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11. 发明授权

US08778999B2 Non-steroidal anti-inflammatory ophthalmic compositions 有权
标题翻译：非甾体抗炎眼科组合物
公开(公告)号：US08778999B2
公开(公告)日：2014-07-15
申请号：US12398657
申请日：2009-03-05
申请人： Kamran Hosseini , Lyle Bowman , Erwin C. Si , Stephen Pham
发明人： Kamran Hosseini , Lyle Bowman , Erwin C. Si , Stephen Pham
IPC分类号： A61K31/196 , A61K31/192 , A61K9/00 , A61K45/06 , A61K47/32 , A61K47/34
CPC分类号： A61K31/192 , A61K9/0048 , A61K45/06 , A61K47/32 , A61K47/34 , A61K2300/00
摘要： The disclosure provides compositions and systems for topical ophthalmic application, which include an aqueous mixture of bromfenac and flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.
摘要翻译：本公开提供了用于局部眼用药的组合物和系统，其包括溴芬酸和可流动粘膜粘附聚合物的水性混合物，用于治疗眼睛的炎症和炎症状况。

12. 发明申请

US20130177599A1 METHODS AND KITS FOR EXTENDING CONTACT LENS USE 审中-公开
标题翻译：用于扩展接触镜片的方法和工具
公开(公告)号：US20130177599A1
公开(公告)日：2013-07-11
申请号：US13345087
申请日：2012-01-06
申请人： Lyle M. BOWMAN , Kamran Hosseini
发明人： Lyle M. BOWMAN , Kamran Hosseini
IPC分类号： A61K31/78 , A61P27/02 , A61K9/14
CPC分类号： C11D3/3765 , A61K9/0048 , C11D3/0078
摘要： Provided are method and kits useful for extending the wear-time of a contact lens. The method includes applying an amount of an ophthalmically acceptable solution to the contact lens to improve the comfort of the eye when the contact lens is in the eye. The solution includes an aqueous suspension and chitosan. The aqueous suspension includes about 0.1% to about 6.5% by weight of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent. Upon contact with tear fluid, the solution gels to a second viscosity which is greater than the first viscosity. The kit includes contact lenses, an ophthalmically acceptable solution and instructions for applying the solution to improve the comfort of the eye when the contact lens is in the eye.
摘要翻译：提供了用于延长隐形眼镜的磨损时间的方法和试剂盒。该方法包括将一定量的眼科可接受的溶液施加到隐形眼镜，以在隐形眼镜在眼睛中时提高眼睛的舒适度。该溶液包括水性悬浮液和壳聚糖。含水悬浮液包含约0.1重量％至约6.5重量％的通过聚合一种或多种含羧基的单烯属不饱和单体和小于约5重量％的交联剂制备的含羧基聚合物。当与泪液接触时，溶液凝胶化至大于第一粘度的第二粘度。该套件包括隐形眼镜，眼科可接受的解决方案以及当隐形眼镜在眼睛中时施加该溶液以改善眼睛的舒适性的说明书。

13. 发明申请

US20100227842A1 METHODS FOR TREATING OCULAR INFLAMMATORY DISEASES 审中-公开
标题翻译：治疗眼部炎症性疾病的方法
公开(公告)号：US20100227842A1
公开(公告)日：2010-09-09
申请号：US12399729
申请日：2009-03-06
申请人： Lyle Bowman , Kamran Hosseini
发明人： Lyle Bowman , Kamran Hosseini
IPC分类号： A61K31/56
CPC分类号： A61K31/56
摘要： A method of treating blepharitis includes administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient consists essentially of a glucocorticoid in an ophthalmically acceptable vehicle that includes an aqueous polymer suspension that when mixed with tear fluid provides a sustained release of said active ingredient. The aqueous polymer suspension includes a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and has a viscosity in a range from about 1,000 to about 30,000 centipoises. A kit includes: (a) a composition comprising about 0.1% by weight dexamethasone in this ophthalmically acceptable vehicle and (b) instructions for using the composition of (a) for the treatment of blepharitis.
摘要翻译：一种治疗睑炎的方法包括向受试者的受影响的眼睛施用有效量的眼科可接受载体中的活性成分足够的时间以治疗睑炎。活性成分基本上由眼科可接受的媒介物中的糖皮质激素组成，其包括当与泪液混合时提供所述活性成分的持续释放的水性聚合物悬浮液。含水聚合物悬浮液包括含有少于约5重量％交联剂的含羧基聚合物，其粘度范围为约1,000至约30,000厘泊。试剂盒包括：（a）在该眼科可接受的载体中包含约0.1重量％的地塞米松的组合物和（b）使用（a）的组合物治疗睑炎的说明书。

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