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11. 发明授权

US5877189A Methods for treating central nervous system disorders and other disorders using optically pure (-) norcisapride 失效
标题翻译：使用光学纯（ - ）诺西沙必利治疗中枢神经系统疾病和其他疾病的方法
公开(公告)号：US5877189A
公开(公告)日：1999-03-02
申请号：US933953
申请日：1997-09-19
申请人： John R. McCullough , A. K. Gunnar Aberg
发明人： John R. McCullough , A. K. Gunnar Aberg
IPC分类号： C07D211/58 , A61K31/00 , A61K31/44 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/495 , A61K31/496 , A61K45/06 , A61P1/00
CPC分类号： A61K31/496 , A61K31/44 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K45/06
摘要： Methods are disclosed utilizing the optically pure (-) isomer of norcisapride. This compound is a potent drug for the treatment of gastro-esophageal reflux disease, emesis, dyspepsia and other conditions while substantially reducing the concomitant liability of adverse effects associated with cisapride. The (-) isomer of norcisapride also avoids the adverse drug interactions associated with racemic cisapride and other therapeutic agents.
摘要翻译：公开利用诺西西滨的旋光纯（ - ）异构体的方法。该化合物是用于治疗胃食管反流病，呕吐，消化不良和其他病症的有效药物，同时显着降低与西沙必利相关的副作用的伴随责任。诺西沙必利的（ - ）异构体也避免与外消旋西沙必利和其他治疗剂相关的不良药物相互作用。

12. 发明授权

US08071653B2 Use of RR/SR-ractopamine 有权
标题翻译：使用RR / SR-莱克多巴胺
公开(公告)号：US08071653B2
公开(公告)日：2011-12-06
申请号：US12751134
申请日：2010-03-31
申请人： A. K. Gunnar Aberg , Karl Reuter , Viktor Meier , Florian Stolz , Eliso Gogritchiani
发明人： A. K. Gunnar Aberg , Karl Reuter , Viktor Meier , Florian Stolz , Eliso Gogritchiani
IPC分类号： A61K31/135
CPC分类号： A61K31/137 , C07C211/27 , C07C211/36 , C07C215/60
摘要： A method of promoting weight loss in animals or humans by administering thereto a therapeutically effective amount of a mixture of RR-ractopamine and SR-ractopamine is disclosed.
摘要翻译：公开了通过向其施用治疗有效量的RR-莱克多巴胺和SR-莱克多巴胺的混合物来促进动物或人类体重减轻的方法。

13. 发明申请

US20090149502A1 Optically active isomers of ketotifen and therapeutically active metabolites thereof 有权
公开(公告)号：US20090149502A1
公开(公告)日：2009-06-11
申请号：US12378231
申请日：2009-02-12
申请人： A. K. Gunnar Aberg , George E. Wright , Jan L. Chen , Andrew T. Maioli
发明人： A. K. Gunnar Aberg , George E. Wright , Jan L. Chen , Andrew T. Maioli
IPC分类号： A61K31/4535
CPC分类号： C07D409/04
摘要： Racemic norketotifen, racemic 10-hydroxy-ketotifen, racemic 10-hydroxy-nor-ketotifen and optically active isomers of ketotifen, norketotifen, 10-hydroxy-ketotifen and 10-hydroxy-norketotifen were found to have antiallergic and anti-inflammatory effects while being devoid of the severe dose-limiting sedative side effects of Ketotifen.

14. 发明授权

US07214683B1 Compositions of descarboethoxyloratadine 失效
标题翻译：去氧乙氧基吗啉的组成
公开(公告)号：US07214683B1
公开(公告)日：2007-05-08
申请号：US09039260
申请日：1998-03-16
申请人： A. K. Gunnar Aberg , John R. McCullough , Emil R. Smith
发明人： A. K. Gunnar Aberg , John R. McCullough , Emil R. Smith
IPC分类号： A61K31/44
CPC分类号： A61K31/44 , A61K31/655
摘要： Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines.
摘要翻译：公开了使用氯雷他定的代谢衍生物DCL用于治疗过敏性鼻炎和其他疾病的方法，同时避免与其他非镇静抗组胺剂相关的副作用的伴随的责任。

