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11. 发明授权

US5620675A Radioactive peptides 失效
标题翻译：放射性肽
公开(公告)号：US5620675A
公开(公告)日：1997-04-15
申请号：US95760
申请日：1993-07-21
申请人： William McBride , Richard T. Dean
发明人： William McBride , Richard T. Dean
IPC分类号： A61K51/00 , A61K38/00 , A61K51/08 , C07F7/22 , C07F13/00 , C07K1/04 , C07K5/083 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/655 , A61K38/31
CPC分类号： C07K14/6555 , A61K51/083 , A61K51/088 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing label radiodiagnostic agents. Specifically, the invention relates to linear peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to linear peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention so specifically relates to liner peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provide.
摘要翻译：本发明涉及治疗试剂和肽，放射诊断试剂和肽，以及用于制备标记物放射诊断剂的方法。具体地，本发明涉及生长抑素的线性肽衍生物和类似物，以及用放射性同位素放射性标记的这些肽的实施方案，以及用于制备放射性标记和用于放射诊断和放射治疗目的的这些肽的方法和试剂盒。本发明具体涉及用锝-99m放射性标记的生长抑素的线性肽衍生物和类似物及其作为闪烁照相成像剂的用途。本发明具体涉及用作放射性治疗剂放射性标记的细胞毒性放射性同位素如铼-186（186Re）和铼-188（188Re）的生长抑素的衬垫肽衍生物和类似物。还提供了用于在哺乳动物体内制造，放射性标记和诊断和治疗使用这些肽的方法和试剂盒。

12. 发明申请

US20100088337A1 System and Method for Performing Local Searches Across User Defined Events 有权
标题翻译：用户定义事件执行本地搜索的系统和方法
公开(公告)号：US20100088337A1
公开(公告)日：2010-04-08
申请号：US12572544
申请日：2009-10-02
申请人： William McBride Fesq , Michael Emil Ogrinz
发明人： William McBride Fesq , Michael Emil Ogrinz
IPC分类号： G06F17/30
CPC分类号： G06F17/30241 , G06Q10/10
摘要： The instant invention presents a system and method for performing local searches across one or more events created by one or more users. The system of the present invention comprises an event data structure comprising one or more user defined events, each event associated with a zip code. A zip list processor is provided to receive a zip code and a distance value, e.g., from user defined input, which are used to calculate a zip list comprising all zip codes geographically located with the distance value from the zip code. An event list generator to receives the zip list and queries the event data structure to retrieve events associated with zip codes contained in the zip list. The method of the present invention comprises creating an event data structure comprising one or more user defined events, each event associated with a zip code, calculating a zip list comprising all zip codes geographically located within a distance equal to a received distance value from a received zip code, and querying the event data structure to retrieve events associated with zip codes contained in the zip list.
摘要翻译：本发明提出了一种用于在由一个或多个用户创建的一个或多个事件上执行本地搜索的系统和方法。本发明的系统包括包括一个或多个用户定义的事件的事件数据结构，每个事件与邮政编码相关联。提供压缩列表处理器以接收例如用户定义的输入的邮政编码和距离值，所述距离值用于计算包含地理位置上与邮政编码的距离值的所有邮政编码的邮政编码。一个事件列表生成器，用于接收zip列表，并查询事件数据结构以检索与zip列表中包含的邮政编码相关联的事件。本发明的方法包括创建包括一个或多个用户定义的事件的事件数据结构，与邮政编码相关联的每个事件，计算一个zip列表，该列表包括地理上位于等于从接收到的接收到的距离值的距离内的所有邮政编码邮政编码，并查询事件数据结构，以检索与zip列表中包含的邮政编码相关联的事件。

