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11. 发明申请

US20200345275A1 A METHOD FOR MEASURING A SEDATION STATE OF A PATIENT 审中-公开
公开(公告)号：US20200345275A1
公开(公告)日：2020-11-05
申请号：US16964729
申请日：2019-01-25
申请人： UNIVERSITE D'AIX-MARSEILLE (AMU) , ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE (AP-HM) , INSTITUT FRANCAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS DE L'AMÉNAGEMENT ET DES RÉSEAUX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Harold Noble Ibouanga-Kipoutou , Salah Boussen , Kouider Nacer M'Sirdi , Pierre-Jean Arnoux , Nicolas Bruder , Michel Behr
IPC分类号： A61B5/11 , A61M16/01 , A61B5/0205 , G16H20/40 , G16H50/30 , G16H40/63
摘要： The invention relates to a method for automatic and continuous measurement of a sedation state of a patient in an intensive care unit. The method according to the invention comprises the following steps: providing signals representative of the condition of the patient, said signals comprising cardio-circulatory signals, signals representative of the respiratory activity and signals representative of the motor activity of the patient; and determining a global index representative of the sedation state of the patient.

12. 发明申请

WO2018015778A1 A METHOD OF MODULATING EPILEPTOGENICITY IN A PATIENT'S BRAIN 审中-公开
标题翻译：一种调节患者脑部癫痫发作的方法
公开(公告)号：WO2018015778A1
公开(公告)日：2018-01-25
申请号：PCT/IB2016/001164
申请日：2016-07-18
申请人： UNIVERSITE D'AIX-MARSEILLE (AMU) , CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS) , ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (AP-HM) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： JIRSA, Viktor , BERNARD, Christophe , BARTOLOMEI, Fabrice , GUYE, Maxime
IPC分类号： A61B5/0476 , A61B5/00 , G06F19/00
摘要： The invention relates to modulating epileptogenicity in a brain of an epileptic patient. The method according to the invention comprises the steps of: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading said models in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in said data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing said at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.
摘要翻译：本发明涉及调节癫痫患者脑中的致癫痫性。根据本发明的方法包括以下步骤：提供虚拟脑; 提供癫痫和传播区的模型并将所述模型加载到虚拟大脑中以创建虚拟癫痫脑; 获取癫痫患者的大脑数据; 在所述数据中识别至少一个可能致痫区的位置; 将所述虚拟癫痫脑与从所述癫痫患者获取的数据拟合，并将所述虚拟癫痫脑中的所述至少一个可能致痫区参数化为癫痫发作区; 并在虚拟癫痫脑内模拟模仿患者脑的临床干预的网络调节的效果。

13. 发明申请

WO2022180236A1 N-ACETYL-D-GLUCOSAMINE AS A DIAGNOSTIC BIOMARKER OF A DISEASE INDUCED BY MAST CELL ACTIVATION 审中-公开
公开(公告)号：WO2022180236A1
公开(公告)日：2022-09-01
申请号：PCT/EP2022/054855
申请日：2022-02-25
申请人： UNIVERSITE D'AIX-MARSEILLE (AMU) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT JEAN PAOLI & IRENE CALMETTES (IPC)
发明人： BRENET, Fabienne , DUBREUIL, Patrice , DA COSTA, Quentin
IPC分类号： G01N33/68
摘要： The invention relates to the field of medicine and diagnostic. Inventors herein describe the use of GlcNAc as a biomarker of a disease induced by mast cell activation. Methods are also described for diagnosing a disease induced by mast cell activation; for assessing the severity a disease induced by mast cell activation; for monitoring the evolution a disease induced by mast cell activation; or for determining the efficacy of a therapy of a disease induced by mast cell activation. Kits are also described as well as uses thereof.

14. 发明申请

WO2019145506A1 A METHOD FOR MEASURING A SEDATION STATE OF A PATIENT 审中-公开
公开(公告)号：WO2019145506A1
公开(公告)日：2019-08-01
申请号：PCT/EP2019/051903
申请日：2019-01-25
申请人： UNIVERSITE D'AIX-MARSEILLE (AMU) , ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE (AP-HM) , INSTITUT FRANÇAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS DE L'AMÉNAGEMENT ET DES RÉSEAUX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： IBOUANGA-KIPOUTOU, Harold, Noble , BOUSSEN, Salah , M' SIRDI, Kouider, Nacer , ARNOUX, Pierre-Jean , BRUDER, Nicolas , BEHR, Michel
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/11 , G16H40/63 , G16H50/20 , A61M16/00 , A61M16/01
CPC分类号： A61B5/4821 , A61B5/0205 , A61B5/1118 , A61B5/7275 , A61M16/01 , A61M2016/003 , A61M2205/502 , A61M2230/005 , A61M2230/06 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/42 , G16H40/63 , G16H50/20 , G16H50/30
摘要： The invention relates to a method for automatic and continuous measurement of a sedation state of a patient in an intensive care unit. The method according to the invention comprises the following steps: providing signals representative of the condition of the patient, said signals comprising cardio-circulatory signals, signals representative of the respiratory activity and signals representative of the motor activity of the patient; and determining a global index representative of the sedation state of the patient.

