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11. 发明申请

WO2004081561A1 METHOD FOR DETECTION MUSTARD 审中-公开
标题翻译：检测方法MUSTARD
公开(公告)号：WO2004081561A1
公开(公告)日：2004-09-23
申请号：PCT/GB2004/001083
申请日：2004-03-11
申请人： THE SECRETARY OF STATE FOR DEFENCE , BUSSEY, Alison , CLARKE, Adrian , LAMBERT, John
发明人： BUSSEY, Alison , CLARKE, Adrian , LAMBERT, John
IPC分类号： G01N31/22
CPC分类号： G01N31/224
摘要： This invention relates to a method suitable for detecting nitrogen mustard, sulphur mustard or a mixture of nitrogen and sulphur mustard in a sample solution comprising mixing the sample solution with a reagent wherein the reagent comprises 4-(4'-nitrobenzyl) pyridine or analogues thereof, and an additive selected from the group consisting of mercuric cyanide, a group I or group H metal perchlorate and mixtures thereof; gently warming the mixture; and adding a base. This invention also relates to the use of a kit comprising a reagent comprising 4-(4'-nitrobenzyl) pyridine or analogues thereof, and an additive selected from the group consisting of mercuric cyanide, a group I or group II metal perchlorate and mixtures thereof in such a method.
摘要翻译：本发明涉及一种适合于在样品溶液中检测氮芥，硫芥或氮芥和硫芥混合物的方法，包括将样品溶液与试剂混合，其中试剂包含4-（4'-硝基苄基）吡啶或其类似物和选自氰化汞，第I族或第H族金属高氯酸盐及其混合物的添加剂; 轻轻加热混合物; 并增加一个基数。本发明还涉及包含试剂的试剂盒的用途，该试剂包含4-（4'-硝基苄基）吡啶或其类似物，以及选自氰化汞氰化物，第I族或第II族金属高氯酸盐及其混合物的添加剂在这种方法中。

12. 发明申请

WO1994000478A1 STEROIDAL BETA-O-CELLOBIOSIDE HEPTAALKANOATE PROCESS 审中-公开
公开(公告)号：WO1994000478A1
公开(公告)日：1994-01-06
申请号：PCT/US1993001709
申请日：1993-03-02
申请人： PFIZER INC. , GOGGIN, Kathleen, Diane , LAMBERT, John, Francis , WALINSKY, Stanley, Walter
发明人： PFIZER INC.
IPC分类号： C07J71/00
CPC分类号： C07J71/0005
摘要： A process for the synthesis of peracyl-1-O-steroidal- beta -cellobiosides that provides excellent beta -anomeric selectivity without the use of a metal salt promoter. The process comprises reacting heptaacyl- beta -D-cellobiosyl-1-fluoride and a trisubstituted silyl-3-O-steroid, wherein the steroid is tigogenin, hecogenin, 11-ketotigogenin or diosgenin in the absence of a metal salt under suitable conditions.
摘要翻译：一种合成过酰基-1-O-甾体-β-胆碱酯酶的方法，其在不使用金属盐促进剂的情况下提供优异的β-异戊醇选择性。该方法包括使七酰基-β-D-纤维二糖基-1-氟化物和三取代的甲硅烷基-3-O-类固醇反应，其中在合适的条件下，在不存在金属盐的情况下，类固醇是替龙根素，hecogenin，11-酮基生育素或薯di皂苷元。

