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11. 发明申请

US20110195895A1 FGF21 MUTANTS AND USES THEREOF 有权
标题翻译： FGF21突变体及其用途
公开(公告)号：US20110195895A1
公开(公告)日：2011-08-11
申请号：US13123205
申请日：2009-10-08
申请人： Kenneth W. Walker , Colin V. Gegg, JR. , Randy I. Hecht , Edward J. Belousky , Yue-Sheng Li , Mark L. Michaels , Jing Xu , Murielle M. Ellison
发明人： Kenneth W. Walker , Colin V. Gegg, JR. , Randy I. Hecht , Edward J. Belousky , Yue-Sheng Li , Mark L. Michaels , Jing Xu , Murielle M. Ellison
IPC分类号： A61K38/18 , C12N15/63 , C12N1/00 , C07H21/00 , C12P21/02 , C07K14/50 , C08F8/32 , C07K19/00 , A61P3/10 , A61P3/04 , A61P3/00
CPC分类号： C07K14/50 , A61K38/00 , A61K47/60
摘要： The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
摘要翻译：本发明提供编码FGF21突变体多肽，FGF21突变体多肽，包含FGF21突变体多肽的药物组合物的核酸分子，以及使用此类核酸，多肽或药物组合物治疗代谢紊乱的方法。

12. 发明授权

US07861744B2 Tubular expansion device and method of fabrication 有权
标题翻译：管状膨胀装置及其制造方法
公开(公告)号：US07861744B2
公开(公告)日：2011-01-04
申请号：US11954942
申请日：2007-12-12
申请人： Charles B. Fly , Gerald W. Fly , Kenneth W. Walker
发明人： Charles B. Fly , Gerald W. Fly , Kenneth W. Walker
IPC分类号： F16L55/12
CPC分类号： F16L55/165 , E21B43/105 , F16L13/147 , F16L55/163 , F16L55/1653 , F16L55/1654 , F16L55/1657 , F28F9/16 , F28F11/00
摘要： The invention comprises a device for expanding tubular members to a controlled diameter and its method of fabrication. The device includes an expandable bladder held in a convoluted form. After the device is inserted into a cylindrical tube to be evenly expanded, the bladder is expanded by hydraulic pressure to a controlled maximum diameter. It is then deflated so the device can then be moved to another location and reused. The bladder is formed from a flexible impervious material having integral reinforcing fibers. It is initially formed in a fully expanded configuration over a convoluted mandrel and a removable cylindrical shell. When the shell is removed vacuum or external pressure draws the bladder against the mandrel. The bladder is overmolded with a resilient cover to hold it in reduced form until pressurized. The bladder cover prevents the bladder from kinking during the expansion.
摘要翻译：本发明包括用于将管状构件膨胀到受控直径的装置及其制造方法。该装置包括保持在卷积形式的可膨胀囊。在将装置插入圆筒管中以均匀膨胀之后，气囊通过液压膨胀至受控的最大直径。然后将其放气，从而可以将设备移动到另一个位置并重新使用。气囊由具有整体增强纤维的柔性不透水材料形成。它首先在卷曲的心轴和可移除的圆柱形壳体上以完全展开的形式形成。当外壳去除真空或外部压力将气囊拉到心轴上时。气囊用弹性盖包覆成型，以将其保持在减小的形式，直到加压。膀胱盖防止膀胱在扩张期间发生扭结。

