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11. 发明申请

WO2016180235A1 SYSTEM AND METHOD FOR LIGHT OPTIMIZATION 审中-公开
标题翻译：用于光优化的系统和方法
公开(公告)号：WO2016180235A1
公开(公告)日：2016-11-17
申请号：PCT/CN2016/080365
申请日：2016-04-27
申请人： SHENZHEN UNIVERSITY
发明人： YAO, Qi
IPC分类号： H05B37/02 , H05B33/08
CPC分类号： G01J3/40 , G01M11/02 , H05B33/0869 , H05B33/0872 , H05B37/02
摘要： A method and related system for spectrum optimization of an illumination light source. Spectrum optimization according to the present disclosure can be based on various optimization parameters, including but not limited to luminous efficacy, color rendering effect, luminous efficacy of radiation, mesopic efficacy of radiation，circadian efficacy of radiation, etc. The present method and system are capable of optimizing illumination performance of a light source in various aspects in an individual or integrated manner. Further the present method and system are capable of accommodating different illumination purposes and conditions by combining and prioritizing different optimization parameters.
摘要翻译：一种照明光源频谱优化的方法及相关系统。根据本公开的光谱优化可以基于各种优化参数，包括但不限于发光效率，显色效果，辐射的发光效率，辐射的中效，辐射的昼夜效能等。本方法和系统是能够以个别或集成的方式在各个方面优化光源的照明性能。此外，本方法和系统能够通过组合和优先化不同的优化参数来适应不同的照明目的和条件。

12. 发明申请

WO2021179214A1 Methods for enhancing anti-apoptotic pathway to prevent DOX toxicity 审中-公开
公开(公告)号：WO2021179214A1
公开(公告)日：2021-09-16
申请号：PCT/CN2020/078840
申请日：2020-03-11
申请人： SHENZHEN UNIVERSITY
发明人： LIU, Baohua , PENG, Linyuan , QIAN, Minxian
IPC分类号： A61K45/00 , A61K38/16 , A61K38/45 , A61P9/00 , A61P35/00 , A61P39/02 , C12N9/10
摘要： Provided is a method for promoting anti-apoptotic pathway in mammal cells by enhancing acetylation of a transcription factor GATA4. The method includes contacting the mammal cells with an agent in an amount effective to increase the acetylation of GATA4, wherein the agent is configured to enhance the acetylation of GATA4 at 328th and 330th lysine residues (K328 and K330) within a carboxyl terminal Zn-finger region. Provided is a method for promoting anti-apoptotic pathway in mammal cells by inhibiting deacetylase activity of SIRT6. The method includes contacting the mammal cells with an agent in an amount effective to inhibit the deacetylase activity of SIRT6, wherein the agent is a peptide including an amino acid sequence represented by SEQ ID NO: 2, or an analog thereof.

13. 发明申请

WO2021068242A1 AN AGENT THAT ENABLES SIRT7 GENE EXPRESSION AND THE USE THEREOF 审中-公开
公开(公告)号：WO2021068242A1
公开(公告)日：2021-04-15
申请号：PCT/CN2019/110813
申请日：2019-10-12
申请人： SHENZHEN UNIVERSITY
发明人： LIU, Baohua , SUN, Shimin , TANG, Xiaolong
IPC分类号： A61K48/00 , C12N5/10 , A61P3/00 , A61P9/00
摘要： Provided is an agent that enables Sirt7 gene expression, especially a recombinant adeno-associated virus(rAVV) that enables vascular endothelium(VE)-specific Sirt7 gene expression, and the use thereof. A method for improving neovascularizaiton, ameliorating aging features, extending lifespan and treating age-related diseases by using the agent especially the rAAV is also provided.

14. 发明申请

WO2020172854A1 USE OF ENDOTHELIAL PROGENITOR CELLS (EPCS) IN REJUVENATING MICROVASCULATURE, PREVENTING AGING AND TREATING AGE-RELATED DISEASES 审中-公开
公开(公告)号：WO2020172854A1
公开(公告)日：2020-09-03
申请号：PCT/CN2019/076488
申请日：2019-02-28
申请人： SHENZHEN UNIVERSITY
发明人： LIU, Baohua , SUN, Shimin
IPC分类号： A61K35/44 , A61P9/10
摘要： Disclosed are endothelial progenitor cells (EPCs), their role in preventing aging, extending lifespan and treating age-related diseases, and in particular, the use of endothelial progenitor cells in clinical progeria treatment.

15. 发明公开

EP3876434A1 DATA-DRIVEN BEAM TRACKING METHOD AND APPARATUS FOR MOBILE MILLIMETER WAVE COMMUNICATION SYSTEM 审中-实审
公开(公告)号：EP3876434A1
公开(公告)日：2021-09-08
申请号：EP19933796.5
申请日：2019-12-11
申请人： Shenzhen University
发明人： QUAN, Zhi , MA, Yuan
IPC分类号： H04B7/06
摘要： Based on real-time measurement data, disclosed is a data-driven beam tracking solution for a mobile Millimeter Wave (mmWave) communication system. A disclosed data driving method is based on a dynamically linearized representation of a time-varying pseudo-gradient parameter estimation process. In the disclosure, an effective codebook design method is introduced, so that beam tracking may further be accelerated with a low overhead by beam rotation. A simulation result of the disclosure shows that, through the solution, tracking performance higher than that of an existing reliable communication solution may be achieved.

