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11. 发明专利

DK3423113T3 RADIOMÆRKET MAKROCYKLISK EGFR-HÆMMER 未知
公开(公告)号：DK3423113T3
公开(公告)日：2020-11-30
申请号：DK17707055
申请日：2017-02-28
申请人： ONCODESIGN SA
发明人： HOFLACK JAN MARIE CYRIEL JOZEF , VERCOUILLIE JOHNNY , ROBIC CAROLINE , CATOEN SARAH , BERTHET CYRIL , VIOT GILLES , DELOYE JEAN-BERNARD , BLOM PETRA MARCELLA FRANÇOISE
IPC分类号： A61K51/04 , A61K101/02 , C07B59/00 , C07D498/08

12. 发明专利

LT3194407T MAKROCIKLINIAI RIP2 KINAZĖS INHIBITORIAI 未知
公开(公告)号：LT3194407T
公开(公告)日：2020-01-27
申请号：LT15766800
申请日：2015-09-17
申请人： ONCODESIGN SA
发明人： HOFLACK JAN , BLOM PETRA , BENDERITTER PASCAL
IPC分类号： C07D498/22 , A61K31/529 , A61P29/00

13. 发明专利

IL251054A Macrocyclic lrrk2 kinase inhibitors 未知
公开(公告)号：IL251054A
公开(公告)日：2019-03-31
申请号：IL25105417
申请日：2017-03-09
申请人： ONCODESIGN SA , IPSEN PHARMA SAS
IPC分类号： A61K31/529 , A61P25/28
摘要： The present invention relates to novel macrocyclic compounds of formula (I) and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.

14. 发明专利

ES2635021T3 Inhibidores macrocíclicos de la LRRK2 quinasa 未知
公开(公告)号：ES2635021T3
公开(公告)日：2017-10-02
申请号：ES14709962
申请日：2014-03-14
申请人： ONCODESIGN SA
发明人： HOFLACK JAN , BLOM PETRA , LAVERGNE OLIVIER
IPC分类号： C07D498/18 , A61K31/437 , A61K31/504 , A61P25/16
摘要： Un compuesto de fórmula I o un estereoisómero, tautómero, racémico, sal, hidrato, forma N-óxido, o solvato del mismo, en la que A1 y A2 se seleccionan entre C y N; en la que cuando A1 es C, entonces A2 es N; y en la que cuando A2 es C, entonces A1 es N; R1 y R7 cada uno se selecciona independientemente entre -H, -halo, -OH, -alquilo C1-6, -O-alquilo C1-6, -S-alquilo C1-6, - NR9R10, -(C>=O)-R4, -SO2-R4, -CN, -NR9-SO2-R4, -cicloalquilo C3-6, y -Het6; en la que cada uno de dicho -alquilo C1-6 es opcional e independientemente sustituido con desde 1 a 3 sustituyentes seleccionados entre -halo, -OH, -NR11R12, -Oalquilo C1-6, y -S-alquilo C1-6; R2 se selecciona entre -H, -halo, -OH, -alquilo C1-6, -O-alquilo C1-6, -S-alquilo C1-6, -(C>=O)-alquilo C1-6, -(C>=O)-O-alquilo C1-6, -(C>=O)-NR27R28, -Het3, -(C>=O)-Het3, -SO2-alquilo C1-6, y -cicloalquilo C3-6; en la que cada uno de dicho -alquilo C1-6 es opcional e independientemente sustituido con desde 1 a 3 sustituyentes seleccionados entre -halo, -OH, -O-alquilo C1-6, -S-alquilo C1-6, -Het3, -Ar2, y -NR13R14; R3 se selecciona entre -H, -halo, -OH, -alquilo C1-6, -O-alquilo C1-6, -S-alquilo C1-6, -(C>=O)-alquilo C1-6, -(C>=O)-O-alquilo C1-6, -Het2, -cicloalquilo C3-6 -(C>=O)-Het2, -(C>=O)-NR29R30, y -SO2-alquilo C1-6; en la que cada uno de dicho -alquilo C1-6 es opcional e independientemente sustituido con desde 1 a 3 sustituyentes seleccionados entre -halo, -OH, -O-alquilo C1-6, -S-alquilo C1-6, -NR15R16, -Het2, y -Ar3; R4 se selecciona independientemente entre -halo, -OH, -alquilo C1-6, -O-alquilo C1-6, -S-alquilo C1-6, -NR17R18, y -Het4; R5 se selecciona entre -H, -alquilo C1-6, -cicloalquilo C3-6; en la que cada uno de dicho alquilo C1-6 o -cicloalquilo C3-6 es opcional e independientemente sustituido con desde 1 a 3 sustituyentes seleccionados entre -halo, -OH, -O-alquilo C1-6, -S-alquilo C1-6, -Het5, -CN y -NR31R32; R6 se selecciona entre -H, -OH, -halo, -alquilo C1-6, -O-alquilo C1-6, -S-alquilo C1-6, -NR33R34, y -Het8; R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, R37 y R38 cada uno se selecciona independientemente entre -H, >=O, -alquilo C1-6, y -Het1; en la que cada uno de dicho - alquilo C1-6 es opcional e independientemente sustituido con desde 1 a 3 sustituyentes seleccionados entre -halo, -OH, - O-alquilo C1-6, -S-alquilo C1-6, -NR35R36, -Het7, y -Ar4; R35 y R36 cada uno se selecciona independientemente entre -H, >=O, y -alquilo C1-6; en la que cada uno de dicho -alquilo C1-6 es opcional e independientemente sustituido con desde 1 a 3 sustituyentes seleccionados entre -halo, -OH, -Oalquilo C1-6, y -S-alquilo C1-6; X1 se selecciona entre -alquilo C1-6-, -O-alquilo C1-6-, -S-alquilo C1-6-, -(C>=O)-, -NR3-(C>=O)-, -alquilo C1-6-NR3-, -NR3-, - (C>=O)-, -NR3-(C>=O)-NR37-, -NR3-alquilo C1-6-, -NR3-SO2-, -NR3(C>=O)-alquilo C1-6-, -(C>=O)-NR3-alquilo C1-6-, -O-alquilo C1- 6-O-alquilo C1-6- y -alquilo C1-6-NR3-alquilo C1-6-; en la que cada uno de dicho -alquilo C1-6 es opcional e independientemente sustituido con desde 1 a 3 sustituyentes seleccionados entre -halo, -OH, -alquilo C1-6, -O-alquilo C1- 6, -S-alquilo C1-6, -fenilo, y -NR23R24

