专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US5438054A 2-(substituted pyrrolidinylthio) carbapenem derivatives 失效
标题翻译： 2-（取代的吡咯烷硫基）碳青霉烯衍生物
公开(公告)号：US5438054A
公开(公告)日：1995-08-01
申请号：US208046
申请日：1994-03-09
申请人： Susumu Nakagawa , Norikazu Ohtake , Fumio Nakano , Koji Yamada , Ryosuke Ushijima , Satoshi Murase , Hiroshi Fukatsu
发明人： Susumu Nakagawa , Norikazu Ohtake , Fumio Nakano , Koji Yamada , Ryosuke Ushijima , Satoshi Murase , Hiroshi Fukatsu
IPC分类号： C07D477/20 , A01N43/00 , A61K31/395 , C07D487/04
CPC分类号： C07D477/20
摘要： Carbapenem compounds of formula I and their pharmaceutically acceptable salts and esters are provided: ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, p, q and r are as defined herein, which are useful as antibacterial agents.
摘要翻译：提供式I的碳青霉烯化合物及其药学上可接受的盐和酯：其中R，R 1，R 2，R 3，p，q和r如本文所定义，其可用作抗菌剂。

12. 发明授权

US5112818A 2-(2-cyclopropylpyrrolidin-4-ylthio)carbapenhem derivatives 失效
标题翻译： 2-（2-环丙基吡咯烷-4-基）乙酰胺衍生物
公开(公告)号：US5112818A
公开(公告)日：1992-05-12
申请号：US635218
申请日：1990-12-28
申请人： Susumu Nakagawa , Koji Yamada , Ryosuke Ushijima
发明人： Susumu Nakagawa , Koji Yamada , Ryosuke Ushijima
IPC分类号： C07D477/20
CPC分类号： C07D477/20
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, each of R.sup.2 and R.sup.3 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R.sup.2 and R.sup.3 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group and a morpholino group, A is a carbonyl group or a single bond, and n is an integer of from 0 to 3; or a pharmaceutically acceptable salt or ester thereof.

13. 发明授权

US5068322A Crystalline cephalosporin compounds 失效
标题翻译：晶体环磷酰胺化合物
公开(公告)号：US5068322A
公开(公告)日：1991-11-26
申请号：US522817
申请日：1990-05-14
申请人： Susumu Nakagawa , Ryosuke Ushijima , Fumio Nakano , Koji Yamada , Eiichi Mano
发明人： Susumu Nakagawa , Ryosuke Ushijima , Fumio Nakano , Koji Yamada , Eiichi Mano
IPC分类号： A61K31/545 , C07D501/46
CPC分类号： C07D501/46 , C07D501/18 , C07D501/38 , Y02P20/55
摘要： The present invention relates to stable crystalline (6R,7R)-7-(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxylimino)acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)methyl-3-cephem-4-carboxylate sulfate or its hydrate, a process for production of the compound and (6R,7R)-7-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)methyl-3-cephem-4-carboxylate hydrochloride or its hydrate which is a starting material useful for the production of the desired compound of the present invention.

14. 发明申请

US20120289856A1 SYMPATHETIC SKIN RESPONSE MEASURING APPARATUS 审中-公开
标题翻译： SYMPATHETIC皮肤反应测量装置
公开(公告)号：US20120289856A1
公开(公告)日：2012-11-15
申请号：US13467440
申请日：2012-05-09
申请人： Jun MOTOGI , Yoshinobu ONO , Ryosuke USHIJIMA , Takeshi KOJIMA
发明人： Jun MOTOGI , Yoshinobu ONO , Ryosuke USHIJIMA , Takeshi KOJIMA
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0492 , A61B5/4266 , A61B5/441 , A61B5/4827 , A61N1/0456 , A61N1/0472 , A61N1/0502 , A61N1/0551 , A61N1/36014 , A61N1/36017
摘要： A sympathetic skin response measuring apparatus includes: a stimulation power supplying section configured to supply a power for stimulating only C fibers in a living body, to a stimulation electrode adapted to be applied to the living body; a measuring section configured to measure information of a sympathetic skin response based on a signal obtained from a measurement electrode adapted to be applied to the living body; and an outputting section configured to output the information measured by the measuring section.
摘要翻译：交感皮肤响应测量装置包括：刺激供电部，被配置为将能够仅将生物体中的C纤维刺激的电力提供给适用于生物体的刺激电极; 测量部，被配置为基于从适用于所述生物体的测量电极获得的信号来测量交感神经皮肤响应的信息; 以及输出部，被配置为输出由所述测量部测量的信息。

