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11. 发明申请

WO2010017445A3 IMAGING WITH MULTIPLE APERTURE MEDICAL ULTRASOUND AND SYNCHRONIZATION OF ADD-ON SYSTEMS 审中-公开
标题翻译：成像多孔医学超声和同步系统
公开(公告)号：WO2010017445A3
公开(公告)日：2010-04-22
申请号：PCT/US2009053096
申请日：2009-08-07
申请人： MAUI IMAGING INC , SPECHT DONALD F , BREWER KENNETH D
发明人： SPECHT DONALD F , BREWER KENNETH D
IPC分类号： A61B8/00 , G01N29/24 , G01N29/36
CPC分类号： A61B8/5207 , A61B8/4281 , A61B8/4477 , A61B8/54 , G01S7/52046 , G01S7/52087 , G01S15/8913 , G01S15/8927 , G01S15/8929 , G01S15/8997
摘要： The benefits of a multi-aperture ultrasound probe can be achieved with add-on devices. Synchronization and correlation of echoes from multiple transducer elements located in different arrays is essential to the successful processing of multiple aperture imaging. The algorithms disclosed here teach methods to successfully process these signals when the transmission source is coming from another ultrasound system and synchronize the add-on system to the other ultrasound system. Two-dimensional images with different noise components can be constructed from the echoes received by individual transducer elements. The disclosed techniques have broad application in medical imaging and are ideally suited to multi-aperture cardiac imaging using two or more intercostal spaces.
摘要翻译：多孔径超声探头的优点可以通过附加设备实现。来自位于不同阵列中的多个换能器元件的回波的同步和相关性对于多孔成像的成功处理是至关重要的。这里公开的算法教导当传输源来自另一超声系统并且将附加系统同步到另一超声系统时成功处理这些信号的方法。可以从各个换能器元件接收的回波构建具有不同噪声分量的二维图像。所公开的技术在医学成像中具有广泛的应用，并且理想地适用于使用两个或更多个肋间空间的多孔心脏成像。

12. 发明申请

WO2008051639A3 METHOD AND APPARATUS TO PRODUCE ULTRASONIC IMAGES USING MULTIPLE APERTURES 审中-公开
标题翻译：使用多种方法生产超声波图像的方法和装置
公开(公告)号：WO2008051639A3
公开(公告)日：2008-09-25
申请号：PCT/US2007073615
申请日：2007-07-16
申请人： MAUI IMAGING INC , SPECHT DONALD F
发明人： SPECHT DONALD F
IPC分类号： A61B8/00
CPC分类号： A61B8/145 , A61B5/725 , A61B8/08 , A61B8/085 , A61B8/42 , A61B8/4209 , A61B8/4218 , A61B8/4245 , A61B8/4281 , A61B8/4455 , A61B8/4483 , A61B8/4494 , A61B8/483 , A61B8/5207 , A61B8/5253 , A61B8/543 , G01S7/52046 , G01S7/5205 , G01S15/8977
摘要： An ultrasonic scanner and an omnidirectional receive transducer for producing a two-dimensional image from the echoes received by single omnidirectional transducer. Two-dimensional images with different noise components can be constructed from the echoes received and combinable to produce images with better signal to noise ratios and lateral resolution. A method based on information content to compensate for the different delays and paths through intervening tissue is described. Specular reflections are attenuated using a single omnidirectional receiver displaced from the insonifying probe. These techniques have broad application in medical imaging suited to multi-aperture cardiac imaging using two or more intercostal spaces Another method employs multiple transducers increasing the lateral resolution and reducing noise and includes two or more active phased array transducers in the same scan plane The phase delays are computed such that the transducers operate as one larger phased array with a gap (or gaps) in the middle.
摘要翻译：超声波扫描器和全向接收换能器，用于从由单向全向换能器接收的回波产生二维图像。可以从接收到的回波构建具有不同噪声分量的二维图像，并且可以组合以产生具有更好的信噪比和横向分辨率的图像。描述了基于信息内容以补偿通过中间组织的不同延迟和路径的方法。使用从失真探头移位的单个全向接收器来衰减镜面反射。这些技术在适用于使用两个或多个肋间空间的多孔心脏成像的医学成像中具有广泛的应用。另一种方法使用多个换能器来增加横向分辨率并降低噪声，并且在同一扫描平面中包括两个或更多个有源相控阵转换器。相位延迟被计算为使得换能器作为一个较大的相控阵列工作，在中间具有间隙（或间隙）。