16. 发明公开

EP3744810A1 FLUORESCENT DYE, PREPARATION METHOD THEREFOR AND USE THEREOF 有权
公开(公告)号：EP3744810A1
公开(公告)日：2020-12-02
申请号：EP17935203.4
申请日：2017-12-21
申请人： Shenzhen University
发明人： YANG, Zhigang , QU, Junle
IPC分类号： C09K11/06 , C07D403/08 , C07D413/08 , C07D417/08 , G01N21/64
摘要： Disclosed are a fluorescent dye, a preparation method and an application thereof. The fluorescent dye has a general structural formula as shown in formula (I), wherein X and Y are same or different and selected from O, S, C(CH 3 ) 2 or NR 6 ; R 2 and R 3 are the same or different and selected from hydrogen or a functional group; R 1 , R 4 , R 5 and R 6 are all functional groups; and Z - is a negative ion. The fluorescent dye has an ability to permeate the living cell membrane, so that it can be used in the fluorescence imaging of living cell microstructures, and can also be used in the STED super-resolution fluorescence imaging and laser scanning confocal microscopy of live cells.

17. 发明授权

EP3088574B1 TERNARY INORGANIC COMPOUND CRYSTAL AND PREPARATION METHOD AND APPLICATION THEREOF 有权
公开(公告)号：EP3088574B1
公开(公告)日：2018-10-31
申请号：EP13900440.2
申请日：2013-12-26
申请人： Shenzhen University
发明人： XING, Feng , ZHANG, Ning , DING, Zhu , LIU, Biao , HAN, Ningxu , WANG, Weilun , LI, Dawang , LONG, Wujian , DONG, Biqin , WANG, Xiaodong
IPC分类号： C30B29/10 , C04B7/32 , C01B25/32 , C01B25/34 , C01B37/06 , C01B25/45 , C04B35/447 , C04B35/624 , C04B35/645 , C30B1/02 , C30B1/04 , C30B1/10 , C30B29/14 , C30B29/22 , C04B12/02 , C04B103/44
CPC分类号： C01B25/45 , C01B25/32 , C01B25/34 , C01B37/065 , C04B12/02 , C04B28/02 , C04B35/447 , C04B35/624 , C04B35/6455 , C04B2103/445 , C04B2235/3208 , C04B2235/3217 , C04B2235/447 , C04B2235/6567 , C04B2235/661 , C30B1/02 , C30B1/04 , C30B1/10 , C30B29/14 , C30B29/22 , C04B22/16 , C04B18/023
摘要： Provided is a ternary inorganic compound crystal having a molecular formula of Ca 8 Al 12 P 2 O 31 , and a preparation method thereof comprising the following steps: weighing calcium salts, aluminum salts and phosphate respectively according to the molar ratio of calcium, aluminum and phosphorus in the molecular formula Ca 8 Al 12 P 2 O 31 ; calcining at 1550ˆ¼1570°C, cooling, and grinding to obtain the ternary inorganic compound crystal. Also provided is an application of the ternary inorganic compound in gelling materials and molecular sieves, nonlinear optical crystals, and photochromic materials.

