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11. 发明申请

WO2008069962A2 METHOD AND APPARATUS FOR COLLISIONAL ACTIVATION OF POLYPEPTIDE IONS 审中-公开
标题翻译：多肽离子激活的方法和装置
公开(公告)号：WO2008069962A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/024616
申请日：2007-11-30
申请人： PURDUE RESEARCH FOUNDATION , MCLUCKEY, Scott, A. , HAN, Hongling , XIA, Yu
发明人： MCLUCKEY, Scott, A. , HAN, Hongling , XIA, Yu
CPC分类号： H01J49/4225 , H01J49/0072
摘要： A method and apparatus for identification of activating ions by collisions is described. The method uses a plurality of linear ion traps and a plurality of sources of ions and a mass measuring device. A first source is operated to dispense first ions into a first trap, where the ions may be kinetically cooled. A second source is operated to dispense second ions into the firs trap, where the first and the second ions are stored. Ions in the first trap are ejected so as to enter a second trap, where the ions are stored prior to mass spectrometry. The apparatus may use quadrupole rods to form the ion traps, and the voltage and pressure differences between the first and second traps are controllable values.
摘要翻译：描述了通过碰撞识别激活离子的方法和装置。该方法使用多个线性离子阱和多个离子源和质量测量装置。操作第一源以将第一离子分配到第一阱中，其中离子可以被动力学冷却。操作第二源将第二离子分配到第一捕集阱中，其中存储第一和第二离子。第一个陷阱中的离子被排出以便进入第二个陷阱，其中在质谱之前存储离子。该装置可以使用四极杆形成离子阱，并且第一和第二陷阱之间的电压和压力差是可控的值。

12. 发明申请

WO2005114703A3 TANDEM-IN-TIME AND TANDEM-IN-SPACE MASS AND ION MOBILITY SPECTROMETER AND METHOD 审中-公开
标题翻译：时间和空间质量和离子移动光谱仪和方法
公开(公告)号：WO2005114703A3
公开(公告)日：2006-10-05
申请号：PCT/US2005016191
申请日：2005-05-10
申请人： UT BATTELLE LLC , GOERINGER DOUG E , MCLUCKEY SCOTT A
发明人： GOERINGER DOUG E , MCLUCKEY SCOTT A
IPC分类号： H01J49/40 , H01J49/00 , H01J49/42
CPC分类号： H01J49/0081 , H01J49/40 , H01J49/4205
摘要： A tandem configuration apparatus (100) according to the invention generates a threedimensional mass or ion mobility spectrum of parent and associated product ions from a single, stored population of heterogeneous ions. The apparatus (100) comprises a multipole ion storage and sorting element (1) for receiving ions from an ion source and providing a sorted ion stream on the basis of mass-to-charge ratio of the received ions, a collision cell (5) for receiving the sorted ion stream and fragmenting at least a portion of ions comprising the ion stream, and a time-of-flight mass spectrometer or ion mobility spectrometer (10), the time-of-flight mass spectrometer or ion mobility spectrometer (10) receiving and identifying ions provided by the collision cell (5).
摘要翻译：根据本发明的串联配置装置（100）从单个存储的异质离子群体生成母体和相关产物离子的三维质量或离子迁移谱。装置（100）包括多极离子存储和分选元件（1），用于从离子源接收离子，并且基于所接收的离子的质荷比提供分选的离子流;碰撞池（5）为了接收分选的离子流并将包含离子流的至少一部分离子和飞行时间质谱仪或离子迁移谱仪（10）分离，飞行时间质谱仪或离子迁移谱仪（10））接收和识别由所述碰撞单元（5）提供的离子。

