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11. 发明授权

US06673825B2 Urazole compounds useful as anti-inflammatory agents 有权
标题翻译：乌唑类化合物可用作抗炎剂
公开(公告)号：US06673825B2
公开(公告)日：2004-01-06
申请号：US10152117
申请日：2002-05-21
申请人： Michele Launay , Dominique Potin , Magali Jeannine Blandine Maillet , Eric Antoine Nicolai , Edwin J. Iwanowicz , T. G. Murali Dhar
发明人： Michele Launay , Dominique Potin , Magali Jeannine Blandine Maillet , Eric Antoine Nicolai , Edwin J. Iwanowicz , T. G. Murali Dhar
IPC分类号： A61K314196
CPC分类号： C07D487/04
摘要： Urazole compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective as anti-inflammatory or immunosuppressive agents, wherein L and K are O or S; Q is a linker such as —O—, —S—, C(═O), and so forth, R1 is an aryl or heteroaryl group, and R3, R4a, R4c, Z, r, s and t are as defined in the specification.
摘要翻译：具有式（I）的吖唑化合物或其药学上可接受的盐作为抗炎或免疫抑制剂是有效的，其中L和K是O或S; Q是诸如-O - ， - S - ，C（= O）等的连接基，R 1是芳基或杂芳基，R 3，R 4a，R 4c，，Z，r，s和t如说明书中所定义。

12. 发明授权

US4886805A Novel aminoalkylthio derivatives of triazolopyridine or triazoloquinoline, the processes for their preparation, and drugs, useful especially as analgesics, in which they are present 失效
标题翻译：三唑并吡啶或三唑并喹啉的新型氨基烷基硫代衍生物，其制备方法和药物，特别是其中存在的止痛剂
公开(公告)号：US4886805A
公开(公告)日：1989-12-12
申请号：US72337
申请日：1987-07-10
申请人： Nicole Bru-Magniez , Jean-Marie Teulon , Michele Launay
发明人： Nicole Bru-Magniez , Jean-Marie Teulon , Michele Launay
IPC分类号： A61K31/435 , A61P25/04 , A61P25/20 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to novel compounds corresponding to the formula: ##STR1## in which: n represents an integer between 1 and 8 and optimally 2 or 3; (CH.sub.2).sub.n --N can also form a ring or a heterocycle, for example having 5 to 7 atoms and preferably 6 atoms;R.sub.1 and R.sub.2 can represent hydrogen or a lower alkyl having 1 to 5 carbon atoms or can form, together with the nitrogen, a ring such as pyrrolidine, piperidine, morpholine, thiomorpholine, phenyltetrahydropyridine, piperazine or piperazine N-substituted by an alkyl, a phenyl or a heterocycle; in the case of the phenyltetrahydropyridines and the phenylpiperazines or heteroarylpiperazines, the phenyl or the heterocycle may or may not be substituted by halogens or methoxy, thiomethyl, hydroxyl, nitro, amino, cyano, lower alkyl, trifluoromethyl or trichloromethyl groups; andR.sub.3, R.sub.4 and R.sub.5 can represent hydrogen, a lower alkyl, a hydroxyalkyl or hydroxybenzyl group, a halogen, a trifluoromethyl, a methoxy, a thiomethyl or a nitro or two of them can form a ring, in particular a phenyl in the case of the triazoloquinolines or the triazoloisoquinolines; and the non-toxic acid addition salts.These products are useful as drugs and possess analgesic properties, acting especially on the central nervous system as minor tranquilizers.
摘要翻译：本发明涉及对应于下式的新化合物：其中：n表示1至8之间的整数，最佳为2或3; （CH 2）n -N也可以形成环或杂环，例如具有5至7个原子，优选6个原子; R 1和R 2可以表示氢或具有1至5个碳原子的低级烷基，或者可以与氮一起形成诸如吡咯烷，哌啶，吗啉，硫代吗啉，苯基四氢吡啶，哌嗪或被烷基N-取代的哌嗪的环，苯基或杂环; 在苯基四氢吡啶和苯基哌嗪或杂芳基哌嗪的情况下，苯基或杂环可以被卤素或甲氧基，硫代甲基，羟基，硝基，氨基，氰基，低级烷基，三氟甲基或三氯甲基取代; 并且R 3，R 4和R 5可以表示氢，低级烷基，羟基烷基或羟基苄基，卤素，三氟甲基，甲氧基，硫代甲基或硝基或它们中的两个可以形成环，特别是在这种情况下的苯基的三唑并喹啉或三唑并异喹啉; 和无毒的酸加成盐。这些产品作为药物是有用的，具有镇痛作用，特别是作为轻度镇定剂对中枢神经系统起作用。