15. 发明授权

US07141696B2 Smooth muscle spasmolytic agents 失效
标题翻译：平滑肌解痉药
公开(公告)号：US07141696B2
公开(公告)日：2006-11-28
申请号：US10850868
申请日：2004-05-21
申请人： A. K. Gunnar Aberg , Jan L. Chen , Andrew T. Maioli , George E. Wright
发明人： A. K. Gunnar Aberg , Jan L. Chen , Andrew T. Maioli , George E. Wright
IPC分类号： C07C211/03 , C07C211/04 , C07C211/05 , C07C211/06 , C07C211/07 , C07C211/08 , A61K31/135
CPC分类号： C07C215/54
摘要： The present invention relates to smooth muscle spasmolytic agents, pharmaceutical compositions containing them and method of using said compounds and compositions for the treatment of urinary incontinence, and other smooth muscle contractility conditions. More particularly, the present invention relates to certain metabolically stabilized secondary amines having smooth muscle relaxing properties while avoiding, on administration to a mammal, adverse side effects such as prominent antimuscarinic, arrhythmogenic and cardiodepressive effects.
摘要翻译：本发明涉及平滑肌解痉剂，含有它们的药物组合物和使用所述化合物和组合物治疗尿失禁的方法和其它平滑肌收缩状况。更具体地说，本发明涉及具有平滑肌松弛特性的某些代谢稳定的仲胺，同时在给予哺乳动物时避免诸如突出的抗毒蕈碱性，致心律失常性和心脏抑制作用之类的副作用。

16. 发明授权

US06384054B1 Compositions for treating allergic and other disorders using norastemizole in combination with other active ingredients 失效
标题翻译：使用诺尔阿司咪唑与其他活性成分组合治疗过敏性和其它病症的组合物
公开(公告)号：US06384054B1
公开(公告)日：2002-05-07
申请号：US09956003
申请日：2001-09-20
申请人： Raymond L. Woosley , A. K. Gunnar Aberg
发明人： Raymond L. Woosley , A. K. Gunnar Aberg
IPC分类号： A61K31445
CPC分类号： A61K31/454 , A61K31/445 , A61K2300/00
摘要： Methods and compositions are disclosed utilizing metabolic derivatives of astemizole for the treatment of allergic disorders while avoiding the concomitant liability of adverse effects associated with the astemizole. The metabolic derivatives of astemizole are also useful for the treatment of retinopathy and other small vessel disorders associated with diabetes mellitus and such other conditions as may be related to the antihistamine activity of astemizole. For example, the metabolic derivatives of astemizole are useful for the treatment of asthma, motion sickness, and vertigo, without the concomitant liability of adverse effects associated with astemizole. Furthermore, the metabolic derivatives of astemizole, in combination with non-steroidal anti-inflammatory agents or other non-narcotic analgesics, or in combination with a decongestant, cough suppressant/antitussive or expectorant, are useful for the treatment of cough, cold, cold-like, and/or flu symptoms and the discomfort, headache, pain, fever, and general malaise associated therewith, without the concomitant liability of adverse effects associated with astemizole.
摘要翻译：公开了利用阿司咪唑的代谢衍生物治疗过敏性疾病的方法和组合物，同时避免与阿司咪唑相关的副作用的伴随的责任。阿司咪唑的代谢衍生物也可用于治疗与糖尿病相关的视网膜病变和其它小血管障碍以及可能与阿司咪唑的抗组织胺活性相关的其它病症。例如，阿司咪唑的代谢衍生物可用于治疗哮喘，晕车和眩晕，而不伴随与阿司咪唑有关的不良反应。此外，阿司咪唑的代谢衍生物与非甾体抗炎剂或其他非麻醉止痛剂组合，或与减充血剂，止咳剂/镇咳药或祛痰剂组合可用于治疗咳嗽，感冒，感冒类似，和/或流感症状以及与之相关的不适，头痛，疼痛，发烧和全身不适，而不伴随与阿司咪唑有关的不良反应。

17. 发明授权

US06337339B2 Methods and compositions for treating infection using optically pure (S)-lomefloxacin 失效
标题翻译：使用光学纯（S） - 洛美沙星治疗感染的方法和组合物
公开(公告)号：US06337339B2
公开(公告)日：2002-01-08
申请号：US09794006
申请日：2001-02-28
申请人： James W. Young , A. K. Gunnar Aberg
发明人： James W. Young , A. K. Gunnar Aberg
IPC分类号： A61K3147
CPC分类号： A61K31/47 , A61K31/496 , Y02A50/475 , Y02A50/481
摘要： Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of Mycobacteria infection.
摘要翻译：公开了使用洛美沙星的光学纯（S） - 异构体来治疗细菌感染的方法和组合物。特别地，该化合物是用于治疗分枝杆菌感染的有效药物。