13. 发明申请

WO2003098190A2 PROTEIN IDENTIFICATION FROM PROTEIN PRODUCT ION SPECTRA 审中-公开
标题翻译：蛋白质鉴定蛋白产品离子谱
公开(公告)号：WO2003098190A2
公开(公告)日：2003-11-27
申请号：PCT/US2003/016029
申请日：2003-05-20
申请人： PURDUE RESEARCH FOUNDATION , REID, Gavin, E. , HOGAN, Jason, M. , MCLUCKEY, Scott, A.
发明人： REID, Gavin, E. , HOGAN, Jason, M. , MCLUCKEY, Scott, A.
IPC分类号： G01N
CPC分类号： G01N33/6848 , H01J49/00
摘要： Mass spectrometry is used to identify a protein of interest. The protein is first ionized then fragmented into protein product ions. Masses of the observed product ions are compared to product ion masses calculated in silico for database protein sequences to identify product ion matches within a predetermined mass tolerance. An algorithm that weights the product ion to matches based upon one or more factors such as product ion abundance, favored cleavage sites, product ion type, precursor ion charge state and polarity is used to score the possible matches to database proteins in order to identify the protein of interest. The invention represents a "top down" approach and is particularly well-suited for identification of a protein in a complex mixture.
摘要翻译：质谱用于鉴定感兴趣的蛋白质。蛋白质首先被电离，然后被分解成蛋白质产物离子。将观察到的产物离子的质量与对于数据库蛋白质序列计算的产物离子质量进行比较，以在预定质量公差内鉴定产物离子匹配。使用基于一个或多个因素（例如产物离子丰度，有利的切割位点，产物离子类型，前体离子电荷状态和极性）对产物离子进行匹配的算法来评估与数据库蛋白质的可能匹配，以便鉴定感兴趣的蛋白质本发明代表“自上而下”的方法，并且特别适合于鉴定复杂混合物中的蛋白质。

14. 发明申请

WO2003017319A2 METHOD OF SELECTIVELY INHIBITING REACTION BETWEEN IONS 审中-公开
标题翻译：选择性地抑制离子反应的方法
公开(公告)号：WO2003017319A2
公开(公告)日：2003-02-27
申请号：PCT/US2002/025419
申请日：2002-08-12
申请人： PURDUE RESEARCH FOUNDATION , McLUCKEY, Scott, A. , REID, Gavin, E. , WELLS, James, Mitchell
发明人： McLUCKEY, Scott, A. , REID, Gavin, E. , WELLS, James, Mitchell
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0072 , H01J49/0077 , H01J49/04 , H01J49/42
摘要： A method of inhibiting the reaction between ions of opposite polarity is disclosed. The method includes exposing a population of ions to a resonance excitation frequency during a mass-to-charge altering reaction between a first subpopulation of ions and a second subpopulation of ions, the resonance excitation frequency being tuned to inhibit the mass-to-charge altering reaction between an ion of the first subpopulation of ions having a predetermined mass-to-charge ratio and an ion of the second subpopulation of ions so that when an ion of the first subpopulation of ions attains the predetermined mass-to-charge ratio, the ion having the predetermined mass-to-charge ratio is selectively inhibited from reacting with ions of the second subpopulation of ions.
摘要翻译：公开了抑制相反极性的离子之间的反应的方法。该方法包括在离子的第一亚群和第二亚离子群之间的质量 - 电荷改变反应期间将离子群体暴露于共振激发频率，谐振激发频率被调谐以抑制质量 - 电荷改变具有预定质荷比的第一亚群的离子与第二子离子群的离子之间的反应，使得当离子的第一亚群离子达到预定的质荷比时，选择性地抑制具有预定质荷比的离子与第二亚离子群的离子反应。