13. 发明申请

US20050119279A1 Spiro-cyclic compounds useful as anti-inflammatory agents 有权
标题翻译：用作抗炎剂的螺环化合物
公开(公告)号：US20050119279A1
公开(公告)日：2005-06-02
申请号：US10957255
申请日：2004-10-01
申请人： T. G. Dhar , Edwin Iwanowicz , Michele Launay , Dominique Potin , Magali Blandine Maillet , Eric Nicolai
发明人： T. G. Dhar , Edwin Iwanowicz , Michele Launay , Dominique Potin , Magali Blandine Maillet , Eric Nicolai
IPC分类号： C07D498/20 , C07D513/20 , A61K31/519 , A61K31/4188 , A61K31/4747 , C07D487/12
CPC分类号： C07D498/20 , C07D513/20
摘要： The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(═O)— or optionally substituted C1-6alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3 and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; R1 is N or C(R9); and R2, and R3, are as defined in the specification.
摘要翻译：本发明涉及具有式（I）的化合物：可用于治疗其中K和L独立地为O或S的炎症和免疫疾病; Q是-C（-O） - 或任选取代的C 1-6 - 亚烷基; Ar是任选取代的芳基或杂芳基; 选择J 1，J 2，J 3和Y，使得环A为5至6元任选取代的环烯基或具有0至2个氮杂原子的杂环; R 1是N或C（R 9）; 和R 2 R 3和R 3'如说明书中所定义。

14. 发明授权

US5364860A Naphthyridine compounds which inhibit tyrosine kinase and their pharmaceutical compositions 失效
标题翻译：抑制酪氨酸激酶的萘吡啶化合物及其药物组成
公开(公告)号：US5364860A
公开(公告)日：1994-11-15
申请号：US97239
申请日：1993-07-27
申请人： Nicole Bru-Magniez , Michele Launay , Jean-Marie Teulon
发明人： Nicole Bru-Magniez , Michele Launay , Jean-Marie Teulon
IPC分类号： A61K31/435 , A61P9/10 , A61P17/00 , A61P35/00 , C07D471/04 , A61K31/44 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially as drugs having antiproliferative properties and affording an effective treatment for diseases such as atherosclerosis, restenosis phenomena or any other pathological condition due to cell proliferation.
摘要翻译：本发明涉及下式的衍生物及其加成盐，以及它们在治疗学中的用途，特别是作为具有抗增殖性质的药物，并且对诸如动脉粥样硬化，再狭窄现象或任何其他病理状况的疾病进行有效治疗到细胞增殖。

15. 发明授权

US07375237B2 Pyrrolizine compounds useful as anti-inflammatory agents 有权
标题翻译：可用作抗炎剂的吡咯嗪化合物
公开(公告)号：US07375237B2
公开(公告)日：2008-05-20
申请号：US11206558
申请日：2005-08-18
申请人： T. G. Murali Dhar , Dharmpal S. Dodd , Dominique Potin , Michele Launay
发明人： T. G. Murali Dhar , Dharmpal S. Dodd , Dominique Potin , Michele Launay
IPC分类号： C07D209/32 , A01N43/38
CPC分类号： C07D487/04 , A61K31/407
摘要： Pyrrolizine compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R1, R2, R3 n, and M are defined in the specification.
摘要翻译：具有式（I）的吡咯嗪化合物或其药学上可接受的盐在治疗炎症或免疫疾病方面是有效的，其中A是4至7元饱和环，K是O或S，R 1 R 2，R 3，R 3和M在说明书中定义。