18. 发明授权

US06207683B1 Benzocycloheptathiophene compounds 有权
标题翻译：苯并环庚噻嗪化合物
公开(公告)号：US06207683B1
公开(公告)日：2001-03-27
申请号：US09381351
申请日：1999-10-29
申请人： A. K. Gunnar Aberg , George E. Wright , Jan L. Chen
发明人： A. K. Gunnar Aberg , George E. Wright , Jan L. Chen
IPC分类号： A61K31445
CPC分类号： C07D409/04
摘要： Disclosed are N-substituted hydroxyalkyl or carboxyalkyloxyalkyl analogs of 9- and/or 10-oxo-4Hbenzo[4,5]cycloheptal[1,2-b]thiophene compounds, or 9-OH and/or 10-OH-substituted analogs thereof, which possess antihistaminic and antiasthmatic properties with reduced sedative side effects. The optically active isomers and pharmaceutically acceptable salts thereof are also described. The compounds were also found to prevent smooth muscle hyperreactivity.
摘要翻译：公开了9-和/或10-氧代-4H-苯并[4,5]环庚烯并[1,2-b]噻吩化合物或其9-OH和/或10-OH取代的类似物的N-取代的羟基烷基或羧基烷氧基烷基类似物，具有抗组胺和抗哮喘性质，降低镇静作用。还描述了旋光异构体及其药学上可接受的盐。还发现化合物可预防平滑肌高反应性。

19. 发明授权

US5731319A Methods for treating disorders using descarboethoxyloratadine 失效
标题翻译：使用去甲氧基乙酰氨喋呤治疗疾病的方法
公开(公告)号：US5731319A
公开(公告)日：1998-03-24
申请号：US783393
申请日：1997-01-13
申请人： A. K. Gunnar Aberg , John R. McCullough , Emil R. Smith
发明人： A. K. Gunnar Aberg , John R. McCullough , Emil R. Smith
IPC分类号： C07D401/04 , A61K31/4427 , A61K31/445 , A61K31/451 , A61K31/4545 , A61K45/06 , A61P3/08 , A61P3/10 , A61P25/04 , A61P27/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P31/12 , A61P31/16 , A61P37/08 , A61K31/44
CPC分类号： A61K31/4545 , A61K31/451 , A61K45/06 , Y10S514/826
摘要： Methods are disclosed utilizing DCL, a metabolic derivative of loratadine, for the treatment of allergic rhinitis, and other disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines.
摘要翻译：公开了使用氯雷他定的代谢衍生物DCL用于治疗过敏性鼻炎和其他疾病的方法，同时避免与其他非镇静抗组胺剂相关的副作用的伴随的责任。

20. 发明授权

US07985775B2 Methods of accelerating muscle growth, decreasing fat deposits and improving feed efficiency in livestock animals 有权
标题翻译：加速肌肉生长，减少脂肪沉积和提高牲畜动物饲料效率的方法
公开(公告)号：US07985775B2
公开(公告)日：2011-07-26
申请号：US11942455
申请日：2007-11-19
申请人： A. K. Gunnar Aberg
发明人： A. K. Gunnar Aberg
IPC分类号： A61K31/138
CPC分类号： A61K31/137 , A61K31/138 , A61K31/7048
摘要： A method of promoting or improving the feed efficiency and the muscle to fat ratio in animals by administering to the animals a therapeutically effective amount of a pure or substantially pure RR-isomer of ractopamine is disclosed. Also disclosed are animal feed preparations and compositions and pharmaceutical preparations capable of increasing lean meat deposition in an animal or decreasing body fat, or promoting or improving the growth of an animal or improving the feed efficiency of an animal. Feed preparation, compositions and pharmaceutical preparations including therapeutically effective amounts of a pure or substantially pure RR-isomer of ractopamine are disclosed.
摘要翻译：公开了一种通过向动物施用治疗有效量的纯赖碱或基本上纯的莱克多巴胺的RR-异构体来促进或改善动物的饲料效率和肌肉与脂肪比的方法。还公开了能够增加动物中瘦肉沉积或减少体脂肪的动物饲料制剂和组合物和药物制剂，或促进或改善动物的生长或提高动物的饲料效率。公开了饲料制备，组合物和药物制剂，包括治疗有效量的纯赖或基本上纯的莱克多巴胺的RR-异构体。

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