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11. 发明专利

HK1249915A1 肽激素的降鈣素CGRP家族的肽拮抗劑和它們的用途未知
公开(公告)号：HK1249915A1
公开(公告)日：2018-11-16
申请号：HK18109409
申请日：2018-07-20
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： C07K20060101 , A61K20060101

12. 发明专利

DK2807187T3 PEPTIDANTAGONISTER AF CALCITONIN-CGRP-FAMILIEN AF PEPTIDHORMONER OG DERES ANVENDELSE 未知
公开(公告)号：DK2807187T3
公开(公告)日：2017-09-11
申请号：DK13703494
申请日：2013-01-25
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： C07K14/585 , A61K38/00 , A61K38/22 , C07K14/575

13. 发明专利

MX347229B ANTAGONISTAS DE PÉPTIDO DE LA FAMILIA CGRP DE CALCITONINA DE HORMONAS DE PÉPTIDO Y SU USO. 未知
公开(公告)号：MX347229B
公开(公告)日：2017-04-19
申请号：MX2014008960
申请日：2013-01-25
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： C07K14/585 , A61K38/23 , C07K14/575
摘要： La presente invención se refiere a las modalidades proporcionan un antagonista del péptido relacionado con el gen de calcitonina modificado que incluye un fragmento N terminal de un péptido relacionado con el gen de calcitonina modificado o un miembro de la familia de proteína relacionado en donde al menos dos residuos del fragmento N terminal son cisteína (Cys) y al menos un aminoácido comprende una sustitución no de treonina de un residuo de treonina (Thr); un núcleo central en donde el núcleo central comprende una hélice a; y un fragmento C terminal del péptido relacionado con el gen de calcitonina modificado o un miembro de la familia de proteína relacionado que comprende una amida C terminal y en donde al menos un aminoácido del fragmento C terminal es fenilalanina (Phe), prolina (Pro), tirosina (Tyr) o hidroxiprolina (Hyp) o una sal farmacéuticamente aceptable del mismo, así como composiciones, incluyendo composiciones farmacéuticas, que comprenden el péptido en cuestión. Las modalidades proporcionan además métodos de tratamientos que incluyen métodos para tratar una migraña, implicando en general los métodos la administración a un individuo que lo necesita de una cantidad efectiva de un péptido o la composición en cuestión.

14. 发明专利

AU2013211929B2 Peptide antagonists of the calcitonin CGRP family of peptide hormones and their use 未知
公开(公告)号：AU2013211929B2
公开(公告)日：2016-05-26
申请号：AU2013211929
申请日：2013-01-25
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： C07K14/585 , A61K38/22
摘要： The embodiments provide a modified calcitonin gene-related peptide antagonist including an N-terminal fragment of modified calcitonin gene-related peptide or related protein family member where at least two residues of the N-terminal fragment are cysteine (Cys) and at least one amino acid comprises a non-threonine substitution of a threonine (Thr) residue; a central core where the central core comprises an oc-helix; and a C-terminal fragment of modified calcitonin gene -related peptide or related protein family member comprising a C-terminal amide and where at least one amino acid of the C-terminal fragment is phenylalanine (Phe), proline (Pro), tyrosine (Tyr) or hydroxyproline (Hyp) or pharmaceutically acceptable salt thereof, as well as compositions, including pharmaceutical compositions, comprising a subject peptide. The embodiments further provide treatment methods, including methods of treating a migraine, the methods generally involving administering to an individual in need thereof an effective amount of a subject peptide or composition.

15. 发明专利

HK1201068A1 PEPTIDE ANTAGONISTS OF THE CALCITONIN CGRP FAMILY OF PEPTIDE HORMONES AND THEIR USE CGRP 未知
公开(公告)号：HK1201068A1
公开(公告)日：2015-08-21
申请号：HK15101555
申请日：2015-02-12
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： C07K20060101 , A61K20060101
摘要： The embodiments provide a modified calcitonin gene-related peptide antagonist including an N-terminal fragment of modified calcitonin gene-related peptide or related protein family member where at least two residues of the N-terminal fragment are cysteine (Cys) and at least one amino acid comprises a non-threonine substitution of a threonine (Thr) residue; a central core where the central core comprises an ±-helix; and a C-terminal fragment of modified calcitonin gene-related peptide or related protein family member comprising a C-terminal amide and where at least one amino acid of the C-terminal fragment is phenylalanine (Phe), proline (Pro), tyrosine (Tyr) or hydroxyproline (Hyp) or pharmaceutically acceptable salt thereof, as well as compositions, including pharmaceutical compositions, comprising a subject peptide. The embodiments further provide treatment methods, including methods of treating a migraine, the methods generally involving administering to an individual in need thereof an effective amount of a subject peptide or composition.

