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11. 发明申请

WO2010005809A3 POSTURE STATE RESPONSIVE THERAPY DELIVERY USING DWELL TIMES 审中-公开
标题翻译：使用DWELL时间的心理状态的治疗方法
公开(公告)号：WO2010005809A3
公开(公告)日：2010-05-27
申请号：PCT/US2009048852
申请日：2009-06-26
申请人： MEDTRONIC INC , SKELTON DENNIS M , DAVIS JON P , PANKEN ERIC J
发明人： SKELTON DENNIS M , DAVIS JON P , PANKEN ERIC J
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： Techniques related to classifying a posture state of a living body are disclosed. One aspect relates to sensing at least one signal indicative of a posture state of a living body. Posture state detection logic classifies the living body as being in a posture state based on the at least one signal, wherein this classification may take into account at least one of posture and activity state of the living body. The posture state detection logic further determines whether the living body is classified in the posture state for at least a predetermined period of time. Response logic is described that initiates a response as a result of the body being classified in the posture state only after the living body has maintained the classified posture state for at least the predetermined period of time. This response may involve a change in therapy delivered to the living body.
摘要翻译：公开了对活体姿势状态进行分类的技术。一个方面涉及感测指示生物体的姿势状态的至少一个信号。姿势状态检测逻辑基于至少一个信号将生物体分为处于姿势状态，其中该分类可以考虑活体的姿势和活动状态中的至少一个。姿势状态检测逻辑进一步确定生物体是否至少在预定时间段内分类为姿势状态。描述了响应逻辑，其仅在生物体至少在预定时间段内保持分类姿势状态之后，作为身体被分类为姿势状态的结果而发起响应。这种反应可能涉及向生物体递送的治疗方法的改变。

12. 发明申请

WO2010005802A3 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的姿态分类
公开(公告)号：WO2010005802A3
公开(公告)日：2010-05-27
申请号：PCT/US2009048686
申请日：2009-06-25
申请人： MEDTRONIC INC , PANKEN ERIC J , SKELTON DENNIS M
发明人： PANKEN ERIC J , SKELTON DENNIS M
IPC分类号： A61B5/11
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： One embodiment relates to a medical device including a sensor to provide signals indicative of a detected posture state of a patient. A memory stores one or more defined vectors, each defined vector being associated with a tolerance describing a relationship with the defined vector. A processor determines a respective similarity between the detected vector and each of one or more of the defined vectors and classifies a posture state of the patient based on whether any similarity has a relationship to the respective defined vector that is described by the associated tolerance. In one embodiment, the similarity is determined without regard to a coordinate system of the patient. Another embodiment relates to determining the similarity based on at least one of an inner product, a length of the defined posture vector and a length of the detected vector.
摘要翻译：一个实施例涉及一种医疗装置，其包括用于提供指示患者的检测到的姿势状态的信号的传感器。存储器存储一个或多个定义的矢量，每个定义的矢量与描述与定义的矢量的关系的容差相关联。处理器确定检测到的矢量与一个或多个定义的矢量中的每一个之间的相应相似性，并且基于任何相似性是否与由相关容差描述的相应定义矢量有关系来对患者的姿势状态进行分类。在一个实施例中，不考虑患者的坐标系来确定相似性。另一个实施例涉及基于内积，所定义的姿势向量的长度和检测到的向量的长度中的至少一个来确定相似性。

13. 发明申请

WO2010005822A2 BLENDED POSTURE STATE CLASSIFICATION AND THERAPY DELIVERY 审中-公开
标题翻译：混合状态分类和治疗交付
公开(公告)号：WO2010005822A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/049071
申请日：2009-06-29
申请人： MEDTRONIC, INC. , PANKEN, Eric, J.
发明人： PANKEN, Eric, J.
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques for classification of a posture state of a patient using multiple posture state definitions, and for delivering therapy according to the patient's classified posture state. Detected parameter values describing a patient's posture state are compared to posture state definitions. This comparison is used to determine similarity values describing how similar the patient's posture state is to each of the posture states described by the posture state definitions. Weighting factors may be determined from the similarity values and used to weight therapy parameter values that are associated with each of the posture state definitions. The resulting weighted therapy parameter values may be used to derive a blended therapy parameter value for use in delivering therapy to the patient. The patient's posture state may be expressed in terms of a blending of the multiple posture state definitions.
摘要翻译：用于使用多个姿势状态定义对患者的姿势状态进行分类的技术，以及根据患者分类的姿势状态进行治疗的技术。将描述患者姿势状态的检测参数值与姿势状态定义进行比较。该比较用于确定描述患者姿势状态与由姿势状态定义描述的每个姿势状态相似的相似性值。加权因子可以根据相似度值确定并用于与每个姿势状态定义相关联的加权治疗参数值。所得到的加权治疗参数值可用于导出用于向患者递送疗法的混合治疗参数值。患者的姿势状态可以用多姿势状态定义的混合来表示。

