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11. 发明专利

DE69634671D1 未知
公开(公告)号：DE69634671D1
公开(公告)日：2005-06-02
申请号：DE69634671
申请日：1996-10-28
申请人： SALK INST FOR BIOLOG STUDIES L
发明人： HUNTER TONY , LU PING
IPC分类号： A61K38/00 , C12N9/90 , A61K38/16 , A61K31/00 , C07K16/00 , C12P21/08 , C07H21/02 , C07H21/04 , C12N15/00 , C12N5/00 , C12N1/20
摘要： A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or expression are also provided.

12. 发明专利

DE69034138T2 未知
公开(公告)号：DE69034138T2
公开(公告)日：2005-05-12
申请号：DE69034138
申请日：1990-10-25
申请人： SALK INST FOR BIOLOG STUDIES L
发明人： HEINEMANN FOX , BOULTER RICHARD , HOLLMANN MICHAEL , BETTLER BERNHARD , JENSEN EGEBIERG
IPC分类号： C07K14/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/94 , C07K14/47 , C12N15/11 , G01N33/50
摘要： The present invention discloses novel DNAs that encode proteins having electrophysiological and pharmacological properties characteristic of glutamate receptors. The glutamate receptors are exemplified by proteins encoded by representative cDNA clones GluR1, GluR2, GluR3, GluR4, GluR5, GluR6 and GluR7, fragments thereof, and functional combinations of these glutamate receptor proteins and/or fragments. DNA sequences from the cDNA clones for GluR1, GluR2, GluR3, GluR5 and GluR5 are especially useful as probes, thus enabling those skilled in the art to identify, without undue experimentation, other members of the L-glutamate receptor family.

13. 发明专利

DE69434217D1 未知
公开(公告)号：DE69434217D1
公开(公告)日：2005-02-03
申请号：DE69434217
申请日：1994-06-27
申请人： SALK INST FOR BIOLOG STUDIES L , UNIV UTAH RES FOUND
发明人： OLIVERA BALDOMERO M , RIVIER JEAN E F , CRUZ LOURDES J , ABOGADIE FE , HOPKINS CHRIS E , DYKERT JOHN , TORRES JOSEP L
IPC分类号： A61K38/00 , A61K39/00 , A61P21/00 , C07K14/435 , C12N15/12 , A61K38/17 , G01N33/68
摘要： Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defence genes into plant species of interest.

14. 发明专利

DE69434118D1 未知
公开(公告)号：DE69434118D1
公开(公告)日：2004-12-09
申请号：DE69434118
申请日：1994-05-25
申请人： SALK INST FOR BIOLOG STUDIES L
发明人： PERRIN H , CHEN RUOPING , LEWIS A , VALE W , DONALDSON J
IPC分类号： G01N33/53 , C07K14/72 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/566 , G01N33/68
摘要： In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of /=50% of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. The invention CRF-R can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies.

15. 发明专利

DE69232537D1 未知
公开(公告)号：DE69232537D1
公开(公告)日：2002-05-08
申请号：DE69232537
申请日：1992-09-08
申请人： SALK INST FOR BIOLOG STUDIES L
发明人： EVANS M , MANGELSDORF J , ONG S , ORO E , BORGMEYER K , GIGUERE VINCENT , YAO TSO-PANG
IPC分类号： C07K14/705 , C12N15/12 , C12Q1/68 , C07K14/435 , C12N5/10 , C12N15/62

16. 发明专利

DE69232188D1 未知
公开(公告)号：DE69232188D1
公开(公告)日：2001-12-13
申请号：DE69232188
申请日：1992-08-21
申请人： SALK INST FOR BIOLOG STUDIES L , LIGAND PHARM INC
发明人： EVANS RONALD M , HEYMAN RICHARD A , BERGER CHRISTINA S , STEIN ROBERT B
IPC分类号： A61K45/00 , A61K31/00 , A61K31/07 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/20 , A61K31/203 , A61P5/00 , A61P17/00 , A61P35/02 , A61P43/00
摘要： In accordance with the present invention, there is provided a method for the treatment of subjects afflicted with steroid or steroid-like hormone-responsive disease states. The invention method comprises administering to the subject an effective amount of a ligand which selectively interacts with the receptor subtype associated with the steroid or steroid-like hormone-responsive disease state, wherein said ligand interacts with said receptor subtype to a significantly greater extent than with other subtypes of the same receptor class.

17. 发明专利

DE69132411T2 未知
公开(公告)号：DE69132411T2
公开(公告)日：2001-06-07
申请号：DE69132411
申请日：1991-01-22
申请人： SALK INST FOR BIOLOG STUDIES L
发明人： MANGELSDORF JOHN , EVANS MARK
IPC分类号： C07H21/04 , C07K14/00 , C07K14/705 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/64 , C12N15/67 , C12N15/85 , C12P21/02 , C12Q1/68 , C12R1/91 , C12N5/00 , C07H15/12 , C07K1/00
摘要： The present invention relates to novel receptor polypeptides, which, upon interaction with certain ligands, or activation by certain compounds, modulate transcription of certain genes by binding to cognate response elements associated with promoters of such genes. The novel receptors of the invention modulate transcription in the presence of retinoid compounds. The receptors of the present invention differ significantly from known retinoid acid receptors, in protein primar yseqence and in responsiveness to exposure to various retinoids. The invention provides DNAs encoding the novel receptors, expression vectors for expression of the receptors, cells transformed with such expression vectors, cells co-transformed with such expression vectors and with reporter vectors to monitor modulation of transcription by the receptors, and methods of using such co-transformed cells in screening for compounds which are capable, directly or indirectly, of activating the receptors. The invention also provides nucleic acid probes for identifying DNAs which encode additional retinoid receptors of the same class as the novel receptors disclosed herein.