15. 发明申请

WO2012174198A2 METHOD AND APPARATUS FOR DIPOLAR DC COLLISIONAL ACTIVATION OF IONS TRANSMITTED THROUGH AN ELECTRODYNAMIC MULTIPOLE DEVICE 审中-公开
标题翻译：通过电动多功能装置传输的离子的DIPOLAR直流冲击激活的方法和装置
公开(公告)号：WO2012174198A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042384
申请日：2012-06-14
申请人： PURDUE RESEARCH FOUNDATION , MCLUCKEY, Scott, A. , WEBB, Ian, K.
发明人： MCLUCKEY, Scott, A. , WEBB, Ian, K.
IPC分类号： H01J49/26 , H01J49/10 , G01N27/62
CPC分类号： H01J49/0031 , H01J49/005 , H01J49/063
摘要： A method of operating a quadrupole mass spectrometer is described where one of the stages thereof has a pairs of opposing rods and one of the pair of rods is operated with a zero voltage potential difference therebetween and the other of the pair of opposing rods is operated with a voltage potential difference therebetween. The potential field unbalance causes the analyte ions to deviate from the axial centerline of the stage so as to undergo additional RF heating. The stage is operated in a transmission mode and the resultant reaction products may be further processed in subsequent stages or output to a mass spectrometer.
摘要翻译：描述了操作四极质谱仪的方法，其中一个阶段具有一对相对的杆，并且一对杆中的一个杆之间以零电压电位差操作，并且一对相对的杆中的另一个用它们之间的电压电位差。潜在的场不平衡导致分析物离子偏离舞台的轴向中心线，以便进行额外的RF加热。阶段以透射模式操作，并且所得反应产物可以在后续阶段进一步处理或输出到质谱仪。

16. 发明申请

WO2008069959A3 METHOD AND APPARATUS FOR TRANSMISSION MODE ION/ION DISSOCIATION 审中-公开
公开(公告)号：WO2008069959A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/024613
申请日：2007-11-30
申请人： PURDUE RESEARCH FOUNDATION , MCLUCKEY, Scott, A. , LIANG, Xiaorong , XIA, Yu
发明人： MCLUCKEY, Scott, A. , LIANG, Xiaorong , XIA, Yu
IPC分类号： H01J49/42 , H01J49/00
摘要： A method an apparatus for analyzing biomolecules is described. The method includes injecting and storing one species of ionized molecule in a linear ion trap and injecting second species of oppositely polarity ionized molecule such that the second species is transmitted through the stored first species. The resultant reaction products may be analyzed by a mass analyzed taking account of the remaining charge values. In an aspect, a linear ion trap may be used as the reaction volume, and the ionized species injected along the axis of the trap in a substantially collinear manner. The mass analysis may be performed by mass selective axial ejection or by a mass spectrometer.

17. 发明申请

WO2008069959A2 METHOD AND APPARATUS FOR TRANSMISSION MODE ION/ION DISSOCIATION 审中-公开
标题翻译：用于传输模式离子/离子解离的方法和装置
公开(公告)号：WO2008069959A2
公开(公告)日：2008-06-12
申请号：PCT/US2007024613
申请日：2007-11-30
申请人： PURDUE RESEARCH FOUNDATION , MCLUCKEY SCOTT A , LIANG XIAORONG , XIA YU
发明人： MCLUCKEY SCOTT A , LIANG XIAORONG , XIA YU
CPC分类号： H01J49/4225 , H01J49/0072
摘要： A method an apparatus for analyzing biomolecules is described. The method includes injecting and storing one species of ionized molecule in a linear ion trap and injecting second species of oppositely polarity ionized molecule such that the second species is transmitted through the stored first species. The resultant reaction products may be analyzed by a mass analyzed taking account of the remaining charge values. In an aspect, a linear ion trap may be used as the reaction volume, and the ionized species injected along the axis of the trap in a substantially collinear manner. The mass analysis may be performed by mass selective axial ejection or by a mass spectrometer.
摘要翻译：描述了用于分析生物分子的装置的方法。该方法包括将一种离子化分子注入并存储在线性离子阱中并注入第二种相反极性的电离分子，使得第二种通过存储的第一种传播。可以通过考虑剩余电荷值的质量分析所得到的反应产物。一方面，可以使用线性离子阱作为反应体积，并且离子化物质以基本上共线的方式沿着阱的轴线注入。质量分析可以通过质量选择性轴向喷射或通过质谱仪进行。

