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11. 发明公开

EP1975184A2 Serine or threonine phosphorylation sites 审中-公开
标题翻译：丝氨酸 - 苏氨酸磷酸化
公开(公告)号：EP1975184A2
公开(公告)日：2008-10-01
申请号：EP08102942.3
申请日：2008-03-26
申请人： Moritz, Albrecht , Farnsworth, Charles , Stokes, Matthew , Possemato, Anthony
发明人： Moritz, Albrecht , Farnsworth, Charles , Stokes, Matthew , Possemato, Anthony
IPC分类号： C07K16/44 , G01N33/68
CPC分类号： C07K16/44 , G01N33/573 , G01N33/57407 , G01N2333/912 , G01N2800/2871
摘要： The invention discloses 345 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和白血病中鉴定的345个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

12. 发明申请

WO2006113050A4 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS 审中-公开
标题翻译：检测CARCINOMA信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2006113050A4
公开(公告)日：2009-03-26
申请号：PCT/US2006010868
申请日：2006-03-24
申请人： CELL SIGNALING TECHNOLOGY INC , GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , LI YU , FARNSWORTH CHARLES , LEE KIMBERLY , POLAKIEWICZ ROBERTO
发明人： GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , LI YU , FARNSWORTH CHARLES , LEE KIMBERLY , POLAKIEWICZ ROBERTO
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： G01N33/57496 , C07K14/4748 , C07K16/44
摘要： The invention discloses (214) novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeleton proteins, GTP Signaling proteins, Kinases, Metabolism proteins, Phosphatases/Phospho- diesterases/ Proteases, Receptor proteins, RNA Processing proteins, Transcription proteins, Translation proteins, Transporter proteins, and Ubitquitin proteins, as well as other protein types.
摘要翻译：本发明公开了（214）信号转导蛋白中鉴定的新型磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，以及为此目的使用试剂的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：适配器/支架蛋白，细胞骨架蛋白，GTP信号蛋白，激酶，代谢蛋白，磷酸酶/磷酸二酯酶/蛋白酶，受体蛋白，RNA加工蛋白，转录蛋白，翻译蛋白质，转运蛋白和Ubitquitin蛋白质，以及其他蛋白质类型。

13. 发明申请

WO2008009004A3 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测信号通路中的蛋白质磷酸化的试剂
公开(公告)号：WO2008009004A3
公开(公告)日：2008-10-30
申请号：PCT/US2007073542
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY INC , HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
发明人： HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
IPC分类号： G01N33/53 , A61K38/00 , C07K16/00
CPC分类号： G01N33/57426 , C07B59/008 , C07K14/47 , C07K16/44 , G01N33/6842 , G01N2458/15
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白质和途径中鉴定的新的磷酸化位点，并提供用于选择性检测和定量这些磷酸化位点/蛋白质的磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），以及使用用于此目的的试剂。在所鉴定的磷酸化位点中存在发生在以下蛋白质类型中的位点：衔接子/支架蛋白质，粘附/细胞外基质蛋白质，凋亡蛋白质，钙结合蛋白质，细胞周期调节蛋白质，分子伴侣蛋白质，染色质，DNA结合/修复/ 细胞骨架蛋白，内质网或高尔基蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr） RNA结合蛋白，转录调节因子，肿瘤抑制蛋白，泛素缀合系统蛋白和功能未知的蛋白。

14. 发明申请

WO2008054597A9 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：WO2008054597A9
公开(公告)日：2008-07-31
申请号：PCT/US2007021086
申请日：2007-09-28
申请人： CELL SIGNALING TECHNOLOGY INC , HORNBECK PETER , GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , SPEK ERIK , POSSEMATO ANTHONY , FARNSWORTH CHARLES , BOCCALATTE FRANCESCO , YU JIAN , MITCHELL JEFFREY , RUSH JOHN , GOSS VALERIE , GU TING-LEI , LI YU , STOKES MATTHEW
发明人： HORNBECK PETER , GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , SPEK ERIK , POSSEMATO ANTHONY , FARNSWORTH CHARLES , BOCCALATTE FRANCESCO , YU JIAN , MITCHELL JEFFREY , RUSH JOHN , GOSS VALERIE , GU TING-LEI , LI YU , STOKES MATTHEW
IPC分类号： G01N33/574
CPC分类号： C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要： The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的318个新磷酸化位点，包含本发明磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新型磷酸化位点的抗体，以及上述的诊断和治疗用途。