15. 发明授权

US5707987A Carbapenem derivatives 失效
标题翻译：卡巴培南衍生物
公开(公告)号：US5707987A
公开(公告)日：1998-01-13
申请号：US696910
申请日：1996-08-23
申请人： Susumu Nakagawa , Hiroshi Fukatsu , Ryosuke Ushijima
发明人： Susumu Nakagawa , Hiroshi Fukatsu , Ryosuke Ushijima
IPC分类号： A61K31/407 , A61K31/695 , A61P31/04 , C07D477/20 , C07D519/06 , C07F7/10 , A61K31/40 , C07D487/04
CPC分类号： C07D477/20
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group, R.sup.2 is a hydrogen atom or a negative charge, R.sup.3 is a hydrogen atom or a lower alkyl group, Ar is a phenyl group, a naphthyl group or a group of: ##STR2## (wherein each of A.sub.4 and A.sub.5 is a single bond, --NHSO.sub.2 -- or the like, and Het is a pyrrolinyl group, a 1,4-diazabicyclo�2.2.2!octanyl group or the like which may be substituted with a hydroxyl group, a carbamoyl lower alkyl group or the like) which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfonyl group or the like; a hydroxyl group; a di-lower alkylsulfamoyl group or the like, each of A.sub.1, A.sub.2 and A.sub.3 is a single bond or a lower alkylene group which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfamoyl group or the like; a pyridyl group or a pyridino group; and W is a sulfur atom, a single bond; or a pharmaceutically acceptable salt or ester; a process for its production and an antibacterial agent containing it as an active ingredient.
摘要翻译： PCT No.PCT / JP95 / 00280 Sec。 371日期：1996年8月23日 102（e）日期1996年8月23日PCT提交1995年2月24日PCT公布。公开号WO95 / 23150 PCT 日期：1995年8月31日具有下式的化合物：其中R 1为氢原子或低级烷基，R 2为氢原子或负电荷，R 3为氢原子或低级烷基， Ar是苯基，萘基或基团，-NHSO 2 - 等，Het是可被取代的吡咯啉基，1,4-二氮杂双环[2.2.2]辛烷基等可以被可被羟基，二低级烷基磺酰基等取代的低级烷基，低级烷基氨磺酰基等取代的羟基，氨基甲酰基低级烷基等）。羟基; 二低级烷基氨磺酰基等，A1，A2和A3各自为可以被羟基取代的低级烷基，低级烷基氨磺酰基等取代的单键或低级亚烷基基，二低级烷基氨磺酰基等; 吡啶基或吡啶基; W是硫原子，单键; 或药学上可接受的盐或酯; 其生产方法和含有它作为活性成分的抗菌剂。

16. 发明授权

US4959469A Crystalline cephalosporin compounds 失效
标题翻译：结晶头孢菌素化合物
公开(公告)号：US4959469A
公开(公告)日：1990-09-25
申请号：US315917
申请日：1989-02-27
申请人： Susumu Nakagawa , Ryosuke Ushijima , Fumio Nakano , Koji Yamada , Eiichi Mano
发明人： Susumu Nakagawa , Ryosuke Ushijima , Fumio Nakano , Koji Yamada , Eiichi Mano
IPC分类号： A61K31/545 , C07D501/46
CPC分类号： C07D501/46 , A61K31/545 , C07D501/18 , C07D501/38
摘要： The present invention relates to stable cyrstalline (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)-3-cephem-4-carboxylate sulfate or its hydrate, a process for production of the compound and (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxyl-1-methylethoxyimino)acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)methyl-3-cephem-4-carboxylate hydrochloride or its hydrate which is a starting material useful for the production of the desired compound of the present invention.
摘要翻译：本发明涉及稳定的cyrstalline（6R，7R）-7 - [（Z）-2-（2-氨基噻唑-4-基）-2-（1-羧基-1-甲基乙氧基亚氨基）乙酰氨基] -3-（ 5,6-二羟基-2-甲基-2-异二氢吲哚鎓）-3-头孢烯-4-羧酸甲酯硫酸盐或其水合物，该化合物的制备方法和（6R，7R）-7 - [（Z）-2 - （2-氨基噻唑-4-基）-2-（1-羧基-1-甲基乙氧基亚胺）乙酰胺基] -3-（5,6-二羟基-2-甲基-2-异二氢吲哚鎓）甲基-3-环丙基 - 4-羧酸盐酸盐或其水合物，其为可用于制备本发明所需化合物的原料。

