专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2003075888A2 MATERIALS CONTAINING MULTIPLE LAYERS OF VESICLES 审中-公开
标题翻译：包含多层VESICLES的材料
公开(公告)号：WO2003075888A2
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002564
申请日：2003-03-12
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , LALLY, John, Martin , KOTOV, Nicholas
发明人： LALLY, John, Martin , KOTOV, Nicholas
IPC分类号： A61K9/127
CPC分类号： G02B1/043 , A61K9/127
摘要： The present invention provides a composite material, preferably an opthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.
摘要翻译：本发明提供了一种复合材料，优选的是眼科装置，更优选的是隐形眼镜，其包括含囊泡的涂层，其包含至少一层囊泡和一层具有与囊泡的电荷相反的电荷的聚离子材料。这种复合材料可用于生物医学应用，例如用于局部药物递送的装置和体内分析物传感器，例如葡萄糖感测隐形眼镜。通过从基材上取出含囊泡的涂层，可以制备能够包封各种客体材料的自立膜（膜）。另外，本发明提供了制造本发明的含囊泡复合材料和薄膜材料的方法。

12. 发明申请

WO2002097481A1 POLYMERIC MATERIALS FOR MAKING CONTACT LENSES 审中-公开
标题翻译：用于制造接触镜的聚合材料
公开(公告)号：WO2002097481A1
公开(公告)日：2002-12-05
申请号：PCT/EP2002/005939
申请日：2002-05-29
申请人： NOVARTIS AG , NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , AGUADO, Celeste , LALLY, John, Martin , NICOLSON, Paul, Clement , QIU, Yongxing , SCHREMMER, Jacalyn, Mary , WINTERTON, Lynn, Cook
发明人： AGUADO, Celeste , LALLY, John, Martin , NICOLSON, Paul, Clement , QIU, Yongxing , SCHREMMER, Jacalyn, Mary , WINTERTON, Lynn, Cook
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , A61L27/18 , A61L27/26 , A61L27/34 , A61L2430/16 , Y10T428/31663 , C08L51/085
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含量大分子单体和离子单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

13. 发明申请

WO0157118A2 PROCESS FOR COATING A SURFACE 审中-公开
标题翻译：涂层表面处理
公开(公告)号：WO0157118A2
公开(公告)日：2001-08-09
申请号：PCT/EP0101154
申请日：2001-02-02
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , WINTERTON LYNN COOK , LALLY JOHN MARTIN , RUBNER MICHAEL F , QIU YONGXING
发明人： WINTERTON LYNN COOK , LALLY JOHN MARTIN , RUBNER MICHAEL F , QIU YONGXING
IPC分类号： G02C7/04 , A61L27/34 , B05D1/18 , B05D7/00 , B05D7/02 , B05D7/24 , C08J7/04 , G02B1/04 , G02B1/10 , C08J7/00
CPC分类号： G02B1/043 , A61L27/34 , B05D1/185 , B05D7/52 , C08J7/04 , C08J2375/04
摘要： A method of forming a coating of polyionic materials in a layer-by-layer-like manner onto a polymeric material is provided. A polymeric material, such as a contact lens, can be dipped once into a solution of polyionic materials such that layers of polyionic material can be formed thereon. A single dip solution of the present invention typically contains a polyanionic material and a polycationic material in a non-stoichiometric amount and maintained within a certain pH range.
摘要翻译：提供了将聚离子材料的涂层以逐层状的方式形成在聚合物材料上的方法。诸如隐形眼镜的聚合物材料可以浸渍一次到聚离子材料的溶液中，使得可以在其上形成聚离子材料层。本发明的单浸液通常含有非离子性材料和非化学计量的聚阳离子材料并保持在一定pH范围内。

