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11. 发明授权

US06599721B2 Process for preparing optically active 3,3,3-trifluoromethyl-2-alkylpropionic acid derivatives 失效
标题翻译：光学活性3,3,3-三氟甲基-2-烷基丙酸衍生物的制备方法
公开(公告)号：US06599721B2
公开(公告)日：2003-07-29
申请号：US09938333
申请日：2001-08-23
申请人： Andrew Naughton , Nicholas Shaw
发明人： Andrew Naughton , Nicholas Shaw
IPC分类号： C12P1302
CPC分类号： C07C235/06 , C07B2200/07
摘要： The invention relates to a novel method for the preparation of optically active 3,3,3-trifluoromethyl-2-alkyl propionic acid derivatives of the general formulae (I) and (II), in which R is ethyl or methyl and X is OH or NH2, provided that if R is methyl X≠—OH. The method comprises the reaction of a racemic propionic acid amide of the general formula (III) either by means of microorganisms which are able to use the propionic acid amide in the form of the racemate or one of its optically active isomers as the only nitrogen source or by means of a polypeptide with amidohydrolase activity which is able to hydrolyze the propionic acid amide. The invention also relates to new optically active representatives of this category of compounds.
摘要翻译：本发明涉及一种制备通式（I）和（II）的光学活性3,3,3-三氟甲基-2-烷基丙酸衍生物的新方法，其中R是乙基或甲基，X是OH 或NH 2，条件是如果R是甲基X≠-OH。该方法包括通过能够使用外消旋体形式的丙酰胺或其旋光异构体之一的微生物作为唯一的氮源，使通式（III）的外消旋丙酸酰胺反应或通过能够水解丙酸酰胺的具有酰胺水解酶活性的多肽。本发明还涉及这类化合物的新的光学活性代表。

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