13. 发明申请

WO2007092054A3 METHOD AND APPARATUS TO VISUALIZE THE CORONARY ARTERIES USING ULTRASOUND 审中-公开
公开(公告)号：WO2007092054A3
公开(公告)日：2007-08-16
申请号：PCT/US2006/035995
申请日：2006-09-14
申请人： SPECHT, Donald, F.
发明人： SPECHT, Donald, F.
IPC分类号： A61B8/14
摘要： A non-invasive screening technique for visualizing coronary arteries which overcomes the problems of visualizing the curved arteries by projecting the three dimensional volume of the arteries onto a two dimensional screen. Blood filled areas, and in particular, the coronary arteries and veins, are highlighted to contrast them with other nearby tissues using non-linear classification and segmentation techniques. Data is gathered as a sequence of 2D slices stored as a 3D volume. Software is employed to interpolate voxels intermediate to the slices. Wiener filtering or LMS spatial filtering can be implemented on each 2D scan to improve lateral resolution and reduce noise prior to the use of the scan data with the classification and segmentation algorithms. A traditional handheld ultrasound probe is employed to enable the technician to locate the area of interest, but a gyroscopic stabilizer is added to minimize unwanted variation on two axes of rotation while scanning through angles on the third axis of rotation.

14. 发明申请

WO2007092054A2 METHOD AND APPARATUS TO VISUALIZE THE CORONARY ARTERIES USING ULTRASOUND 审中-公开
标题翻译：使用超声视觉证实冠状动脉的方法和装置
公开(公告)号：WO2007092054A2
公开(公告)日：2007-08-16
申请号：PCT/US2006035995
申请日：2006-09-14
申请人： SPECHT DONALD F
发明人： SPECHT DONALD F
CPC分类号： G06T7/0012 , A61B5/02007 , A61B5/7257 , A61B5/7264 , A61B8/06 , A61B8/08 , A61B8/0883 , A61B8/0891 , A61B8/4254 , A61B8/483 , A61B8/543 , G06T2207/10136 , G06T2207/20092 , G06T2207/30048 , G06T2207/30101
摘要： A non-invasive screening technique for visualizing coronary arteries which overcomes the problems of visualizing the curved arteries by projecting the three dimensional volume of the arteries onto a two dimensional screen. Blood filled areas, and in particular, the coronary arteries and veins, are highlighted to contrast them with other nearby tissues using non-linear classification and segmentation techniques. Data is gathered as a sequence of 2D slices stored as a 3D volume. Software is employed to interpolate voxels intermediate to the slices. Wiener filtering or LMS spatial filtering can be implemented on each 2D scan to improve lateral resolution and reduce noise prior to the use of the scan data with the classification and segmentation algorithms. A traditional handheld ultrasound probe is employed to enable the technician to locate the area of interest, but a gyroscopic stabilizer is added to minimize unwanted variation on two axes of rotation while scanning through angles on the third axis of rotation.
摘要翻译：一种用于可视化冠状动脉的非侵入性筛查技术，其通过将三维体积的动脉投影到二维屏幕上来克服可视化弯曲动脉的问题。突出显示血液填充区域，特别是冠状动脉和静脉，使用非线性分类和分割技术将其与其他附近组织进行对比。数据被收集为作为3D体积存储的2D片段的序列。使用软件来插入片段中间的体素。维纳滤波或LMS空间滤波可以在每个2D扫描上实现，以便在使用分类和分割算法的扫描数据之前提高横向分辨率并降低噪点。采用传统的手持式超声波探头来使技术人员能够定位感兴趣的区域，但是增加一个陀螺稳定器以最小化两个旋转轴上的不必要的变化，同时扫描第三个旋转轴上的角度。