14. 发明申请

WO2010005809A2 POSTURE STATE RESPONSIVE THERAPY DELIVERY USING DWELL TIMES 审中-公开
标题翻译：姿势状态反应性治疗的用药时间
公开(公告)号：WO2010005809A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/048852
申请日：2009-06-26
申请人： MEDTRONIC, INC. , SKELTON, Dennis, M. , DAVIS, Jon, P. , PANKEN, Eric, J.
发明人： SKELTON, Dennis, M. , DAVIS, Jon, P. , PANKEN, Eric, J.
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques related to classifying a posture state of a living body are disclosed. One aspect relates to sensing at least one signal indicative of a posture state of a living body. Posture state detection logic classifies the living body as being in a posture state based on the at least one signal, wherein this classification may take into account at least one of posture and activity state of the living body. The posture state detection logic further determines whether the living body is classified in the posture state for at least a predetermined period of time. Response logic is described that initiates a response as a result of the body being classified in the posture state only after the living body has maintained the classified posture state for at least the predetermined period of time. This response may involve a change in therapy delivered to the living body.
摘要翻译：公开了与分类活体姿势状态有关的技术。一个方面涉及感测指示活体的姿势状态的至少一个信号。姿势状态检测逻辑基于至少一个信号将生物体分类为处于姿势状态，其中该分类可以考虑活体的姿势和活动状态中的至少一个。姿势状态检测逻辑进一步确定活体是否在姿势状态中被分类了至少预定的时间段。描述响应逻辑，其仅在生物体已经保持分类姿势状态达至少预定时间段之后才开始响应，作为身体被分类到姿势状态的结果。这种反应可能涉及到对生物体进行治疗的改变。

15. 发明申请

WO2010005802A2 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的状态分类
公开(公告)号：WO2010005802A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/048686
申请日：2009-06-25
申请人： MEDTRONIC, INC. , PANKEN, Eric, J. , SKELTON, Dennis, M.
发明人： PANKEN, Eric, J. , SKELTON, Dennis, M.
IPC分类号： A61B5/103 , A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： One embodiment relates to a medical device including a sensor to provide signals indicative of a detected posture state of a patient. A memory stores one or more defined vectors, each defined vector being associated with a tolerance describing a relationship with the defined vector. A processor determines a respective similarity between the detected vector and each of one or more of the defined vectors and classifies a posture state of the patient based on whether any similarity has a relationship to the respective defined vector that is described by the associated tolerance. In one embodiment, the similarity is determined without regard to a coordinate system of the patient. Another embodiment relates to determining the similarity based on at least one of an inner product, a length of the defined posture vector and a length of the detected vector.
摘要翻译：一个实施例涉及一种医疗设备，其包括用于提供指示患者的检测到的姿势状态的信号的传感器。存储器存储一个或多个定义的向量，每个定义的向量与描述与所定义的向量的关系的公差相关联。处理器确定检测到的矢量与一个或多个定义矢量中的每一个之间的各自的相似度，并且基于任何相似性是否与由相关联的容限描述的相应定义的矢量具有关系来对患者的姿势状态进行分类。在一个实施例中，不考虑患者的坐标系确定相似度。另一实施例涉及基于内积，所定义的姿态向量的长度和所检测的向量的长度中的至少一个来确定相似性。

16. 发明申请

WO2008039242A1 IMPLANTABLE MEDICAL DEVICE WITH SENSOR SELF-TEST FEATURE 审中-公开
标题翻译：具有传感器自检功能的可植入医疗器械
公开(公告)号：WO2008039242A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/009852
申请日：2007-04-24
申请人： MEDTRONIC, INC. , PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
发明人： PANKEN, Eric, J. , MIESEL, Keith, A. , LEE, Brian, B. , DENISON, Timothy, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/3706 , A61B2560/0276 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.
摘要翻译：当感测装置产生指示事件的传感器信号时，或者当传感器用于验证另一个设备检测到的事件时，可植入医疗设备（IMD）应用传感器自检。事件可以基于触发操作调整的感测条件，例如IMD内的治疗或诊断调整。传感器自检可以验证可植入的感测装置是否起作用，并且可以在启动或不启动传感器的情况下执行。激活传感器可能涉及施加导致传感器产生输出信号的电输入信号。或者，可以通过分析传感器和传感器接口电路之间的信号路径的连续性而不激活传感器来执行传感器自检。在任一种情况下，传感器自检将验证正确的操作，以便可以更有信心地进行操作调整。