18. 发明专利

DE69230345D1 未知
公开(公告)号：DE69230345D1
公开(公告)日：1999-12-30
申请号：DE69230345
申请日：1992-10-07
申请人： SALK INST FOR BIOLOG STUDIES L
发明人： EVANS GLEN , SELLERI LICIA FOURTH STREET , EUBANKS JAMES
IPC分类号： G01N33/50 , C07H21/04 , C12Q1/68
摘要： Nucleotide sequence defining a polymorphic locus useful for identification of an individual. Also disclosed are oligonucleotide primers useful in amplification of the locus and methods for detecting the amplified locus.

19. 发明专利

DE68914205D1 未知
公开(公告)号：DE68914205D1
公开(公告)日：1994-05-05
申请号：DE68914205
申请日：1989-07-13
申请人： SALK INST FOR BIOLOG STUDIES L
发明人： RIVIER JEAN EDOUARD FREDERIC , VALE WYLIE WALKER , RIVIER CATHERINE LAURE
IPC分类号： A61K38/04 , A61K38/00 , A61P5/00 , C07K14/575 , C07K14/60 , C07K7/10 , A61K37/43
摘要： Synthetic peptides which stimulate the release of pituitary GH in animals, including humans, and are more resistant to enzymatic degradation in the body than hGRF having the sequence: (B)R1-R2-R3-Ala-Ile-Phe-Thr-R8-Ser- THETA 10-Arg-R12-R13-Leu-R15-Gln-Leu-R18-Ala-A rg-R21-R22-Leu-R24-R @5-Ile-R27-R28-R @9-Gln-Gln-Gly-Glu-R34-Asn-Gln-Glu-R38-R39-R40-Arg-R42-R43-R44 wherein R1 is Tyr, D-Tyr, Met, D-Met, Phe, D-Phe, pCl-Phe, Leu, His or D-His; B is H, C Me, N Me, desamino, Ac or For; R2 is Ala, D-Ala, NMA or D-NMA; R3 is Asp or D-Asp; R8 is Ser, Asn, Lys, Arg, Asp or Gln; R10 is Tyr, D-Tyr or Phe; R12 is Arg or Lys; R13 is Ile, Val, Leu or Ala; R15 is Gly, Ala or beta -Ala; R18 is Ser or Tyr; R21 is Lys, D-Lys, Arg or D-Arg; R22 is Leu, Ile, Ala or Val; R24 is Gln or His; R25 is cys, abu, asp, glu, orn, lys, dab or dap; R27 is Met, D-Met, Ala, Nle, Ile, Leu, Nva or Val; R28 is Asn or Ser; R29 is cys, abu, asp, glu, orn, lys, dab or dap; R34 is Ser or Arg; R38 is Arg or Gln; R39 is Gly or Arg; R40 is Ala or Ser; R42 is Phe or Ala; R43 is Asn or Arg; R44 is a natural amino acid, such as Leu or Val. C-terminal sequences of from 1 to 15 residues beginning at R44 and extending as far as up to R29 may be deleted. These peptides as well as their nontoxic salts may also be used diagnostically.

20. 发明专利

DE3486238T2 未知
公开(公告)号：DE3486238T2
公开(公告)日：1994-03-03
申请号：DE3486238
申请日：1984-04-13
申请人： SALK INST FOR BIOLOG STUDIES L
发明人： RIVIER JEAN E F , SPIESS JOACHIM , VALE WYLIE W
IPC分类号： C12N15/09 , A61K35/30 , A61K38/00 , A61K38/02 , A61K38/04 , A61K38/22 , A61P5/00 , A61P9/12 , C07K14/00 , C07K14/575 , C12N15/00 , C07K7/10 , A61K37/02
摘要： Rat Corticotropin Releasing Factor (rCRF) and the human counterpart thereof have the formula:… H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-… Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-… Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-… Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2.… Analogs are disclosed that are at least as potent. One which has been found to be particularly potent is:… H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-… Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-… Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-… Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2.… These analogs or pharmaceutically or veterinarily acceptable salts thereof, dispersed in a pharmaceutically or veterinarily acceptable liquid or solid carrier, can be administered to mammals, including humans, to achieve a substantial elevation of ACTH, beta -endorphin, beta -lipotropin, other products of the pro-opiomelanocortin gene and corticosterone levels and/or a lowering of blood pressure over an extended period of time. They may also be used as stimulants to elevate mood and improve memory and learning, as well as diagnostically. … In the analogs, one or more of the first three N-terminal residues may be deleted or may be substituted by a peptide up to 10 amino acids long and/or by an acylating agent containing up to 7 carbon atoms. A number of other substitutions may also be made throughout the chain.

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