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11. 发明专利

JPS63119698A DIAGNOSTIC VECTOR OF RETINOBLASTOMA 失效
公开(公告)号：JPS63119698A
公开(公告)日：1988-05-24
申请号：JP20075587
申请日：1987-08-11
申请人： MASSACHUSETTS EYE & EAR INFIRM , WHITEHEAD BIOMEDICAL INST
发明人： DRYJA THADDEUS P , FRIEND STEPHEN
IPC分类号： G01N33/50 , A61B10/00 , A61K38/00 , A61K39/395 , A61K48/00 , A61P27/02 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/00 , C07K16/06 , C07K16/32 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/185 , G01N33/53 , G01N33/574

12. 发明专利

JP2001017171A CLASSIFICATION OF SAMPLES, AND IDENTIFICATION OF UNKNOWN CLASS 失效
公开(公告)号：JP2001017171A
公开(公告)日：2001-01-23
申请号：JP2000144136
申请日：2000-04-07
申请人： WHITEHEAD BIOMEDICAL INST
发明人： GOLUB TODD R , LANDER ERIC S , MESIROV JILL , SLONIM DONNA , TAMAYO PABLO
IPC分类号： C12N15/09 , C12M1/00 , C12Q1/68 , G01N33/48 , G01N33/50 , G01N37/00 , G06F19/20
摘要： PROBLEM TO BE SOLVED: To provide a method for identifying an unknown class basing on the gene expression by sorting genes depending on a degree of their expression in a sample correlating to the class identification, determining whether the correlation is stronger than that which can be obtained by an accident, followed by identifying a set of genes. SOLUTION: This method comprises the steps of sorting genes depending on a degree of their expression in a sample correlating to the class identification such as known class identification and disease class identification such as cancer class identification, determining whether or not the correlation is stronger than that which can be obtained by an accident, wherein a gene whose expression is correlated to stronger class identification than that which can be obtained by an accident is a useful gene which gives information, and identifying a set of useful genes which give information. The cancer class identification is selected from leukemia class identification, intracranial tumor class identification, and lymphoma class identification. A useful gene which gives information is C-myb, proteasome-iota and the like.

13. 发明专利

JPH11335296A VACCINE OF RECOMBINANT MYCOBACTERIUM 失效
公开(公告)号：JPH11335296A
公开(公告)日：1999-12-07
申请号：JP7770699
申请日：1999-03-23
申请人： WHITEHEAD BIOMEDICAL INST
发明人： BLOOM BARRY R , DAVIS RONALD W , JACOBS WILLIAM R JR , YOUNG RICHARD A
IPC分类号： C12N1/21 , A61K39/00 , A61K39/02 , A61K39/04 , A61K39/12 , C12N15/00 , C12N15/09 , C12N15/74 , C12N15/87 , C12R1/32
摘要： PROBLEM TO BE SOLVED: To obtain the subject vaccine capable of stimulating an immunity sufficient for protecting a body from pathogens for a long time without producing a side effect and useful for prophylaxis of tuberculosis, Hanse's disease, etc., by inducing a recombinant mycobacterium expressing an extrinsic DNA encoding a protein antibody and capable of being cultured. SOLUTION: This vaccine contains a recombinant mycobacterium expressing a foreign DNA encoding at least a protein antibody and capable of being cultured. The recombinant mycobacterium capable of being cultured is preferably Mycobacterium bovis-BCG, Mycobacterium smegmatis or its genetic mutant. The extrinsic DNA includes a DNA encoding the protein antibody of Mycobacterium leprae, a Hansen's disease parasite. The vaccine is prepared by transducing the extrinsic DNA encoding at least a protein antigen against each of one or more pathogens into a mycobacterium by the use of a shuttle phasmid.

14. 发明专利

JPH1084974A ENHANCEMENT OF TRANSCRIPTION OF GENE 失效
公开(公告)号：JPH1084974A
公开(公告)日：1998-04-07
申请号：JP12856697
申请日：1997-05-19
申请人： MASSACHUSETTS INST TECHNOLOGY , WHITEHEAD BIOMEDICAL INST
发明人： BALTIMORE DAVID , SEN RANJAN , SHARP PHILLIP A , SINGH HARINDER , STAUDT LOUIS A
IPC分类号： G01N33/53 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/42 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/85 , C12P21/00 , C12P21/02 , C12Q1/68 , C12R1/91 , G01N27/26 , G01N27/447 , G01N33/566 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To sufficiently enhance the transcription of the objective gene by joining strong promoter to a gene capable of coding an intranuclear factor of a human lymphoid cell and then transfecting the resultant genetic construct in a multi-copy state into a cell containing the objective gene. SOLUTION: A strong promoter is joined to a DNA capable of coding a structural gene of a regulation factor selected from the group consisting of four kinds of intranuclear factors IgNF-A, IgNF-E, IgNF-B and IgNF-κ 3, isolated from a nuclear extract of a lymphoid cell and capable of joining to a transcriptionally regulating DNA component of an Ig gene to prepare an expressible genetic construct. Furthermore, the resultant genetic construct in a multi- copy state so as to sufficiently enhance the transcription of the objective gene is then transfected into a cell containing the objective gene. The regulation factor can readily be identified by a high-sensitivity get electrophoretic DNA- binding assay for adding an alternating copolymer double-stranded poly(dI- dC).poly(dI-DC) thereto.

