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11. 发明公开

US20240094112A1 DETERMINING TIME RESPONSE VALUE OF AN ANALYTE IN A LIQUID 审中-公开
公开(公告)号：US20240094112A1
公开(公告)日：2024-03-21
申请号：US18258579
申请日：2021-12-20
申请人： Radiometer Medical ApS
发明人： Thomas KJAER
IPC分类号： G01N21/03 , G01N21/55
CPC分类号： G01N21/0303 , G01N21/55 , G01N2021/1789
摘要： There is presented an apparatus for determining one or more time response values of an analyte or a group of analytes (96) in a liquid (99) comprising a translucent element comprising pores (6), wherein the pores (6) are dead end pores (6) extending into the translucent element from respective openings (7) in the translucent element, wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris from entering the pores (6), while allowing the analyte or the group of analytes in the liquid (99) to enter the pores (6) via diffusion, one or more light sources (10) being adapted to illuminate at least the pores (6) in the translucent element (2), and a light detector (20) being adapted to at each of multiple points in time receive light (21) emerging from the pores (6) in response to illumination (11) by the one or more light sources, wherein the light detector is further adapted to generate one or more signals based on the received light, each of the one or more signals being temporally resolved and representative of at least a part of the received light, and wherein the apparatus is further comprising a data processing device comprising a processor configured to determine one or more time response values based on the one or more signals.

12. 发明授权

US11860095B2 Method and sensor for detecting presence or absence of a contaminant 有权
公开(公告)号：US11860095B2
公开(公告)日：2024-01-02
申请号：US17649564
申请日：2022-02-01
申请人： Radiometer Medical ApS
发明人： Peter Frischauf , Michael Taagaard , Flemming Aas
IPC分类号： G01N21/64 , G01N33/49
CPC分类号： G01N21/6428 , G01N21/6408 , G01N33/49 , G01N2021/6432 , G01N2021/6439 , G01N2201/062 , G01N2201/06113
摘要： The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200). The sample analyzer (200) comprises an optical sensor with a sensor layer (205) comprising a luminophor (201), wherein the sensor layer (205) has a sensor surface (206) forming an interface to the measurement chamber (201). The method comprises steps of: filling the measurement chamber with a fluid sample; applying a stimulus to the luminophor in the sensor layer; detecting luminescence emitted from the luminophor in the sensor layer in response to the stimulus as a function of time; obtaining a time sequence of measurement values for the detected luminescence; based on the time sequence, determining an actual value of a first parameter and an actual value of a second parameter, wherein one of the first and second parameters is sensitive to a change in refractive index across the interface between the sensor layer and the measurement chamber, and wherein the other one of the first and second parameters is not sensitive to said change in refractive index across the interface between the sensor layer and the measurement chamber; developing an expected value for the second parameter based on the actual value of the first parameter; comparing the expected value for the second parameter to the actual value of the second parameter; and determining the presence (or absence) of a contaminant based on the comparison. In a further aspect, a sample analyzer configured for detecting contaminants in the measurement chamber using embodiments of the above method is provided.

13. 发明授权

US11577243B2 Multiple-use sensor assembly for body fluids 有权
公开(公告)号：US11577243B2
公开(公告)日：2023-02-14
申请号：US17355492
申请日：2021-06-23
申请人： Radiometer Medical ApS
发明人： Christian Strange , Peter Frischauf
IPC分类号： B01L3/00 , G01N33/487
摘要： The present invention relates to a sensor assembly (1) for body fluids. The sensor assembly (1) comprises: a measurement chamber (2) extending in an axial direction from an inlet end (3) to an outlet end (4), the measurement chamber having a transverse cross-section with side walls (5, 6) defining a chamber width in a horizontal direction, and with top and bottom walls (8, 7) defining a chamber height in a vertical direction, each of the side walls (5, 6), top wall (8) and bottom wall (7) having a respective wall wettability for aqueous solutions; a first sensor (10a-h) adapted to measure a first parameter of body fluids, the first sensor (10 a-h) having a first sensor surface (11a-h) exposed to the inside of the measurement chamber at a first axial position, the first sensor surface (11a-h) having a first wettability for aqueous solutions; and a second sensor (20) adapted to measure a second parameter of body fluids, the second sensor (20) having a second sensor surface (21) exposed to the inside of the measurement chamber (2) at a second axial position upstream or downstream from the first axial position, the second sensor surface (21) having a second wettability for aqueous solutions higher than the first wettability. At the second axial position, the chamber width exceeds the width of the second sensor surface (21), and the measurement chamber has a widening (22) in a horizontal direction as compared to the first axial position.