15. 发明申请

WO02082304A8 STRING SEARCH NEURON FOR ARTIFICIAL NEURAL NETWORKS 审中-公开
标题翻译：搜索神经网络的人造神经网络
公开(公告)号：WO02082304A8
公开(公告)日：2004-02-05
申请号：PCT/US0210966
申请日：2002-04-08
申请人： SPECHT DONALD F , PAILLET GUY
发明人： SPECHT DONALD F , PAILLET GUY
IPC分类号： G06E1/00 , G06E3/00 , G06F15/18 , G06G7/00 , G06N3/02 , G06N3/063 , G06N3/10
CPC分类号： G06K9/6273 , G06N3/063 , G06N3/105
摘要： An improved neuron and corresponding search operation for use in matching strings of characters from a character set or strings of pixels from an image is at least partly based on ZISC technology. Each neuron contains only one character in the string of characters to be searched or, equivalently, one pixel in the image to be searched. The neurons are lined up in order (unlike standard ZISC). The inventive system matches two strings of base-pairs, one of which is stored in the neurons, and the other of which is entered into the system input one character at a time and thereafter broadcast to all of the neurons. The inputs, outputs and contents of each neuron in the system include one stored base pair, a left_errors register; a right_errors register; a parallel sort bus; and a neuron number or location register. The operation may include the following steps: at the start of the operation, all left_errors and right_errors registers are reset to "0". When one base-pair is entered into the system input, all neurons compare it to their own stored base-pair. If it is the same, right_errors=left_errors + 0 (which becomes left_errors to the next neuron in the left to right arrangement). If it is different, right_errors=left_errors + 1. This operation continues for all of the base-pairs in the input sub string. At the end of the sub string of "m" characters, each right_errors register will record the number of errors (or mismatched pairs) in the "m" characters to the left of its position in the sequence (including itself). A "0" result indicates that there was a perfect match of the input to this part of the sequence. A "l" indicates that there is an almost perfect match with only one mismatch. A "2" through "6" result indicates that number of mismatches. If left_errors equals "7", then right_errors will always equal "7". The fourth bit indicates that an end of the stored substring character has been reached. When this bit is turned on, then left_errors will always be transferred to right_errors unchanged until the end of the input sub string. At the end of an input sub string (i.e., the end of a search), a parallel search in the manner of a standard ZISC search is performed.
摘要翻译：用于匹配来自图像的字符集或像素串的字符串的改进的神经元和相应的搜索操作至少部分地基于ZISC技术。每个神经元只包含要搜索的字符串中的一个字符，或者相当于要搜索的图像中的一个像素。神经元按顺序排列（与标准ZISC不同）。本发明的系统匹配两串碱基对，其中一个碱基对存储在神经元中，另一个碱基对一次被输入到系统输入中一个字符，然后广播到所有的神经元。系统中每个神经元的输入，输出和内容包括一个存储的基对，一个左错误寄存器; 一个right_errors注册表并行排序总线和神经元号或位置寄存器。该操作可以包括以下步骤：在操作开始时，所有的left_errors和right_errors寄存器都被重置为“0”。当一个碱基对被输入到系统输入中时，所有神经元将它们与它们自己存储的碱基对进行比较。如果它是一样的，right_errors = left_errors + 0（从左到右排列成为下一个神经元的left_errors）。如果不同，则right_errors = left_errors + 1。对于输入子字符串中的所有基对，此操作将继续。在“m”个字符串的末尾，每个right_errors寄存器将在序列（包括其自身）中将“m”个字符中的错误数量（或不匹配的对）记录到其位置的左侧。 “0”结果表示与序列的这一部分的输入完美匹配。 “l”表示几乎完美匹配，只有一个不匹配。 “2”到“6”的结果表示不匹配的数量。如果left_errors等于“7”，则right_errors将始终等于“7”。第四位表示存储的子字符串的结尾已经到达。当该位打开时，left_errors将始终传递到right_errors，直到输入子字符串的结尾。在输入子字符串的末尾（即搜索结束），以标准ZISC搜索的方式执行并行搜索。

