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11. 发明申请

WO1995029395A1 UNITARY SANDWICH ENZYME IMMUNOASSAY CASSETTE, DEVICE AND METHOD OF USE 审中-公开
标题翻译：单位三重奏酶免疫测定仪，装置及使用方法
公开(公告)号：WO1995029395A1
公开(公告)日：1995-11-02
申请号：PCT/US1995005156
申请日：1995-04-26
申请人： THE REGENTS OF UNIVERSITY OF MICHIGAN , MEYERHOFF, Mark, E. , DUAN, Chaunming
发明人： THE REGENTS OF UNIVERSITY OF MICHIGAN
IPC分类号： G01N21/00
CPC分类号： G01N33/54366 , G01N33/5438 , G01N33/553 , Y10S435/975 , Y10S436/807
摘要： An enzyme sandwich immunoassay, device and cassette therefor for determining a target analyte are described. The enzyme sandwich immunoassay cassette (B) comprises a microporous membrane support (m) having coated thereon a conductive metal layer overlaid with a capture antibody layer (e). The electrochemical device (A) comprises a first chamber (b) into which sample and an enzyme labelled antibody capable of specifically binding to the target analyte are placed, wherein the enzyme is capable of catalyzing the production of an electrochemically detectable product; a second chamber (a) adjoining the first chamber (b) into which a substrate for the enzyme is placed, wherein the substrate is capable of producing, when catalyzed by the enzyme, the electrochemically detectable product; and, separating the first (b) and second (a) chambers, a microporous membrane support (m) as described above, wherein the conductive metal layer (e) of the microporous membrane support (m) acts as an electrode to detect, directly or indirectly, the presence of the electrochemically detectable product.
摘要翻译：描述了用于确定目标分析物的酶夹心免疫测定，其装置和盒。酶切夹心免疫测定盒（B）包括在其上涂覆有覆盖有捕获抗体层（e）的导电金属层的微孔膜载体（m）。电化学装置（A）包括第一室（b），其中放置样品和能够特异性结合靶分析物的酶标记抗体，其中所述酶能够催化产生电化学上可检测的产物; 毗邻第一室（b）的第二室（a），其中放置用于酶的底物，其中所述底物能够在被酶催化时产生电化学上可检测的产物; 并且分离第一（b）和第二（a）室，如上所述的微孔膜载体（m），其中微孔膜载体（m）的导电金属层（e）用作电极直接检测或间接地存在电化学上可检测的产物。

12. 发明申请

WO2012094312A1 METHODS AND SYSTEMS FOR MEASUREMENT OF TEAR GLUCOSE LEVELS 审中-公开
标题翻译：测量葡萄糖水平的方法和系统
公开(公告)号：WO2012094312A1
公开(公告)日：2012-07-12
申请号：PCT/US2012/020073
申请日：2012-01-03
申请人： EYELAB GROUP, LLC , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MEYERHOFF, Mark E. , COHAN, Bruce E. , YAN, Qinyi , PENG, Bo , FLANDERS, Zvi
发明人： MEYERHOFF, Mark E. , COHAN, Bruce E. , YAN, Qinyi , PENG, Bo , FLANDERS, Zvi
IPC分类号： A61B5/01 , A61B5/1459
CPC分类号： G01N27/3271 , A61B5/1486
摘要： A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.
摘要翻译：用于测定泪液样品中的葡萄糖浓度的传感器系统包括工作电极，其包括用于与泪液样品中的葡萄糖反应的固定的葡萄糖氧化酶部分和用于提高对泪液中的电活性干扰物种的葡萄糖选择性的选择性部分流体样品。或者，用于接收泪液样品的容器可以包括在其内壁上的酶部分。参考电极设置在工作电极附近，其中酶部分与泪液样品中的葡萄糖的电化学反应产生与泪液样品中的葡萄糖浓度相关的电流。

13. 发明申请

WO2010022132A3 BIOCOMPATIBLE COATINGS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：生物涂料，以及制备和使用它们的方法
公开(公告)号：WO2010022132A3
公开(公告)日：2010-06-10
申请号：PCT/US2009054280
申请日：2009-08-19
申请人： UNIV MICHIGAN , MEYERHOFF MARK E , YANG JUN
发明人： MEYERHOFF MARK E , YANG JUN
IPC分类号： A61L27/34 , A61L27/04 , A61L27/14 , A61L27/50
CPC分类号： A61L27/34 , A61L17/145 , A61L29/085 , A61L31/10
摘要： Disclosed herein are biocompatible coatings for a substrate, the biocompatible coating including at least one polyanionic/polycationic bilayer including at least one nitric oxide generating moiety, wherein the polyanionic/polycationic bilayer has a layer of a polycationic polymeric material; and a layer of polyanionic material capable of non-covalently bonding to the polycationic polymeric material. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein.
摘要翻译：本文公开了用于底物的生物相容性涂层，所述生物相容性涂层包括至少一种包含至少一种一氧化氮产生部分的聚阳离子/阳离子双层，其中所述聚阴离子/阳离子双层具有聚阳离子聚合物材料层; 以及能够与聚阳离子聚合物材料非共价键合的聚阴离子材料层。包含这种涂层的装置以及制造和使用这种涂层的方法也在本文中公开。