13. 发明申请

WO1993011150A1 METHOD FOR MAKING STEROIDAL PERACYL GLYCOSIDES 审中-公开
标题翻译：用于制备非甾体类胰蛋白酶的方法
公开(公告)号：WO1993011150A1
公开(公告)日：1993-06-10
申请号：PCT/US1992008638
申请日：1992-10-15
申请人： PFIZER INC. , ALLEN, Douglas, John, M. , BUSCH, Frank, Robert , LAMBERT, John, Francis , SHINE, Russell, James , WALINSKY, Stanley, Walter
发明人： PFIZER INC.
IPC分类号： C07J71/00
CPC分类号： C07J71/0005
摘要： Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypocholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting alpha -cellobiosyl bromide heptaalkanoate and beta -tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl beta -O-cellobioside heptaalkanoate. The analogous preparations of hecogenin beta -O-cellobioside heptaalkanoate 11-ketotigogenin beta -O-cellobioside heptaalkanoate, and diosgenin beta -O-cellobioside heptaalkanoate are also disclosed. The process provides both high beta -anomeric selectivity and high yields.
摘要翻译：用于合成已知低血胆固醇代谢细胞因子β-纤维二糖苷的中间体的七叶酸孕酮β-O-纤维二糖苷七链烷酸酯的方法。该方法包括在能够形成所述tigogenylβ-O-二十七烷基硫酸酯的条件的条件下，在氟化锌或氰化锌存在下，使α-烯烃二溴七烷酸酯和β-同位素配合物反应。还公开了类胡萝卜素β-O-二十一碳烯酰基七烯酸二十一酯-11-酮维生素β-O-二十二碳烯酸七烷酸酯和薯di皂苷α-O- 该方法提供高β-丁二醇选择性和高产率。

14. 发明申请

WO2011127538A1 COMPOUND FOR TREATMENT OF RESPIRATORY CONDITION OR DISEASE 审中-公开
标题翻译：用于治疗呼吸道疾病或疾病的化合物
公开(公告)号：WO2011127538A1
公开(公告)日：2011-10-20
申请号：PCT/AU2011/000434
申请日：2011-04-14
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY LTD , LAMBERT, John Nicholas , RYAN, Jane , WILSON, Janet Marie
发明人： LAMBERT, John Nicholas , RYAN, Jane , WILSON, Janet Marie
IPC分类号： A61K31/501 , A61P11/06 , A61P31/16
CPC分类号： A61K31/501 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the treatment, alleviation, prevention or reduction of symptoms or exacerbations of asthma or chronic obstructive pulmonary disease (COPD), of which reduced lung function is typically symptomatic.
摘要翻译：本发明涉及治疗，减轻，预防或减轻哮喘或慢性阻塞性肺疾病（COPD）的症状或恶化，其中肺功能降低通常是有症状的。

15. 发明申请

WO2008141385A1 VIRAL POLYMERASE INHIBITORS 审中-公开
标题翻译：病毒聚合酶抑制剂
公开(公告)号：WO2008141385A1
公开(公告)日：2008-11-27
申请号：PCT/AU2008/000714
申请日：2008-05-21
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY LTD , MITCHELL, Jeffrey, Peter , LILLY, Michael, John , LAMBERT, John, Nicholas , DRAFFAN, Alistair, George , BOND, Silas , HUFTON, Richard , JAHANGIRI, Saba
发明人： MITCHELL, Jeffrey, Peter , LILLY, Michael, John , LAMBERT, John, Nicholas , DRAFFAN, Alistair, George , BOND, Silas , HUFTON, Richard , JAHANGIRI, Saba
IPC分类号： C07D231/56 , A61K31/427 , C07D401/12
CPC分类号： C07D401/12 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to viral polymerase inhibitors, in particular inhibitors of viral polymerases within the Flaviviridae family such as hepatitis C virus (HCV), processes for their preparation and their use in the treatment of infections.
摘要翻译：本发明涉及病毒聚合酶抑制剂，特别是黄病毒科中的病毒聚合酶如丙型肝炎病毒（HCV）的抑制剂，其制备方法及其在治疗感染中的用途。