17. 发明授权

US06251891B1 Carbapenem derivatives 失效
标题翻译：卡巴培南衍生物
公开(公告)号：US06251891B1
公开(公告)日：2001-06-26
申请号：US09294091
申请日：1999-04-19
申请人： Susumu Nakagawa , Norikazu Otake , Hideo Kiyonaga , Koji Yamada , Hideki Jona , Shigemitsu Okada , Masayuki Ogawa , Hideaki Imamura , Ryosuke Ushijima
发明人： Susumu Nakagawa , Norikazu Otake , Hideo Kiyonaga , Koji Yamada , Hideki Jona , Shigemitsu Okada , Masayuki Ogawa , Hideaki Imamura , Ryosuke Ushijima
IPC分类号： C07D47720
CPC分类号： C07D477/20
摘要： A compound represented by the general formula wherein R1 either represents a hydrogen atom or a lower alkyl group, R2 represents a hydrogen atom, an ester residue, an alkali metal or negative charge, and R3 and R4 are the same or different, and each represent a hydrogen atom or a hydrocarbonic group optionally containing hetero atom(s) selected from the group consisting of oxygen atom(s), sulfur atom(s) and nitrogen atom(s), or they are combined together with the nitrogen atom to which they bound to form a heterocyclic group, and the use thereof as an antibacterial agent.
摘要翻译：由通式化合物R1表示的化合物表示氢原子或低级烷基，R2表示氢原子，酯残基，碱金属或负电荷，R3和R4相同或不同，分别表示氢原子或任选含有选自氧原子，硫原子和氮原子的杂原子的烃基，或它们与它们所结合的氮原子结合在一起形成杂环基，其用作抗菌剂。

18. 发明授权

US6114524A Process for producing halogenated heteroaryl compounds 失效
标题翻译：卤化杂芳基化合物的制备方法
公开(公告)号：US6114524A
公开(公告)日：2000-09-05
申请号：US319642
申请日：1999-06-08
申请人： Shigemitsu Okada , Ryosuke Ushijima , Kiyofumi Ishikawa
发明人： Shigemitsu Okada , Ryosuke Ushijima , Kiyofumi Ishikawa
IPC分类号： C07D213/61 , C07D213/79 , C07D213/85 , C07D215/48 , C07D241/44 , C07D213/02 , C07D215/18 , C07D215/20 , C07D237/12 , C07D237/14
CPC分类号： C07D213/79 , C07D213/61 , C07D213/85 , C07D215/48 , C07D241/44
摘要： The present invention relates to a process for producing a compound represented by the formula (II): ##STR1## wherein X is a halogen atom, each of A.sup.1, A.sup.2 and A.sup.3 are the same or different and are selected from a carbon atom or a nitrogen atom, provided that at least A.sup.1, A.sup.2, or A.sup.3 is a nitrogen atom. Each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and are selected from a hydrogen atom, a lower alkyl group, a cyano group, a carboxyl group, a lower alkoxycarbonyl group, a halogen atom, and a nitro group. It is also provided that where R.sup.1 and R.sup.2 are adjacent to each other, R.sup.1 and R.sup.2 may be combined with each other to form a 5- or 6-membered ring which may carry on the ring thereof one substituent selected from the group consisting of a lower alkyl group, a nitrile group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a halogen atom, a nitro group, and an amino-(lower alkyl) group. The compound is prepared by reacting a compound represented by the formula (I): ##STR2## with a quaternary ammonium halide in the presence of phosphorus pentoxide.
摘要翻译： PCT No.PCT / JP97 / 04508 Sec。 371 1999年6月8日第 102（e）日期1999年6月8日PCT 1997年12月9日PCT公布。第WO98 / 25906号公报日期：1998年6月18日本发明涉及式（II）表示的化合物的制造方法：其中，X为卤素原子，A1，A2和A3各自相同或不同，选自碳原子数或氮原子，条件是至少A1，A2或A3为氮原子。 R 1，R 2，R 3和R 4各自相同或不同，选自氢原子，低级烷基，氰基，羧基，低级烷氧基羰基，卤素原子和硝基。还提供其中R 1和R 2彼此相邻，R 1和R 2可以彼此组合以形成5-或6-元环，其可以在其环上带有一个选自以下的取代基：低级烷基，腈基，羧基，低级烷氧基羰基，氨基甲酰基，卤素原子，硝基和氨基 - （低级烷基）基。该化合物通过在五氧化二磷存在下使式（I）表示的化合物与季铵卤化物反应来制备。