13. 发明授权

US07833979B2 Toxin peptide therapeutic agents 有权
标题翻译：毒素肽治疗剂
公开(公告)号：US07833979B2
公开(公告)日：2010-11-16
申请号：US11406454
申请日：2006-04-17
申请人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg , Stefan I. McDonough
发明人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg , Stefan I. McDonough
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60 , C07K14/43504 , C07K2319/30 , C07K2319/55
摘要： Disclosed is a composition of matter of the formula (X1)a—(F1)d—(X2)b—(F2)e—(X3)c (I) and multimers thereof, in which F1 and F2 are half-life extending moieties, and d and e are each independently 0 or 1, provided that at least one of d and e is 1; X1, X2, and X3 are each independently -(L)f-P-(L)g-, and f and g are each independently 0 or 1; P is a toxin peptide of no more than about 80 amino acid residues in length, comprising at least two intrapeptide disulfide bonds; L is an optional linker; and a, b, and c are each independently 0 or 1, provided that at least one of a, b and c is 1. Linkage to the half-life extending moiety or moieties increases the in vivo half-life of the toxin peptide, which otherwise would be quickly degraded. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are a DNA encoding the inventive composition of matter, an expression vector comprising the DNA, and a host cell comprising the expression vector. Methods of treating an autoimmune disorder, such as, but not limited to, multiple sclerosis, type 1 diabetes, psoriasis, inflammatory bowel disease, contact-mediated dermatitis, rheumatoid arthritis, psoriatic arthritis, asthma, allergy, restinosis, systemic sclerosis, fibrosis, scleroderma, glomerulonephritis, Sjogren syndrome, inflammatory bone resorption, transplant rejection, graft-versus-host disease, and lupus and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
摘要翻译：公开了式（X1）a-（F1）d-（X2）b-（F2）e-（X3）c（Ⅰ）及其多元素的物质组成，其中F1和F2是半衰期延长部分，d和e各自独立地为0或1，条件是d和e中的至少一个为1; X1，X2和X3各自独立地为 - （L）f-P-（L）g-，f和g各自独立地为0或1; P是长度不超过约80个氨基酸残基的毒素肽，其包含至少两个肽内二硫键; L是可选的接头; 并且a，b和c各自独立地为0或1，条件是a，b和c中的至少一个为1.与半衰期延长部分或部分的连接增加毒素肽的体内半衰期，否则会很快退化。药物组合物包含该组合物和药学上可接受的载体。还公开了编码本发明组合物的DNA，包含DNA的表达载体和包含表达载体的宿主细胞。治疗自身免疫性疾病，例如但不限于多发性硬化，1型糖尿病，牛皮癣，炎性肠病，接触介导性皮炎，类风湿性关节炎，银屑病关节炎，哮喘，过敏，再狭窄，系统性硬化，纤维化，还公开了硬皮病，肾小球肾炎，干燥综合征，炎性骨吸收，移植排斥反应，移植物抗宿主病和狼疮以及预防或减轻多发性硬化症状的复发。

14. 发明申请

US20090299044A1 DNA encoding chimeric toxin peptide fusion proteins and vectors and mammalian cells for recombinant expression 失效
标题翻译：编码嵌合毒素肽融合蛋白的DNA和用于重组表达的载体和哺乳动物细胞
公开(公告)号：US20090299044A1
公开(公告)日：2009-12-03
申请号：US11978104
申请日：2007-10-25
申请人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, JR. , Taruna Arora Khare , Beverly S. Adler , Francis H. Martin
发明人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, JR. , Taruna Arora Khare , Beverly S. Adler , Francis H. Martin
IPC分类号： C07H21/04
CPC分类号： C07K14/43522 , A61K38/00 , A61K47/60 , C07K2319/30 , C07K2319/31
摘要： Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
摘要翻译：公开了包含OSK1肽类似物的物质组合物，并且在一些实施方案中为其药学上可接受的盐。药物组合物包含该组合物和药学上可接受的载体。还公开了编码本发明组合物的DNA，包含DNA的表达载体和包含表达载体的宿主细胞。还公开了治疗自身免疫性疾病和预防或减轻多发性硬化症状的复发的方法。