16. 发明申请

WO2012051305A3 MULTIPLE APERTURE PROBE INTERNAL APPARATUS AND CABLE ASSEMBLIES 审中-公开
标题翻译：多孔探头内部装置和电缆组件
公开(公告)号：WO2012051305A3
公开(公告)日：2012-08-16
申请号：PCT/US2011055973
申请日：2011-10-12
申请人： MAUI IMAGING INC , ADAM SHARON L , SMITH DAVID M , SPECHT DONALD F , BREWER KENNETH D
发明人： ADAM SHARON L , SMITH DAVID M , SPECHT DONALD F , BREWER KENNETH D
IPC分类号： A61B8/00 , G01N29/24 , H01B7/04
CPC分类号： A61B8/12 , A61B8/4477 , A61B8/4483 , G01S7/52047 , G01S7/52079 , G01S15/8915 , G01S15/8927 , G10K11/004
摘要： A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate physical apertures of ultrasound arrays. The probe can include separate backing plates configured to secure the ultrasound arrays in predetermined positions and orientations relative to one another. Some embodiments of the probe include flex circuit connected to the ultrasound arrays. In additional embodiments, a flex/PC board comprising flex connectors and an array of terminals is connected to the ultrasound arrays. Algorithms can solve for variations in tissue speed of sound, thus allowing the probe apparatus to be used virtually anywhere in or on the body.
摘要翻译：多孔超声成像（MAUI）探头或换能器独特地能够同时从超声阵列的物理孔径成像感兴趣的区域。探针可以包括被配置为将超声阵列固定在相对于彼此的预定位置和取向的单独背板。探针的一些实施例包括连接到超声阵列的柔性电路。在另外的实施例中，包括柔性连接器和端子阵列的柔性/ PC板连接到超声阵列。算法可以解决声音组织速度的变化，从而允许探针设备实际上用于身体内部或身体的任何位置。

17. 发明申请

WO2012051305A8 MULTIPLE APERTURE PROBE INTERNAL APPARATUS AND CABLE ASSEMBLIES 审中-公开
标题翻译：多孔探头内部设备和电缆组件
公开(公告)号：WO2012051305A8
公开(公告)日：2012-07-05
申请号：PCT/US2011055973
申请日：2011-10-12
申请人： MAUI IMAGING INC , ADAM SHARON L , SMITH DAVID M , SPECHT DONALD F , BREWER KENNETH D
发明人： ADAM SHARON L , SMITH DAVID M , SPECHT DONALD F , BREWER KENNETH D
IPC分类号： A61B8/00 , G01N29/24 , H01B7/04
CPC分类号： A61B8/12 , A61B8/4477 , A61B8/4483 , G01S7/52047 , G01S7/52079 , G01S15/8915 , G01S15/8927 , G10K11/004
摘要： A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate physical apertures of ultrasound arrays. The probe can include separate backing plates configured to secure the ultrasound arrays in predetermined positions and orientations relative to one another. Some embodiments of the probe include flex circuit connected to the ultrasound arrays. In additional embodiments, a flex/PC board comprising flex connectors and an array of terminals is connected to the ultrasound arrays. Algorithms can solve for variations in tissue speed of sound, thus allowing the probe apparatus to be used virtually anywhere in or on the body.
摘要翻译：多孔径超声成像（MAUI）探头或换能器独特地能够同时成像来自超声阵列的单独物理孔径的感兴趣区域。探针可以包括单独的背板，其被构造成将超声阵列相对于彼此固定在预定的位置和方向上。探针的一些实施例包括连接到超声阵列的柔性电路。在另外的实施例中，包括柔性连接器和端子阵列的柔性/ PC板连接到超声阵列。算法可以解决组织声速变化的问题，从而使探头装置几乎可以用在身体内部或身体上的任何地方。

