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11. 发明申请

US20140328461A1 ORTHOVOLTAGE RADIOTHERAPY 有权
公开(公告)号：US20140328461A1
公开(公告)日：2014-11-06
申请号：US14337122
申请日：2014-07-21
申请人： Oraya Therapeutics, Inc.
发明人： Michael Gertner , Steven D. Hansen
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，并且在一些实施方案中，用辐射剂量治疗身体的其它病症或组织。在一些实施例中，将目标组织放置在基于眼睛成像的全局坐标系中。在一些实施方案中，使用基准标记来鉴定靶组织的位置。

12. 发明授权

US09025727B2 Methods and devices for orthovoltage ocular radiotherapy and treatment planning 有权
标题翻译：用于正射电眼放疗和治疗计划的方法和装置
公开(公告)号：US09025727B2
公开(公告)日：2015-05-05
申请号：US13949063
申请日：2013-07-23
申请人： Oraya Therapeutics, Inc.
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1017 , A61N5/103 , A61N5/1064 , A61N2005/1091
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.
摘要翻译：公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

13. 发明申请

US20130301800A1 ORTHOVOLTAGE RADIOTHERAPY 有权
公开(公告)号：US20130301800A1
公开(公告)日：2013-11-14
申请号：US13670405
申请日：2012-11-06
申请人： Oraya Therapeutics., Inc
发明人： Michael Gertner , Steven D. Hansen
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，并且在一些实施方案中，用辐射剂量治疗身体的其它病症或组织。在一些实施例中，将目标组织放置在基于眼睛成像的全局坐标系中。在一些实施方案中，使用基准标记来鉴定靶组织的位置。

14. 发明申请

WO2008124801A3 ORTHOVOLTAGE RADIOSURGERY 审中-公开
公开(公告)号：WO2008124801A3
公开(公告)日：2008-12-31
申请号：PCT/US2008059808
申请日：2008-04-09
申请人： ORAYA THERAPEUTICS INC , GERTNER MICHAEL , HANSEN STEVEN D
发明人： GERTNER MICHAEL , HANSEN STEVEN D
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。在一些实施方案中，使用基准标记来鉴定靶组织的位置。在一些实施例中，眼睛被保持并且与系统对准。在一些实施例中，设备沿着眼睛的轴线的对准内部的过度运动自动关闭。在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后随同伴随地递送。

15. 发明授权

US09272161B2 Orthovoltage radiotherapy 有权
标题翻译：电磁放电
公开(公告)号：US09272161B2
公开(公告)日：2016-03-01
申请号：US14337122
申请日：2014-07-21
申请人： Oraya Therapeutics, Inc.
发明人： Michael Gertner , Steven D. Hansen
IPC分类号： A61N5/10 , A61B6/00
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，并且在一些实施方案中，用辐射剂量治疗身体的其它病症或组织。在一些实施例中，将目标组织放置在基于眼睛成像的全局坐标系中。在一些实施方案中，使用基准标记来鉴定靶组织的位置。

16. 发明授权

US08787524B2 Orthovoltage radiotherapy 有权
标题翻译：电磁放电
公开(公告)号：US08787524B2
公开(公告)日：2014-07-22
申请号：US13670405
申请日：2012-11-06
申请人： Oraya Therapeutics, Inc.
发明人： Michael Gertner , Steven D. Hansen
IPC分类号： A61N5/10 , A61B6/08 , G21K5/08 , G21K5/10
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： Radiosurgery systems are described that are configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, and in some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, a fiducial marker is used to identify the location of the target tissues.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，并且在一些实施方案中，用辐射剂量治疗身体的其它病症或组织。在一些实施例中，将目标组织放置在基于眼睛成像的全局坐标系中。在一些实施方案中，使用基准标记来鉴定靶组织的位置。

17. 发明申请

US20140126700A1 METHOD AND DEVICE FOR OCULAR ALIGNMENT AND COUPLING OF OCULAR STRUCTURES 审中-公开
标题翻译：用于OCALAR对比和耦合的方法和装置
公开(公告)号：US20140126700A1
公开(公告)日：2014-05-08
申请号：US14154112
申请日：2014-01-13
申请人： Oraya Therapeutics, Inc.
发明人： Michael Gertner , Mark Arnoldussen , Matt Herron , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61B3/14 , A61B3/113 , A61B3/12 , A61B3/152 , A61F9/008 , A61F9/00802 , A61F9/009 , A61F2009/00846 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1091
摘要： Embodiments provide method and systems for determining or measuring objective eye alignment in an external-coordinate system so as to define a reference axis. Additional embodiments provide a method and system of aligning an objectively determined reference axis of the eye in a selected relationship to a therapeutic axis of an ophthalmic therapeutic apparatus and/or a diagnostic axis of an ophthalmic diagnostic apparatus. Embodiments provide a method and system for planning an ophthalmic treatment procedure based on objective eye alignment in an external-coordinate system so as to define a reference axis of an eye to be treated. The reference axis may be used to position a therapeutic energy component, for example, an orthovoltage X-ray treatment device, e.g., positioned to provide treatment to tissue on the retina, such as the macula.
摘要翻译：实施例提供了用于确定或测量外部坐标系中的客观眼睛对准以便限定参考轴线的方法和系统。另外的实施例提供了将所选择的眼睛的客观确定的参考轴线与眼科治疗仪器的治疗轴线和/或眼科诊断设备的诊断轴线对准的方法和系统。实施例提供了一种用于根据外部坐标系中的客观眼睛对准来规划眼科治疗程序以定义要治疗的眼睛的参考轴线的方法和系统。参考轴可以用于定位治疗能量组分，例如正电压X射线治疗装置，例如定位成为视网膜上的组织（例如黄斑）提供治疗。

18. 发明申请

US20130315374A1 METHODS AND DEVICES FOR DETECTING, CONTROLLING, AND PREDICTING RADIATION DELIVERY 有权
公开(公告)号：US20130315374A1
公开(公告)日：2013-11-28
申请号：US13958475
申请日：2013-08-02
申请人： Oraya Therapeutics, Inc.
发明人： Michael Gertner , Mark Arnoldussen , Erik Chell , Steven D. Hansen , Matt Herron , Igor Koruga , Junzhong Liang
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61F9/008 , A61F2009/00844 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1072 , A61N2005/1091
摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.

19. 发明专利

HK1219912A1 眼放射外科未知
公开(公告)号：HK1219912A1
公开(公告)日：2017-04-21
申请号：HK16108015
申请日：2016-07-08
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN , ARNOLDUSSEN MARK , HERRON MATT , PAN KUANG-HUNG
IPC分类号： A61N20060101

20. 发明专利

HK1219863A1 眼放射外科未知
公开(公告)号：HK1219863A1
公开(公告)日：2017-04-21
申请号：HK16108013
申请日：2016-07-08
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN , ARNOLDUSSEN MARK , HERRON MATT , PAN KUANG-HUNG
IPC分类号： A61F20060101 , A61B20060101

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