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11. 发明申请

US20070066588A1 Benzothiazole cyclobutyl amine derivatives 有权
标题翻译：苯并噻唑环丁基胺衍生物
公开(公告)号：US20070066588A1
公开(公告)日：2007-03-22
申请号：US11518132
申请日：2006-09-08
申请人： Marlon Cowart , Minghua Sun , Chen Zhao , Guo Zheng
发明人： Marlon Cowart , Minghua Sun , Chen Zhao , Guo Zheng
IPC分类号： C07D417/02 , A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/428
CPC分类号： C07D277/64 , C07D417/04 , C07D417/08 , C07D417/12 , C07D487/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译：式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。

12. 发明授权

US06455571B1 Inhibitors of neuraminidases 有权
标题翻译：神经氨酸酶抑制剂
公开(公告)号：US06455571B1
公开(公告)日：2002-09-24
申请号：US09421787
申请日：1999-10-19
申请人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
发明人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
IPC分类号： A61K3140
CPC分类号： C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
摘要： Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译：公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

13. 发明授权

US06331564B1 Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease 有权
标题翻译：三芳基甲烷化合物用于抑制与炎性疾病相关的不想要的细胞增殖
公开(公告)号：US06331564B1
公开(公告)日：2001-12-18
申请号：US09159335
申请日：1998-09-23
申请人： Carlo Brugnara , Jose Halperin , Emile M. Bellot, Jr. , Mark Froimowitz , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Falguni M. Kher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
发明人： Carlo Brugnara , Jose Halperin , Emile M. Bellot, Jr. , Mark Froimowitz , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Falguni M. Kher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
IPC分类号： A61K31275
CPC分类号： A61K31/03 , A61K31/05 , A61K31/075 , A61K31/085 , A61K31/10 , A61K31/15 , A61K31/381 , C07C15/16 , C07C17/35 , C07C22/04 , C07C25/18 , C07C33/34 , C07C33/46 , C07C39/367 , C07C43/164 , C07C43/225 , C07C43/23 , C07C45/004 , C07C45/44 , C07C47/23 , C07C47/273 , C07C49/215 , C07C49/233 , C07C57/38 , C07C57/40 , C07C57/58 , C07C69/616 , C07C69/65 , C07C69/76 , C07C211/27 , C07C211/52 , C07C211/54 , C07C215/68 , C07C233/11 , C07C239/22 , C07C255/33 , C07C255/35 , C07C259/06 , C07C2601/14 , C07D207/26 , C07D213/16 , C07D213/20 , C07D213/30 , C07D295/145 , C07D307/33 , C07F7/081 , C07F7/30 , C07F9/5352
摘要： The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P, the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.
摘要翻译：本发明提供了一类用于治疗镰状细胞疾病的有效药物的化合物和特征在于不想要的或异常细胞增殖的疾病，特别是与不想要的细胞增殖相关的炎性疾病。活性化合物是取代的三芳基甲烷化合物或其类似物，其中一个或多个芳基被杂芳基，环烷基或杂环烷基代替，和/或叔碳原子被不同的原子代替，例如Si，Ge，N或 P，化合物抑制哺乳动物细胞增殖，抑制红细胞的Gardos通道，减少镰状红细胞脱水和/或延缓红细胞镰状或变形的发生。

