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11. 发明授权

US06346652B1 Asymmetric ring-closing metathesis reactions involving achiral and meso substrates 失效
标题翻译：涉及非手性和内消旋底物的不对称闭环复分解反应
公开(公告)号：US06346652B1
公开(公告)日：2002-02-12
申请号：US09114692
申请日：1998-07-13
申请人： Richard R. Schrock , Amir H. Hoveyda
发明人： Richard R. Schrock , Amir H. Hoveyda
IPC分类号： C07C602
CPC分类号： C07B53/00 , C07B57/00 , C07F7/1892 , C07F11/005 , Y02P20/582 , Y10S585/94
摘要： A composition and method for the catalytic conversion of a racemic mixture of dienes to a cyclic olefin by a ring-closing metathesis (RCM) reaction are disclosed. The composition, a transition metal complex with an M═C reaction site, contains a bidentate dialkoxide of at least 80% optical purity. Because the M═C reaction site is of a sufficient shape specificity, conferred in part by the dialkoxide of sufficient rigidity and a M═N—R1 site, reacting the composition with a mixture of two enantiomeric dienes results in an olefin metathesis product that has at least a 50% enantiomeric excess of one enantiomer in the mixture. A method is also provided for reacting a composition with a racemic diene mixture to generate a metathesis product that has an enantiomeric excess of at least 50%. Methods are also provided for catalytic enantioselective desymmetrization. One method involves an olefin metathesis reaction with a molecular substrate having a plane of symmetry to form a product free of a plane of symmetry. Another method provides a desymmetrization reaction to occur in the absence of solvent. A method for producing quaternary carbon centers through a desymmetrization reaction is also described.
摘要翻译：公开了通过闭环复分解（RCM）反应将二烯的外消旋混合物催化转化成环状烯烃的组合物和方法。该组合物是具有M = C反应位点的过渡金属络合物，其含有至少80％光学纯度的二齿二烷氧基化物。由于M = C反应位点具有足够的形状特异性，部分由二烷氧基赋予足够的刚性和M = N-R1位点，使组合物与两种对映异构体二烯的混合物反应，得到烯烃复分解产物，其具有在混合物中至少50％对映异构体过量的一种对映异构体。还提供了使组合物与外消旋二烯混合物反应以产生具有至少50％的对映异构体过量的复分解产物的方法。还提供了催化对映选择性去对称化的方法。一种方法涉及与具有对称平面的分子底物的烯烃复分解反应以形成不具有对称平面的产物。另一种方法提供在不存在溶剂的情况下发生的不对称反应。还描述了通过不对称反应生产季碳中心的方法。

12. 发明授权

US5889128A Living olefin polymerization processes 失效
公开(公告)号：US5889128A
公开(公告)日：1999-03-30
申请号：US843161
申请日：1997-04-11
申请人： Richard R. Schrock , Robert Baumann
发明人： Richard R. Schrock , Robert Baumann
IPC分类号： C07C217/08 , C07C217/90 , C07F7/00 , C07F7/28 , C08F2/00 , C08F2/46 , C08F4/18 , C08F4/64 , C08F10/00 , C08F297/06
CPC分类号： C07F7/28 , C07C217/08 , C07C217/90 , C07F7/00 , C07F7/006 , C08F10/00 , Y10S526/903
摘要： Processes for the living polymerization of olefin monomers with terminal carbon-carbon double bonds are disclosed. The processes employ initiators that include a metal atom and a ligand having two group 15 atoms and a group 16 atom or three group 15 atoms. The ligand is bonded to the metal atom through two anionic or covalent bonds and a dative bond. The initiators are particularly stable under reaction conditions in the absence of olefin monomer. The processes provide polymers having low polydispersities, especially block copolymers having low polydispersities. It is an additional advantage of these processes that, during block copolymer synthesis, a relatively small amount of homopolymer is formed.