15. 发明申请

WO2019121257A1 SYSTEME DE CONTROLE DE LA PRESSION EXPIRATOIRE D'UN PLONGEUR POUR UN EQUIPEMENT DE VENTILATION DE PLONGEE 审中-公开
公开(公告)号：WO2019121257A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/084611
申请日：2018-12-12
申请人： UNIVERSITE D'AIX-MARSEILLE (AMU) , ASSISTANCE PUBLIQUE DES HOPITAUX DE MARSEILLE (AP-HM)
发明人： COULANGE, Mathieu , MICHELET, Pierre
IPC分类号： B63C11/18 , B63C11/22 , B63C11/24
CPC分类号： B63C11/18 , B63C11/24 , B63C2011/182
摘要： Système de contrôle de la pression expiratoire d'un plongeur pour un équipement de plongée ayant un circuit ventilatoire, comprenant une valve unidirectionnelle agissant sur une sortie expiratoire du circuit ventilatoire, et un frein configuré pour exercer une contrainte réglable sur la valve unidirectionnelle afin de contrôler la pression du gaz issu de la sortie expiratoire de manière à générer une pression positive expiratoire dans le circuit ventilatoire de l'équipement et ainsi prévenir ou traiter les œdèmes pulmonaires d'immersion.

16. 发明公开

EP3855453A1 A METHOD OF OPTIMIZING AN INTRACRANIAL IMPLANTATION SCHEME OF A SET OF ELECTROENCEPHALOGRAPHIC ELECTRODES 审中-公开
公开(公告)号：EP3855453A1
公开(公告)日：2021-07-28
申请号：EP20153732.1
申请日：2020-01-24
申请人： Universite d'Aix-Marseille (AMU) , Institut National de la Santé et de la Recherche Médicale
发明人： JIRSA, Viktor , EL HOUSSAINI, Kenza , WANG, Huifang
IPC分类号： G16H50/20 , G16H50/50
摘要： The invention relates to a method of optimizing an intracranial implantation scheme of a set of electroencephalographic electrodes for identification of an epileptogenic zone in an epileptic patient's brain. This method comprises the steps of - providing a model of the epileptogenic zone and a model of the propagation of an epileptic discharge from said epileptic zone to a propagation zone, and loading said models in a computerized platform personalized according to the patient's brain; - providing at least one hypothesis of the localization of the epileptogenic zone in the patient brain; - for said at least hypothesis of the localization of the epileptogenic zone, simulating, in the personalized computerized patient's brain, epileptic seizures, and determining, for said hypothesis and epileptic seizures, a network of propagation zones; - for a plurality of intracranial implantation schemes of the electroencephalographic electrodes, obtaining, using the personalized computerized patient's brain, simulated electroencephalographic signals activity that is to be measured by the intracranial electrodes implanted according to said plurality of schemes; and - determining, from said plurality of intracranial implantation schemes, an optimized intracranial implantation scheme of the set of electroencephalographic electrodes.

17. 发明公开

EP3346262A1 OPTICAL THERMAL METHOD AND SYSTEM FOR DIAGNOSING PATHOLOGIES 审中-公开
公开(公告)号：EP3346262A1
公开(公告)日：2018-07-11
申请号：EP17150839.3
申请日：2017-01-10
申请人： Universite d'Aix-Marseille (AMU) , INSERM (Institut National de la Santé et de la Recherche Médicale)
发明人： Tsvetkov, Philipp , Devred, François
IPC分类号： G01N25/48 , G01N33/48
CPC分类号： G01N25/4866 , G01N33/48
摘要： The invention concerns a method and a system for diagnosing a pathology in a mammal in need thereof. The method according to the invention comprises the following steps: collecting a biological sample from said mammal, said biological sample comprising a protein mixture; obtaining an optical thermal denaturation profile of said biological sample; comparing said optical thermal denaturation profile of said biological sample with an optical thermal denaturation reference profile; and diagnosing the pathology.