15. 发明申请

WO2008013954A2 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：WO2008013954A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016937
申请日：2007-07-27
申请人： CELL SIGNALING TECHNOLOGY, INC. , RIKOVA, Klarisa , FARNSWORTH, Charles , MORITZ, Albrecht , LEE, Kimberly , POLAKIEWICZ, Roberto , GUO, Ailan , SPEK, Erik
发明人： RIKOVA, Klarisa , FARNSWORTH, Charles , MORITZ, Albrecht , LEE, Kimberly , POLAKIEWICZ, Roberto , GUO, Ailan , SPEK, Erik
IPC分类号： A61K39/395
CPC分类号： C07K16/44
摘要： The invention discloses 349 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的349个新的磷酸化位点，包含本发明磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新型磷酸化位点的抗体，以及诊断和治疗用途以上。

16. 发明申请

WO2008013934A2 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：WO2008013934A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016888
申请日：2007-07-27
申请人： CELL SIGNALING TECHNOLOGY, INC. , POLAKIEWICZ, Roberto , LEE, Kimberly , FARNSWORTH, Charles , GUO, Ailan , RIKOVA, Klarisa , MORITZ, Albrecht , SPEK, Erik
发明人： POLAKIEWICZ, Roberto , LEE, Kimberly , FARNSWORTH, Charles , GUO, Ailan , RIKOVA, Klarisa , MORITZ, Albrecht , SPEK, Erik
IPC分类号： C07K16/40
CPC分类号： C07K16/44 , C07K16/30 , C07K2317/34 , G01N33/573 , G01N33/574 , G01N33/6854
摘要： The invention discloses 347 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的347个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

17. 发明申请

WO2005083444A1 PROTEIN PHOSPHORYLATION IN T-CELL RECEPTOR SIGNALING PATHWAYS 审中-公开
标题翻译：蛋白质磷酸化在T细胞受体信号通路中的作用
公开(公告)号：WO2005083444A1
公开(公告)日：2005-09-09
申请号：PCT/US2004/032511
申请日：2004-10-04
申请人： CELL SIGNALING TECHNOLOGY, INC. , MORITZ, Albrecht , LEE, Kimberly , RUSH, John , POLAKIEWICZ, Roberto
发明人： MORITZ, Albrecht , LEE, Kimberly , RUSH, John , POLAKIEWICZ, Roberto
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , C07K14/47 , C07K16/44 , C12Q1/25 , C12Q1/485 , G01N33/6842
摘要： The invention discloses 95 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of the T-cell receptor, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Adhesion proteins, Calcium-binding proteins, Cell Cycle Regulation or Channel proteins, Chaperones, Cofactor proteins, Cytoskeletal proteins, DNA Binding proteins, G protein or GTPase Activating proteins, Ligases, Lipid Kinases and Binding proteins, Oxidoreductases, Protein Kinases, Protein Phosphatases, Receptor proteins, RNA Binding proteins, Transcription Factor/Initiation Complex proteins, Transcription Coactivator/Corepressor proteins, Translation Initiation Complex proteins, Ubitquitin Conjugating System proteins, and Vesicle proteins.
摘要翻译：本发明公开了在T细胞受体下游的信号转导蛋白和途径中鉴定的95个新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/ 蛋白质，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：肌动蛋白结合蛋白，衔接/支架蛋白，粘附蛋白，钙结合蛋白，细胞周期调节或通道蛋白，伴侣蛋白，辅因子蛋白，细胞骨架蛋白，DNA结合蛋白， G蛋白或GTPase激活蛋白，连接酶，脂质激酶和结合蛋白，氧化还原酶，蛋白激酶，蛋白磷酸酶，受体蛋白，RNA结合蛋白，转录因子/起始复合蛋白，转录共激活因子/ Corepressor蛋白，翻译起始复合蛋白，Ubitquitin缀合系统蛋白和囊泡蛋白。