13. 发明授权

US4727215A Catalyst composition for effecting metathesis of olefins 失效
标题翻译：用于实现烯烃复分解的催化剂组合物
公开(公告)号：US4727215A
公开(公告)日：1988-02-23
申请号：US872142
申请日：1986-06-09
申请人： Richard R. Schrock
发明人： Richard R. Schrock
IPC分类号： B01J31/16 , B01J31/18 , B01J31/22 , C07C6/04 , C07C6/00
CPC分类号： B01J31/2265 , B01J31/1805 , C07C6/04 , B01J2231/543 , B01J2531/64 , B01J2531/66 , B01J31/1608 , C07C2531/22
摘要： Compounds of the formula:M(NR.sup.1)(OR.sup.2).sub.2 (CHR.sup.3)whereinM is molybdenum or tungsten;R.sup.1 and R.sup.2 are alkyl, aryl, aralkyl or halogen-substituted derivatives or silicon-containing analogs thereof;R.sup.3 is an alkyl, aryl, aralkyl or any substituent that results from the initial reaction between the M.dbd.CHR.sup.3 complex and the olefin(s) that is(are) being metathesized;alkyl has 1-20 carbons, aryl has 6-20 carbons and aralkyl has 7-20 carbons.These compounds are catalysts for the metathesis of ordinary olefins (hydrocarbons) and especially functionalized olefins in the homogeneous phase.
摘要翻译：下式的化合物：M（NR1）（OR2）2（CHR3）其中M是钼或钨; R1和R2是烷基，芳基，芳烷基或卤素取代的衍生物或其含硅类似物; R3是烷基，芳基，芳烷基或任何由M = CHR 3络合物和被分解的烯烃之间的初始反应产生的取代基; 烷基具有1-20个碳原子，芳基具有6-20个碳原子，芳烷基具有7-20个碳原子。这些化合物是普通烯烃（烃）和特别是均相中官能化烯烃复分解的催化剂。

14. 发明授权

US4245131A Dimerization of olefins using tantalum and niobium catalysts 失效
标题翻译：使用钽和铌催化剂对烯烃进行二聚
公开(公告)号：US4245131A
公开(公告)日：1981-01-13
申请号：US54211
申请日：1979-07-02
申请人： Richard R. Schrock
发明人： Richard R. Schrock
IPC分类号： C07C2/34 , C07F9/00 , C07C2/26
CPC分类号： C07F9/00 , C07C2/34 , C07C2531/22
摘要： Tantalum and niobium catalysts or catalyst precursors of the formula: ##STR1## wherein R is cyclopentadienyl, which can be substituted with methyl up to five positions, or neopentylidene, R.sup.1 is neopentyl or benzyl, n is 0 or 1, R.sup.2 is neopentylidene, benzylidene, tetramethylene, or 2,3-dimethyltetramethylene, A is halo or a moiety of the formula YR.sup.3 R.sup.4 R.sup.5 wherein Y is a group 5 element including N, P, As, Sb and Bi and R.sup.3, R.sup.4, R.sup.5 can be the same or different and are C.sub.1 -C.sub.4 alkyl, aralkyl such as naphthyl, neophyl, tolyl or xylyl, aryl such as benzyl or phenyl or bipyridyl and Z is tantalum or niobium. The compounds selectively dimerize 1-olefins to 1-butenes; m=1 or 2.
摘要翻译：钽和铌催化剂或下式的催化剂前体：其中R是环戊二烯基，其可以被甲基取代至五个位置，或新戊基，R1是新戊基或苄基，n是0或1，R2是新亚戊基，亚苄基，四亚甲基或2,3-二甲基四亚甲基，A是卤素或式YR 3 R 4 R 5的部分，其中Y是包括N，P，As，Sb和Bi的第5族元素，并且R 3，R 4，R 5可以相同或不同，是C 1 -C 4烷基，芳烷基如萘基，烯丙基，甲苯基或二甲苯基，芳基如苄基或苯基或联吡啶基，Z是钽或铌。该化合物选择性地将1-烯烃二聚成1-丁烯; m = 1或2。

15. 发明授权

US08598400B2 Efficient methods for Z- or cis-selective cross-metathesis 有权
标题翻译：用于Z-或顺式选择性交叉复分解的有效方法
公开(公告)号：US08598400B2
公开(公告)日：2013-12-03
申请号：US13023400
申请日：2011-02-08
申请人： Amir H. Hoveyda , Simon J. Meek , Robert V. O'Brien , Josep Llaveria Cros , Richard R. Schrock
发明人： Amir H. Hoveyda , Simon J. Meek , Robert V. O'Brien , Josep Llaveria Cros , Richard R. Schrock
IPC分类号： C07C6/04 , C07C6/02
CPC分类号： C07D209/48 , C07C6/04 , C07C41/30 , C07C213/08 , C07C269/06 , C07C2601/14 , C07F7/083 , C07F7/1892 , C07C15/50 , C07C271/16 , C07C271/12 , C07C217/46 , C07C43/166
摘要： The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.
摘要翻译：本发明一般涉及用于进行复分解反应的方法，包括交叉复分解反应。相对于已知方法，本文描述的方法表现出增强的活性和立体选择性，并且可用于合成大量生物学和治疗学上重要的药剂。