19. 发明授权

US5061794A Cephalosporin derivatives, and antibacterial agents 失效
标题翻译： CEPHALOSPORIN衍生物和抗菌剂
公开(公告)号：US5061794A
公开(公告)日：1991-10-29
申请号：US377086
申请日：1989-07-10
申请人： Susumu Nakagawa , Koji Yamada , Fumio Nakano , Norikazu Otake , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima , Ryuji Mitomo
发明人： Susumu Nakagawa , Koji Yamada , Fumio Nakano , Norikazu Otake , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima , Ryuji Mitomo
IPC分类号： C07D235/28 , C07D263/46 , C07D263/58 , C07D271/10 , C07D271/113 , C07D277/20 , C07D277/36 , C07D277/56 , C07D285/12 , C07D285/125 , C07D501/36
CPC分类号： C07D263/58 , C07D235/28 , C07D263/46 , C07D271/113 , C07D277/36 , C07D277/56 , C07D277/587 , C07D285/125
摘要： A compound having the formula: ##STR1## wherein R is a straight chain or branched chain lower alkyl, cyclic lower alkyl, lower alkenyl (except for 1-carboxy-1-vinyl), lower alkynyl, aralkyl, phenyl or 2-pyrrolidon-3-yl group which may be substituted, and Q is ##STR2## (wherein R.sup.1 is a hydrogen atom or an acetyl group, R.sup.2 is a hydrogen atom, a carboxyl group or a carboxymethyl group, Y is a sulfur atom or an oxygen atom, Z is a sulfur atom, an oxygen atom or an imino group which may be substituted by a lower alkyl group); or a pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.
摘要翻译：具有下式的化合物：其中R是直链或支链的低级烷基，环状低级烷基，低级烯基（1-羧基-1-乙烯基），低级炔基，芳烷基，苯基或2 可以被取代的吡咯烷酮-3-基，Q是氢原子或乙酰基，R2是氢原子，羧基或羧甲基， Y是硫原子或氧原子，Z是硫原子，氧原子或可被低级烷基取代的亚氨基）; 或其药学上可接受的盐，生理上可水解的酯或其溶剂合物。

20. 发明授权

US4958029A Process for the production of isoindoline derivatives, novel intermediates and process for their production 失效
标题翻译：生产异二氢吲哚衍生物的方法，新型中间体及其生产方法
公开(公告)号：US4958029A
公开(公告)日：1990-09-18
申请号：US140996
申请日：1988-01-05
申请人： Susumu Nakagawa , Satoshi Murase , Ryosuke Ushijima , Yoshiaki Kato
发明人： Susumu Nakagawa , Satoshi Murase , Ryosuke Ushijima , Yoshiaki Kato
IPC分类号： C07D209/44
CPC分类号： C07D209/44 , Y02P20/55
摘要： A process for producing a compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group or an aralkyl group, and R.sup.2 is a hydrogen atom or a hydroxyl-protecting group, or a salt thereof, which comprises removing from a compound of the formula: ##STR2## wherein R.sup.3 is a hydrogen atom or a hydroxyl-protecting group, R.sup.4 and R.sup.5 which may be the same or different are N-protecting groups selected from the group consisting of lower alkyl groups and aralkyl groups, and X.sup..crclbar. is an anion, the N-protecting group(s), if necessary, together with the hydroxyl-protecting group.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式