16. 发明申请

WO2006113623A3 ELIMINATION OF HETEROGENEOUS OR MIXED CELL POPULATION IN TUMORS 审中-公开
标题翻译：消除肿瘤中异种或混合细胞群体
公开(公告)号：WO2006113623A3
公开(公告)日：2008-09-12
申请号：PCT/US2006014411
申请日：2006-04-14
申请人： IMMUNOGEN INC , GOLDMAKHER VIKTOR S , LUTZ ROBERT J , CHARI RAVI V J , KOVTUN YELENA V , LAMBERT JOHN M , STEEVES RITA , ERICKSON HANS K
发明人： GOLDMAKHER VIKTOR S , LUTZ ROBERT J , CHARI RAVI V J , KOVTUN YELENA V , LAMBERT JOHN M , STEEVES RITA , ERICKSON HANS K
IPC分类号： A61K39/00
CPC分类号： C07K16/3046 , A61K31/5383 , A61K31/58 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07D498/18 , C07K2317/24
摘要： Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
摘要翻译：描述了杀死或抑制包含异源或混合细胞群的肿瘤的方法。通过选择性地靶向疑似在特定细胞群体上表达的独特配体也杀死缺乏独特配体的细胞群体来实现肿瘤的杀伤或抑制。这些缀合物具有治疗用途，因为它们被递送到特定细胞群以杀死这些细胞，并释放细胞毒性药物以杀死非靶向细胞，从而消除肿瘤。

17. 发明申请

WO2007104938A1 A PARALLEL HINGE 审中-公开
标题翻译：平行铰链
公开(公告)号：WO2007104938A1
公开(公告)日：2007-09-20
申请号：PCT/GB2007/000823
申请日：2007-03-12
申请人： SECURISTYLE LIMITED , LAMBERT, John, F.
发明人： LAMBERT, John, F.
IPC分类号： E05F11/24 , E05F11/34 , E05D15/30
CPC分类号： E05D15/34 , E05D15/00 , E05D15/1013 , E05D15/30 , E05D15/44 , E05F11/24 , E05Y2900/148 , F16C11/04 , Y10T16/54 , Y10T16/544 , Y10T16/547 , Y10T16/5474 , Y10T16/5476 , Y10T16/553 , Y10T16/558 , Y10T403/32073
摘要： A parallel hinge (1) comprising a first and second parallel tracks (3, 4) for mounting the hinge (1) to a vent. The first track (3) is for attaching to a fixed frame 5 of the vent and the second track (4) is for attaching to an opening member of the vent. A cross member comprising a pair of diagonally crossing links (7) pivotally connected to each track (3, 4) and to each other at a central pivot (9). A drive mechanism (10) is mounted to the track (4) attached to the opening member for moving the vent between open and closed positions. The drive mechanism (10) comprises a gear assembly (16) operably coupled between a longitudinally extending drive rack (18) which engages the shoe (12) of the track (4) mounted to the opening member, and an actuating member (20). The actuating member drives the gear assembly (16), which drives the drive rack (18) and in turn the shoe (12) for opening or closing the hinge/window.
摘要翻译：一种平行铰链（1），包括用于将铰链（1）安装到排气口的第一和第二平行轨道（3,4）。第一轨道（3）用于连接到通风口的固定框架5，第二轨道（4）用于附接到通风口的开口构件。一种横向构件，包括一对在所述轨道（3,4）枢转地连接并且在中心枢轴（9）处彼此枢转连接的对角交叉连杆（7）。驱动机构（10）安装到附接到打开构件的轨道（4）上，用于在打开位置和关闭位置之间移动排气口。驱动机构（10）包括可操作地连接在纵向延伸的驱动齿条（18）上的齿轮组件（16），所述驱动齿条（18）接合安装到打开构件的轨道（4）的滑块（12）和致动构件（20）。致动构件驱动齿轮组件（16），其驱动驱动齿条（18），然后驱动滑块（12）以打开或关闭铰链/窗口。