14. 发明申请

WO2006023693A3 MULTI-FUNCTIONAL BIOCOMPATIBLE COATINGS FOR INTRAVASCULAR DEVICES 审中-公开
标题翻译：用于血管内装置的多功能生物活性涂层
公开(公告)号：WO2006023693A3
公开(公告)日：2007-03-15
申请号：PCT/US2005029490
申请日：2005-08-18
申请人： UNIV MICHIGAN , MICHIGAN CRITICAL CARE CONSULT , ZHOU ZHENGRONG , MEYERHOFF MARK E , REYNOLDS MELISSA M
发明人： ZHOU ZHENGRONG , MEYERHOFF MARK E , REYNOLDS MELISSA M
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61K31/655 , A61K31/727 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/114 , A61L2300/42 , A61L2300/608 , A61L2420/08
摘要： A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.
摘要翻译：聚合物涂层适于在与血液接触时基本上消除血栓形成。聚合物涂层包括第一聚合物层和第二聚合物层。介于第一和第二聚合物层之间的是掺杂有一氧化氮供体和一氧化氮发生器中的至少一种的聚合物基质层。一氧化氮供体和/或一氧化氮发生器能够释放或产生NO。或者将生物活性剂固定在第二聚合物层的表面上，或者被结合到聚合物基质层中。

15. 发明申请

WO2005094913A1 GENERATION OF NITRIC OXIDE IN SITU AT SUBSTRATE/BLOOD INTERFACES AND NITRIC OXIDE SENSOR FOR DETECTING NITROSOTHIOLS 审中-公开
标题翻译：用于检测硝基酪氨酸的底物/血液接口和氮氧化物传感器中的氮氧化物的产生
公开(公告)号：WO2005094913A1
公开(公告)日：2005-10-13
申请号：PCT/US2004/034613
申请日：2004-10-20
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MEYERHOFF, Mark, E. , REYNOLDS, Melissa, M. , OH, Bong, K. , CHA, Wansik , FROST, Megan , HWANG, Sangyeul , SIM, Sylvie , WU, Yidou
发明人： MEYERHOFF, Mark, E. , REYNOLDS, Melissa, M. , OH, Bong, K. , CHA, Wansik , FROST, Megan , HWANG, Sangyeul , SIM, Sylvie , WU, Yidou
IPC分类号： A61L27/04
CPC分类号： C12N11/02 , A61K33/34 , A61L31/16 , A61L2300/114 , A61M1/3672 , A61M1/3673 , A61M2202/0275 , B01J23/72 , B01J31/003 , B01J31/1805 , C12N11/14 , C12Q1/005 , G01N33/84
摘要： A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, and/or nitrosothiol reductase activity. The reactive agent also converts at least one of nitrites, nitrates and nitrosothiols to nitric oxide when in contact with blood. A reproducible nitrosothiol sensor is also disclosed.
摘要翻译：材料包括表面和反应剂，其位于材料的表面，共价连接到材料的骨架上和/或位于材料内。活性剂具有亚硝酸还原酶活性，硝酸还原酶活性和/或亚硝基硫醇还原酶活性。当与血液接触时，反应剂还将至少一种亚硝酸盐，硝酸盐和亚硝基硫醇转化为一氧化氮。还公开了可再现的亚硝基硫醇传感器。

16. 发明申请

WO2003087775A2 METHOD AND APPARATUS FOR NON-INVASIVE MONITORING OF BLOOD SUBSTANCES USING SELF-SAMPLED TEARS 审中-公开
标题翻译：使用自拍样本进行非自动监测血液物质的方法和装置
公开(公告)号：WO2003087775A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/009954
申请日：2003-04-01
申请人： EYELAB GROUP,LLC , COHAN, Bruce, E. , CHA, Geun, Sig , MEYERHOFF, Mark, E. , NAM, Hakhyun , GILLESPIE, Donald, E. , CUI, Gang , KIM, Jong, Sik , FLANDERS, Zvi
发明人： COHAN, Bruce, E. , CHA, Geun, Sig , MEYERHOFF, Mark, E. , NAM, Hakhyun , GILLESPIE, Donald, E. , CUI, Gang , KIM, Jong, Sik , FLANDERS, Zvi
IPC分类号： G01N
CPC分类号： C12Q1/006 , A61B5/1486 , A61B2562/0295 , C12Q1/32 , C12Q1/54 , G01N27/3272 , G01N33/528 , G01N2001/1056 , G01N2001/149 , G01N2035/0465 , Y10T436/144444
摘要： A method and apparatus for non-invasively determining the concentration of a substance in blood, such as glucose, include a sample portion arranged for contacting an eye region of a user to obtain a tear fluid sample, a sensor in communication with the sample portion for generating a signal related to the tear substance concentration, and a processor in communication with the sensor for determining a blood substance concentration corresponding to the tear substance concentration.
摘要翻译：用于非侵入性地确定血液中的物质如葡萄糖的浓度的方法和装置包括布置成用于接触使用者的眼睛区域以获得泪液样品的样品部分，与样品部分连通的传感器，用于产生与泪液物质浓度相关的信号，以及处理器，与传感器通信，用于确定对应于泪液物质浓度的血液物质浓度。