14. 发明申请

WO9854603A8 COMPOSITE OPHTHALMIC LENS 审中-公开
标题翻译：复合眼镜
公开(公告)号：WO9854603A8
公开(公告)日：1999-03-25
申请号：PCT/EP9803071
申请日：1998-05-25
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , AUTEN RICHARD DALE , LALLY JOHN MARTIN , ZHANG XIAOXIAO
发明人： AUTEN RICHARD DALE , LALLY JOHN MARTIN , ZHANG XIAOXIAO
IPC分类号： G02C7/04 , A61L27/00 , B29D11/00 , C08J5/00 , C08L29/04 , G02B1/04
CPC分类号： G02B1/043
摘要： The invention provides a molded ophthalmic lens having at least first and second optical components, wherein the first optical component is cast molded to encapsulate the second optical component such that the first optical component provides an optical function and the second optical component provides an additional optical function. The invention additionally provides a process for producing a molded composite ophthalmic lens.
摘要翻译：本发明提供一种具有至少第一和第二光学部件的模制眼科镜片，其中第一光学部件被铸造以封装第二光学部件，使得第一光学部件提供光学功能，并且第二光学部件提供附加的光学功能。本发明另外提供了一种用于生产模制复合眼科镜片的方法。

15. 发明申请

WO2006117228A2 OPHTHALMIC DEVICES FOR SUSTAINED DELIVERY OF ACTIVE COMPOUNDS 审中-公开
标题翻译：用于持续输送活性化合物的透明设备
公开(公告)号：WO2006117228A2
公开(公告)日：2006-11-09
申请号：PCT/EP2006/004193
申请日：2006-05-04
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , WINTERTON, Lynn, Cook , LALLY, John, Martin
发明人： WINTERTON, Lynn, Cook , LALLY, John, Martin
IPC分类号： G02B1/04 , A61K9/00 , B29D11/00
CPC分类号： G02B1/043 , A61K9/0051 , B29D11/00038 , B29D11/00865 , C08L29/04
摘要： The invention relates to an ophthalmic product which has a capability of delivering a guest material (e.g., a lubricant or a drug) in a time-controlled-releasing manner. The invention also provides a process for making an ophthalmic product of the invention. In addition, the invention provides a method for time-controlled delivery of a drug or a lubricant.
摘要翻译：本发明涉及具有以时间控制释放方式递送客体材料（例如润滑剂或药物）的能力的眼用产品。本发明还提供了制备本发明的眼用产品的方法。另外，本发明提供了药物或润滑剂的时间控制递送方法。

16. 发明申请

WO2005058587A3 METHOD FOR PRODUCING TINTED CONTACT LENSES 审中-公开
标题翻译：生产浅色隐形眼镜的方法
公开(公告)号：WO2005058587A3
公开(公告)日：2005-08-18
申请号：PCT/EP2004014427
申请日：2004-12-17
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , WINTERTON LYNN COOK , LALLY JOHN MARTIN , VOGT JUERGEN
发明人： WINTERTON LYNN COOK , LALLY JOHN MARTIN , VOGT JUERGEN
IPC分类号： B29C67/00 , B29D11/00
CPC分类号： B29D11/00317
摘要： The invention provides a method of producing a full-body tinted contact lens. The method of the invention comprises the steps of: preconditioning particles of a pigments; dispersing the preconditioned pigment particles in a polymerizable fluid composition to obtain a pigment-containing polymerizable dispersion; introducing an amount of the pigment-containing polymerizable dispersion in a mold for making a contact lens; polymerizing the polymerizable dispersion in the mold to form a full-body tinted contact lens with the particles of the pigment entrapped and distributed therein. In addition, the invention provides a method for preparing preconditioned pigment particles and full-body tinted contact lenses produced according the method of the invention.
摘要翻译：本发明提供了一种生产全身着色隐形眼镜的方法。本发明的方法包括以下步骤：预处理颜料颗粒; 将预处理过的颜料颗粒分散在可聚合流体组合物中以获得含颜料的可聚合分散体; 将一定量的含颜料的可聚合分散体引入用于制造隐形眼镜的模具中; 在模具中聚合可聚合的分散体以形成全色染色隐形眼镜，其中颜料颗粒包埋并分布于其中。此外，本发明提供了一种制备根据本发明方法生产的预处理颜料颗粒和全身着色隐形眼镜的方法。

