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11. 发明申请

WO2008091925A2 TREATMENT OF AORTIC DISSECTION OR ANEURYSM 审中-公开
标题翻译：治疗动态断层或神经损伤
公开(公告)号：WO2008091925A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/051762
申请日：2008-01-23
申请人： COOK INCORPORATED , MED INSTITUTE, INC. , GREWE, David, D. , BIGGS, David, Paul , RAGHEB, Anthony, O. , RUANE, Patrick, H.
发明人： GREWE, David, D. , BIGGS, David, Paul , RAGHEB, Anthony, O. , RUANE, Patrick, H.
IPC分类号： A61L27/00 , A61L31/16 , A61K31/415 , A61K38/16
CPC分类号： A61K38/556 , A61F2/07 , A61F2/915 , A61F2002/91541 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0068 , A61K9/0024 , A61K31/415 , A61L31/10 , A61L31/16 , A61L2300/434
摘要： This application relates to methods for treating an aneurysm or an aortic dissection (230; 530). The methods include delivering a medical device (10; 100; 150; 200; 400) and a c-Jun N-terminal kinase (JNK) inhibitor compound to a body lumen at a point of treatment within a subject having the aneurysm or aortic dissection (230; 530), the medical device (10; 100; 150; 200; 400) being adapted to release the JNK inhibitor within the body lumen of the subject. This application also relates to medical devices (10; 100; 150; 200; 400) and JNK inhibitor compounds, where the medical device (10; 100; 150; 200; 400) is adapted to release the JNK inhibitor compound within a patient. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.
摘要翻译：本申请涉及治疗动脉瘤或主动脉夹层的方法（230; 530）。所述方法包括在具有动脉瘤或主动脉夹层的受试者内的治疗点将医疗装置（10; 100; 150; 200; 400）和c-Jun N-末端激酶（JNK）抑制剂化合物递送至体腔（230; 530），所述医疗装置（10; 100; 150; 200; 400）适于将所述JNK抑制剂释放到所述受试者的体腔内。本申请还涉及医疗装置（10; 100; 150; 200; 400）和JNK抑制剂化合物，其中医疗装置（10; 100; 150; 200; 400）适于释放患者体内的JNK抑制剂化合物。医疗装置可以包括涂覆支架，移植物，支架移植物，气囊和导管。

12. 发明申请

WO2008076383A2 STENT GRAFT WITH RELEASABLE THERAPEUTIC AGENT 审中-公开
标题翻译：具有可释放治疗药物的STENT GRAFT
公开(公告)号：WO2008076383A2
公开(公告)日：2008-06-26
申请号：PCT/US2007025665
申请日：2007-12-17
申请人： MED INST INC , RUANE PATRICK H , VIBBERT AMY M
发明人： RUANE PATRICK H , VIBBERT AMY M
IPC分类号： A61L31/16 , A61L31/10
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , C08L75/04
摘要： Medical devices for implantation within a body vessel comprising a graft material and a releasable therapeutic agent are provided. The graft material preferably comprises a biocompatible polyurethane and a therapeutic agent. Preferably, the medical device is a stent graft formed by attaching a graft material comprising an elutable taxane therapeutic agent to a radially expandable frame.
摘要翻译：提供了用于植入包含移植材料和可释放治疗剂的体内容器内的医疗装置。接枝材料优选包含生物相容性聚氨酯和治疗剂。优选地，医疗装置是通过将包含可洗脱紫杉烷治疗剂的移植材料附着到可径向扩张的框架而形成的支架移植物。

13. 发明申请

WO2007089592A3 IMPLANTABLE MEDICAL DEVICE COATED WITH BIOACTIVE AGENT 审中-公开
标题翻译：用生物活性剂涂覆的可植入医疗器械
公开(公告)号：WO2007089592A3
公开(公告)日：2008-05-08
申请号：PCT/US2007002183
申请日：2007-01-26
申请人： MED INST INC , RUANE PATRICK , LITTLE JEFFERY P , ISCH ANDREW P
发明人： RUANE PATRICK , LITTLE JEFFERY P , ISCH ANDREW P
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/606 , C08L35/04
摘要： The present invention provides an implantable medical device comprising a bioactive agent and poly(alkyl cyanoacrylate) polymer. In one embodiment of the invention, the bioactive agent is a water-soluble material, such as an antisense agent.
摘要翻译：本发明提供了包含生物活性剂和聚（氰基丙烯酸烷基酯）聚合物的可植入医疗装置。在本发明的一个实施方案中，生物活性剂是水溶性物质，例如反义剂。

