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11. 发明申请

WO2003102543A3 A METHOD OF USING DATA BINNING IN THE ANALYSIS OF CHROMATOGRAHPY/SPECTROMETRY DATA 审中-公开
公开(公告)号：WO2003102543A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/017190
申请日：2003-05-30
申请人： WATERS INVESTMENTS LIMITED , PLUMB, Robert Stephen , STUMPF, Chris Lee , GORENSTEIN, Marc V.
发明人： PLUMB, Robert Stephen , STUMPF, Chris Lee , GORENSTEIN, Marc V.
IPC分类号： G06F19/00
摘要： Disclosed herein is a method of analyzing three-dimensional data obtainedfrom a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sample. The information obtained from such a procedure typically depends on retention time (R). As the analytes progress through the system, they enter the MS region of the LC/MS system. There they are ionized and a mass detector then detects these ionized species. The information procured from this procedure is generally reported as intensity for a corresponding m/z value. Therefore, an LC/MS system provides at least three pieces of information. Principle component analysis (PCA) is a robust method of multivariant analysis of this type of data between different samples. However, typically, PCA analysis is performed using only two-dimensional data. Therefore, it is expected that at least one parameter of data obtained from a LC/MS operation is lost, however, the methods disclosed herein preserves all three mathematical dimensions.

12. 发明申请

WO03102543A2 A METHOD OF USING DATA BINNING IN THE ANALYSIS OF CHROMATOGRAHPY/SPECTROMETRY DATA 审中-公开
标题翻译：在色谱分析数据分析中使用数据的方法
公开(公告)号：WO03102543A2
公开(公告)日：2003-12-11
申请号：PCT/US0317190
申请日：2003-05-30
申请人： WATERS INVESTMENTS LTD , PLUMB ROBERT STEPHEN , STUMPF CHRIS LEE , GORENSTEIN MARC V
发明人： PLUMB ROBERT STEPHEN , STUMPF CHRIS LEE , GORENSTEIN MARC V
IPC分类号： G01N30/86 , G01N20060101 , G01N30/62 , G01N30/72 , G01N30/74 , G06F19/24 , H01J49/00 , H01J49/04 , H01J49/16 , G01N
CPC分类号： H01J49/0036 , G01N30/8675 , G06F19/24
摘要： Disclosed herein is a method of analyzing three-dimensional data obtainedfrom a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sample. The information obtained from such a procedure typically depends on retention time (R). As the analytes progress through the system, they enter the MS region of the LC/MS system. There they are ionized and a mass detector then detects these ionized species. The information procured from this procedure is generally reported as intensity for a corresponding m/z value. Therefore, an LC/MS system provides at least three pieces of information. Principle component analysis (PCA) is a robust method of multivariant analysis of this type of data between different samples. However, typically, PCA analysis is performed using only two-dimensional data. Therefore, it is expected that at least one parameter of data obtained from a LC/MS operation is lost, however, the methods disclosed herein preserves all three mathematical dimensions.
摘要翻译：本文公开了一种分析从色谱/光谱法过程获得的三维数据的方法，特别是使用二维多变量统计分析的LC / MS方法。 LC部分允许分离样品内的分析物。从这种方法获得的信息通常取决于保留时间（R）。当分析物通过系统进入时，它们进入LC / MS系统的MS区域。在那里它们被离子化，质量检测器然后检测这些电离物质。从该程序获得的信息通常被报告为对应的m / z值的强度。因此，LC / MS系统提供至少三条信息。原理分量分析（PCA）是一种对不同样本之间的这种数据进行多变量分析的可靠方法。然而，通常，仅使用二维数据来执行PCA分析。因此，期望从LC / MS操作获得的数据的至少一个参数丢失，然而，本文公开的方法保留所有三个数学维度。

13. 发明专利

CA959363A ARCHERY BOW STRING DRAW AND RELEASE DEVICE 未知
公开(公告)号：CA959363A
公开(公告)日：1974-12-17
申请号：CA135326
申请日：1972-02-22
申请人： PLUMB ROBERT D
发明人： PLUMB ROBERT D