17. 发明申请

WO2007143234A2 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：用于检测神经系统病症的方法和装置
公开(公告)号：WO2007143234A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/061145
申请日：2007-01-26
申请人： MEDTRONIC, INC. , CARLSON, David, L. , PANKEN, Eric, J. , GIFTAKIS, Jonathon, E.
发明人： CARLSON, David, L. , PANKEN, Eric, J. , GIFTAKIS, Jonathon, E.
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/048 , A61B5/4094 , A61B5/7275 , A61N1/36082 , G06F19/00
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：公开了用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施例总体上涉及适用于检测和治疗IMD患者的神经系统病症的可植入医疗装置（IMD）。本发明的某些实施例包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施例包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测癫痫发作活动。

18. 发明申请

WO2007124192A1 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：WO2007124192A1
公开(公告)日：2007-11-01
申请号：PCT/US2007/061147
申请日：2007-01-26
申请人： MEDTRONIC, INC. , CARLSON, David, L. , PANKEN, Eric, J. , DREW, Touby, A. , WERDER, Jonathan, C.
发明人： CARLSON, David, L. , PANKEN, Eric, J. , DREW, Touby, A. , WERDER, Jonathan, C.
IPC分类号： A61B5/04 , A61N1/08
CPC分类号： A61B5/048 , A61B5/4094 , A61B5/7275 , A61N1/08 , G06F19/00
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an. IMD. Certain embodiments of the invention include detection of seizures. based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：公开了用于检测和/或治疗诸如癫痫发作的神经系统疾病的系统和方法。本发明的某些实施方案一般涉及适于在患者中检测和治疗神经系统疾病的可植入医疗装置（IMD）。 IMD。本发明的某些实施方案包括检测癫痫发作。基于生理信号的长期和短期表示的比较。其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测发作活动。

19. 发明申请

WO2010005816A3 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的姿态分类
公开(公告)号：WO2010005816A3
公开(公告)日：2010-05-27
申请号：PCT/US2009048995
申请日：2009-06-29
申请人： MEDTRONIC INC , PANKEN ERIC J , SKELTON DENNIS M
发明人： PANKEN ERIC J , SKELTON DENNIS M
IPC分类号： A61B5/11
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： Techniques for posture classification of a patient in a coordinate system of a sensor. According to one aspect, a defined vector is obtained from a sensor disposed in a substantially fixed manner relative to the patient. The defined vector is described in a coordinate system of the sensor and without regard to an orientation in which the sensor is disposed in relation to the patient. A detected vector is obtained from the sensor that is described using the coordinate system of the sensor. The detected vector and the defined vector to are used to classify the posture state of the patient without regard to the orientation in which the sensor is disposed in relation to the patient. A response may be initiated by a medical device, which may include adjusting therapy delivery.
摘要翻译：在传感器的坐标系中对患者进行姿态分类的技术。根据一个方面，从相对于患者以基本上固定的方式布置的传感器获得定义的矢量。所定义的矢量在传感器的坐标系中进行描述，并且不考虑传感器相对于患者布置的方向。检测到的矢量是从使用传感器的坐标系描述的传感器获得的。检测到的矢量和定义的矢量用于分类患者的姿势状态，而不考虑传感器相对于患者布置的方向。响应可以由医疗设备发起，该医疗设备可以包括调整治疗递送。

20. 发明申请

WO2010005800A3 POSTURE STATE DETECTION USING SELECTABLE SYSTEM CONTROL PARAMETERS 审中-公开
标题翻译：姿态检测采用可选系统控制参数
公开(公告)号：WO2010005800A3
公开(公告)日：2010-05-27
申请号：PCT/US2009048676
申请日：2009-06-25
申请人： MEDTRONIC INC , PANKEN ERIC J , SKELTON DENNIS M
发明人： PANKEN ERIC J , SKELTON DENNIS M
IPC分类号： A61B5/11
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535
摘要： Techniques for detecting and classifying a posture state of a patient are disclosed, wherein a posture state includes at least one of a posture and/or an activity state related to motion. In one embodiment, one or more signals indicative of at least one of posture and activity state of the patient may be sensed by a sensor. Control logic may be provided to process the one or more sensed signals in a selectable manner. This selectable manner may be based on current posture state data describing a posture state in which the patient has previously been classified. Alternatively or additionally, this current posture state data may describe a posture state transition previously undergone by the patient. The one or more signals that are so processed may then be used to classify a posture state of the patient.
摘要翻译：公开了用于检测和分类患者的姿势状态的技术，其中姿势状态包括与运动有关的姿势和/或活动状态中的至少一个。在一个实施例中，可以由传感器感测指示患者的姿势和活动状态中的至少一个的一个或多个信号。可以提供控制逻辑以便以可选方式处理一个或多个感测信号。该可选择的方式可以基于描述患者先前已被分类的姿势状态的当前姿势状态数据。可选地或另外地，该当前姿势状态数据可以描述患者先前经历的姿势状态转变。然后可以使用如此处理的一个或多个信号来分类患者的姿势状态。

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