17. 发明申请

WO2004056403A3 METHOD FOR MAKING MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：用于制造具有抗微生物涂层的医疗装置的方法
公开(公告)号：WO2004056403A3
公开(公告)日：2004-09-23
申请号：PCT/EP0314531
申请日：2003-12-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MIT MASSACHUSETTS INST OF TECH , RUBNER MICHAEL F , YANG SUNG YUN , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN
发明人： RUBNER MICHAEL F , YANG SUNG YUN , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN
IPC分类号： A61L27/34 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/10 , G02B1/04
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having -COOAg groups and/or silver nanoparticles formed by reducing Ag ions associated with the -COO groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
摘要翻译：本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层， -COOAg基团和/或银纳米颗粒通过还原与负电聚合物材料的-COO - 基团相关的Ag +离子而形成。此外，本发明提供了根据本发明的方法制备的医疗装置。

18. 发明申请

WO2004056403A2 METHOD FOR MAKING MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：用于制造具有抗微生物涂层的医疗器械的方法
公开(公告)号：WO2004056403A2
公开(公告)日：2004-07-08
申请号：PCT/EP2003/014531
申请日：2003-12-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MIT MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RUBNER, Michael, F. , YANG, Sung, Yun , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin
发明人： RUBNER, Michael, F. , YANG, Sung, Yun , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin
IPC分类号： A61L27/34
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having -COOAg groups and/or silver nanoparticles formed by reducing Ag + ions associated with the -COO - groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
摘要翻译：本发明提供了用于制备在医疗装置上具有含抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包含至少一种具有-COOAg基团的负电荷聚离子材料层和/或通过还原与负电荷聚离子材料的-COO - 基团缔合的Ag + +离子形成的银纳米颗粒。另外，本发明提供了根据本发明的方法制备的医疗装置。

19. 发明申请

WO2004050132A2 MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 审中-公开
标题翻译：具有抗微生物涂层的医疗器械
公开(公告)号：WO2004050132A2
公开(公告)日：2004-06-17
申请号：PCT/EP2003/013598
申请日：2003-12-02
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , CARNEY, Fiona, Patricia , GABRIEL, Manal, M. , MORRIS, Carol, Ann , LALLY, John, Martin
发明人： CARNEY, Fiona, Patricia , GABRIEL, Manal, M. , MORRIS, Carol, Ann , LALLY, John, Martin
IPC分类号： A61L27/34
CPC分类号： A61L27/54 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/608
摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial peptides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.
摘要翻译：本发明提供医疗装置，优选隐形眼镜，其包含含有一种或多种抗微生物肽的抗微生物LbL涂层。本发明的抗微生物涂层可赋予医学以增加的表面亲水性和相对高的抗微生物活性以及低细胞毒性。本发明的抗微生物涂层对隐形眼镜的所需整体性质（例如透氧性，离子渗透性和光学性质）具有最小的不利影响。本发明的抗微生物涂层可以特别用于长效隐形眼镜。另外，本发明提供了一种用于制造其上具有抗微生物LbL涂层的医疗装置，优选隐形眼镜的方法。

20. 发明申请

WO2004024203A1 LBL-COATED MEDICAL DEVICE AND METHOD FOR MAKING THE SAME 审中-公开
标题翻译： LBL涂层医疗装置及其制造方法
公开(公告)号：WO2004024203A1
公开(公告)日：2004-03-25
申请号：PCT/EP2003/010046
申请日：2003-09-10
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin
发明人： QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin
IPC分类号： A61L27/34
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
摘要翻译：本发明提供一种医疗装置，优选为眼科装置，更优选隐形眼镜，其包括非共价连接到所述芯材料的芯材料和生物相容性LbL涂层。生物相容的LbL涂层包含至少一个电荷/非电荷双层，其中所述电荷/非电荷双层以无特别的顺序由一层带电荷的聚合物材料和一层非带电聚合物材料组成，其中能够非共价地键合到带电的聚合物材料上。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式