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    • 14. 发明申请
    • Scaffolds with viable tissue
    • 具有活组织的支架
    • US20050177249A1
    • 2005-08-11
    • US10775034
    • 2004-02-09
    • Stephanie KladakisSridevi DhanarajRobert Boock
    • Stephanie KladakisSridevi DhanarajRobert Boock
    • A61L27/00A61F2/00A61L27/36A61L27/48A61L27/56A61L27/58A61F2/02
    • A61L27/48A61L27/56A61L27/58
    • A composite implant is provided for repairing a tissue defect in a patient. In one embodiment, the implant is a porous tissue scaffold having at least one pocket formed therein and adapted to contain a viable tissue. The tissue scaffold can have a variety of configurations, and in one embodiment it includes top and bottom portions that can be at least partially mated to one another, and in an exemplary embodiment that are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween. The pocket is preferably sealed with a viable tissue disposed therein. In another embodiment, the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold, and/or at least one lumen extending into the tissue scaffold. The tissue scaffold can also optionally include at least one surface feature formed thereof to promote blood vessel formation.
    • 提供复合植入物来修复患者的组织缺损。 在一个实施例中,植入物是多孔组织支架,其具有形成在其中的至少一个口袋并且适于容纳活组织。 组织支架可以具有各种构造,并且在一个实施例中,其包括可以彼此至少部分地配合的顶部和底部部分,并且在示例性实施例中,围绕其周边彼此加热密封以形成 封闭口袋。 口袋优选用设置在其中的活组织密封。 在另一个实施例中,组织支架基本上是楔形的,并且口袋包括形成在组织支架中的中空内部和/或延伸到组织支架中的至少一个腔。 组织支架还可以任选地包括形成于其中的至少一个表面特征以促进血管形成。