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11. 发明申请

WO2012054417A1 AMIDE DERIVATIVES OF BENZENE-SULFONANILIDE, PHARMACEUTICAL COMPOSITION THEREOF AND METHOD FOR CANCER TREATMENT USING THE SAME 审中-公开
标题翻译：苯并噻喃的酰胺衍生物及其药物组合物及使用其的癌症治疗方法
公开(公告)号：WO2012054417A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/056619
申请日：2011-10-18
申请人： CLEVELAND STATE UNIVERSITY , SU, Bin , ZHOU, Aimin , XU, Yan
发明人： SU, Bin , ZHOU, Aimin , XU, Yan
IPC分类号： A61K31/18 , A61K31/165
CPC分类号： C07C311/08 , C07C2601/08 , C07D261/18 , C07D307/68 , C07D317/60 , C07D333/38
摘要： The invention provides a compound of formula (I), a pharmaceutical composition thereof, a method of preparing a medicament for the treatment of a cancer, and a method of treating cancers. The invention exhibits merits against cancers such as significantly higher potency and effectiveness over a broader range of cancers. In formula (I), Ra is a benzyl group with alkyl and/or alkoxy; Rb is selected from H and alkyl groups; Rf is an alkyl; and R3 is selected from a (Formula) substituted phenyl, a heterocyclic group, and, Formula, wherein Rc is selected from a fused ring, fused rings, and any bivalent cyclic group. Formula (I)
摘要翻译：本发明提供式（I）化合物，其药物组合物，制备用于治疗癌症的药物的方法和治疗癌症的方法。本发明表现出对癌症的优点，例如在更广泛的癌症上显着更高的效力和有效性。在式（I）中，R a为具有烷基和/或烷氧基的苄基; Rb选自H和烷基; Rf是烷基; 并且R 3选自（式）取代的苯基，杂环基，和式中R c选自稠合环，稠合环和任何二价环状基团。式（I）

12. 发明申请

WO2007120379A3 SULFONANILIDE ANALOGS AS SELECTIVE AROMATASE MODULATORS 审中-公开
公开(公告)号：WO2007120379A3
公开(公告)日：2007-10-25
申请号：PCT/US2007/003152
申请日：2007-02-05
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , BRUEGGEMEIER, Robert, W. , SU, Bin , DIAZ-CRUZ, Edgar, S. , LANDINI, Serena
发明人： BRUEGGEMEIER, Robert, W. , SU, Bin , DIAZ-CRUZ, Edgar, S. , LANDINI, Serena
IPC分类号： C07C307/02 , C07C233/00
摘要： Compounds and methods suppressing aromatase activity expression in cancer cells. Provided are compounds are those of formula I: wherein R1 may be alkyl, cycloakyl, haloalkyl, aryl, substituted aryl, haloaryl, alkoxy, alkylaryl, and arylalkyl; R2 is H, alkyl, aryl, alkylaryl, arylalkyl, and cycloalkyl; R3, with the base nitrogen, forms an amide or sulfonamide; R4 is selected from nitro, amine, amide, and benzamide; or a pharmaceutically acceptable salts thereof. Also provided are small molecule selective aromatase inhibitors having a molecular weight of less 500 g/mol. In some embodiments, the small molecule selective aromatase inhibitors described herein have a molecular weight of less than 450 g/mol. Also provided are methods for suppressing aromatase activity expression in cancer cells comprising the step of administering a pharmaceutically effective amount of a small molecule aromatase inhibitor to a subject in need of such treatment. In one embodiment, the cancer cells are breast cancer cells.

13. 发明申请

WO2013181809A1 METHOD FOR IDENTIFYING FAULT BY CURRENT DIFFERENTIAL PROTECTION AND DEVICE THEREOF 审中-公开
标题翻译：通过电流差分保护识别故障的方法及其装置
公开(公告)号：WO2013181809A1
公开(公告)日：2013-12-12
申请号：PCT/CN2012/076525
申请日：2012-06-06
申请人： ABB TECHNOLOGY LTD. , LI, Youyi , LIU, Kai , SU, Bin
发明人： LI, Youyi , LIU, Kai , SU, Bin
IPC分类号： H02H3/28 , H04B14/06
CPC分类号： G01R31/3278 , H02H3/28 , H02H3/283
摘要： A method for identifying the fault by current differential protection and a device thereof are provided. The method comprises: measuring the full component currents of the two terminals of a two-terminal line system and calculating the corresponding fault component current vectors; obtaining an operate value by calculating a first difference between an absolute value of the sum of the fault component current vectors and Iset1; obtaining a restrain value by multiplying a second difference with a control factor, in which the second difference is calculated between the maximum of the absolute values of the fault component currents and Iset2 or between the absolute value of the difference of said fault component currents and Iset2; and identifying a fault as an external one or internal one by comparing the operate value with the restrain value. The solutions of the present intention achieve better reliability, sensitivity and faster speed than existing products.
摘要翻译：提供了一种通过电流差动保护来识别故障的方法及其装置。该方法包括：测量两端线路系统的两端的全分量电流，并计算相应的故障分量电流矢量; 通过计算故障分量电流矢量和Iset1的和的绝对值之间的第一差来获得操作值; 通过将第二差异与控制因子相乘获得抑制值，其中在故障分量电流的绝对值和Iset2的绝对值的最大值之间或在所述故障分量电流的差异的绝对值与Iset2之间计算第二差异 ; 并通过将操作值与限制值进行比较来识别故障为外部故障或外部故障。本意图的解决方案实现了比现有产品更好的可靠性，灵敏度和更快的速度。