14. 发明申请

WO2013028774A1 ANALYSIS OF DRIED BLOOD SPOT SAMPLES IN A MICROFLUIDIC SYSTEM WITH DILUTION OF EXTRACTED SAMPLES 审中-公开
标题翻译：在具有稀释样品的微流控系统中的干燥血液样品样品的分析
公开(公告)号：WO2013028774A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051892
申请日：2012-08-22
申请人： WATERS TECHNOLOGIES CORPORATION , MURPHY, James, P. , TOMANY, Michael, J. , MICHIENZI, Joseph, D. , RAINVILLE, Paul , PLUMB, Robert, S. , GERHARDT, Geoff, C. , JUNG, Moon Chul
发明人： MURPHY, James, P. , TOMANY, Michael, J. , MICHIENZI, Joseph, D. , RAINVILLE, Paul , PLUMB, Robert, S. , GERHARDT, Geoff, C. , JUNG, Moon Chul
IPC分类号： G01N33/00 , G01N30/02 , G01N21/00
CPC分类号： G01N30/06 , B01L3/502715 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/1827 , G01N30/16 , G01N30/6095 , G01N30/88 , G01N33/49 , G01N2001/383 , G01N2030/009 , G01N2030/062
摘要： An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column.
摘要翻译：用于色谱系统的装置包括具有配置为分析色谱柱的流体通道和在微流体衬底的一侧上的流体端口的微流体衬底。流体端口在分析色谱柱的头端打开。干血斑（DBS）收集装置容纳一个或多个干燥的生物样品。 DBS收集装置直接耦合到微流体底物，其中一个生物样品被放置成与微流体底物的流体通道流体连通，并且该生物样品的提取流向分析色谱柱的头端。流体耦合到流体端口的稀释剂源将溶剂提供到分析柱的头端，以在生物样品流入分析色谱柱之前稀释提取的生物样品。

15. 发明申请

WO2006003429A3 MASS SPECTROMETER 审中-公开
公开(公告)号：WO2006003429A3
公开(公告)日：2006-01-12
申请号：PCT/GB2005/002610
申请日：2005-07-01
申请人： MICROMASS UK LIMITED , CASTRO-PEREZ, Jose , MILLAR, Alan , PLUMB, Robert
发明人： CASTRO-PEREZ, Jose , MILLAR, Alan , PLUMB, Robert
IPC分类号： H01J49/00
摘要： A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound.

16. 发明申请

WO2005001443A1 AN APPARATUS USED TO PREVENT CROSS-CONTAMINATION ALONG A PLATFORM AND METHODS OF MANUFACTURING THE SAME 审中-公开
标题翻译：用于防止平台上的交叉污染的装置及其制造方法
公开(公告)号：WO2005001443A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/020131
申请日：2004-06-24
申请人： WATERS INVESTMENTS LIMITED , GRANGER,, Jennifer H. , PLUMB,, Robert , STUMPF,, Chris , FINCH,, Jeffrey W.
发明人： GRANGER,, Jennifer H. , PLUMB,, Robert , STUMPF,, Chris , FINCH,, Jeffrey W.
IPC分类号： G01N21/03
CPC分类号： H01J49/0418 , B01L3/5085 , B01L3/50853 , B01L2200/141 , B01L2300/0819 , B01L2300/0822 , B01L2300/0887 , G01N21/03 , G01N21/11 , G01N21/253
摘要： Disclosed herein is an apparatus designed to prevent cross-contamination of a fluid along the surface of a platform comprising a cover slip (12) having one or more defined orifices (14).
摘要翻译：本文公开了一种设计用于防止流体沿着包括具有一个或多个限定孔（14）的盖板（12）的平台的表面的交叉污染的装置。

17. 发明申请

WO2004071615A3 POLYMERIC SOLID SUPPORTS FOR CHROMATOGRAPHY NANOCOLUMNS 审中-公开
标题翻译：用于色谱纳米微粒的聚合物固体载体
公开(公告)号：WO2004071615A3
公开(公告)日：2004-11-18
申请号：PCT/US2004003484
申请日：2004-02-06
申请人： WATERS INVESTMENTS LTD , GRANGER JENNIFER H , PLUMB ROBERT
发明人： GRANGER JENNIFER H , PLUMB ROBERT
IPC分类号： B01D20060101 , B01J19/00 , B01J20/28 , G01N30/60
CPC分类号： B01J19/0093 , B01J20/28026 , B01J20/28057 , B01J20/28069 , B01J20/28083 , B01J20/281 , B01J20/282 , B01J20/283 , B01J20/284 , B01J20/285 , B01J20/286 , B01J2220/54 , B01J2220/84 , G01N30/603 , G01N30/6095 , Y10T436/255
摘要： Nanocolumn chromatography devices useful, e.g., in CEC and nanoLC are disclosed. An exemplary chromatography device of the invention includes a nanocolumn, e.g., a capillary, packed with a particulate stationary phase material and a solid support. The solid support, or in situ frit, is adjacent to and integral with the stationary phase material. An in situ frit of the invention may be a mixture of the stationary phase material and a polymeric network of cross-linked poly(diorganosiloxane), e.g., poly(dimethylsiloxane), which may optionally be sintered. The invention also provides methods of making and using such devices.
摘要翻译：公开了可用于例如CEC和纳米LC的纳柱色谱装置。本发明的示例性色谱装置包括纳米柱，例如毛细管，填充有颗粒状固定相材料和固体支持物。固体载体或原位玻璃料与固定相材料相邻并与之成为一体。本发明的原位玻璃料可以是固定相材料和交联聚（二有机硅氧烷）（例如聚（二甲基硅氧烷））的聚合物网络的混合物，其可任选烧结。本发明还提供了制造和使用这种装置的方法。