18. 发明申请

WO2012051308A3 CONCAVE ULTRASOUND TRANSDUCERS AND 3D ARRAYS 审中-公开
标题翻译：引入超声波传感器和3D阵列
公开(公告)号：WO2012051308A3
公开(公告)日：2012-06-28
申请号：PCT/US2011055976
申请日：2011-10-12
申请人： MAUI IMAGING INC , SMITH DAVID M , SPECHT DONALD F , CABRERA LINDA V , BREWER KENNETH D , SPECHT DAVID J
发明人： SMITH DAVID M , SPECHT DONALD F , CABRERA LINDA V , BREWER KENNETH D , SPECHT DAVID J
IPC分类号： A61B8/00 , G01N29/24
CPC分类号： A61B8/4494 , A61B8/14 , A61B8/145 , A61B8/4444 , A61B8/4483 , A61B8/461 , A61B8/467 , A61B8/5207 , A61B8/523 , A61B8/58 , B06B1/0622 , G01S7/5205 , G01S7/52084 , G01S15/8913 , G01S15/892 , G01S15/8927 , G01S15/8929 , G01S15/8934
摘要： A Multiple Aperture Ultrasound Imaging (MAUI) probe or transducer is uniquely capable of simultaneous imaging of a region of interest from separate apertures of ultrasound arrays. Some embodiments provide systems and methods for designing, building and using ultrasound probes having continuous arrays of ultrasound transducers which may have a substantially continuous concave curved shape in two or three dimensions (i.e. concave relative to an object to be imaged). Other embodiments herein provide systems and methods for designing, building and using ultrasound imaging probes having other unique configurations, such as adjustable probes and probes with variable configurations.
摘要翻译：多孔超声成像（MAUI）探针或换能器独特地能够从超声阵列的单独孔径同时成像感兴趣的区域。一些实施例提供了用于设计，构建和使用具有连续的超声换能器阵列的超声波探头的系统和方法，所述超声波探头可具有两维或三维的基本上连续的凹形弯曲形状（即，相对于要成像的物体是凹的）。本文的其它实施例提供了用于设计，构建和使用具有其他独特配置的超声成像探针的系统和方法，例如具有可变构型的可调探针和探针。

19. 发明申请

WO2011103303A2 POINT SOURCE TRANSMISSION AND SPEED-OF-SOUND CORRECTION USING MULT-APERTURE ULTRASOUND IMAGING 审中-公开
标题翻译：使用原始超声波成像的点源传输和速度校正
公开(公告)号：WO2011103303A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025263
申请日：2011-02-17
申请人： MAUI IMAGING, INC. , SPECHT, Donald F. , BREWER, Kenneth D.
发明人： SPECHT, Donald F. , BREWER, Kenneth D.
IPC分类号： A61B8/14
CPC分类号： A61B8/5246 , A61B8/14 , A61B8/145 , A61B8/4444 , A61B8/4455 , A61B8/4477 , A61B8/4483 , A61B8/463 , A61B8/5207 , A61B8/5269 , G01S7/52049 , G01S15/8913 , G01S15/8927 , G01S15/8961 , G01S15/8977 , G01S15/8993 , G01S15/8997
摘要： A Multiple Aperture Ultrasound Imaging system and methods of use are provided with any number of features. In some embodiments, a multi-aperture ultrasound imaging system is configured to transmit and receive ultrasound energy to and from separate physical ultrasound apertures. In some embodiments, a transmit aperture of a multi-aperture ultrasound imaging system is configured to transmit an omni-directional unfocused ultrasound waveform approximating a first point source through a target region. In some embodiments, the ultrasound energy is received with a single receiving aperture. In other embodiments, the ultrasound energy is received with multiple receiving apertures. Algorithms are described that can combine echoes received by one or more receiving apertures to form high resolution ultrasound images. Additional algorithms can solve for variations in tissue speed of sound, thus allowing the ultrasound system to be used virtually anywhere in or on the body.
摘要翻译：多孔径超声成像系统和使用方法具有任意数量的特征。在一些实施例中，多孔超声成像系统被配置为向独立的物理超声波孔径传送和接收超声能量。在一些实施例中，多孔径超声成像系统的发射孔径被配置为透射通过目标区域近似于第一点源的全向未聚焦超声波。在一些实施例中，用单个接收孔接收超声波能量。在其他实施例中，超声能量被接收有多个接收孔。描述了可组合由一个或多个接收孔径接收的回波以形成高分辨率超声图像的算法。附加的算法可以解决组织声速的变化，从而允许超声系统实际上在身体中或身体上的任何地方使用。