15. 发明申请

US20090297520A1 Methods of using conjugated toxin peptide therapeutic agents 失效
标题翻译：使用缀合毒素肽治疗剂的方法
公开(公告)号：US20090297520A1
公开(公告)日：2009-12-03
申请号：US11978111
申请日：2007-10-25
申请人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, JR. , Taruna Arora Khare , Beverly S. Adler , Francis H. Martin
发明人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, JR. , Taruna Arora Khare , Beverly S. Adler , Francis H. Martin
IPC分类号： A61K39/395 , A61K38/16
CPC分类号： C07K14/43522 , A61K38/00 , A61K47/60 , C07K2319/30 , C07K2319/31
摘要： Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
摘要翻译：公开了包含OSK1肽类似物的物质组合物，并且在一些实施方案中为其药学上可接受的盐。药物组合物包含该组合物和药学上可接受的载体。还公开了编码本发明组合物的DNA，包含DNA的表达载体和包含表达载体的宿主细胞。还公开了治疗自身免疫性疾病和预防或减轻多发性硬化症状的复发的方法。

16. 发明申请

US20090126436A1 TUBULAR EXPANSION DEVICE AND METHOD OF FABRICATION 有权
标题翻译：管状膨胀装置和制造方法
公开(公告)号：US20090126436A1
公开(公告)日：2009-05-21
申请号：US11954942
申请日：2007-12-12
申请人： Charles B. Fly , Gerald W. Fly , Kenneth W. Walker
发明人： Charles B. Fly , Gerald W. Fly , Kenneth W. Walker
IPC分类号： B21D39/20 , F16L55/12
CPC分类号： F16L55/165 , E21B43/105 , F16L13/147 , F16L55/163 , F16L55/1653 , F16L55/1654 , F16L55/1657 , F28F9/16 , F28F11/00
摘要： The invention comprises a device for expanding tubular members to a controlled diameter and its method of fabrication. The device includes an expandable bladder held in a convoluted form. After the device is inserted into a cylindrical tube to be evenly expanded, the bladder is expanded by hydraulic pressure to a controlled maximum diameter. It is then deflated so the device can then be moved to another location and reused. The bladder is formed from a flexible impervious material having integral reinforcing fibers. It is initially formed in a fully expanded configuration over a convoluted mandrel and a removable cylindrical shell. When the shell is removed vacuum or external pressure draws the bladder against the mandrel. The bladder is overmolded with a resilient cover to hold it in reduced form until pressurized. The bladder cover prevents the bladder from kinking during the expansion.
摘要翻译：本发明包括用于将管状构件膨胀到受控直径的装置及其制造方法。该装置包括保持在卷积形式的可膨胀囊。在将装置插入圆筒管中以均匀膨胀之后，气囊通过液压膨胀至受控的最大直径。然后将其放气，从而可以将设备移动到另一个位置并重新使用。气囊由具有整体增强纤维的柔性不透水材料形成。它首先在卷曲的心轴和可移除的圆柱形壳体上以完全展开的形式形成。当外壳去除真空或外部压力将气囊拉到心轴上时。气囊用弹性盖包覆成型，以将其保持在减小的形式，直到加压。膀胱盖防止膀胱在扩张期间发生扭结。

17. 发明授权

US08043829B2 DNA encoding chimeric toxin peptide fusion proteins and vectors and mammalian cells for recombinant expression 失效
标题翻译：编码嵌合毒素肽融合蛋白的DNA和用于重组表达的载体和哺乳动物细胞
公开(公告)号：US08043829B2
公开(公告)日：2011-10-25
申请号：US11978104
申请日：2007-10-25
申请人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, Jr. , Taruna Arora Khare , Beverly S. Adler , Francis H. Martin
发明人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, Jr. , Taruna Arora Khare , Beverly S. Adler , Francis H. Martin
IPC分类号： C12P21/00 , C12N15/62 , C12N15/63 , C12N5/10 , C07H21/04
CPC分类号： C07K14/43522 , A61K38/00 , A61K47/60 , C07K2319/30 , C07K2319/31
摘要： Disclosed is a composition of matter comprising a ShK toxin peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
摘要翻译：公开了包含ShK毒素肽类似物的物质组合物，在一些实施方案中，其药学上可接受的盐。药物组合物包含该组合物和药学上可接受的载体。还公开了编码本发明组合物的DNA，包含DNA的表达载体和包含表达载体的宿主细胞。还公开了治疗自身免疫性疾病和预防或减轻多发性硬化症状的复发的方法。