16. 发明专利

CA2861392A1 PEPTIDE ANTAGONISTS OF THE CALCITONIN CGRP FAMILY OF PEPTIDE HORMONES AND THEIR USE 未知
公开(公告)号：CA2861392A1
公开(公告)日：2013-08-01
申请号：CA2861392
申请日：2013-01-25
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： C07K14/585 , A61K38/22
摘要： The embodiments provide a modified calcitonin gene-related peptide antagonist including an N-terminal fragment of modified calcitonin gene-related peptide or related protein family member where at least two residues of the N-terminal fragment are cysteine (Cys) and at least one amino acid comprises a non-threonine substitution of a threonine (Thr) residue; a central core where the central core comprises an oc-helix; and a C-terminal fragment of modified calcitonin gene -related peptide or related protein family member comprising a C-terminal amide and where at least one amino acid of the C-terminal fragment is phenylalanine (Phe), proline (Pro), tyrosine (Tyr) or hydroxyproline (Hyp) or pharmaceutically acceptable salt thereof, as well as compositions, including pharmaceutical compositions, comprising a subject peptide. The embodiments further provide treatment methods, including methods of treating a migraine, the methods generally involving administering to an individual in need thereof an effective amount of a subject peptide or composition.

17. 发明专利

AU2017319512A2 Use of CGRP receptor antagonists in neuroprotection and neurological disorders 未知
公开(公告)号：AU2017319512A2
公开(公告)日：2019-07-11
申请号：AU2017319512
申请日：2017-08-30
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： A61K38/17 , A61P25/00 , A61P27/06
摘要： Provided herein are treatment methods, including methods of treating nerve damage, methods of neuroprotection, methods of treating glaucoma and methods of lowering LDL levels. The methods generally involve administering to an individual in need thereof an effective amount of a CGRP receptor antagonist peptide or composition.

18. 发明专利

AU2017319512A1 Use of CGRP receptor antagonists in neuroprotection and neurological disorders 未知
公开(公告)号：AU2017319512A1
公开(公告)日：2019-03-21
申请号：AU2017319512
申请日：2017-08-30
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： A61K38/17 , A61P25/00 , A61P27/06
摘要： Provided herein are treatment methods, including methods of treating nerve damage, methods of neuroprotection, methods of treating glaucoma and methods of lowering LDL levels. The methods generally involve administering to an individual in need thereof an effective amount of a CGRP receptor antagonist peptide or composition.

19. 发明专利

CA2861392C PEPTIDE ANTAGONISTS OF THE CALCITONIN CGRP FAMILY OF PEPTIDE HORMONES AND THEIR USE 未知
公开(公告)号：CA2861392C
公开(公告)日：2021-08-17
申请号：CA2861392
申请日：2013-01-25
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER J
IPC分类号： C07K14/585 , A61K38/22
摘要： The embodiments provide a modified calcitonin gene-related peptide antagonist including an N-terminal fragment of modified calcitonin gene-related peptide or related protein family member where at least two residues of the N-terminal fragment are cysteine (Cys) and at least one amino acid comprises a non-threonine substitution of a threonine (Thr) residue; a central core where the central core comprises an oc-helix; and a C-terminal fragment of modified calcitonin gene -related peptide or related protein family member comprising a C-terminal amide and where at least one amino acid of the C-terminal fragment is phenylalanine (Phe), proline (Pro), tyrosine (Tyr) or hydroxyproline (Hyp) or pharmaceutically acceptable salt thereof, as well as compositions, including pharmaceutical compositions, comprising a subject peptide. The embodiments further provide treatment methods, including methods of treating a migraine, the methods generally involving administering to an individual in need thereof an effective amount of a subject peptide or composition.

20. 发明专利

ES2641325T3 Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso 未知
公开(公告)号：ES2641325T3
公开(公告)日：2017-11-08
申请号：ES13703494
申请日：2013-01-25
申请人： SOARES CHRISTOPHER J
发明人： SOARES CHRISTOPHER
IPC分类号： C07K14/585 , A61K38/00 , A61K38/22 , C07K14/575
摘要： Un antagonista del péptido relacionado con el gen de la calcitonina que tiene la estructura de Fórmula I: X1-Y1-Z1 (I), en la que X1 comprende X11-X12-X13-X14-X15-X16-X17 (SEQ ID NO: 16), en la que X11 se selecciona del grupo que consiste en alanina (Ala), cisteína (Cys) y glicina (Gly), y en la que X12 se selecciona del grupo que consiste en cisteína (Cys) y serina (Ser), siempre que uno de X11 y X12 sea Cys; X13 se selecciona del grupo que consiste en arginina (Arg), asparagina (Asn), ácido aspártico (Asp) y valina (Val); X14 se selecciona del grupo que consiste en leucina (Leu), fenilalanina (Phe) y treonina (Thr); X15 se selecciona del grupo que consiste en alanina (Ala), glicina (Gly) y serina (Ser); X16 se selecciona del grupo que consiste en alanina (Ala), isoleucina (Ile), leucina (Leu) y serina (Ser); X17 es Cys; y en la que Y1 es -Val-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn- (SEQ ID NO: 34); y Z1 es -Val-Gly-Ser-Lys-Ala-Phe-NH2 (SEQ ID NO: 46).

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