18. 发明申请

WO2005114703A2 TANDEM-IN-TIME AND TANDEM-IN-SPACE MASS AND ION MOBILITY SPECTROMETER AND METHOD 审中-公开
标题翻译：时间和空间质量和离子移动光谱仪和方法
公开(公告)号：WO2005114703A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/016191
申请日：2005-05-10
申请人： UT-BATTELLE, LLC , GOERINGER, Doug, E. , MCLUCKEY, Scott, A.
发明人： GOERINGER, Doug, E. , MCLUCKEY, Scott, A.
IPC分类号： H01J49/40
CPC分类号： H01J49/0081 , H01J49/40 , H01J49/4205
摘要： A tandem configuration apparatus (100) according to the invention generates a threedimensional mass or ion mobility spectrum of parent and associated product ions from a single, stored population of heterogeneous ions. The apparatus (100) comprises a multipole ion storage and sorting element (1) for receiving ions from an ion source and providing a sorted ion stream on the basis of mass-to-charge ratio of the received ions, a collision cell (5) for receiving the sorted ion stream and fragmenting at least a portion of ions comprising the ion stream, and a time-of-flight mass spectrometer or ion mobility spectrometer (10), the time-of-flight mass spectrometer or ion mobility spectrometer (10) receiving and identifying ions provided by the collision cell (5).
摘要翻译：根据本发明的串联配置装置（100）从单个存储的异质离子群体生成母体和相关产物离子的三维质量或离子迁移谱。装置（100）包括多极离子存储和分选元件（1），用于从离子源接收离子，并且基于所接收的离子的质荷比提供分选的离子流;碰撞池（5）为了接收分选的离子流并将包含离子流的至少一部分离子和飞行时间质谱仪或离子迁移谱仪（10）分离，飞行时间质谱仪或离子迁移谱仪（10））接收和识别由所述碰撞单元（5）提供的离子。

19. 发明申请

WO2003098190A3 PROTEIN IDENTIFICATION FROM PROTEIN PRODUCT ION SPECTRA 审中-公开
公开(公告)号：WO2003098190A3
公开(公告)日：2003-11-27
申请号：PCT/US2003/016029
申请日：2003-05-20
申请人： PURDUE RESEARCH FOUNDATION , REID, Gavin, E. , HOGAN, Jason, M. , MCLUCKEY, Scott, A.
发明人： REID, Gavin, E. , HOGAN, Jason, M. , MCLUCKEY, Scott, A.
IPC分类号： B01D59/44
摘要： Mass spectrometry is used to identify a protein of interest. The protein is first ionized then fragmented into protein product ions. Masses of the observed product ions are compared to product ion masses calculated in silico for database protein sequences to identify product ion matches within a predetermined mass tolerance. An algorithm that weights the product ion to matches based upon one or more factors such as product ion abundance, favored cleavage sites, product ion type, precursor ion charge state and polarity is used to score the possible matches to database proteins in order to identify the protein of interest. The invention represents a "top down" approach and is particularly well-suited for identification of a protein in a complex mixture.

20. 发明申请

WO2003017319A3 METHOD OF SELECTIVELY INHIBITING REACTION BETWEEN IONS 审中-公开
公开(公告)号：WO2003017319A3
公开(公告)日：2003-02-27
申请号：PCT/US2002/025419
申请日：2002-08-12
申请人： PURDUE RESEARCH FOUNDATION , McLUCKEY, Scott, A. , REID, Gavin, E. , WELLS, James, Mitchell
发明人： McLUCKEY, Scott, A. , REID, Gavin, E. , WELLS, James, Mitchell
IPC分类号： H01J49/42
摘要： A method of inhibiting the reaction between ions of opposite polarity is disclosed. The method includes exposing a population of ions to a resonance excitation frequency during a mass-to-charge altering reaction between a first subpopulation of ions and a second subpopulation of ions, the resonance excitation frequency being tuned to inhibit the mass-to-charge altering reaction between an ion of the first subpopulation of ions having a predetermined mass-to-charge ratio and an ion of the second subpopulation of ions so that when an ion of the first subpopulation of ions attains the predetermined mass-to-charge ratio, the ion having the predetermined mass-to-charge ratio is selectively inhibited from reacting with ions of the second subpopulation of ions.

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