14. 发明申请

US20220415488A1 SYSTEM AND METHOD FOR CONTROLLING A TIMING OF CONSECUTIVE BIOLOGICAL SAMPLES 有权
公开(公告)号：US20220415488A1
公开(公告)日：2022-12-29
申请号：US17756093
申请日：2020-11-25
申请人： RADIOMETER MEDICAL APS
发明人： Jakob Ohm ERIKSEN
IPC分类号： G16H40/20 , G16H10/65 , G16H10/40
摘要： System (10) for controlling a timing of consecutive biological samples (s0, s1) from a patient for a medical test (T), comprising: a registration device (30), configured for determining a patient id (PID) indicating an identity of the patient, and a first sample time point (t0) indicating a time of obtaining a first biological sample (s0) from the patient at a first time point (t0); a processing system (20), communicatively connected to the registration device (30), configured for receiving the patient id (PID) and the first sample time point (t0) from the registration device (30); determining a protocol rule (R) for the medical test (T) relating to timing requirements of obtaining biological samples (s0, s1) from the patient depending on the medical test (T); and determining a sample timing dependent on the protocol rule (R) and the first sample time point (t0), indicating when to obtain a second biological sample (s1) from the patient in compliance with the protocol rule (R).

15. 发明授权

US11422107B2 System and method for estimating a temperature of a liquid sample 有权
公开(公告)号：US11422107B2
公开(公告)日：2022-08-23
申请号：US16466419
申请日：2017-11-30
申请人： RADIOMETER MEDICAL APS
发明人： Flemming Aas , Peter Frischauf , Erik Helllesø Nicolajsen
IPC分类号： G01N27/327 , G01N33/49
摘要： The disclosure relates to an apparatus for the analysis of biological liquid samples, the apparatus having a measurement chamber defining a sample volume with an inlet and an outlet; a fluid handling system adapted for feeding a liquid to the sample volume through the inlet and for removing the liquid through the outlet; a thermostatic sample heater device adapted for controlling a sample temperature of a liquid sample in the measurement chamber; and a processor unit. An analyte sensor output may be corrected on the basis of the initial temperature thus determined. A corresponding method for the analysis of biological liquid samples is provided. Furthermore, a method of performing a quality control procedure using the apparatus or the method is disclosed.

16. 发明申请

US20210316307A1 MULTIPLE-USE SENSOR ASSEMBLY FOR BODY FLUIDS 有权
公开(公告)号：US20210316307A1
公开(公告)日：2021-10-14
申请号：US17355492
申请日：2021-06-23
申请人： Radiometer Medical ApS
发明人： Christian STRANGE , Peter FRISCHAUF
IPC分类号： B01L3/00 , G01N33/487
摘要： The present invention relates to a sensor assembly (1) for body fluids. The sensor assembly (1) comprises: a measurement chamber (2) extending in an axial direction from an inlet end (3) to an outlet end (4), the measurement chamber having a transverse cross-section with side walls (5, 6) defining a chamber width in a horizontal direction, and with top and bottom walls (8, 7) defining a chamber height in a vertical direction, each of the side walls (5, 6), top wall (8) and bottom wall (7) having a respective wall wettability for aqueous solutions; a first sensor (10a-h) adapted to measure a first parameter of body fluids, the first sensor (10a-h) having a first sensor surface (11a-h) exposed to the inside of the measurement chamber at a first axial position, the first sensor surface (11a-h) having a first wettability for aqueous solutions; and a second sensor (20) adapted to measure a second parameter of body fluids, the second sensor (20) having a second sensor surface (21) exposed to the inside of the measurement chamber (2) at a second axial position upstream or downstream from the first axial position, the second sensor surface (21) having a second wettability for aqueous solutions higher than the first wettability. At the second axial position, the chamber width exceeds the width of the second sensor surface (21), and the measurement chamber has a widening (22) in a horizontal direction as compared to the first axial position.