18. 发明申请

US20090305399A1 DNA encoding OSK1 toxin peptide analogs and vectors and cells for combinant expression 有权
标题翻译：编码OSK1毒素肽类似物的DNA和用于组合表达的载体和细胞
公开(公告)号：US20090305399A1
公开(公告)日：2009-12-10
申请号：US11978105
申请日：2007-10-25
申请人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, JR.
发明人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, JR.
IPC分类号： C12N5/00 , C07H21/04 , C12N15/63 , C12N1/00
CPC分类号： C07K14/43522 , A61K38/00 , A61K47/60 , C07K2319/30 , C07K2319/31
摘要： Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
摘要翻译：公开了包含OSK1肽类似物的物质组合物，并且在一些实施方案中为其药学上可接受的盐。药物组合物包含该组合物和药学上可接受的载体。还公开了编码本发明组合物的DNA，包含DNA的表达载体和包含表达载体的宿主细胞。还公开了治疗自身免疫性疾病和预防或减轻多发性硬化症状的复发的方法。

19. 发明申请

US20080254020A1 Therapeutic Peptides 有权
标题翻译：治疗肽
公开(公告)号：US20080254020A1
公开(公告)日：2008-10-16
申请号：US11631461
申请日：2005-07-08
申请人： Kenneth W. Walker , Olaf B. Kinstler , Karen C. Sitney
发明人： Kenneth W. Walker , Olaf B. Kinstler , Karen C. Sitney
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N1/21 , C12P21/06 , C12N15/00
CPC分类号： A61K47/6811 , A61K47/60
摘要： The invention relates to compounds that exhibit improved bioefficacy in multidose administration. More specifically, the invention relates to polypeptides or peptides modified to include an antibody Fc region and one or more water soluble polymers.
摘要翻译：本发明涉及在多剂量给药中表现出改善的生物功效的化合物。更具体地，本发明涉及经修饰以包括抗体Fc区和一种或多种水溶性聚合物的多肽或肽。

20. 发明授权

US08420779B2 Compositions and methods for producing bioactive fusion proteins 失效
公开(公告)号：US08420779B2
公开(公告)日：2013-04-16
申请号：US12154507
申请日：2008-05-22
申请人： Kenneth W. Walker , Colin V. Gegg, Jr.
发明人： Kenneth W. Walker , Colin V. Gegg, Jr.
IPC分类号： A61K38/16 , C07K14/00 , C07K17/00 , C07K19/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/21 , C12N15/09
CPC分类号： C07K14/78 , A61K47/60 , C07K14/43504 , C07K14/43522 , C07K14/524 , C07K16/18 , C07K2319/00 , C07K2319/30 , C07K2319/31 , C07K2319/35
摘要： Disclosed is a composition of matter involving a recombinant fusion protein comprising a a pharmacologically active protein partner, and a small pharmacologically inactive protein domain partner of human origin, such as but not limited to, a 10th fibronectin III domain, a SH3 domain, a SH2 domain, a CH2 domain of IgG1, a PDZ domain, a thrombospondin repeat domain, an ubiquitin domain, a leucine-rich repeat domain, a villin headpiece HP35 domain, a villin headpiece HP76 domain, or a fragment or modification of any of these. Also disclosed are nucleic acids (e.g., DNA constructs) encoding the fusion protein, expression vectors and recombinant host cells for expression of the fusion protein, and pharmaceutical compositions containing the recombinant fusion protein and a pharmaceutically acceptable carrier, and method of producing a pharmacologically active recombinant fusion protein.

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