18. 发明申请

WO2005083113A1 PROTEIN PHOSPHORYLATION IN C-SRC SIGNALING PATHWAYS 审中-公开
标题翻译： C-SRC信号通路中的蛋白质磷酸化
公开(公告)号：WO2005083113A1
公开(公告)日：2005-09-09
申请号：PCT/US2004/026199
申请日：2004-08-12
申请人： CELL SIGNALING TECHNOLOGY, INC. , MORITZ, Albrecht , LEE, Kimberly , RUSH, John , POLAKIEWICZ, Roberto
发明人： MORITZ, Albrecht , LEE, Kimberly , RUSH, John , POLAKIEWICZ, Roberto
IPC分类号： C12Q1/48
CPC分类号： G01N33/6872 , C07K14/47 , C07K16/44 , C12Q1/25 , C12Q1/485 , G01N33/6842
摘要： The invention discloses 102 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of c-Src kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/ Scaffold proteins, Actin Binding proteins, Cytoskeletal proteins, G protein/ GTPase Activating protein/Guanine Nucleotide Exchange Factor proteins, Helicases, RNA Binding proteins, Transcription/Translation Factor or Initiation Complex proteins, Cellular Metabolism Enzymes, and Vesicle proteins.
摘要翻译：本发明公开了在c-Src激酶下游的信号转导蛋白和途径中鉴定的102个新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是以下蛋白质类型的位点：适配器/支架蛋白，肌动蛋白结合蛋白，细胞骨架蛋白，G蛋白/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，Helicases，RNA结合蛋白，转录因子/翻译因子或起始复合蛋白，细胞代谢酶和囊泡蛋白。

19. 发明申请

WO2006086111A3 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测白血病信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2006086111A3
公开(公告)日：2009-04-16
申请号：PCT/US2006000979
申请日：2006-01-12
申请人： CELL SIGNALING TECHNOLOGY INC , GOSS VALERIE , MORITZ ALBRECHT , GU TING-LEI , LEE KIMBERLY , POLAKIEWICZ ROBERTO
发明人： GOSS VALERIE , MORITZ ALBRECHT , GU TING-LEI , LEE KIMBERLY , POLAKIEWICZ ROBERTO
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C07K14/47 , C07K16/18 , C07K16/40 , C07K16/44
摘要： The invention discloses 424 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的424个新的磷酸化位点和人类白血病的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质作为使用试剂用于此目的的方法。所鉴定的磷酸化位点是以下蛋白质类型的位点：适配器/支架蛋白，细胞骨架蛋白，细胞代谢酶，G蛋白/ GTP酶激活/鸟嘌呤核苷酸交换因子蛋白，免疫球蛋白超家族蛋白，抑制蛋白，脂质激酶，核DNA 修复/ RNA结合/转录蛋白，丝氨酸/苏氨酸蛋白激酶，酪氨酸激酶，蛋白磷酸酶和翻译/转运蛋白。

20. 发明申请

WO2006113050A3 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS 审中-公开
标题翻译：检测CARCINOMA信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2006113050A3
公开(公告)日：2008-12-24
申请号：PCT/US2006010868
申请日：2006-03-24
申请人： CELL SIGNALING TECHNOLOGY INC , GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , LI YU , FARNSWORTH CHARLES , LEE KIMBERLY , POLAKIEWICZ ROBERTO
发明人： GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , LI YU , FARNSWORTH CHARLES , LEE KIMBERLY , POLAKIEWICZ ROBERTO
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： G01N33/57496 , C07K14/4748 , C07K16/44
摘要： The invention discloses (214) novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeleton proteins, GTP Signaling proteins, Kinases, Metabolism proteins, Phosphatases/Phospho- diesterases/ Proteases, Receptor proteins, RNA Processing proteins, Transcription proteins, Translation proteins, Transporter proteins, and Ubitquitin proteins, as well as other protein types.
摘要翻译：本发明公开了（214）信号转导蛋白中鉴定的新型磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，以及为此目的使用试剂的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：适配器/支架蛋白，细胞骨架蛋白，GTP信号蛋白，激酶，代谢蛋白，磷酸酶/磷酸二酯酶/蛋白酶，受体蛋白，RNA加工蛋白，转录蛋白，翻译蛋白质，转运蛋白和Ubitquitin蛋白质，以及其他蛋白质类型。

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