14. 发明申请

WO2007062036A3 IMPLANTABLE MEDICAL DEVICE COATINGS WITH BIODEGRADABLE ELASTOMER AND RELEASABLE THERAPEUTIC AGENT 审中-公开
标题翻译：具有生物可降解弹性体和可释放治疗剂的可植入医疗器械涂层
公开(公告)号：WO2007062036A3
公开(公告)日：2008-03-27
申请号：PCT/US2006045055
申请日：2006-11-21
申请人： MED INST INC , REYES PRISCILLA T , RUANE PATRICK H , PEREZ-SEGARRA WALESKA
发明人： REYES PRISCILLA T , RUANE PATRICK H , PEREZ-SEGARRA WALESKA
IPC分类号： A61L31/10
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/608 , A61L2420/08 , C08L67/04
摘要： A coated medical device, such as a stent, that elutes a therapeutic agent in a controlled manner is provided. The medical device may be coated with a layer of therapeutic agent and a layer of bioabsorbable elastomer over the layer of therapeutic agent. Methods of manufacturing a coated medical device and of coating a medical device are also provided.
摘要翻译：提供了以受控方式洗脱治疗剂的涂覆医疗装置，例如支架。医疗装置可以在治疗剂层上涂覆有治疗剂层和生物可吸收弹性体层。还提供了制造涂覆的医疗装置和涂覆医疗装置的方法。

15. 发明申请

WO2007143609A2 USE OF PLASMA IN FORMATION OF BIODEGRADABLE STENT COATING 审中-公开
标题翻译：等离子体在生物降解性硬质合金涂层中的应用
公开(公告)号：WO2007143609A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/070335
申请日：2007-06-04
申请人： XTENT, INC. , KAPLAN, Stephen L. , RUANE, Patrick H. , LANG, Eric A. , KIMURA, Torsten
发明人： KAPLAN, Stephen L. , RUANE, Patrick H. , LANG, Eric A. , KIMURA, Torsten
IPC分类号： A61L33/00 , B32B1/08 , B32B27/08 , A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/826 , A61F2002/9155 , A61F2002/91558 , A61F2210/0004 , A61F2230/0013 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/606 , B05B13/0228 , B05B13/0442 , Y10T428/1352
摘要： Metallic stents are treated with a gaseous species in a plasma state under conditions causing the species to polymerize and to be deposited in polymerized form on the metallic stent surface prior to the application of a drug-polymer mixture, which is done by conventional non-plasma deposition methods. The drug-polymer mixture once applied forms a coating on the stent surface that releases the drug in a time-release manner and gradually erodes, leaving only the underlying plasma-deposited polymer. In certain cases, the plasma-deposited polymer itself erodes or dissolves into the physiological medium over an extended period of time, leaving only the metallic stent. While the various polymers and drug remain on the stent, the plasma-deposited polymer enhances the adhesion of the drug-polymer anchor coating and maintains the coating intact upon exposure to the mechanical stresses encountered during stent deployment.
摘要翻译：在施加药物 - 聚合物混合物之前，在等离子体状态下，使物质聚合并以聚合形式沉积在金属支架表面上的条件下，处于等离子体状态的金属支架，其通过常规非等离子体沉积方法。一次施用的药物 - 聚合物混合物在支架表面上形成涂层，其以时间释放方式释放药物并逐渐侵蚀，仅留下下面的等离子体沉积聚合物。在某些情况下，等离子体沉积的聚合物本身在延长的时间内侵蚀或溶解到生理介质中，仅留下金属支架。虽然各种聚合物和药物保留在支架上，等离子体沉积的聚合物增强了药物 - 聚合物锚固涂层的粘附，并且在暴露于支架展开期间遇到的机械应力的同时保持涂层完整。