16. 发明授权

US07186727B2 Pyridyl-substituted spiro-hydantoin compounds and use thereof 有权
标题翻译：吡啶基取代的螺 - 乙内酰脲化合物及其用途
公开(公告)号：US07186727B2
公开(公告)日：2007-03-06
申请号：US11301454
申请日：2005-12-13
申请人： T. G. Murali Dhar , Michele Launay , Dominique Potin , Scott Hunter Watterson , Zili Xiao
发明人： T. G. Murali Dhar , Michele Launay , Dominique Potin , Scott Hunter Watterson , Zili Xiao
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D487/10
摘要： A class of substituted spiro-hydantoin compounds (II) having the formula: its pharmaceutically acceptable salts, enantiomers, solvates, or prodrugs thereof, wherein R16 is a substituted pyridinyl group, as defined herein, is provided. Pharmaceutical compositions and methods of treating anti-inflammatory and/or immune diseases with the pyridyl-substituted spiro-hydantoin compounds are also objectives of this invention.
摘要翻译：一类具有下式的取代的螺 - 乙内酰脲化合物（II）：其药学上可接受的盐，对映异构体，溶剂合物或前药，其中R 16是如本文所定义的取代的吡啶基，。用吡啶基取代的螺 - 乙内酰脲化合物治疗抗炎和/或免疫疾病的药物组合物和方法也是本发明的目的。

17. 发明授权

US07078420B2 Spiro-hydantoin compounds useful as anti-inflammatory agents 有权
标题翻译：螺 - 乙内酰脲化合物可用作抗炎剂
公开(公告)号：US07078420B2
公开(公告)日：2006-07-18
申请号：US10852576
申请日：2004-05-24
申请人： T. G. Murali Dhar , Dominique Potin , Magali Jeannine Blandine Maillet , Michele Launay , Eric Antoine Nicolai , Edwin J. Iwanowicz
发明人： T. G. Murali Dhar , Dominique Potin , Magali Jeannine Blandine Maillet , Michele Launay , Eric Antoine Nicolai , Edwin J. Iwanowicz
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D235/02 , C07D233/96 , C07D487/10
摘要： Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2, R4a, R4b, and R4c are as defined in the specification.
摘要翻译：具有式（I）的化合物及其药学上可接受的盐，水合物，对映异构体和非对映异构体及其前药可用作LFA-1 / ICAM的抑制剂和作为抗炎剂的其中L和K为O或S ; Z是N或CR 4b; Ar是任选取代的芳基或杂芳基; G是连接于T或M或不存在的接头; 选择J，M和T来定义三至六元饱和或部分不饱和的非芳香环; 和R 2，R 4a，R 4b和R 4c如说明书中所定义。

18. 发明授权

US06710064B2 Hydantoin compounds useful as anti-inflammatory agents 有权
标题翻译：乙内酰脲化合物可用作抗炎剂
公开(公告)号：US06710064B2
公开(公告)日：2004-03-23
申请号：US10000389
申请日：2001-11-30
申请人： Michele Launay , Dominique Potin , Magali Jeannine Blandine Maillet , Eric Antoine Nicolai , T. G. Murali Dhar , Edwin J. Iwanowicz
发明人： Michele Launay , Dominique Potin , Magali Jeannine Blandine Maillet , Eric Antoine Nicolai , T. G. Murali Dhar , Edwin J. Iwanowicz
IPC分类号： A61K314184
CPC分类号： C07D471/04 , C07D487/04
摘要： Compounds having the formula (I): and pharmaceutically-acceptable salts thereof, are useful for treating inflammatory or immune diseases, in which A is a four to seven membered heterocyclic or carbocyclic saturated ring; L and K are O or S; M is N or CH; Y is N or CH; Z is hydrogen, alkyl or substituted alkyl; and R1-R4 are as defined in the specification.
摘要翻译：具有式（I）的化合物及其药学上可接受的盐可用于治疗其中A为4至7元杂环或碳环饱和环的炎症或免疫疾病; L和K为O或S; M为N或CH; Y为N或CH; Z是氢，烷基或取代的烷基; 和R1-R4如说明书中所定义。

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