15. 发明专利

JPH0354450A APPARATUS AND METHOD OF CATAPHORESIS 失效
公开(公告)号：JPH0354450A
公开(公告)日：1991-03-08
申请号：JP1511790
申请日：1990-01-26
申请人： WHITEHEAD BIOMEDICAL INST
发明人： DON ESU DERINGU , POORU TEI MATSUDAIRA
IPC分类号： B01D57/02 , G01N27/447
摘要： PURPOSE: To proceed to next process without disturbing molecules eluded and held by membrane by piling an upper buffer liquid room on the top of a lower buffer liquid room which each holds a certain amount of eluded liquid and applying proper electric field to this eluded liquid. CONSTITUTION: An upper buffer liquid room 10 is piled on the top of a lower buffer liquid room 12 which each holds a certain amount of eluded liquid and proper electric field is impressed to this eluded liquid. The current flows through the eluded liquid in the buffer rooms 10 and 12, makes the desired molecule in a sample gel piece 30 go from the piece 30 through the lower end of the sample holder 28 and a condenser 26 and elude to its lower part membrane 38. The membrane 38 holds the molecules eluded by a method proper for directly processing in the next. As the upper part of the condenser 26 does not recontrol and reorientate the condenser 26, next process is made possible without disturbing the molecules held by the membrane 38 and eluded.

16. 发明申请

WO2016040824A3 METHODS OF IDENTIFYING MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USE OF SAME TO MODULATE mTORC1 审中-公开
标题翻译：鉴定SESTRIN-GATOR2相互作用的调节剂的方法和使用它们来调节mTORC1
公开(公告)号：WO2016040824A3
公开(公告)日：2016-06-02
申请号：PCT/US2015049727
申请日：2015-09-11
申请人： WHITEHEAD BIOMEDICAL INST
发明人： SABATINI DAVID M , CHANTRANUPONG LYNNE , WOLFSON RACHEL L , OROZCO JOSE , SAXTON ROBERT A , SENGUPTA SHOMIT
IPC分类号： A61K38/17 , C07K14/47 , C12Q1/68
CPC分类号： G01N33/6872 , G01N33/5041 , G01N33/53 , G01N2500/02
摘要： The present invention provides methods of identifying modulators of mTORC1 based upon their effect on GATOR2-Sestrin binding or Sestrin-leucine binding; and the use of such modulators to alter mTORC1 activity in a cell and to treat disease and conditions that are effected by mTORC1 activity.
摘要翻译：本发明提供了基于它们对GATOR2-Sestrin结合或Sestrin-亮氨酸结合的影响来鉴定mTORC1调节剂的方法; 以及使用这些调节剂来改变细胞中的mTORC1活性并治疗由mTORC1活性影响的疾病和病症。

17. 发明申请

WO2016025533A2 COMPOSITIONS AND METHODS FOR TREATING SYNUCLEINOPATHIES 审中-公开
标题翻译：用于治疗综合征的组合物和方法
公开(公告)号：WO2016025533A2
公开(公告)日：2016-02-18
申请号：PCT/US2015044736
申请日：2015-08-11
申请人： WHITEHEAD BIOMEDICAL INST
发明人： PISO GABRIELA CARAVEO , LINDQUIST SUSAN , WHITESELL LUKE J
IPC分类号： A61K31/436
CPC分类号： A61K31/436 , C07K14/39
摘要： In some aspects, described herein are methods of treating synucleinopathies using FK506.
摘要翻译：在一些方面，本文描述的是使用FK506治疗突触核蛋白病的方法。