17. 发明授权

US11079319B2 Porous mirror for optical detection of an analyte in a fluid 有权
公开(公告)号：US11079319B2
公开(公告)日：2021-08-03
申请号：US16854136
申请日：2020-04-21
申请人： RADIOMETER MEDICAL APS
发明人： Thomas Kjaer
IPC分类号： G01N21/31 , G01N33/49 , B01L3/00 , G01N33/72 , G01N21/03 , A61B5/00 , G01N15/00 , A61B5/15
摘要： A porous mirror (1) for detection of an analyte (96) in a fluid (99) by optical probing, comprising a translucent slab (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a fluid (99), and a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer from the backside (4) of the translucent slab (2), wherein the translucent slab (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) at the front side (3) into the translucent slab (2), through the reflective layer (5), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (6), while allowing the analyte (96) in the fluid (99) to enter the pores (6) via diffusion.

18. 发明申请

US20210193305A1 SYSTEM OF MEDICAL DEVICES 有权
公开(公告)号：US20210193305A1
公开(公告)日：2021-06-24
申请号：US16771785
申请日：2018-12-10
申请人： Radiometer Medical ApS
发明人： Thomas JUNKER , Jakob SKOV , Halina TOMASZEWSKA
IPC分类号： G16H40/20 , G16H10/40
摘要： A system of medical devices, the system comprising: a medical device data management system; a plurality of medical devices communicatively connected to the medical device data management system; each medical device being operable to analyze one or more samples of biological material; and to communicate information about an operational state of the medical device to the medical device data management system; a plurality of portable electronic devices, each operable to be carried by an operator, each portable electronic device communicatively connectable to the medical device data management system and configured to receive, from the medical device data management system, information indicative of an operational state of respective medical devices and to display the received information in respect of one or more selected ones of the medical devices.

19. 发明授权

US10969358B2 Method for correcting Crea sensor for calcium inhibition 有权
公开(公告)号：US10969358B2
公开(公告)日：2021-04-06
申请号：US15742121
申请日：2016-06-20
申请人： Radiometer Medical ApS
发明人： Thomas Steen Hansen , Thomas Pedersen Nygaard
IPC分类号： G01N27/327 , G01N33/70 , C12Q1/00
摘要： A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the device comprising an enzyme layer, the method comprising: determining sensitivities of the device for each of one or more calibration solutions; determining a degree of modulation for the sample to be measured, determining a degree of modulation for each calibration solution; wherein said determining of each of the degrees of modulation comprises estimating the concentration of an enzyme modulator in the enzyme layer of the device; and calculating the sensitivity of the device for the sample, wherein the said calculating comprises adjusting the sensitivity of the device for each calibration solution by a factor comprising the determined degrees of modulation of the sample and the calibration solution.

20. 发明申请

US20190011429A1 METHOD OF DETECTING PRESENCE OR ABSENCE OF A CLOT IN A LIQUID SAMPLE ANALYZER 审中-公开
公开(公告)号：US20190011429A1
公开(公告)日：2019-01-10
申请号：US16064742
申请日：2016-12-19
申请人： Radiometer Medical Aps
发明人： Michael TAAGAARD , Peter Aage FRISCHAUF , Flemming AAS
IPC分类号： G01N33/49
摘要： The invention relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second one or more sequence of measurement results, (e) comparing the change of the first sequence of measurement results with the second sequence of measurement results, (f) determining presence or absence of a clot in the measurement chamber based on said comparison.

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