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11. 发明申请

WO2004101347A1 PNEUMATIC CYLINDER DEVICE FOR TRAILER OR SEMITRAILER VEHICLES 审中-公开
标题翻译：用于拖拉机或半导体车辆的气动缸装置
公开(公告)号：WO2004101347A1
公开(公告)日：2004-11-25
申请号：PCT/IT2004/000288
申请日：2004-05-19
申请人： H.T.S. HYDRO TECH SYSTEMS S.R.L. , BIONDI, Armando , MARTINI, Paolo
发明人： BIONDI, Armando , MARTINI, Paolo
IPC分类号： B62D13/02
CPC分类号： B62D13/025 , B62D13/04 , B62D13/06
摘要： A pneumatic cylinder device (10) for trailer or semitrailer vehicles which, according to the angle of rotation between the truck (46) and the semi-trailer (35) or between the tractor (47) and the trailer (48), assumes an angular position which transmits the command for power assisted steering of the wheels on the steering or self-steering axle of the respective semi-trailer (35) or trailer (48). The pneumatic cylinder (11) is a single-action device and a base (24), the end of the latter attached to an additional pin (28) fixed on a semi-trailer (35) or, respectively, on a trailer (48), the cylinder (11) housing a piston (21) which slides along the cylinder and a rod (14; 26) connected to the piston (21), the rod (14; 26) acting as a longitudinally extending and transversally rigid tie rod for the presence of pressurised air supplied to the inside of the cylinder through a supply hole (23).
摘要翻译：一种用于拖车或半挂车的气缸装置（10），其根据卡车（46）和半挂车（35）之间或拖拉机（47）与拖车（48）之间的旋转角度，假定为在各个半挂车（35）或拖车（48）的转向或自转轴上传递用于车轮的辅助转向的指令的角位置。气动气缸（11）是单作用装置和底座（24），其底端安装在固定在半挂车（35）上的附加销（28）上，或分别安装在拖车（48）），容纳沿着气缸滑动的活塞（21）的气缸（11）和连接到活塞（21）的杆（14; 26），杆（14; 26）用作纵向延伸且横向刚性的带杆，用于通过供应孔（23）供应到气缸内部的加压空气的存在。

12. 发明申请

WO2019092529A1 SOFTWARE FOR THE CHARACTERISATION OF A MODEL OF ANATOMICAL PARTS 审中-公开
公开(公告)号：WO2019092529A1
公开(公告)日：2019-05-16
申请号：PCT/IB2018/058193
申请日：2018-10-22
申请人： TINAZZI MARTINI, Paolo , PREGARZ, Massimo
发明人： TINAZZI MARTINI, Paolo , PREGARZ, Massimo
IPC分类号： G16H30/40 , G16H15/00
CPC分类号： G16H30/40 , G16H15/00
摘要： The present invention relates to a software for the characterisation of an anatomical part, comprising a computer code (1) that, when executed by an electronic processor (10), carries out the following steps: the step (S1) of making available a model of the anatomical part, the step (S7) of displaying a two- dimensional image (21) of said model (20) of the anatomical part, the step (S4) of making available an archive provided with a plurality of lesion models (40, 41, 42...59), the step (S10) of displaying a graphic element (60) for each lesion model (40, 41, 42...59) in the archive, the step (S11) of allowing the selection of a graphic element (60) corresponding to a lesion model (52), the step (S12) of allowing the positioning of the graphic element (60) on the displayed two- dimensional image (21), so as to generate a comprehensive two-dimensional image (71), the step (S13) of acquiring the value of at least one parameter indicating at least the dimensions of the lesion, and the step (S15) of changing, on the basis of value of the acquired parameter, at least one dimension of the lesion model (52).

