日：2006-12-04
申请人： GENENCOR INT , HARDING FIONA A
发明人： HARDING FIONA A
IPC分类号： C12N9/16 , C11D3/386 , G01N33/50
CPC分类号： C12N9/18 , C11D3/38636 , C12N9/16 , G01N33/505
摘要： The present invention provides perhydrolase enzyme CD4+ T-cell epitopes, as well as variants that exhibit reduced immunogenic responses, as compared to the parental perhydrolase . The present invention further provides DNA molecules that encode perhydrolase variants, and host cells comprising DNA encoding perhydrolase variants, as well as methods for making perhydrolase enzymes less immunogenic. In addition, the present invention provides variou compositions that comprise perhydrolase variants that are less immunogenic than the wild- type perhydrolase. In some specific embodiments, the present invention provides perhydrolase variants with reduced immunogenicity identified and/or characterized using the methods of the present invention. These enzymes find use in cleaning and other applications. In some preferred embodiments, the present invention finds particular use in applications involving cleaning, bleaching and disinfecting.
摘要翻译：与亲本过氧化氢酶相比，本发明提供了过水解酶酶CD4 + T细胞表位，以及表现出降低的免疫原性应答的变体。本发明还提供了编码过水解酶变体的DNA分子和包含编码过水解酶变体的DNA的宿主细胞，以及制备过水解酶较少免疫原性的方法。此外，本发明提供了包含与野生型过水解酶相比较少免疫原性的过水解酶变体的变种组合物。在一些具体实施方案中，本发明提供使用本发明的方法鉴定和/或表征的具有降低的免疫原性的过水解酶变体。这些酶可用于清洁和其他应用。在一些优选实施方案中，本发明特别用于涉及清洁，漂白和消毒的应用。

14. 发明申请

WO2005044838A3 CD4+ EPITOPES OF BONE MORPHOGENETIC PROTEINS 审中-公开
标题翻译：骨形态蛋白的CD4 +外显子
公开(公告)号：WO2005044838A3
公开(公告)日：2005-09-01
申请号：PCT/US2004034679
申请日：2004-10-21
申请人： GENENCOR INT , HARDING FIONA A
发明人： HARDING FIONA A
IPC分类号： C07K20060101 , C07K14/51 , G01N33/53 , G01N33/567 , G01N33/74
CPC分类号： G01N33/74 , C07K14/51 , G01N2333/51
摘要： The present invention provides CD4+ T-cell epitopes in bone morphogenetic proteins (BMPs). In particular embodiments, the present invention provides CD4+ T-cell epitopes of BMP-7 and BMP-14. In some preferred embodiments, the present invention provides CD4+ T-cell epitopes of BMP-7 and BMP-14 that are suitable for modification to reduce the immunogenicity of the BMP-7 and BMP-14 proteins.
摘要翻译：本发明在骨形态发生蛋白（BMP）中提供CD4 + T细胞表位。在具体实施方案中，本发明提供BMP-7和BMP-14的CD4 + T细胞表位。在一些优选的实施方案中，本发明提供适于修饰以降低BMP-7和BMP-14蛋白的免疫原性的BMP-7和BMP-14的CD4 + T细胞表位。

15. 发明专利

AU2002360745A1 PROTEASES PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME 未知
公开(公告)号：AU2002360745A1
公开(公告)日：2003-07-24
申请号：AU2002360745
申请日：2002-12-20
申请人： GENENCOR INT , ESTELL DAVID A , HARDING FIONA A
发明人： ESTELL DAVID A , HARDING FIONA A
IPC分类号： C12N15/09 , A61K8/00 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/365 , A61K8/42 , A61K8/64 , A61K8/66 , A61K8/72 , A61K8/86 , A61K8/89 , A61K8/891 , A61Q11/00 , A61Q11/02 , A61Q19/00 , A61Q19/10 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/54 , C12N9/56

16. 发明申请

WO2005058236A8 CAB MOLECULES 审中-公开
标题翻译： CAB分子
公开(公告)号：WO2005058236A8
公开(公告)日：2006-09-21
申请号：PCT/US2004041429
申请日：2004-12-10
申请人： GENENCOR INT , FOX JUDITH A , HARDING FIONA A , SCHELLENBERGER VOLKER
发明人： FOX JUDITH A , HARDING FIONA A , SCHELLENBERGER VOLKER
IPC分类号： A61K38/00 , A61K20060101 , C07H5/00 , C07H7/00 , C07H17/00 , C07K16/30 , C07K16/40
CPC分类号： C07K16/3007 , A61K2039/505 , C07K16/40 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/00