18. 发明公开

EP2918596A1 IMMUNE RECEPTOR MODIFIER CONJUGATE AND PREPARATION METHOD AND USE THEREOF, COUPLING PRECURSOR FOR PREPARING SAME, AND COMPOUND FOR SYNTHESIZING COUPLING PRECURSOR 审中-公开
标题翻译： IMMUNREZEPTORMODIFIKATORKONJUGAT及方法和用途，以及功率PRE对这类在合并后的先行者建立生产和连接
公开(公告)号：EP2918596A1
公开(公告)日：2015-09-16
申请号：EP13845289.1
申请日：2013-06-26
申请人： Shenzhen University , Shenzhen Kangjuzheng Pharmaceutical Technology Co., Ltd
发明人： JIN, Guangyi , WANG, Zhulin
IPC分类号： C07K1/107 , C07K7/06 , C07K14/47 , C07K14/11 , C07K14/705 , C07D473/18 , A61K39/00 , A61K39/145 , A61P37/02 , A61P31/12 , A61P3/10 , A61P35/00
CPC分类号： C07K14/70596 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/39 , A61K47/55 , A61K47/64 , A61K47/65 , A61K47/66 , A61K2039/55511 , C07D473/18 , C07K14/4727
摘要： Disclosed is an immune receptor modifier conjugate, obtained from the reaction between a coupling precursor and a biotic ligand, the coupling precursor being a 9-position aminomethyl benzyl purine biotic coupling precursor, and the biotic ligand being selected from one or more of polypeptide, protein, glycoprotein, polysaccharide, polynucleotide, inactivated cells and inactivated microbes. The immune receptor modifier couplet can be used for immunomodulation, antibody preparation, anti-virus, diabetes, tumor immunomodulation, and tumor bio-immunotherapy. The conjugate compounds or salts thereof can be prepared into various therapeutic drugs, and can be prepared into a compound drug together with other drugs, or pharmaceutically acceptable carrier composites or conjugates. Also disclosed are compounds for synthesizing the coupling precursor and salts thereof.
摘要翻译：本发明公开了一种免疫受体调节剂缀合物，从耦合前体和生物配体，联接前体是一个9位氨基甲基苄基嘌呤生物偶联前体，并且所述生物配体之间的反应获得的是从一种或多种多肽的蛋白质选择，糖蛋白，多糖，多核苷酸，灭活细胞和灭活的微生物。免疫受体调节剂联可用于免疫调节，抗体制备，抗病毒，糖尿病，肿瘤免疫调节和肿瘤生物免疫治疗。该缀合物的化合物或它们的盐可制备成各种治疗药物，并且可与其它药物或药学上可接受的载体复合物或缀合物一起下载到的化合物的药物。所以圆盘游离缺失是用于合成耦合前体和它们的盐的化合物。

19. 发明公开

EP2239242A1 A SELF REPAIRING CONCRETE CONTAINING MICROCAPSULES OF UREA FORMALDEHYDE RESIN AND PRODUCING METHOD THEREOF 有权转让
标题翻译：自修复混凝土含有微小胶囊状脲醛树脂及其制造方法
公开(公告)号：EP2239242A1
公开(公告)日：2010-10-13
申请号：EP08874352.1
申请日：2008-10-24
申请人： Shenzhen University , Xing, Feng , Ni, Zhuo
发明人： XING, Feng , NI, Zuo
IPC分类号： C04B28/00
CPC分类号： C04B28/00 , C04B14/02 , C04B20/1037 , C04B28/02 , C04B2103/0058 , C04B2103/0077 , C04B2111/343 , C04B2111/70 , C04B2111/72 , C04B24/281 , C04B14/06 , C04B40/0067 , C04B40/0295 , C04B40/0641 , C04B2103/0046
摘要： A self-repairing concrete includes urea-formaldehyde resin polymer micro-capsules, in which the urea-formaldehyde resin polymer micro-capsules are mixed for a fixed function of micro-cracks. The quality mixture ratio is: concrete/ micro capsules/ water = 100:1-15:15 -50. The manufacturing method is weighing a full amount of water in a container, adding urea-formaldehyde resin polymer micro-capsules, stirring, until fully dispersed microcapsules; pouring the water into the mixing container, adding the corresponding quality of cement; stirring; adding sand and gravel filling materials, conducting worksite watering, 1/3 volume for each time, vibrating, and air exhausting; until the paste filling mold.

20. 发明公开

EP4450089A1 MICRONEEDLE PATCH FOR ENHANCING ACCUMULATION OF PROTOPORPHYRIN IX IN SOLID TUMOR AND PREPARATION METHOD THEREFOR 审中-公开
公开(公告)号：EP4450089A1
公开(公告)日：2024-10-23
申请号：EP22932930.5
申请日：2022-07-01
申请人： Shenzhen University
发明人： HUANG, Peng , HE, Gang , LI, Yashi , LIN, Jing
IPC分类号： A61K41/00 , A61K9/70 , A61K47/42 , A61P35/00 , A61K49/22 , A61K49/00 , A61M37/00
CPC分类号： A61M37/0015 , A61M2037/004620130101 , A61M2037/005320130101 , A61K9/0021
摘要： A microneedle patch for enhancing an accumulation of protoporphyrin IX in a solid tumor and a preparation method therefor. The method comprises the steps of: dissolving albumin in a Dulbecco's culture medium, using the albumin as a template, and adding CuCl2 and CaCl2 for mineralization to obtain a CCP nanoparticle; by means of a one-step carbodiimide coupling method and an electrostatic adsorption method, loading CAT and 5-ALA to the surface of the CCP nanoparticle, respectively, to obtain a CCPCA nanoparticle; and loading the CCPCA nanoparticle and a microneedle matrix solution in a microneedle mold, drying under vacuum, and demolding to obtain a microneedle patch for enhancing an accumulation of PpIX in a solid tumor. According to the microneedle patch, by means of an integrated nano calcium phosphate carrier and a transdermal administration mode, an accurate delivery of CAT and 5-ALA is achieved, and PpIX and O2 levels in a tumor cell are increased. Meanwhile, the guidance of real-time bimodal PpIX fluorescence imaging and photoacoustic blood oxygen imaging is provided, and the photodynamic therapeutic effect on different cancers is improved.

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