14. 发明授权

US6028103A Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation 失效
标题翻译：三芳基甲烷化合物及其类似物可用于治疗或预防镰状细胞病或以异常细胞增殖为特征的疾病
公开(公告)号：US6028103A
公开(公告)日：2000-02-22
申请号：US822550
申请日：1997-03-19
申请人： Carlo Brugnara , Jose Halperin , Emile M. Bellot, Jr. , Mark Froimowitz , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Falguni M. Kher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
发明人： Carlo Brugnara , Jose Halperin , Emile M. Bellot, Jr. , Mark Froimowitz , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Falguni M. Kher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
IPC分类号： C07D295/14 , A61K31/015 , A61K31/02 , A61K31/045 , A61K31/11 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/34 , A61K31/40 , A61K31/44 , A61K31/4453 , A61P35/00 , A61P43/00 , C07C15/16 , C07C17/35 , C07C22/04 , C07C25/18 , C07C33/24 , C07C33/28 , C07C33/34 , C07C33/46 , C07C39/15 , C07C39/367 , C07C43/164 , C07C43/225 , C07C43/23 , C07C45/00 , C07C45/44 , C07C47/23 , C07C47/24 , C07C47/273 , C07C49/163 , C07C49/215 , C07C49/233 , C07C57/38 , C07C57/40 , C07C57/46 , C07C57/58 , C07C69/616 , C07C69/65 , C07C69/76 , C07C211/27 , C07C211/52 , C07C211/54 , C07C215/68 , C07C229/14 , C07C233/11 , C07C239/20 , C07C239/22 , C07C255/33 , C07C255/35 , C07C259/06 , C07C321/10 , C07D207/26 , C07D213/06 , C07D213/16 , C07D213/20 , C07D213/30 , C07D295/145 , C07D307/33 , C07F7/08 , C07F7/10 , C07F7/30 , C07F9/50 , C07F9/535 , A61K31/28 , C07C255/04
CPC分类号： C07F9/5352 , C07C15/16 , C07C17/35 , C07C211/27 , C07C211/52 , C07C211/54 , C07C215/68 , C07C22/04 , C07C233/11 , C07C239/22 , C07C25/18 , C07C255/33 , C07C255/35 , C07C259/06 , C07C321/10 , C07C33/34 , C07C33/46 , C07C39/367 , C07C43/164 , C07C43/225 , C07C43/23 , C07C45/004 , C07C45/44 , C07C47/23 , C07C47/24 , C07C49/215 , C07C49/233 , C07C57/38 , C07C57/58 , C07C69/616 , C07C69/65 , C07C69/76 , C07D207/26 , C07D213/16 , C07D213/20 , C07D213/30 , C07D295/145 , C07D307/33 , C07F7/0818 , C07F7/30 , C07F9/5022 , C07C2101/14
摘要： The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. The compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.
摘要翻译：本发明提供了一类用于治疗镰状细胞病和有害或异常细胞增殖的有效药物的化学化合物。活性化合物是取代的三芳基甲烷化合物或其类似物，其中一个或多个芳基被杂芳基，环烷基或杂环烷基代替，和/或叔碳原子被不同的原子代替，例如Si，Ge，N或 P.该化合物抑制哺乳动物细胞增殖，抑制红细胞的Gardos通道，减少镰状红细胞脱水和/或延迟红细胞镰状或变形的发生。

15. 发明申请

US20130023463A1 HIV PROTEASE INHIBITING COMPOUNDS 有权
标题翻译：艾滋病病毒蛋白抑制化合物
公开(公告)号：US20130023463A1
公开(公告)日：2013-01-24
申请号：US13451370
申请日：2012-04-19
申请人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
发明人： Charles A. Flentge , Hui-Ju Chen , David A. DeGoey , William J. Flosi , David J. Grampovnik , Peggy P. Huang , Dale J. Kempf , Larry L. Klein , Allan C. Krueger , Darold L. Madigan , John T. Randolph , Minghua Sun , Ming C. Yeung , Chen Zhao
IPC分类号： A61K31/18 , C07D213/53 , A61K31/4402 , C07D307/14 , A61K31/341 , A61K31/4418 , C07D307/52 , C07D277/30 , A61K31/426 , C07C275/24 , A61K31/197 , C07D213/86 , C07D493/04 , A61K31/34 , C07D333/20 , A61K31/381 , C07C275/16 , A61P31/18 , A61K31/513 , A61K31/496 , A61K31/7072 , A61K31/708 , A61K38/16 , C12N9/99 , C07C311/37
CPC分类号： C07D417/12 , C07C311/18 , C07C311/29 , C07C311/41 , C07C311/47 , C07C317/18 , C07D209/14 , C07D213/30 , C07D213/40 , C07D233/36 , C07D233/64 , C07D233/72 , C07D277/24 , C07D277/28 , C07D307/14 , C07D307/20 , C07D307/52 , C07D333/20 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/10 , C07D409/06 , C07D409/10 , C07D417/06 , C07D417/10 , C07D471/04 , C07D493/04
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

16. 发明授权

US06831096B2 Inhibitors of neuraminidases 有权
标题翻译：神经氨酸酶抑制剂
公开(公告)号：US06831096B2
公开(公告)日：2004-12-14
申请号：US10253152
申请日：2002-09-24
申请人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
发明人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
IPC分类号： A61K3140
CPC分类号： C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
摘要： Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译：公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

17. 发明授权

US06534497B1 Substitute 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation 失效
标题翻译：可用于治疗或预防以异常细胞增殖为特征的疾病的取代的11-苯基 - 二苯并氮杂化合物
公开(公告)号：US06534497B1
公开(公告)日：2003-03-18
申请号：US09554848
申请日：2000-09-22
申请人： Carlo Brugnara , Jose Halperin , Rudolf Fluckiger , Emile M. Bellott, Jr. , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft , Michael H. Zeldin
发明人： Carlo Brugnara , Jose Halperin , Rudolf Fluckiger , Emile M. Bellott, Jr. , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft , Michael H. Zeldin
IPC分类号： C07D22320
CPC分类号： C07D223/20
摘要： The present invention provides substituted 11-phenyl-dibenzazepine compounds that are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.
摘要翻译：本发明提供了取代的11-苯基 - 二苯并氮杂化合物，其是哺乳动物细胞增殖的特异性，有效和安全的抑制剂。该化合物可用于抑制原位的哺乳动物细胞增殖，作为治疗或预防以异常细胞增殖为特征的疾病如癌症的治疗方法。