14. 发明申请

WO2009011811A1 COMPOSITIONS FROM GARCINIA AS AROMATASE INHIBITORS FOR BREAST CANCER CHEMOPREVENTION AND CHEMOTHERAPY 审中-公开
标题翻译：来自GARCINIA的组合物作为用于乳腺癌化疗和化疗的芳香酶抑制剂
公开(公告)号：WO2009011811A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/008572
申请日：2008-07-14
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , BALUNAS, Marcy, J. , SU, Bin , BRUEGGEMEIER, Robert, W. , KINGHORN, Alan, Douglas
发明人： BALUNAS, Marcy, J. , SU, Bin , BRUEGGEMEIER, Robert, W. , KINGHORN, Alan, Douglas
IPC分类号： A01N65/00 , A61K36/00
CPC分类号： A61K36/38
摘要： Aromatase inhibitors (AIs) are disclosed which are useful in the treatment and prevention of post-menopausal breast cancer. New AIs derived from natural products are disclosed that are evaluated for clinical utility for treating post- menopausal breast cancer and may also act as chemopreventive agents for preventing breast cancer. Several pure compounds demonstrated Al activity using a noncellular, enzyme-based microsomal and a cell-based aromatase assay. Correlations are made between structural classes with levels of aromatase inhibition. The disclosure may be utilized to direct synthetic modification of natural product scaffolds to enhance aromatase inhibition or to standardize botanical dietary supplements for increased aromatase inhibition activity.
摘要翻译：公开了可用于治疗和预防绝经后乳腺癌的芳香酶抑制剂（AI）。公开了衍生自天然产物的新的AIs，用于治疗绝经后乳腺癌的临床效用，并且还可以作为预防乳腺癌的化学预防剂。几种纯化合物使用非细胞，基于酶的微粒体和基于细胞的芳香酶测定法证实了Al活性。在具有芳香酶抑制水平的结构类之间进行相关性。本公开可用于引导天然产物支架的合成修饰以增强芳香酶抑制或标准化植物性膳食补充剂以增加芳香酶抑制活性。

15. 发明公开

EP2502319A1 METHOD AND APPARATUS FOR GROUND DISTANCE PROTECTION 审中-公开
标题翻译：方法和设备为地面间隔的保护
公开(公告)号：EP2502319A1
公开(公告)日：2012-09-26
申请号：EP09851370.8
申请日：2009-11-18
申请人： ABB Research Ltd.
发明人： SU, Bin , LI, Youyi , YANG, Ying
IPC分类号： H02H7/26
CPC分类号： H02H3/402
摘要： A ground distance protection method comprises the following steps: measuring a local source impedance based on the fault component at both ends (M, N) of a transmission line when a ground fault has occurred; sending the measured local source impedance from a first end to a second end; adjusting a protection criterion at the second end based on the measured local source impedance; and judging the ground fault as an internal fault or an external fault according to the adjusted protection criterion. The ground distance protection can suppress over-reaching or under-reaching trip during a protection operation.

16. 发明公开

EP2304857A1 FAST POWER SWING UNBLOCKING METHOD AND APPARATUS FOR DISTANCE PROTECTION IN POWER SYSTEM 有权转让
标题翻译：电力系统远距离保护的快速电源摆动解耦方法及装置
公开(公告)号：EP2304857A1
公开(公告)日：2011-04-06
申请号：EP08773120.4
申请日：2008-07-07
申请人： ABB Research Ltd.
发明人： SU, Bin , JING, Lei , LIU, Qianjin
IPC分类号： H02H7/26 , G01R31/08
CPC分类号： H02H3/40 , G01R31/085 , G01R31/088
摘要： A fast power swing unblocking method and the corresponding apparatus for a distance protection in a power system are able to ensure fast phase-segregated tripping of distance protection for faults during a power swing (3 -phase or 2-phase swing). The power swing unblocking method comprises calculating changing rates of impedances for all operating loops including phase-phase loops and phase-ground loops in the power system and identifying a fault loop based on the calculated changing rates. If a fault loop is identified, a blocked distance zone in the fault loop is unblocked and the corresponding protective relays can be excited.
摘要翻译：用于电力系统中的距离保护的快速动力摆动解锁方法和相应的装置能够确保在动力摆动期间（3相或2相摆动）期间的故障的距离保护的快速相位分离跳闸。该功率摆动解除阻塞方法包括计算包括电力系统中的相 - 相回路和相 - 地回路的所有操作回路的阻抗的变化率，并且基于计算出的变化率来识别故障回路。如果识别出故障回路，故障回路中的阻塞距离区域将被解锁并且相应的保护继电器可被激励。

