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11. 发明专利

SK136696A3 FACTOR XA INHIBITORS 未知
公开(公告)号：SK136696A3
公开(公告)日：1997-05-07
申请号：SK136696
申请日：1995-04-25
申请人： SELECTIDE CORP
发明人： AL-OBEIDI FAHAD , LEBL MICHAL , OSTREM JAMES A , SAFAR PAVEL , STIERANDOVA ALENA , STROP PETER , WALSER ARMIN
IPC分类号： A61K38/43 , A61K38/00 , A61K38/06 , A61K38/08 , A61P7/02 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/02 , C07K7/06 , C07K7/64 , C07K14/81 , C12Q1/56 , C07K7/04

12. 发明专利

HU9602954D0 FACTOR XA INHIBITORS 未知
公开(公告)号：HU9602954D0
公开(公告)日：1996-12-30
申请号：HU9602954
申请日：1995-04-25
申请人： SELECTIDE CORP
发明人： AL-OBEIDI FAHAD , LEBL MICHAL , OSTREM JAMES A , SAFAR PAVEL , STIERANDOVA ALENA , STROP PETER , WALSER ARMIN
IPC分类号： A61K38/43 , A61K38/00 , A61K38/06 , A61K38/08 , A61P7/02 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/02 , C07K7/06 , C07K7/64 , C07K14/81 , C12Q1/56

13. 发明专利

FI964317A0 未知
公开(公告)号：FI964317A0
公开(公告)日：1996-10-25
申请号：FI964317
申请日：1996-10-25
申请人： SELECTIDE CORP
发明人： AL-OBEIDI FAHAD , LEBL MICHAL , OSTREM JAMES A , SAFAR PAVEL , STIERANDOVA ALENA , STROP PETER , WALSER ARMIN
IPC分类号： A61K38/43 , A61K38/00 , A61K38/06 , A61K38/08 , A61P7/02 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/02 , C07K7/06 , C07K7/64 , C07K14/81 , C12Q1/56 , C07K

14. 发明专利

CA2207435A1 COMBINATORIAL LIBRARIES HAVING A PREDETERMINED FREQUENCY OF EACH SPECIES OF TEST COMPOUND 未知
公开(公告)号：CA2207435A1
公开(公告)日：1996-06-20
申请号：CA2207435
申请日：1995-12-07
申请人： SELECTIDE CORP
发明人： LEBL MICHAL
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B30/04 , C40B40/10 , C40B60/14 , C40B70/00 , G01N33/543 , G01N33/68

15. 发明专利

AU4844893A Peptide sequencing using mass spectrometry 未知
公开(公告)号：AU4844893A
公开(公告)日：1994-03-29
申请号：AU4844893
申请日：1993-09-02
申请人： SELECTIDE CORP
发明人： SEPETOV NIKOLAI , ISSAKOVA OLGA , KREHNAK VIKTOR , LEBL MICHAL
IPC分类号： G01N33/68
摘要： The present invention relates to methods for determining the amino acid composition, and more preferably the sequence, of a peptide using mass spectrometric techniques. The method is particularly useful for sequencing peptides isolated from natural sources or from libraries of peptides that have been prepared synthetically, and for peptides that are not amenable to Edman degradation sequencing. In one embodiment, the method for determining the amino acid composition or sequence of a peptide comprises determining the difference of the mass of the peptide from the mass of a deuterium-hydrogen exchanged peptide, and from this difference determining the number of exchangeable (labile) hydrogen atoms (protons). Candidate peptides having amino acid compositions or sequences that do not contain the observed number of exchangeable protons are eliminated. In another embodiment, synthesis of a portion of the peptides in a library of peptides is terminated after each coupling step, whereby a set of sequentially truncated fragments of each peptide is formed. Thus the sequence of the peptide can be determined by determining the difference in the molecular weight between each peptide or fragment thereof and the sequentially smaller fragment of the peptide.

16. 发明专利

FI120494B 未知
公开(公告)号：FI120494B
公开(公告)日：2009-11-13
申请号：FI964317
申请日：1996-10-25
申请人： SELECTIDE CORP
发明人： AL-OBEIDI FAHAD , LEBL MICHAL , OSTREM JAMES A , SAFAR PAVEL , STIERANDOVA ALENA , STROP PETER , WALSER ARMIN
IPC分类号： A61K38/43 , C07K5/08 , A61K38/00 , A61K38/06 , A61K38/08 , A61P7/02 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/02 , C07K7/06 , C07K7/64 , C07K14/81 , C12Q1/56

17. 发明专利

CA2186497C FACTOR XA INHIBITORS 未知
公开(公告)号：CA2186497C
公开(公告)日：2008-06-17
申请号：CA2186497
申请日：1995-04-25
申请人： SELECTIDE CORP
发明人： AL-OBEIDI FAHAD , LEBL MICHAL , OSTREM JAMES A , SAFAR PAVEL , STIERANDOVA ALENA , STROP PETER , WALSER ARMIN
IPC分类号： A61K38/43 , C07K14/81 , A61K38/00 , A61K38/04 , A61K38/06 , A61K38/08 , A61K38/55 , A61P7/02 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/097 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/02 , C07K7/04 , C07K7/06 , C07K7/50 , C07K7/64 , C12Q1/56
摘要： The invention provides compounds which specifically inhibit factor Xa activity. The compounds consist of the structure X1-YIR-X2, wherein X1 is H, acyl, alkyl, acylalkyl, arylalkyl or one or more amino acids, and X2 is a modified C-terminal group, one or more carboxy-protecting groups or one or more amino acids or other substituent, and Y, I and R are tyrosine, isoleucine and arginine, respectively, or peptidomimetic or organic structures that possess the same functional activity as Y, I and R, respectively. In addition, the present invention provides a compound having the structure A1-A2-(A3)m-B, where m is 0 or 1. A compound of the invention can be linear or cyclic and can be about 2 and 43 residues in length. A compound of the invention is characterized, in part, in that it exhibits a specific inhibition of factor Xa activity with a Ki of

18. 发明专利

DE69432147D1 未知
公开(公告)号：DE69432147D1
公开(公告)日：2003-03-27
申请号：DE69432147
申请日：1994-05-27
申请人： SELECTIDE CORP
发明人： LEBL MICHAL , LAM KIT S , SALMON SYDNEY E , KRCHNAK VICTOR , SEPETOV NIKOLAI , KOCIS PETER
IPC分类号： G01N33/53 , C07B61/00 , C07K1/04 , C07K17/00 , C40B70/00 , G01N33/543 , G01N33/566 , C12P21/00 , C12Q1/68

19. 发明专利

DK0797776T3 未知
公开(公告)号：DK0797776T3
公开(公告)日：2002-10-07
申请号：DK95942579
申请日：1995-12-07
申请人： SELECTIDE CORP
发明人： LEBL MICHAL
IPC分类号： B01J19/00 , C07B61/00 , C07K1/04 , C40B30/04 , C40B40/10 , C40B60/14 , C40B70/00 , G01N33/543 , G01N33/68

20. 发明专利

SI0751779T1 SELECTIVELY CLEAVABLE LINKERS BASED ON IMINODIACETIC ACID ESTER BONDS 未知
公开(公告)号：SI0751779T1
公开(公告)日：2002-04-30
申请号：SI9430412
申请日：1994-06-21
申请人： SELECTIDE CORP
发明人： LEBL MICHAL , KRCHNAK VIKTOR , KOCIS PETR , LAM KIT S
IPC分类号： A61K38/00 , C07K1/04

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