18. 发明申请

WO2015035214A1 ETHANOL PRODUCTION IN ENGINEERED YEAST 审中-公开
标题翻译：工程YEAST中的乙醇生产
公开(公告)号：WO2015035214A1
公开(公告)日：2015-03-12
申请号：PCT/US2014054358
申请日：2014-09-05
申请人： MASSACHUSETTS INST OF TECHNOLGY , WHITEHEAD BIOMEDICAL INST
发明人： LAM FELIX , FINK GERALD , STEPHANOPOULOS GREGORY
IPC分类号： C12P7/06
CPC分类号： C12P7/10 , C07K14/39 , C12N15/81 , C12P7/04 , C12P7/16 , C12Y101/01001 , C12Y101/01021 , C12Y102/01005 , Y02E50/10 , Y02E50/16 , Y02E50/17
摘要： The present disclosure provides, in various aspects, engineered alcohol tolerant yeast and methods of producing high concentrations of ethanol. The present disclosure shows that the basis of general alcohol tolerance is the upkeep of the opposing potassium and proton electromotive membrane gradients. Potassium supplementation and acidity reduction of culture medium physically strengthen these gradients, significantly increasing ethanol production in very high sugar and high cell density conditions mimicking industrial fermentation. Ethanol production per viable cell remains unchanged, and the enhancement in total output derives solely from elevated viability. Tolerance to ethanol can be controlled genetically, for example, via modulation of the cognate potassium (K+) and proton (H+) pumps; the artificially facilitated/increased import of K+ and export of H+ confer characteristics on laboratory strains that match or exceed those of industrial strains.
摘要翻译：本公开在各个方面提供了工程醇耐受酵母和生产高浓度乙醇的方法。本公开显示，一般酒精耐受性的基础是相对的钾和质子电动膜梯度的维持。培养基的补钾和酸度降低，物理强化了这些梯度，显着增加了非常高的糖和模拟工业发酵的高细胞密度条件下的乙醇生产。每个活细胞的乙醇产量保持不变，总产出的增加仅来自升高的生存力。对乙醇的耐受性可以在遗传上进行控制，例如通过调节相关钾（K +）和质子（H +）泵; 人工促进/增加进口K +和出口H +赋予特征的实验室菌株匹配或超过工业菌株。

19. 发明申请

WO2013188789A3 GENOME-WIDE METHOD OF ASSESSING INTERACTIONS BETWEEN CHEMICAL ENTITIES AND THEIR TARGET MOLECULES 审中-公开
标题翻译：评估化学实体与其目标分子之间相互作用的基本方法
公开(公告)号：WO2013188789A3
公开(公告)日：2014-02-20
申请号：PCT/US2013045929
申请日：2013-06-14
申请人： WHITEHEAD BIOMEDICAL INST , DANA FARBER CANCER INST INC
发明人： YOUNG RICHARD A , BRADNER JAMES E , RAHL PETER B , ANDERS LARS , MARINEAU JASON J , QI JUN , GUENTHER MATTHEW G
IPC分类号： G01N33/50
CPC分类号： C12Q1/6837 , G01N33/5008
摘要： The invention is directed to a method of mapping, across a genome, interaction of a drug with one or more factors that associate with the genome.
摘要翻译：本发明涉及一种在基因组上映射药物与与基因组相关联的一个或多个因子的相互作用的方法。

20. 发明申请

WO2013155526A3 SORTASE- MODIFIED VHH DOMAINS AND USES THEREOF 审中-公开
标题翻译：排序改进的VHH域及其用途
公开(公告)号：WO2013155526A3
公开(公告)日：2014-01-30
申请号：PCT/US2013036630
申请日：2013-04-15
申请人： WHITEHEAD BIOMEDICAL INST
发明人： PLOEGH HIDDE , POPP MAXIMILIAN , CRAGNOLINI JUANJO
IPC分类号： C07K14/435 , A61K39/00 , A61P37/02 , C07K1/13 , C07K16/46 , C07K19/00 , C12N15/10 , C12N15/64 , C40B50/06
CPC分类号： C07K16/2833 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K1/13 , C07K16/1018 , C07K16/44 , C07K16/468 , C07K2317/22 , C07K2317/569 , C07K2319/90 , C12N9/50 , G01N33/582
摘要： In some aspects, polypeptides comprising single domain antibodies and methods of identifying single domain antibodies are provided. In some embodiments polypeptides comprising a single domain antibody and a sortase recognition sequence, are provided. In some aspects, products and methods of use in modulating the immune system, e.g., modulating an immune response, are provided.
摘要翻译：在一些方面，提供了包含单域抗体的多肽和鉴定单结构域抗体的方法。在一些实施方案中，提供了包含单结构域抗体和分选酶识别序列的多肽。在一些方面，提供了用于调节免疫系统的产物和方法，例如调节免疫应答。

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