20. 发明申请

WO2002082304A1 STRING SEARCH NEURON FOR ARTIFICIAL NEURAL NETWORKS 审中-公开
标题翻译：搜索神经网络的人造神经网络
公开(公告)号：WO2002082304A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/010966
申请日：2002-04-08
申请人： SPECHT, Donald, F. , PAILLET, Guy
发明人： SPECHT, Donald, F. , PAILLET, Guy
IPC分类号： G06F15/18
CPC分类号： G06K9/6273 , G06N3/063 , G06N3/105
摘要： An improved neuron and corresponding search operation for use in matching strings of characters from a character set or strings of pixels from an image is at least partly based on ZISC technology. Each neuron contains only one character in the string of characters to be searched or, equivalently, one pixel in the image to be searched. The neurons are lined up in order (unlike standard ZISC). The inventive system matches two strings of base-pairs, one of which is stored in the neurons, and the other of which is entered into the system input one character at a time and thereafter broadcast to all of the neurons. The inputs, outputs and contents of each neuron in the system include one stored base pair, a left_errors register; a right_errors register; a parallel sort bus; and a neuron number or location register. The operation may include the following steps: at the start of the operation, all left_errors and right_errors registers are reset to "0". When one base-pair is entered into the system input, all neurons compare it to their own stored base-pair. If it is the same, right_errors=left_errors + 0 (which becomes left_errors to the next neuron in the left to right arrangement). If it is different, right_errors=left_errors + 1. This operation continues for all of the base-pairs in the input sub string. At the end of the sub string of "m" characters, each right_errors register will record the number of errors (or mismatched pairs) in the "m" characters to the left of its position in the sequence (including itself). A "0" result indicates that there was a perfect match of the input to this part of the sequence. A "l" indicates that there is an almost perfect match with only one mismatch. A "2" through "6" result indicates that number of mismatches. If left_errors equals "7", then right_errors will always equal "7". The fourth bit indicates that an end of the stored substring character has been reached. When this bit is turned on, then left_errors will always be transferred to right_errors unchanged until the end of the input sub string. At the end of an input sub string (i.e., the end of a search), a parallel search in the manner of a standard ZISC search is performed.
摘要翻译：用于匹配来自图像的字符集或像素串的字符串的改进的神经元和相应的搜索操作至少部分地基于ZISC技术。每个神经元只包含要搜索的字符串中的一个字符，或者相当于要搜索的图像中的一个像素。神经元按顺序排列（与标准ZISC不同）。本发明的系统匹配两串碱基对，其中一个碱基对存储在神经元中，另一个碱基对一次被输入到系统输入中一个字符，然后广播到所有的神经元。系统中每个神经元的输入，输出和内容包括一个存储的基对，一个左错误寄存器; 一个right_errors注册表并行排序总线和神经元号或位置寄存器。该操作可以包括以下步骤：在操作开始时，所有的left_errors和right_errors寄存器都被重置为“0”。当一个碱基对被输入到系统输入中时，所有神经元将它们与它们自己存储的碱基对进行比较。如果它是一样的，right_errors = left_errors + 0（从左到右排列成为下一个神经元的left_errors）。如果不同，则right_errors = left_errors + 1。对于输入子字符串中的所有基对，此操作将继续。在“m”个字符串的末尾，每个right_errors寄存器将在序列（包括其自身）中将“m”个字符中的错误数量（或不匹配的对）记录到其位置的左侧。 “0”结果表示与序列的这一部分的输入完美匹配。 “l”表示几乎完美匹配，只有一个不匹配。 “2”到“6”的结果表示不匹配的数量。如果left_errors等于“7”，则right_errors将始终等于“7”。第四位表示存储的子字符串的结尾已经到达。当该位打开时，left_errors将始终传递到right_errors，直到输入子字符串的结尾。在输入子字符串的末尾（即搜索结束），以标准ZISC搜索的方式执行并行搜索。

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