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11. 发明专利

CA2772051C COAGULATION FACTOR IX COMPOSITIONS AND METHODS OF MAKING AND USING SAME 未知
公开(公告)号：CA2772051C
公开(公告)日：2020-08-18
申请号：CA2772051
申请日：2010-08-02
申请人： AMUNIX OPERATING INC
发明人： SCHELLENBERGER VOLKER , SILVERMAN JOSHUA , STEMMER WILLEM PETER , WANG CHIA-WEI , SPINK BENJAMIN , GEETHING NATHAN CARL , TO WAYNE
IPC分类号： C12N9/64 , A61K38/48 , A61K47/64 , A61P7/04 , C12N9/96
摘要： The present invention relates to compositions comprising factor DC coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

13. 发明专利

BR112012004104A2 composições de fator ix de coagulação e métodos para fazer e usar as mesmas 未知
公开(公告)号：BR112012004104A2
公开(公告)日：2016-03-15
申请号：BR112012004104
申请日：2010-08-02
申请人： AMUNIX OPERATING INC
发明人： SPINK BENJAMIN , WANG CHIA-WEI , SILVERMAN JOSHUA , GEETHING NATHAN , SCHELLENBERGER VOLKER , TO WAYNE , STEMMER WILLEM P
IPC分类号： C07K14/475

14. 发明专利

AU2010290131B2 Coagulation factor VII compositions and methods of making and using same 未知
公开(公告)号：AU2010290131B2
公开(公告)日：2015-08-06
申请号：AU2010290131
申请日：2010-08-02
申请人： AMUNIX OPERATING INC
发明人： SCHELLENBERGER VOLKER , SILVERMAN JOSHUA , STEMMER WILLEM PETER , WANG CHIA-WEI , SPINK BENJAMIN , GEETHING NATHAN CARL , TO WAYNE
IPC分类号： C07K14/745 , A61K38/00 , C12P21/04
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

16. 发明专利

NZ628987A Extended recombinant polypeptides and compositions comprising same 未知
公开(公告)号：NZ628987A
公开(公告)日：2015-11-27
申请号：NZ62898710
申请日：2010-02-03
申请人： AMUNIX OPERATING INC
发明人： SCHELLENBERGER VOLKER , CLELAND JEFFREY L , SILVERMAN JOSHUA , STEMMER WILLEM P , WANG CHIA-WEI , GEETHING NATHAN , TO WAYNE , SPINK BENJAMIN
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00
摘要： Disclosed is an syringe or a kit comprising a pharmaceutical compositions comprising an extended recombinant polypeptide (XTEN) comprising greater than about 36 to about 3000 amino acid residues, wherein the XTEN is characterized in that: (a) the sum of glycine (G), alanine (A), serine (S), threonine (T), glutamate (E) and proline (P) residues constitutes more than about 80% of the total amino acid sequence of the XTEN; (b) the XTEN sequence is substantially non-repetitivesuch that (i) the XTEN contains no three contiguous amino acids that are identical unless the amino acids are serine; (ii) at least about 80% of the XTEN sequence consists of non-overlapping sequence motifs, each of the sequence motifs comprising about 9 to about 14 amino acid residues consisting of four to six types of amino acids selected from glycine (G), alanine (A), serine (S), threonine (T), glutamate (E) and proline (P), wherein any two contiguous amino acid residues do not occur more than twice in each of the non-overlapping sequence motifs; or (iii) the XTEN sequence has a subsequence score of less than 10; (c) the XTEN sequence lacks a predicted T-cell epitope when analyzed by TEPITOPE algorithm, wherein the TEPITOPE algorithm prediction for epitopes within the XTEN sequence is based on a score of –9 or greater. (d) the XTEN sequence has greater than 90% random coil formation as determined by GOR algorithm; and (e) the XTEN sequence has less than 2% alpha helices and 2% beta-sheets as determined by Chou-Fasman algorithm.

17. 发明专利

CA2771999A1 COAGULATION FACTOR VII COMPOSITIONS AND METHODS OF MAKING AND USING SAME 未知
公开(公告)号：CA2771999A1
公开(公告)日：2011-03-10
申请号：CA2771999
申请日：2010-08-02
申请人： AMUNIX OPERATING INC
发明人： SCHELLENBERGER VOLKER , SILVERMAN JOSHUA , STEMMER WILLEM PETER , WANG CHIA-WEI , SPINK BENJAMIN , GEETHING NATHAN CARL , TO WAYNE
IPC分类号： C12N9/64 , A61K38/48 , A61K47/48 , A61P7/04 , C12N9/96
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

18. 发明专利

CA2748314A1 EXTENDED RECOMBINANT POLYPEPTIDES AND COMPOSITIONS COMPRISING SAME 未知
公开(公告)号：CA2748314A1
公开(公告)日：2010-08-12
申请号：CA2748314
申请日：2010-02-03
申请人： AMUNIX OPERATING INC
发明人： SCHELLENBERGER VOLKER , SILVERMAN JOSHUA , WANG CHIA-WEI , SPINK BENJAMIN , STEMMER WILLEM P , GEETHING NATHAN , TO WAYNE , CLELAND JEFFREY L
IPC分类号： C07K14/00 , A61K47/42 , A61K47/48 , C07K1/00 , C07K7/08 , C07K19/00 , C12N15/00
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose- related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.

19. 发明专利

BRPI1008061B1 Polipeptídeos recombinantes estendidos (xten), proteína de fusão isolada compreendendo os mesmos e método de aprimoramento de uma propriedade de uma proteína biologicamente ativa 未知
公开(公告)号：BRPI1008061B1
公开(公告)日：2022-01-25
申请号：BRPI1008061
申请日：2010-02-03
申请人： AMUNIX OPERATING INC , AMUNIX PHARMACEUTICALS INC
发明人： SPINK BENJAMIN , WANG CHIA-WEI , JEFFREY L CLELAND , SILVERMAN JOSHUA , GEETHING NATHAN , SCHELLENBERGER VOLKER , TO WAYNE , WILLEM P STEMMER
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00
摘要： polipeptídeos recombinantes estendidos e composições compreendendo os mesmos. a presente invenção refere-se a composições compreendendo proteínas biologicamente ativas ligadas a um polipeptídeo recombinante estendido (xten), ácidos nucleicos isolados que codificam as composições e os vetores e células hospedeiras compreendendo as mesmas e métodos de uso de tais composições no tratamento de doenças relacionadas à glicose, doenças metabólicas, distúrbios de coagulação e distúrbios e condições relacionados ao hormônio de crescimento.

20. 发明专利

HRP20161807T1 PRODULJENI REKOMBINANTNI POLIPEPTIDI I SASTAVI KOJI IH SADRŽE 未知
公开(公告)号：HRP20161807T1
公开(公告)日：2017-02-24
申请号：HRP20161807
申请日：2016-12-29
申请人： AMUNIX OPERATING INC
发明人： SCHELLENBERGER VOLKER , SILVERMAN JOSHUA , WANG CHIA-WEI , SPINK BENJAMIN , STEMMER WILLEM P , GEETHING NATHAN , TO WAYNE , CLELAND JEFFREY L
IPC分类号： C07K1/00 , A61K38/19 , A61K38/22 , A61K38/26 , A61K38/36 , C07K14/00 , C07K14/47 , C07K14/50 , C07K14/545 , C07K14/58 , C07K14/605 , C07K14/61 , C07K14/715 , C07K14/745 , C07K17/00 , C12N15/62

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