16. 发明授权

US08222469B2 Catalysts and processes for the formation of terminal olefins by ethenolysis 有权
标题翻译：通过乙烯分解形成末端烯烃的催化剂和方法
公开(公告)号：US08222469B2
公开(公告)日：2012-07-17
申请号：US12503608
申请日：2009-07-15
申请人： Richard R. Schrock , Smaranda C. Marinescu , Amir H. Hoveyda
发明人： Richard R. Schrock , Smaranda C. Marinescu , Amir H. Hoveyda
IPC分类号： C07C2/02
CPC分类号： C07C6/06 , B01J31/1805 , B01J31/181 , B01J31/1825 , B01J31/2226 , B01J31/2265 , B01J2231/543 , B01J2531/0266 , B01J2531/0288 , B01J2531/64 , B01J2531/66 , B01J2540/225 , C07C6/04 , C07C67/333 , C07C2531/22 , C07C11/02 , C07C11/12 , C07C69/533
摘要： The present invention relates generally to catalysts and processes for the formation of terminal olefin(s) from internal olefin(s) via ethenolysis reactions. The ethenolysis reactions may proceed with high conversion, high turnover, and/or high selectivity.
摘要翻译：本发明一般涉及通过乙烯分解反应从内部烯烃形成末端烯烃的催化剂和方法。乙烯分解反应可以进行高转化率，高转化率和/或高选择性。

17. 发明申请

US20110245477A1 EFFICIENT METHODS FOR Z- OR CIS-SELECTIVE CROSS-METATHESIS 有权
标题翻译：用于Z-或CIS选择性交叉分析的有效方法
公开(公告)号：US20110245477A1
公开(公告)日：2011-10-06
申请号：US13023400
申请日：2011-02-08
申请人： Amir H. Hoveyda , Simon J. Meek , Robert V. O'Brien , Josep Llaveria Cros , Richard R. Schrock
发明人： Amir H. Hoveyda , Simon J. Meek , Robert V. O'Brien , Josep Llaveria Cros , Richard R. Schrock
IPC分类号： C07H15/04 , C07C41/30 , C07C67/31 , C07F7/08 , C07C213/08 , C07F7/18 , C07C269/06 , C07D209/48
CPC分类号： C07D209/48 , C07C6/04 , C07C41/30 , C07C213/08 , C07C269/06 , C07C2601/14 , C07F7/083 , C07F7/1892 , C07C15/50 , C07C271/16 , C07C271/12 , C07C217/46 , C07C43/166
摘要： The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.
摘要翻译：本发明一般涉及用于进行复分解反应的方法，包括交叉复分解反应。相对于已知方法，本文描述的方法表现出增强的活性和立体选择性，并且可用于合成大量生物学和治疗学上重要的药剂。

18. 发明申请

US20110077421A1 HIGHLY Z-SELECTIVE OLEFINS METATHESIS 有权
标题翻译：高选择性脂蛋白METATHESIS
公开(公告)号：US20110077421A1
公开(公告)日：2011-03-31
申请号：US12571036
申请日：2009-09-30
申请人： Richard R. Schrock , Annie J. King , Yu Zhao , Margaret M. Flook
发明人： Richard R. Schrock , Annie J. King , Yu Zhao , Margaret M. Flook
IPC分类号： C07F7/08 , C07C6/04 , C07C69/34 , C07F5/02 , C07C43/20 , C07C303/00 , C07C211/00
CPC分类号： B01J31/2295 , B01J31/1805 , B01J31/181 , B01J31/1825 , B01J31/2226 , B01J31/2265 , B01J31/2278 , B01J2231/54 , B01J2231/543 , B01J2531/0266 , B01J2531/0288 , B01J2531/64 , B01J2531/66 , B01J2540/225 , B01J2540/40 , C07B2200/09 , C07C6/04 , C07C41/30 , C07C67/475 , C07C209/64 , C07C209/68 , C07C303/40 , C07C2531/18 , C07C2531/22 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07F5/025 , C07F7/083 , C07F11/00 , C07F11/005 , C07C13/28 , C07C11/02 , C07C15/50 , C07C43/166 , C07C69/593 , C07C311/18 , C07C211/53
摘要： The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.
摘要翻译：本发明一般涉及通过同位素反应从末端烯烃Z选择性形成内部烯烃的催化剂和方法。