13. 发明申请

US20070086942A1 Methods and compositions for generating bioactive assemblies of increased complexity and uses 有权
标题翻译：用于生成增加复杂性和用途的生物活性组件的方法和组合物
公开(公告)号：US20070086942A1
公开(公告)日：2007-04-19
申请号：US11478021
申请日：2006-06-29
申请人： Chien Chang , David Goldenberg , William McBride , Edmund Rossi
发明人： Chien Chang , David Goldenberg , William McBride , Edmund Rossi
IPC分类号： A61K51/00 , C12Q1/68 , G01N33/53 , G01N33/554 , C07K16/46
CPC分类号： A61K47/48438 , A61K31/00 , A61K38/00 , A61K47/48415 , A61K47/48484 , A61K47/485 , A61K47/48538 , A61K47/48546 , A61K47/48561 , A61K47/48569 , A61K47/6811 , A61K47/6817 , A61K47/6829 , A61K47/6833 , A61K47/6843 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K2039/505 , B82Y5/00 , B82Y10/00 , B82Y15/00 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/2803 , C07K16/2833 , C07K16/2851 , C07K16/2863 , C07K16/2881 , C07K16/2887 , C07K16/2896 , C07K16/3007 , C07K16/3092 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/76 , C07K2319/30 , C07K2319/35 , C07K2319/70 , C07K2319/74 , C12N9/12 , C12N9/22 , C12N9/96 , C12Y207/11001 , G01N33/54353 , G01N33/588 , Y02A50/491
摘要： The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which takes advantage of the specific binding interaction between dimerization and docking domains (DDD) and anchoring domains (AD) to form the assembly. In various embodiments, one or more effectors may be attached to a DDD or AD sequence. Complementary AD or DDD sequences may be attached to an adaptor module that forms the core of the bioactive assembly, allowing formation of the assembly through the specific DDD/AD binding interactions. Such assemblies may be attached to a wide variety of effector moieties for treatment, detection and/or diagnosis of a disease, pathogen infection or other medical or veterinary condition.
摘要翻译：本发明涉及用于制备和使用具有多种功能和/或结合特异性的限定组合物的生物活性组合物的方法和组合物。在特定的实施方案中，生物活性组件使用对接和锁定（DNL）方法形成，其利用二聚化和对接结构域（DDD）和锚定结构域（AD）之间的特异性结合相互作用形成组件。在各种实施方案中，一个或多个效应物可以连接到DDD或AD序列。互补AD或DDD序列可以连接到形成生物活性组件核心的适配器模块，从而允许通过特定的DDD / AD结合相互作用形成组装体。这些组合物可以连接到各种各样的效应部分，用于治疗，检测和/或诊断疾病，病原体感染或其他医学或兽医病症。

14. 发明申请

US20060140858A1 Drug pre-targeting by means of bi-specific antibodies and hapten constructs comprising a carrier peptide and the active agent(s) 审中-公开
标题翻译：通过双特异性抗体和包含载体肽和活性剂的半抗原构建体的药物预靶向，
公开(公告)号：US20060140858A1
公开(公告)日：2006-06-29
申请号：US10514632
申请日：2003-05-16
申请人： David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Gu
发明人： David Goldenberg , Hans Hansen , Shui-on Leung , William McBride , Zhengxing Gu
IPC分类号： A61K49/14 , A61K51/00 , C07K7/06
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds the targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the targetable constructs and bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译：本发明涉及可靶向的构建体，其可以由具有特异性结合靶组织的至少一个臂的双特异性抗体或抗体片段和至少一个特异性结合可靶向构建体的其它臂结合。可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。本发明提供用于产生可靶向构建体和双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。

15. 发明申请

US20050100543A1 Multivalent carriers of bi-specific antibodies 审中-公开
标题翻译：双特异性抗体的多价载体
公开(公告)号：US20050100543A1
公开(公告)日：2005-05-12
申请号：US10882151
申请日：2004-07-01
申请人： Hans Hansen , William McBride , Zhengxing Qu
发明人： Hans Hansen , William McBride , Zhengxing Qu
IPC分类号： A61K20060101 , A61K39/395 , A61K47/48 , A61K51/08 , A61K51/10 , C07K16/28 , C07K16/30 , C07K16/44 , C12N9/00
CPC分类号： C07K16/2887 , A61K47/6897 , A61K51/1027 , A61K51/1048 , A61K51/109 , A61K2039/505 , B82Y5/00 , C07K16/3007 , C07K2317/31 , C07K2317/622 , C07K2319/00 , C07K2319/01
摘要： Provided herein are targetable constructs that are multivalent carriers of bi-specific antibodies, i.e., each molecule of a targetable construct can serve as a carrier of two or more bi-specific antibodies. Also provided are targetable complexes formed by the association of a targetable construct with two or more bi-specific antibodies. The targetable constructs and targetable complexes of the invention are incorporated into biosensors, kits and pharmaceutical compositions, and are used in a variety of therapeutic and other methods.
摘要翻译：本文提供作为双特异性抗体的多价载体的可靶向构建体，即可靶向构建体的每个分子可以用作两种或更多种双特异性抗体的载体。还提供了通过可靶向构建体与两种或更多种双特异性抗体缔合形成的可靶向复合物。将本发明的可靶向构建体和可靶向复合物掺入生物传感器，试剂盒和药物组合物中，并且以多种治疗和其它方法使用。

16. 发明申请

US20050003403A1 Polyvalent protein complex 审中-公开
标题翻译：多价蛋白复合物
公开(公告)号：US20050003403A1
公开(公告)日：2005-01-06
申请号：US10829388
申请日：2004-04-22
申请人： Edmund Rossi , Chien Chang , William McBride
发明人： Edmund Rossi , Chien Chang , William McBride
IPC分类号： A61K39/395 , C07H21/04 , C07K14/475 , C07K14/52 , C07K16/00 , C07K16/30 , C07K16/44 , C07K16/46 , C12N20060101 , C12N15/00 , C12P21/04 , C12Q1/68
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/3007 , C07K16/468 , C07K2317/24 , C07K2317/626 , C07K2318/20 , C07K2319/00
摘要： The invention provides for a polyvalent protein complex (PPC) comprising two polypeptide chains generally arranged laterally to one another. Each polypeptide chain typically comprises 3 or 4 “v-regions”, which comprise amino acid sequences capable of forming an antigen binding site when matched with a corresponding v-region on the opposite polypeptide chain. Up to about 6 “v-regions” can be used on each polypeptide chain. The v-regions of each polypeptide chain are connected linearly to one another and may be connected by interspersed linking regions. When arranged in the form of the PPC, the v-regions on each polypeptide chain form individual antigen binding sites.
摘要翻译：本发明提供了包含两条多肽链的多价蛋白质复合物（PPC），其通常彼此横向排列。每个多肽链通常包含3或4个“v区”，其包含当与相对的多肽链上的相应v-区域匹配时能够形成抗原结合位点的氨基酸序列。每个多肽链可以使用多达约6个“v区”。每个多肽链的v-区域彼此线性连接并且可以通过散在的连接区域连接。当以PPC的形式排列时，每个多肽链上的v-区域形成单独的抗原结合位点。

