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    • 18. 发明申请
    • Methods and apparatus for treating infarcted regions of tissue following acute myocardial infarction
    • 用于治疗急性心肌梗死后组织梗死区域的方法和装置
    • US20060074399A1
    • 2006-04-06
    • US10959289
    • 2004-10-05
    • Mark Bates
    • Mark Bates
    • A61M31/00
    • A61M25/10A61M25/0084A61M2025/0002
    • Apparatus and methods are provided for treating an infarcted region of myocardium following acute myocardial infarction by reducing the rate of blood flow through infarcted region, and then injecting a solution containing stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment into the effected region so that the stem cells become embedded therein and promote tissue regeneration. In a first embodiment, delivery of the stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment is accomplished using a catheter that relies upon antegrade flow through the coronary artery and a flow control catheter placed in the coronary sinus. In an alternative embodiment, the delivery catheter delivers the stem cells in a retrograde manner through the coronary sinus, and the delivery catheter further comprises an occlusion balloon for controlling outflow through the coronary sinus ostium.
    • 提供了设备和方法,用于通过降低通过梗塞区域的血流量来治疗急性心肌梗塞后的心肌梗死区域,然后注入含有干细胞动员,迁移和附着的干细胞,内皮祖细胞或介质的溶液 使干细胞嵌入其中并促进组织再生。 在第一个实施方案中,干细胞移动,迁移和附着的干细胞,内皮祖细胞或介体的递送使用依赖于顺流过冠状动脉的导管和放置在冠状窦中的流量控制导管进行。 在替代实施例中,递送导管以逆行方式递送干细胞通过冠状窦,并且输送导管还包括用于控制通过冠状窦口的流出的闭塞球囊。