18. 发明申请

WO2010059590A1 APPARATUS AND METHOD FOR THE STUDY OF METABOLISM 审中-公开
标题翻译：装置和方法研究代谢
公开(公告)号：WO2010059590A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064698
申请日：2009-11-17
申请人： WATERS TECHNOLOGIES CORPORATION , CASTRO-PEREZ, Jose , PLUMB, Robert, S. , GRANGER, Jennifer, Harnisch
发明人： CASTRO-PEREZ, Jose , PLUMB, Robert, S. , GRANGER, Jennifer, Harnisch
IPC分类号： C12M1/34
CPC分类号： C12M41/38 , C12M23/06
摘要： Embodiments of the present invention feature methods and apparatus in which fluids circulating between a plurality of vessels containing different cell types or tissues are monitored for metabolites following the introduction of a sample.
摘要翻译：本发明的实施方案的特征在于在引入样品之后监测在含有不同细胞类型或组织的多个血管之间循环的液体代谢物的方法和装置。

19. 发明申请

WO2005079263A3 APPARATUS AND METHOD FOR IDENTIFYING PEAKS IN LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY DATA AND FOR FORMING SPECTRA AND CHROMATOGRAMS 审中-公开
公开(公告)号：WO2005079263A3
公开(公告)日：2005-09-01
申请号：PCT/US2005/004180
申请日：2005-02-11
申请人： WATERS INVESTMENTS LIMITED , GORENSTEIN, Marc. V. , PLUMB, Robert, S. , STUMPF, Chris, L.
发明人： GORENSTEIN, Marc. V. , PLUMB, Robert, S. , STUMPF, Chris, L.
IPC分类号： H01J49/26 , B01D15/08 , B01D59/44
摘要： Chromatograms and mass spectra produced by an LC/MS system (101) are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer (108) portion of the LC/MS system (101) in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to-charge ratios falling within a specified mass-to-charge ratio window.

20. 发明申请

WO2005007264A3 SEPARATION DEVICE WITH INTEGRAL GUARD COLUMN 审中-公开
标题翻译：具有整体保护柱的分离装置
公开(公告)号：WO2005007264A3
公开(公告)日：2005-05-19
申请号：PCT/US2004022374
申请日：2004-07-12
申请人： WATERS INVESTMENTS LTD , GRANGER JENNIFER HARNISCH , PLUMB ROBERT
发明人： GRANGER JENNIFER HARNISCH , PLUMB ROBERT
IPC分类号： B01D20060101 , B01D15/08 , G01N30/60
CPC分类号： B01D15/22 , G01N30/60 , G01N30/6039 , G01N30/6065 , G01N30/6069 , G01N2030/085
摘要： A separation device (2) is formed of a first tube (10) with a cylindrical wall (11) enclosing a chamber (16) having a first diameter, where the device has a first end (18) for discharging a fluid. At least two stationary phase medias are packed into the chamber (11) with separating frits (24) between the medias. At least one end frit element (22), secured to an inner surface of the first tube (10) contains the media in its section of the chamber (11) and allows the beds (30, 32) formed of the media to be formed and packed. When the separation device (2) so constructed forms a nanocolumn with a guard bed, the guard bed may be cleaved from the separation device (2) extending the useful life of the nanocolumn. When the separation device (2) so constructed comprises two analytical sections, and a plurality guard beds, complex analysis may be performed on a column having an extended useful life.
摘要翻译：分离装置（2）由具有包围具有第一直径的室（16）的圆柱形壁（11）的第一管（10）形成，其中该装置具有用于排出流体的第一端（18）。至少两个固定相介质被填充到腔室（11）中，分离介质之间的玻璃料（24）。固定到第一管（10）的内表面的至少一个端部玻璃料元件（22）在其腔室（11）的部分中包含介质，并允许形成由介质形成的床（30,32）并打包。当如此构造的分离装置（2）形成具有保护床的纳米柱时，保护床可以从延长纳米柱的使用寿命的分离装置（2）裂开。当如此构造的分离装置（2）包括两个分析部分和多个保护床时，可以对具有延长的使用寿命的柱进行复杂分析。

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