13. 发明申请

WO2012112677A3 METHODS FOR TREATING LYSOSOMAL ACID LIPASE DEFICIENCY 审中-公开
标题翻译：用于治疗肝硬脂酸缺乏症的方法
公开(公告)号：WO2012112677A3
公开(公告)日：2014-05-01
申请号：PCT/US2012025233
申请日：2012-02-15
申请人： CHILDRENS HOSP MEDICAL CENTER , GRABOWSKI GREGORY , DU HONG , HEARTLEIN MICHAEL , CONCINO MICHAEL , MARTINI PAOLO , MEIYAPPAN MUTHURAMAN , ROMASHKO ALLA , PESCATORE BRIAN , CHARNAS LAWRENCE
发明人： GRABOWSKI GREGORY , DU HONG , HEARTLEIN MICHAEL , CONCINO MICHAEL , MARTINI PAOLO , MEIYAPPAN MUTHURAMAN , ROMASHKO ALLA , PESCATORE BRIAN , CHARNAS LAWRENCE
IPC分类号： A61K38/46
CPC分类号： A61K38/465
摘要： The present invention provides compositions and methods for effective treatment of a lysosomal acid lipase deficiency (LALD) disease, in particular, Wolman's disease and Cholesteryl Ester Storage Disease (CESD). Among other things, the present invention provides a method of treating a lysosomal acid lipase deficiency (LALD) disease, including administering to an individual suffering from or susceptible to the LALD disease a therapeutic effective amount of a lysosomal acid lipase periodically at an administration interval such that lipid level in liver, spleen and/or small intestine is reduced by at least 20% as compared to an untreated control.
摘要翻译：本发明提供了有效治疗溶酶体酸性脂肪酶缺乏症（LALD）疾病，特别是沃尔曼氏病和胆固醇酯储存疾病（CESD）的组合物和方法。除此之外，本发明提供了一种治疗溶酶体酸性脂肪酶缺乏症（LALD）疾病的方法，包括以给药间隔给予患有或易感LALD疾病的个体治疗有效量的溶酶体酸脂肪酶，与未处理的对照相比，肝脏，脾脏和/或小肠中的脂质水平降低至少20％。

14. 发明公开

EP4348576A1 SOFTWARE FOR CHARACTERISING A TWO-DIMENSIONAL IMAGE OBTAINED BY MEANS OF AN EXAMINATION THROUGH IMAGES 审中-实审
公开(公告)号：EP4348576A1
公开(公告)日：2024-04-10
申请号：EP22724925.7
申请日：2022-05-13
申请人： Tinazzi Martini, Paolo , Tinazzi Martini, Matilde
发明人： Tinazzi Martini, Paolo , Tinazzi Martini, Matilde
IPC分类号： G06T7/11 , G06T11/40 , G06T11/60 , G16H15/00 , G16H30/40

15. 发明专利

IL289098D0 Polynucleotides encoding methylmalonyl-coa mutase 未知
公开(公告)号：IL289098D0
公开(公告)日：2022-02-01
申请号：IL28909821
申请日：2021-12-19
申请人： MODERNATX INC , MARTINI PAOLO G V , PRESNYAK VLADIMIR
发明人： MARTINI PAOLO G V , PRESNYAK VLADIMIR
IPC分类号： A61K38/00 , A61K38/52 , A61K48/00 , A61P43/00 , C12N15/52
摘要： The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.

16. 发明专利

IL259667D0 Polynucleotides encoding methylmalonyl-coa mutase 未知
公开(公告)号：IL259667D0
公开(公告)日：2018-07-31
申请号：IL25966718
申请日：2018-05-29
申请人： MODERNATX INC , MARTINI PAOLO , PRESNYAK VLADIMIR
发明人： MARTINI PAOLO , PRESNYAK VLADIMIR
IPC分类号： C12N20060101
摘要： The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.

17. 发明专利

ITFR20140004U1 BOX DOCCIA MULTIUSO 未知
公开(公告)号：ITFR20140004U1
公开(公告)日：2014-06-07
申请号：ITFR20140004
申请日：2014-03-07
申请人： MARTINI PAOLO

18. 发明专利

IT1209976B 未知
公开(公告)号：IT1209976B
公开(公告)日：1989-08-30
申请号：IT4805586
申请日：1986-05-26
申请人： CEI MARTINI PAOLO
发明人： PAOLA CEI MARTINI
IPC分类号： H01Q20060101 , H01Q

19. 发明专利

IL259667A Polynucleotides encoding methylmalonyl-coa mutase 未知
公开(公告)号：IL259667A
公开(公告)日：2022-01-01
申请号：IL25966718
申请日：2018-05-29
申请人： MODERNATX INC , MARTINI PAOLO G V , PRESNYAK VLADIMIR
发明人： MARTINI PAOLO G V , PRESNYAK VLADIMIR
IPC分类号： A61K38/00 , A61K38/52 , A61K48/00 , A61P43/00 , C12N15/52
摘要： The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.

20. 发明专利

IL281181D0 Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease 未知
公开(公告)号：IL281181D0
公开(公告)日：2021-04-29
申请号：IL28118121
申请日：2021-03-01
申请人： FISH & RICHARDSON P C DC , MARTINI PAOLO , PRESNYAK VLADIMIR , DOUSIS ATHANASIOS , CAO JINGSONG
发明人： MARTINI PAOLO , PRESNYAK VLADIMIR , DOUSIS ATHANASIOS , CAO JINGSONG
IPC分类号： A61K9/00 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61P3/00 , C12N9/16 , C12N15/87

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