18. 发明申请

WO2006113623A2 ELIMINATION OF HETEROGENEOUS OR MIXED CELL POPULATION IN TUMORS 审中-公开
标题翻译：消除肿瘤中异种或混合细胞群体
公开(公告)号：WO2006113623A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014411
申请日：2006-04-14
申请人： IMMUNOGEN, INC. , GOLDMAKHER, Viktor, S. , LUTZ, Robert, J. , CHARI, Ravi, V., J. , KOVTUN, Yelena, V. , LAMBERT, John, M. , STEEVES, Rita , ERICKSON, Hans, K.
发明人： GOLDMAKHER, Viktor, S. , LUTZ, Robert, J. , CHARI, Ravi, V., J. , KOVTUN, Yelena, V. , LAMBERT, John, M. , STEEVES, Rita , ERICKSON, Hans, K.
IPC分类号： A61K39/395 , A61K31/5383 , C07K16/46 , A61K31/58 , A61K38/19
CPC分类号： C07K16/3046 , A61K31/5383 , A61K31/58 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07D498/18 , C07K2317/24
摘要： Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
摘要翻译：描述了杀死或抑制包含异源或混合细胞群的肿瘤的方法。通过选择性地靶向疑似在特定细胞群体上表达的独特配体，还杀死缺乏独特配体的细胞群体来实现肿瘤的杀伤或抑制。这些缀合物具有治疗用途，因为它们被递送到特定细胞群以杀死这些细胞，并释放细胞毒性药物以杀死非靶向细胞，从而消除肿瘤。

19. 发明申请

WO2005021568B1 NOVEL TRICYCLIC NUCLEOSIDES OR NUCLEOTIDES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：新型三核核苷酸或核苷酸作为治疗药物
公开(公告)号：WO2005021568B1
公开(公告)日：2005-06-09
申请号：PCT/US2004027819
申请日：2004-08-27
申请人： BIOTA INC , COOK PHILLIP DAN , EWING GREGORY , JIN YI , LAMBERT JOHN , PRHAVC MARIJA , RAJAPPAN VASANTHAKUMAR , RAJWANSHI VIVEK K , SAKTHIVEL KANDASAMY
发明人： COOK PHILLIP DAN , EWING GREGORY , JIN YI , LAMBERT JOHN , PRHAVC MARIJA , RAJAPPAN VASANTHAKUMAR , RAJWANSHI VIVEK K , SAKTHIVEL KANDASAMY
IPC分类号： A61P31/12 , C07H19/23 , A61K31/7064
CPC分类号： C07H19/04 , C07H19/23
摘要： Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
摘要翻译：含有三环碱基的核酸酶和核苷酸分别用于治疗感染性疾病和增殖性病症，例如病毒感染或癌症。

20. 发明申请

WO2004081561A8 METHOD FOR DETECTION MUSTARD 审中-公开
标题翻译：检测方法MUSTARD
公开(公告)号：WO2004081561A8
公开(公告)日：2005-03-10
申请号：PCT/GB2004001083
申请日：2004-03-11
申请人： SECR DEFENCE , BUSSEY ALISON , CLARKE ADRIAN , LAMBERT JOHN
发明人： BUSSEY ALISON , CLARKE ADRIAN , LAMBERT JOHN
IPC分类号： G01N31/22
CPC分类号： G01N31/224
摘要： This invention relates to a method suitable for detecting nitrogen mustard, sulphur mustard or a mixture of nitrogen and sulphur mustard in a sample solution comprising mixing the sample solution with a reagent wherein the reagent comprises 4-(4'-nitrobenzyl) pyridine or analogues thereof, and an additive selected from the group consisting of mercuric cyanide, a group I or group H metal perchlorate and mixtures thereof; gently warming the mixture; and adding a base. This invention also relates to the use of a kit comprising a reagent comprising 4-(4'-nitrobenzyl) pyridine or analogues thereof, and an additive selected from the group consisting of mercuric cyanide, a group I or group II metal perchlorate and mixtures thereof in such a method.
摘要翻译：本发明涉及一种适用于在样品溶液中检测氮芥，硫芥或氮芥和硫芥混合物的方法，包括将样品溶液与试剂混合，其中试剂包含4-（4'-硝基苄基）吡啶或其类似物和选自氰化汞，第I族或第H族金属高氯酸盐及其混合物的添加剂; 轻轻加热混合物; 并添加基数。本发明还涉及包含试剂的试剂盒的用途，该试剂包含4-（4'-硝基苄基）吡啶或其类似物，以及选自氰化汞，第I族或第II族金属高氯酸盐及其混合物的添加剂在这种方法中。

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