16. 发明申请

WO2007092179A2 DEVICE WITH NANOCOMPOSITE COATING FOR CONTROLLED DRUG RELEASE 审中-公开
标题翻译：用于控制药物释放的纳米复合涂层的装置
公开(公告)号：WO2007092179A2
公开(公告)日：2007-08-16
申请号：PCT/US2007002185
申请日：2007-01-26
申请人： MED INST INC , RUANE PATRICK
发明人： RUANE PATRICK
CPC分类号： A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/602 , A61L2400/12 , A61L2420/04
摘要： An implantable medical device including a nanocomposite coating deposited on at least a portion of a surface to provide a controlled release of a bioactive agent in one or more dosages is described. The nanocomposite coating includes a matrix, a bioactive agent and inorganic particles. The inorganic particles respond to a stimulus, preferably by generating heat. The response of the particles to the stimulus causes the matrix of the nanocomposite coating to undergo a volume change by, for example, contracting or swelling, thereby releasing at least a portion of the bioactive agent. A method of providing a controlled release of a bioactive agent from a nanocomposite coating on an implantable medical device is described. A method for preparing an implantable medical device coated with a nanocomposite coating for the controlled release of a bioactive agent is also described.
摘要翻译：描述了一种包括沉积在表面的至少一部分上以提供一种或多种剂量的生物活性剂的受控释放的纳米复合涂层的可植入医疗装置。纳米复合涂层包括基质，生物活性剂和无机颗粒。无机颗粒对刺激作出反应，优选通过产生热量。颗粒对刺激的反应导致纳米复合涂层的基质通过例如收缩或膨胀而经历体积变化，从而释放至少一部分生物活性剂。描述了从可植入医疗装置上的纳米复合涂层提供生物活性剂的受控释放的方法。还描述了用于制备用于控制释放生物活性剂的纳米复合涂层的可植入医疗装置的制备方法。

17. 发明申请

WO1994012028A1 AN AQUEOUS ALKALINE METAL WORKING FLUID CONTAINING A PRIMARY AMINE 审中-公开
标题翻译：含有主要胺的水性碱性金属工作流体
公开(公告)号：WO1994012028A1
公开(公告)日：1994-06-09
申请号：PCT/SE1993000958
申请日：1993-11-11
申请人： BEROL NOBEL AB , CASTROL LIMITED , SKÖLD, Rolf , RUANE, Patrick, J.
发明人： BEROL NOBEL AB , CASTROL LIMITED
IPC分类号： A01N33/08
CPC分类号： C07C215/08 , A01N33/08 , C07C217/28 , C10M133/08 , C10M173/00 , C10M2201/02 , C10M2201/063 , C10M2207/021 , C10M2207/022 , C10M2207/123 , C10M2207/125 , C10M2207/129 , C10M2207/16 , C10M2207/22 , C10M2207/281 , C10M2207/282 , C10M2207/283 , C10M2207/286 , C10M2211/08 , C10M2215/042 , C10M2215/22 , C10M2215/221 , C10M2215/225 , C10M2215/226 , C10M2215/30 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10N2210/01 , C10N2240/40 , C10N2250/02
摘要： Primary amines having the formula R(OCH2)nCH(OH)CH2NH2 in which R is an acyclic group with 2-12 carbon atoms and n is 0 or 1, or a salt thereof, are used as anticorrosion and antimicrobial agents. They are suitable to be incorporated in aqueous, alkaline, industrial fluids. An aqueous, alkaline metal working fluid is also disclosed.
摘要翻译：具有式R（OCH 2）n CH（OH）CH 2 NH 2的伯胺，其中R是具有2-12个碳原子的非环基团，n是0或1，或其盐被用作抗腐蚀和抗微生物剂。它们适合掺入含水，碱性，工业液体中。还公开了一种水性碱金属工作流体。