17. 发明授权

EP2304857B1 FAST POWER SWING UNBLOCKING METHOD AND APPARATUS FOR DISTANCE PROTECTION IN POWER SYSTEM 有权转让
标题翻译： FAST LEISTUNGSAUSLENKUNGS-ENTBLOCKIERUNGSVERFAHREN和装置在电力系统距离保护
公开(公告)号：EP2304857B1
公开(公告)日：2013-09-04
申请号：EP08773120.4
申请日：2008-07-07
申请人： ABB Research Ltd.
发明人： SU, Bin , JING, Lei , LIU, Qianjin
IPC分类号： H02H3/40 , H02H7/26 , G01R31/08
CPC分类号： H02H3/40 , G01R31/085 , G01R31/088

18. 发明公开

EP2394401A1 METHOD FOR DETECTING NETWORK ASYMMETRICAL STATUS AND ASYMMETRICAL COMMUNICATION CHANNELS FOR POWER SYSTEM 有权转让
标题翻译：法非对称网络地位的动力系统检测与不对称通信渠道
公开(公告)号：EP2394401A1
公开(公告)日：2011-12-14
申请号：EP09839505.6
申请日：2009-02-09
申请人： ABB Research Ltd.
发明人： LI, Youyi , SU, Bin
IPC分类号： H04L12/42
CPC分类号： H04L43/0852 , H04J3/0638 , H04J3/085 , H04J2203/0042 , H04J2203/006 , H04J2203/0062 , H04L12/437
摘要： The present invention provides a new synchronization method named Multi-Node Echo Method (MNEM), which settles the problem of clock/data synchronization with asymmetrical channels. In MNEM, the echo messages are relayed among multi-node loop both by clockwise and anti-clockwise. Based on Multi-Node Echo Method, the invention further provides a method to detect symmetrical status of a communication network, a method to detect asymmetrical status of any channel in a communication network, and a method to calculate the sending and receiving delay values of any channel in a communication network, even when the channel is asymmetrical.

19. 发明公开

EP2331978A1 METHOD AND DEVICE FOR SUPERVISING SECONDARY CIRCUIT OF INSTRUMENT TRANSFORMER IN POWER SYSTEM 有权
标题翻译：方法和设备监督互感器二次回路在电力系统
公开(公告)号：EP2331978A1
公开(公告)日：2011-06-15
申请号：EP08877027.6
申请日：2008-09-24
申请人： ABB Research Ltd.
发明人： SU, Bin , FAN, Jianzhong , JING, Lei , LIU, Qianjin , WANG, Jianping , YANG, Ying
IPC分类号： G01R31/06 , G01R31/00
CPC分类号： H02H7/261 , G01R31/027 , H02H3/05 , H02H3/40
摘要： A method and a protection IED for supervising a secondary circuit of an instrument transformer in a power system are disclosed. The instrument transformer is connected to a power system component. The method includes: detecting, by a protection IED which is connected to the secondary circuit of the instrument transformer and protects the power system component, disturbances in a signal from the instrument transformer; and determining whether a failure occurs in the secondary circuit of the instrument transformer, according to both a disturbance detection result from the protection IED and another disturbance detection result from at least one of other protection IEDs. The other protection IEDs include protection IEDs which are connected to other secondary circuits of the instrument transformer or to secondary circuits of another instrument transformer connected to the power system component, and protection IEDs which are connected to other instrument transformers connected to other power system components connected to the same busbar as the power system component is connected to. The secondary circuit supervision solutions provide more reliable and sensitive performance and need very small amount of information to be collected.

20. 发明公开

EP2301125A1 METHOD AND SYSTEM FOR REARRANGING SOUND CONDUCTORS IN PARALLEL LINES IN POWER TRANSMISSION 有权
标题翻译：方法和系统无错误导体在电力传输平行线的清理
公开(公告)号：EP2301125A1
公开(公告)日：2011-03-30
申请号：EP08773119.6
申请日：2008-07-07
申请人： ABB Research Ltd.
发明人： FAN, Jianzhong , SU, Bin , JING, Lei , LIU, Qianjin , YANG, Ying
IPC分类号： H02H3/06
CPC分类号： H02H7/267
摘要： A method and a system for rearranging sound conductors included in parallel lines in power transmission are provided. The parallel lines include at least a first line (L1) and a second line (L2) each of which includes N conductors (1A, 1B, and 1C; or, 2A, 2B, and 2C), and N is an integer greater than or equal to 3. Any N sound conductors (1B, 1C, 2C) among the 2N conductors (1A, 1B, and 1C; 2A, 2B, and 2C) are selected to form a reconstructed line so that power transmission can be resumed.

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