17. 发明申请

WO2005111078A3 ANTI-CEA SCFV-BETA-LACTAMASE CONTRUCTS (CAB MOLECULES) IN ADEPT 审中-公开
标题翻译：抗-CEA SCFV-BETA-LACTAMASE对照（CAB分子）在ADEPT
公开(公告)号：WO2005111078A3
公开(公告)日：2006-07-27
申请号：PCT/US2005012270
申请日：2005-04-12
申请人： GENENCOR INT , FOX JUDITH A , HARDING FIONA A , RASHID M HARUNUR , SCHELLENBERGER VOLKER
发明人： FOX JUDITH A , HARDING FIONA A , RASHID M HARUNUR , SCHELLENBERGER VOLKER
IPC分类号： C07K19/00 , A61K31/195 , A61P35/00 , C07K14/245 , C07K16/00 , C07K16/30 , C12N9/86
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
摘要翻译：本发明涉及CAB分子，针对CEA的ADEPT构建体及其在治疗中的用途。

18. 发明申请

WO2005119259A9 POPULATION BASED PREDICTION METHODS FOR IMMUNE RESPONSE DETERMINATIONS AND METHODS FOR VERIFYING IMMUNOLOGICAL RESPONSE DATA 审中-公开
标题翻译：基于人群的预测方法，用于免疫应答确定和验证免疫应答数据的方法
公开(公告)号：WO2005119259A9
公开(公告)日：2006-06-01
申请号：PCT/US2005014182
申请日：2005-04-25
申请人： GENENCOR INT , HARDING FIONA A
发明人： HARDING FIONA A
IPC分类号： G01N33/564 , G01N33/50
CPC分类号： G01N33/505 , G01N33/5047
摘要： The present invention provides means to assess immune response profiles of populations. In particular, the present invention provides means to qualitatively assess the immune response of human populations, wherein the immune response directed against any protein of interest is analyzed. The present invention further provides means to rank proteins based on their relative immunogenicity. In further embodiments, the present invention provides means for verifying immunological response data, as well as means for predicting immune responses directed against any antigen/immunogen. In addition, the present invention provides means to create proteins with reduced immunogenicity for use in various applications.
摘要翻译：本发明提供了评估群体的免疫应答谱的方法。特别地，本发明提供了定性评估人群免疫应答的方法，其中分析针对任何目标蛋白的免疫应答。本发明还提供了基于其相对免疫原性对蛋白质进行排序的方法。在进一步的实施方案中，本发明提供用于验证免疫应答数据的手段，以及用于预测针对任何抗原/免疫原的免疫应答的手段。此外，本发明提供了用于产生用于各种应用的具有降低的免疫原性的蛋白质的方法。

19. 发明申请

WO2005111078A9 CAB MOLECULES 审中-公开
标题翻译： CAB分子
公开(公告)号：WO2005111078A9
公开(公告)日：2006-03-30
申请号：PCT/US2005012270
申请日：2005-04-12
申请人： GENENCOR INT , FOX JUDITH A , HARDING FIONA A , RASHID M HARUNUR , SCHELLENBERGER VOLKER
发明人： FOX JUDITH A , HARDING FIONA A , RASHID M HARUNUR , SCHELLENBERGER VOLKER
IPC分类号： C07K16/00 , C07K16/30
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
摘要翻译：本发明涉及CAB分子，针对CEA的ADEPT构建体及其在治疗中的用途。

20. 发明申请

WO2005025497A3 HPV CD8+ T-CELL EPITOPES 审中-公开
标题翻译： HPV CD8 + T细胞EPITOPES
公开(公告)号：WO2005025497A3
公开(公告)日：2005-06-02
申请号：PCT/US2004027263
申请日：2004-08-23
申请人： GENENCOR INT , HARDING FIONA A , MUCHA JEANETTE MARIE
发明人： HARDING FIONA A , MUCHA JEANETTE MARIE
IPC分类号： A61K20060101 , A61K38/00 , C07H21/04 , C07K20060101 , C07K14/01 , C07K14/74 , C12N7/00 , C12P21/04 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/68
CPC分类号： G01N33/6878 , A61K2039/525 , C07K14/005 , C12N7/00 , C12N2710/20022 , G01N33/505 , G01N2333/70517 , G01N2333/70578
摘要： The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention provides modified epitopes suitable for use in prophylactic and/or therapeutic vaccines. In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In particular, the present invention provides means to identify CD8+ T-cell epitopes in HPV strains such as HPV 16 and HPV 18. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
摘要翻译：本发明提供了鉴定任何感兴趣蛋白质中的功能性CD8 + T细胞表位的手段。本发明进一步提供了各种蛋白质的CD8 + T细胞表位。在另外的实施方案中，本发明提供了适用于预防性和/或治疗性疫苗的表位。在特别优选的实施方案中，本发明提供了适用于预防性和/或治疗性疫苗的修饰表位。在一些优选的实施方案中，本发明提供了开发HPV疫苗的手段，特别是用于预防高风险HPV毒株感染的多价疫苗。具体而言，本发明提供了鉴定HPV菌株如HPV16和HPV18中的CD8 + T细胞表位的手段。在另外的实施方案中，本发明提供了开发针对高风险HPV类型的治疗性疫苗的手段，在感染的个体中发展良性和/或恶性肿瘤。本发明还提供了适用于预防性和治疗性疫苗的表位。

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