18. 发明申请

WO2008091925A3 TREATMENT OF AORTIC DISSECTION OR ANEURYSM 审中-公开
标题翻译：治疗动态断层或神经损伤
公开(公告)号：WO2008091925A3
公开(公告)日：2009-07-16
申请号：PCT/US2008051762
申请日：2008-01-23
申请人： COOK INC , MED INST INC , GREWE DAVID D , BIGGS DAVID PAUL , RAGHEB ANTHONY O , RUANE PATRICK H
发明人： GREWE DAVID D , BIGGS DAVID PAUL , RAGHEB ANTHONY O , RUANE PATRICK H
IPC分类号： A61K31/41 , A61L29/16 , A61L31/16
CPC分类号： A61K38/556 , A61F2/07 , A61F2/915 , A61F2002/91541 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0068 , A61K9/0024 , A61K31/415 , A61L31/10 , A61L31/16 , A61L2300/434
摘要： This application relates to methods for treating an aneurysm or an aortic dissection (230; 530). The methods include delivering a medical device (10; 100; 150; 200; 400) and a c-Jun N-terminal kinase (JNK) inhibitor compound to a body lumen at a point of treatment within a subject having the aneurysm or aortic dissection (230; 530), the medical device (10; 100; 150; 200; 400) being adapted to release the JNK inhibitor within the body lumen of the subject. This application also relates to medical devices (10; 100; 150; 200; 400) and JNK inhibitor compounds, where the medical device (10; 100; 150; 200; 400) is adapted to release the JNK inhibitor compound within a patient. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.
摘要翻译：本申请涉及治疗动脉瘤或主动脉夹层的方法（230; 530）。所述方法包括在具有动脉瘤或主动脉夹层的受试者内的治疗点将医疗装置（10; 100; 150; 200; 400）和c-Jun N-末端激酶（JNK）抑制剂化合物递送至体腔（230; 530），所述医疗装置（10; 100; 150; 200; 400）适于将所述JNK抑制剂释放到所述受试者的体腔内。本申请还涉及医疗装置（10; 100; 150; 200; 400）和JNK抑制剂化合物，其中医疗装置（10; 100; 150; 200; 400）适于释放患者体内的JNK抑制剂化合物。医疗装置可以包括涂覆支架，移植物，支架移植物，气囊和导管。

19. 发明申请

WO2009067431A3 CONTROLLED DRUG DELIVERY USING A ZEIN LAYER MODIFIED WITH LEVULINIC ACID 审中-公开
公开(公告)号：WO2009067431A3
公开(公告)日：2009-05-28
申请号：PCT/US2008/083869
申请日：2008-11-18
申请人： COOK INCORPORATED , MED INSTITUTE , LINDSAY, Ashley, P. , PEREZ-SEGARRA, Waleska , RUANE, Patrick, H. , CASTERLINE, Christine
发明人： LINDSAY, Ashley, P. , PEREZ-SEGARRA, Waleska , RUANE, Patrick, H. , CASTERLINE, Christine
IPC分类号： A61L31/10 , A61L31/16
摘要： The disclosure relates to medical devices coated with zein admixed with levulinic acid. The medical device may further include a therapeutic agent in contact with zein admixed with levulinic acid. Zein admixed with levulinic acid allows the therapeutic agent to be retained on the device during delivery and also controls the elution rate of the therapeutic agent following implantation. The disclosure further relates to methods of delivering a therapeutic agent on said medical devices as well as their use especially in the form of stents for prevention of restenosis.

20. 发明申请

WO2009005933A1 ADJUSTABLE-LENGTH DRUG DELIVERY BALLOON 审中-公开
标题翻译：可调节长度药物递送气球
公开(公告)号：WO2009005933A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/065671
申请日：2008-06-03
申请人： XTENT, INC. , SNOW, David W. , RUANE, Patrick H.
发明人： SNOW, David W. , RUANE, Patrick H.
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61F2/958 , A61M2025/105 , A61M2025/1068 , A61M2025/1081
摘要： A drug or agent coated balloon having a length which is adjustable in vivo is described herein. The balloon is configured to be coated or coatable with one or more drugs where the coating may be applied prior to advancement into a patient body or prior to balloon expansion within the patient body. The length of the expandable portion of the balloon is adjustable to approximate a length of the tissue region to be treated. Moreover, the drug-coated balloon may be used alone or it may be utilized to deploy luminal prostheses having one or more linked or otherwise coupled segments.
摘要翻译：本文描述了具有在体内可调节的长度的药物或试剂涂覆的气囊。气囊被配置成与一种或多种药物一起涂覆或涂覆，其中涂层可以在进入患者体内之前或者在患者体内的气囊扩张之前施用。球囊的可扩张部分的长度是可调节的，以近似待处理的组织区域的长度。此外，药物涂覆的球囊可以单独使用，或者可以用于部署具有一个或多个连接的或以其他方式耦合的节段的管腔假体。

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