17. 发明授权

US06086849A Technetium-99m labeled peptides for imaging 失效
标题翻译：锝-99m标记肽成像
公开(公告)号：US06086849A
公开(公告)日：2000-07-11
申请号：US170299
申请日：1995-02-09
申请人： Richard T. Dean , Scott Buttram , William McBride , John Lister-James , Edgar R. Civitello
发明人： Richard T. Dean , Scott Buttram , William McBride , John Lister-James , Edgar R. Civitello
IPC分类号： A61K51/00 , A61K51/08 , C07F13/00 , C07K1/113 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/745 , C07K14/75 , A61M36/14
CPC分类号： A61K51/088 , A61K51/08 , A61K51/082 , A61K2121/00 , A61K2123/00
摘要： This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.
摘要翻译： PCT No.PCT / US93 / 03687 371日期：1995年2月9日 102（e）1995年2月9日PCT PCT 1993年4月19日PCT公布。公开号WO93 / 21962 日期：1月11日，11日本发明涉及放射性标记的肽及其生产方法。具体地说，本发明涉及用于制备这些肽的肽，方法和试剂盒，以及使用这些肽以经锝-99m（Tc-99m）标记的哺乳动物体内的位点，通过形成中性复合物的放射性标记结合部分与Tc-99m。

18. 发明授权

US6017512A Radiolabeled peptides 失效
标题翻译：放射性标记肽
公开(公告)号：US6017512A
公开(公告)日：2000-01-25
申请号：US931095
申请日：1997-09-15
申请人： Richard T. Dean , William McBride , John Lister-James
发明人： Richard T. Dean , William McBride , John Lister-James
IPC分类号： A61K38/00 , A61K51/08 , C07K14/655 , A61K51/00 , A61M36/14
CPC分类号： A61K51/088 , A61K51/083 , C07K14/6555 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to cyclic peptide derivatives and analogs of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provided.
摘要翻译：本发明涉及治疗试剂和肽，包括放射治疗试剂和肽，放射诊断试剂和肽，以及用于制备标记的放射诊断剂的方法。具体地，本发明涉及生长抑素的环肽衍生物和类似物，以及用放射性同位素放射性标记的这种肽的实施方案，以及用于制备放射性标记和用于放射诊断和放射治疗目的的这些肽的方法和试剂盒。本发明具体涉及用锝-99m放射性标记的生长抑素的环肽衍生物和类似物及其用作闪烁照相成像剂。本发明还具体涉及放射性标记的细胞毒性放射性同位素如铼-186（186Re）和铼-188（188Re）用作放射治疗剂的生长抑素的环肽衍生物和类似物。还提供了用于在哺乳动物体内制造，放射性标记和诊断和治疗上使用这些肽的方法和试剂盒。

19. 发明授权

US5866097A Technetium-99m labeled peptides for imaging 失效
标题翻译：锝-99m标记肽成像
公开(公告)号：US5866097A
公开(公告)日：1999-02-02
申请号：US244336
申请日：1994-10-28
申请人： Richard T. Dean , William McBride , Scott Buttram
发明人： Richard T. Dean , William McBride , Scott Buttram
IPC分类号： A61K51/00 , A61K38/00 , A61K51/08 , C07B59/00 , C07F13/00 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/775 , A61M36/14
CPC分类号： C07K7/06 , A61K51/08 , A61K51/082 , A61K51/088 , C07B59/008 , C07K14/775 , A61K2121/00 , A61K2123/00 , A61K38/00 , Y10S930/28
摘要： The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body.
摘要翻译： PCT No.PCT / US92 / 10716 Sec。 371日期：1994年10月28日 102（e）日期1994年10月28日PCT 1992年11月19日PCT PCT。公开号WO93 / 10747 日期1993年6月10日本发明涉及哺乳动物体的放射性标记成像。本发明特别提供了用于这种成像的用锝-99m标记的试剂。本发明提供结合Tc-99m并可靶向哺乳动物体内特定位点的肽。

20. 外观设计

USD285028S Chair frame 失效
公开(公告)号：USD285028S
公开(公告)日：1986-08-12
申请号：US573977
申请日：1984-01-25
申请人： William McBride
设计人： William McBride

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