17. 发明申请

WO2007064895A3 POLYMER COMPOSITIONS, COATINGS AND DEVICES, AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2007064895A3
公开(公告)日：2007-06-07
申请号：PCT/US2006/046013
申请日：2006-12-01
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MICHIGAN CRITICAL CARE CONSULTANTS, INC. (MC3) , MEYERHOFF, Mark, E. , CHA, Wansik , HWANG, Sang-Yeul , REYNOLDS, Melissa, M.
发明人： MEYERHOFF, Mark, E. , CHA, Wansik , HWANG, Sang-Yeul , REYNOLDS, Melissa, M.
IPC分类号： A61L33/00 , A61L33/04
摘要： The disclosure provides for a biocompatible, thromboresistant coating including a chalcogenide compound that induces nitric oxide formation; and a biocompatible matrix incorporating the chalcogenide compound. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein.

18. 发明申请

WO2007064895A2 POLYMER COMPOSITIONS, COATINGS AND DEVICES, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：聚合物组合物，涂料和装置及其制备和使用方法
公开(公告)号：WO2007064895A2
公开(公告)日：2007-06-07
申请号：PCT/US2006046013
申请日：2006-12-01
申请人： UNIV MICHIGAN , MICHIGAN CRITICAL CARE CONSULT , MEYERHOFF MARK E , CHA WANSIK , HWANG SANG-YEUL , REYNOLDS MELISSA M
发明人： MEYERHOFF MARK E , CHA WANSIK , HWANG SANG-YEUL , REYNOLDS MELISSA M
CPC分类号： A61L31/082 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/16 , A61L33/0047 , A61L2300/254 , A61L2300/42
摘要： The disclosure provides for a biocompatible, thromboresistant coating including a chalcogenide compound that induces nitric oxide formation; and a biocompatible matrix incorporating the chalcogenide compound. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein.
摘要翻译：本公开提供了生物相容性抗血栓涂层，其包括诱导一氧化氮形成的硫属化合物; 和含有硫族化合物的生物相容性基质。包含这种涂层的装置以及制造和使用这种涂层的方法也在本文中公开。

19. 发明申请

WO2006094056A2 ENZYME AMPLIFIED ELECTROCHEMICAL DNA DETECTION 审中-公开
标题翻译：酶扩增电化学DNA检测
公开(公告)号：WO2006094056A2
公开(公告)日：2006-09-08
申请号：PCT/US2006/007272
申请日：2006-03-01
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , HYNDYLAB, INC. , MEYERHOFF, Mark, E. , YIM, Hyoungsik , LEE, Youngmi , ALTHAUS, John, S. , WHEELER, Lara, M. , LEE, Kyong-Hoon
发明人： MEYERHOFF, Mark, E. , YIM, Hyoungsik , LEE, Youngmi , ALTHAUS, John, S. , WHEELER, Lara, M. , LEE, Kyong-Hoon
CPC分类号： C07H21/04
摘要： An oligonucleotide probe for DNA detection is disclosed. The oligonucleotide probe includes a site-specific sequence. Either a co-factor or a mediator is conjugated to the site- specific sequence. The co-factor is adapted to produce an enzymatic signal that is electrochemically detectable. The mediator is adapted to enhance an enzymatic signal that is electrochemically detectable.
摘要翻译：公开了用于DNA检测的寡核苷酸探针。寡核苷酸探针包括位点特异性序列。辅因子或介体与位点特异性序列缀合。辅因子适于产生电化学检测的酶信号。介体适于增强电化学检测的酶信号。

20. 发明申请

WO2006023693A2 MULTI-FUNCTIONAL BIOCOMPATIBLE COATINGS FOR INTRAVASCULAR DEVICES 审中-公开
标题翻译：用于血管内装置的多功能生物活性涂层
公开(公告)号：WO2006023693A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/029490
申请日：2005-08-18
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MICHIGAN CRITICAL CARE CONSULTANTS, INC. (MC3) , ZHOU, Zhengrong , MEYERHOFF, Mark, E. , REYNOLDS, Melissa, M.
发明人： ZHOU, Zhengrong , MEYERHOFF, Mark, E. , REYNOLDS, Melissa, M.
IPC分类号： A61K31/727 , A61K31/655 , A61F2/00
CPC分类号： A61L31/10 , A61K31/655 , A61K31/727 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/114 , A61L2300/42 , A61L2300/608 , A61L2420/08
摘要： A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.
摘要翻译：聚合物涂层适于在与血液接触时基本上消除血栓形成。聚合物涂层包括第一聚合物层和第二聚合物层。介于第一和第二聚合物层之间的是掺杂有一氧化氮供体和一氧化氮发生器中的至少一种的聚合物基质层。一氧化氮供体和/或一氧化氮发生器能够释放或产生NO。或者将生物活性剂固定在第二聚合物层的表面上，或者被结合到聚合物基质层中。

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