18. 发明公开

EP3158239A1 DISPOSITIF DISTRIBUTEUR DE FLUIDE A VOIES D'ENTREE/SORTIE FLUIDIQUE MULTIPLES RECONFIGURABLES 审中-公开
标题翻译： DispOSITIF DISTRIBUTEUR DE FLUIDE A VOIES D'ENTREE / SORTIE FLUIDIQUE MULTIPLES RECONFIGURABLES
公开(公告)号：EP3158239A1
公开(公告)日：2017-04-26
申请号：EP15736549.5
申请日：2015-06-16
申请人： Centre National de la Recherche Scientifique , Universite d'Aix-Marseille (AMU)
发明人： LAUNAY, Stéphane
IPC分类号： F16K11/076 , F16K11/085
CPC分类号： F16K11/076 , F16K11/0856
摘要： This fluid dispenser with multiple fluid inlet/outlet channels (114A, 116A) comprises a first cylindrical portion (106), having at least one lateral fluid inlet or outlet channel, comprising at least one fluid connection chamber (146) for fluidly connecting said lateral channel to at least one opening formed in a lower base (110) of said first cylindrical portion (106). It comprises a second cylindrical portion (112), having several lateral fluid inlet/outlet channels (114A, 116A) and with circular cylindrical boring, having an upper base (110) coinciding with the lower base of the first cylindrical portion (106). It comprises a rotary circular cylindrical core (138), disposed inside the second cylindrical portion (112) and having an upper base in contact with the lower base (110) of the first cylindrical portion (106), free in rotation inside the second cylindrical portion (112) and in which there is formed at least one conduit (140, 142) for fluidly connecting said opening to at least any one of the lateral channels (114A, 116A) of the second cylindrical portion (112).
摘要翻译：具有多个流体入口/出口通道（114A，116A）的该流体分配器包括具有至少一个侧向流体入口或出口通道的第一圆柱形部分（106），其包括至少一个流体连接腔室（146），用于流体连接所述侧向通道至形成在所述第一圆柱形部分（106）的下底座（110）中的至少一个开口。它包括具有几个横向流体入口/出口通道（114A，116A）和圆柱形钻孔的第二圆柱形部分（112），其具有与第一圆柱形部分（106）的下基座重合的上基座（110）。它包括设置在第二圆筒形部分（112）内部并具有与第一圆筒形部分（106）的下底座（110）接触的上底座的旋转圆筒形芯体（138），其在第二圆筒形部分（112），并且其中形成有至少一个导管（140,142），用于将所述开口流体连接到所述第二圆柱形部分（112）的至少任何一个所述侧向通道（114A，116A）。

19. 发明公开

EP3156046A1 AMPHIPHILIC MOLECULES LAYERS 无效
标题翻译： AMPHIPHILEMOLEKÜLSCHICHTEN
公开(公告)号：EP3156046A1
公开(公告)日：2017-04-19
申请号：EP15306656.8
申请日：2015-10-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , Universite d'Aix-Marseille (AMU)
发明人： KENAAN, Ahmad , CHARRIER, Anne Magali , LAVANDIER, Sébastien , RAIMUNDO, Jean-Manuel
IPC分类号： A61K9/127 , H01L29/00
CPC分类号： A61K9/1273
摘要： The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.
摘要翻译：本公开涉及包含至少一个亲水部分和至少一个疏水部分的层，该层包含在层的亲水部分和疏水部分上彼此聚合的自组装两亲分子; 检测装置，包括基板和上述层; 和脂质体，胶束，物质输送系统和包含上述层的仿生系统。本公开还涉及一种生产层的方法，该方法包括：提供两亲分子; 允许足够的时间使两亲分子自组装并形成至少一个亲水部分和该层的至少一个疏水部分; 在层的亲水部分和疏水部分上彼此聚合自组装的两亲性分子。

20. 发明公开

EP4004943A1 METHOD FOR DETERMINING AN ONSET TIME AND AN EXCITABILITY OF A BRAIN REGION 审中-实审
公开(公告)号：EP4004943A1
公开(公告)日：2022-06-01
申请号：EP20742742.8
申请日：2020-07-22
申请人： Universite d'Aix-Marseille (AMU) , Institut National de la Santé et de la Recherche Médicale
发明人： JIRSA, Viktor , SIP, Viktor
IPC分类号： G16H50/20 , G16H50/50

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