19. 发明申请

US20080119678A1 Olefin metathesis catalysts and related methods 有权
标题翻译：烯烃复分解催化剂及相关方法
公开(公告)号：US20080119678A1
公开(公告)日：2008-05-22
申请号：US11603951
申请日：2006-11-22
申请人： Adam S. Hock , Richard R. Schrock
发明人： Adam S. Hock , Richard R. Schrock
IPC分类号： B01J31/00 , C07C2/00
CPC分类号： B01J31/2295 , B01J31/122 , B01J31/1805 , B01J31/181 , B01J31/2234 , B01J31/2265 , B01J31/2291 , B01J2231/482 , B01J2231/54 , B01J2231/543 , B01J2531/64 , B01J2531/66 , C07C6/04 , C07C2531/22
摘要： The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to generate a catalytically active species, often under mild conditions and in high yields. In some cases, a wide variety of catalysts may be synthesized from a single catalyst precursor. Methods of the invention may also include the preparation of catalysts which, under reaction conditions known in the art, may have been difficult or impossible to prepare and/or isolate due to, for example, steric crowding at the metal center. The present invention also provides catalyst compositions, and precursors thereof, which may be useful in various chemical reactions including olefin metathesis. In some cases, methods of the invention may reduce the number of synthetic and purification steps required to produce catalysts and/or other reaction products, as well as reducing time, cost, and waste production.
摘要翻译：本发明提供合成催化剂及其前体的方法。本发明的方法可以包括将催化剂前体和至少一种配体结合以产生催化活性物质，通常在温和条件下和高产率下。在一些情况下，可以从单一催化剂前体合成多种催化剂。本发明的方法还可以包括催化剂的制备，其在本领域已知的反应条件下可能由于例如在金属中心的空间拥挤而难以或不可能制备和/或分离。本发明还提供催化剂组合物及其前体，其可用于包括烯烃复分解的各种化学反应。在一些情况下，本发明的方法可以减少制备催化剂和/或其它反应产物所需的合成和纯化步骤的数量，以及减少时间，成本和废物的产生。

20. 发明授权

US5146033A Homogeneous rhenium catalysts for metathesis of olefins 失效
标题翻译：用于烯烃复分解的均相铼催化剂
公开(公告)号：US5146033A
公开(公告)日：1992-09-08
申请号：US810377
申请日：1991-12-19
申请人： Richard R. Schrock , Robert Toreki
发明人： Richard R. Schrock , Robert Toreki
IPC分类号： B01J31/22 , C07C2/02 , C07C2/38 , C07C6/04 , C07C67/475 , C07F13/00 , C08G61/06
CPC分类号： C08G61/06 , B01J31/2226 , B01J31/2265 , C07C2/02 , C07C2/38 , C07C6/04 , C07C67/475 , C07F13/00 , B01J2231/543 , B01J2531/74 , C07C2531/12 , C07C2531/22
摘要： The invention pertains to rhenium (VII) compounds which are catalysts for metathesis of ordinary olefins (hydrocarbons) and functionalized olefins in a homogeneous phase and to methods of synthesizing these compounds. The rhenium compounds comprise a rhenium (VII) atom centrally linked to an alkylidene ligand, an alkylidyne ligand, and two other ligands of which at least one ligand is sufficiently electron withdrawing to render the rhenium atom significantly active for metathesis.
摘要翻译：本发明涉及铼（VII）化合物，它们是均相中普通烯烃（烃）和官能化烯烃复分解的催化剂，以及合成这些化合物的方法。铼化合物包含与亚烷基配体中间连接的铼（VII）原子，亚烷基炔配体和至少一个配体充分吸电子的另外两个配体，使得铼原子对复分解显着有活性。

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