15. 发明专利

PT2970333T INIBIDORES MACROCÍCLICOS DE LRRK2 QUINASE 未知
公开(公告)号：PT2970333T
公开(公告)日：2017-08-01
申请号：PT14709962
申请日：2014-03-14
申请人： ONCODESIGN SA , IPSEN PHARMA SAS
发明人： JAN HOFLACK , PETRA BLOM , OLIVIER LAVERGNE
IPC分类号： C07D498/18 , A61K31/437 , A61K31/504 , A61P25/16

16. 发明专利

IL250544D0 Macrocyclic rip2 kinase inhibitors 未知
公开(公告)号：IL250544D0
公开(公告)日：2017-03-30
申请号：IL25054417
申请日：2017-02-09
申请人： ONCODESIGN SA
IPC分类号： C07D20060101
摘要： The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2 and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.

17. 发明专利

ZA201506327B MACROCYCLIC LRRK2 KINASE INHIBITORS 未知
公开(公告)号：ZA201506327B
公开(公告)日：2017-02-22
申请号：ZA201506327
申请日：2015-08-28
申请人： ONCODESIGN SA , IPSEN PHARMA SAS
发明人： OLIVIER LAVERGNE , PETRA BLOM , HOFLACK JAN

18. 发明专利

CA2960777A1 MACROCYCLIC LRRK2 KINASE INHIBITORS 未知
公开(公告)号：CA2960777A1
公开(公告)日：2016-03-24
申请号：CA2960777
申请日：2015-09-17
申请人： ONCODESIGN SA , IPSEN PHARMA SAS
发明人： HOFLACK JAN , BLOM PETRA , LAVERGNE OLIVIER , GOMEZ SYLVIE
IPC分类号： C07D487/22 , A61K31/529 , A61P25/28 , C07D498/22
摘要： The present invention relates to novel macrocyclic compounds of formula (I) and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.

19. 发明专利

IL241250D0 Macrocyclic rip2 kinase inhibitors 未知
公开(公告)号：IL241250D0
公开(公告)日：2015-11-30
申请号：IL24125015
申请日：2015-09-07
申请人： ONCODESIGN SA
IPC分类号： A61K20060101

20. 发明专利

SG11201507493SA MACROCYCLIC SALT-INDUCIBLE KINASE INHIBITORS 未知
公开(公告)号：SG11201507493SA
公开(公告)日：2015-10-29
申请号：SG11201507493S
申请日：2014-03-14
申请人： ONCODESIGN SA
发明人： BLOM PETRA MARCELLA FRANÇOISE , HOFLACK JAN MARIE CYRIEL JOZEF , BENDERITTER PASCAL ANDRÉ RENÉ
IPC分类号： A61K31/5025 , A61K31/519 , A61P9/00 , A61P17/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , C07D487/18 , C07D487/22 , C07D498/18 , C07D498/22 , C07D513/18 , C07D515/18

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