18. 发明授权

US6127407A Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation 失效
公开(公告)号：US6127407A
公开(公告)日：2000-10-03
申请号：US975391
申请日：1997-11-20
申请人： Carlo Brugnara , Jose Halperin , Rudolf Fluckiger , Emile M. Bellott, Jr. , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
发明人： Carlo Brugnara , Jose Halperin , Rudolf Fluckiger , Emile M. Bellott, Jr. , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
IPC分类号： A61K31/045 , A61K31/075 , A61K31/122 , A61K31/15 , A61K31/22 , A61K31/275 , A61K31/336 , A61K31/357 , A61K31/403 , A61K31/404 , A61P9/08 , A61P9/10 , A61P17/00 , A61P35/00 , C07C13/465 , C07C35/32 , C07C43/18 , C07C43/188 , C07C43/192 , C07C43/243 , C07C43/247 , C07C45/46 , C07C45/68 , C07C49/665 , C07C49/697 , C07C49/747 , C07C69/157 , C07C69/757 , C07C69/76 , C07C233/23 , C07C233/32 , C07C235/34 , C07C235/78 , C07C251/44 , C07C255/33 , C07C255/35 , C07C255/36 , C07C255/40 , C07D209/40 , C07D303/46 , C07D317/20 , A61K31/335 , C07C69/52 , C07C255/00
CPC分类号： C07D317/20 , C07C35/32 , C07C43/188 , C07C43/192 , C07C45/46 , C07C45/68 , C07C235/34 , C07C235/78 , C07C251/44 , C07C255/36 , C07C255/40 , C07C2602/08 , C07D209/40 , C07D303/46 , C07C49/67 , C07C49/697
摘要： The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

19. 发明授权

US6063921A Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines 失效
标题翻译：合成11-芳基-5,6-二氢-11H-二苯并[b，e]吖庚因
公开(公告)号：US6063921A
公开(公告)日：2000-05-16
申请号：US974472
申请日：1997-11-20
申请人： Adel M. Moussa , Richard J. Lombardy , Reem M. Haider , Minghua Sun
发明人： Adel M. Moussa , Richard J. Lombardy , Reem M. Haider , Minghua Sun
IPC分类号： C07C213/00 , C07C215/68 , C07C221/00 , C07C225/22 , C07D223/20 , C07D223/18
CPC分类号： C07C215/68 , C07C225/22 , C07D223/20
摘要： Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by the following structural formula: ##STR1## and a starting material represented by the following structural formula: ##STR2## Phenyl Ring A, Phenyl Ring B and Phenyl Ring C are independently unsubstituted or substituted with one, two or three substituents. Each substituent on Phenyl Ring A, Phenyl Ring B and Phenyl Ring C is independently chosen.R is --H, a aliphatic group, a substituted aliphatic group, an aryl group, a substituted aryl group, --C(O)--R', --C(O)--H, --C(O)--NHR', --S(O).sub.2 R', --C(O)--C(O)--R', --C(O)--C(O)--H, --C(S)--R', --C(S)--H, --C(O)--OR', --C(S)--OR', --C(O)--SR', --C(S)--SR', --C(O)--NR'.sub.2 or --C(O)--C(S)--R'. R' is an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.R.sub.1 is a leaving group.The present invention also includes novel compounds which are intermediates in the preparation of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines.
摘要翻译：公开了由以下结构式表示的2-氨基二苯甲酮的11-芳基-5,6-二氢-11H-二苯并[b，e]吖庚因的三步合成：由以下结构式表示的原料：苯基环A，苯环B和苯环C独立地是未取代的或被一个，两个或三个取代基取代。苯环A，苯环B和苯环C上的每个取代基是独立选择的。 R为-H，脂族基团，取代脂族基团，芳基，取代芳基，-C（O）-R'， - （O）-H，-C（O）-NHR' S（O）2 R'， - C（O）-C（O）-R'， - C（O）-C（O）-H，-C（S）-R'， - ，-C（O）-OR'， - C（S）-OR'， - C（O）-SR'，-C（S）-SR'，-C（O）-NR'2或-C O）-C（S）-R'。 R'是脂族基团，取代的脂族基团，芳基或取代的芳基。 R1是离开组。本发明还包括作为制备11-芳基-5,6-二氢-11H-二苯并[b，e]吖庚因的中间体的新化合物。

20. 发明授权

US6043272A Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation 失效
公开(公告)号：US6043272A
公开(公告)日：2000-03-28
申请号：US975391
申请日：1997-11-20
申请人： Carlo Brugnara , Jose Halperin , Rudolf Fluckiger , Emile M. Bellott, Jr. , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
发明人： Carlo Brugnara , Jose Halperin , Rudolf Fluckiger , Emile M. Bellott, Jr. , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft
摘要： The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

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