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11. 发明申请

WO2011148243A1 EXTENDED RELEASE FORMULATION OF PRAMIPEXOLE 审中-公开
标题翻译：扩展释放公式
公开(公告)号：WO2011148243A1
公开(公告)日：2011-12-01
申请号：PCT/IB2011/001099
申请日：2011-05-23
申请人： LUPIN LIMITED , KULKARNI, Shirishkumar , KULKARNI, Rajesh , JADHAV, Pandharinath , TIWARI, Ashish
发明人： KULKARNI, Shirishkumar , KULKARNI, Rajesh , JADHAV, Pandharinath , TIWARI, Ashish
IPC分类号： A61K9/20 , A61K31/428
CPC分类号： A61K31/428 , A61K9/2013 , A61K9/2027 , A61K9/2054
摘要： An extended release formulation comprising pramipexole or pharmaceutically acceptable salts; derivatives; solvates; and isomers thereof, a weak acid and an extended release polymer. The formulation provides pH independent release profile of pramipexole.
摘要翻译：包含普拉克索或其药学上可接受的盐的延长释放制剂; 衍生物; 溶剂化物; 其异构体，弱酸和缓释聚合物。该制剂提供了普拉克索的pH独立释放曲线。

12. 发明申请

WO2011016057A3 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS OF MILNACIPRAN 审中-公开
标题翻译：米非司酮的控制释放药物组合物
公开(公告)号：WO2011016057A3
公开(公告)日：2011-10-06
申请号：PCT/IN2010000520
申请日：2010-08-04
申请人： LUPIN LTD , KULKARNI SHIRISH KUMAR , KULKARNI RAJESH , JADHAV PANDHARINATH , TIWARI ASHISH
发明人： KULKARNI SHIRISH KUMAR , KULKARNI RAJESH , JADHAV PANDHARINATH , TIWARI ASHISH
IPC分类号： A61K9/20 , A61K31/165
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K9/2095 , A61K31/165
摘要： A controlled release pharmaceutical composition comprising Milnacipran or pharmaceutically acceptable salts thereof and hydrophobic release controlling agent. The composition releases 90 % of the total amount of Milnacipran or pharmaceutically acceptable salts thereof between 8 to 20 hours when dissolution is carried out in 900 ml 0.1N HCl, USP apparatus Type I (Basket) at 100 rpm for 2 hrs, followed by 900 ml Phosphate buffer pH 6.8 USP apparatus Type I (Basket) at 100 rpm. A process of preparing a controlled release pharmaceutical composition comprises: a) preparing a first layer comprising i) melting hydrophobic release controlling agent and Milnacipran or pharmaceutically acceptable salts thereof in it ii) cooling followed by sieving the melted mass to obtain granules and iii) lubricating the granules; and b) preparing a second layer comprising granules which comprises hydrophobic release controlling agent and optionally Milnacipran or pharmaceutically acceptable salts thereof.
摘要翻译：包含米那普仑或其药学上可接受的盐和疏水性释放控制剂的控释药物组合物。当在900ml 0.1N HCl，USP装置I型（篮）以100rpm进行2小时进行溶解时，该组合物释放总量的90％的米那普仑或其药学上可接受的盐，接着900 ml磷酸盐缓冲液pH 6.8 USP装置I型（篮）在100rpm下。制备控释药物组合物的方法包括：a）制备第一层，所述第一层包含i）将疏水释放控制剂和米那普仑或其药学上可接受的盐在其中熔融ii）冷却，然后过滤熔融物质以获得颗粒，和iii）润滑颗粒; 和b）制备包含颗粒的第二层，所述颗粒包含疏水释放控制剂和任选的米那普仑或其药学上可接受的盐。

13. 发明申请

WO2010038239A3 PHARMACEUTICAL COMPOSITION COMPRISING COENZYME Q10 审中-公开
公开(公告)号：WO2010038239A3
公开(公告)日：2010-04-08
申请号：PCT/IN2009/000525
申请日：2009-09-25
申请人： SHARMA, Saumya , THAKUR, Srinath , SETTY, Swati , KULKARNI, Rajesh , KULKARNI, Shirishkumar
发明人： SHARMA, Saumya , THAKUR, Srinath , SETTY, Swati , KULKARNI, Rajesh , KULKARNI, Shirishkumar
IPC分类号： A61K38/43
摘要： A pharmaceutical composition for administration in gum pockets caused by periodontal disease, consisting: coenzyme Q10 and pharmaceutically acceptable excipients selected from the group comprising solubilizer; biodegradable polymer; solvent, and/or combinations thereof. A process for making a pharmaceutical composition for administration in pockets in gums caused by periodontal disease, consisting: coenzyme Q10 and pharmaceutically acceptable excipients wherein the solubilizer was dissolved in the solvent with stirring to obtain a clear solution followed by addition of the biodegradable polymer to this solution with stirring to obtain a clear solution; to this solution CoQ10 was added with vortexing to form a uniform suspension.

14. 发明申请

WO2009125432A2 GAS EMPOWERED EXPANDABLE DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：气体可扩展的药物输送系统
公开(公告)号：WO2009125432A2
公开(公告)日：2009-10-15
申请号：PCT/IN2009000222
申请日：2009-04-01
申请人： LUPIN LTD , JUNGINGER HANS E , SADEGHI ASSAL M M , DORKOOSH FARID , AVADI MOHAMMAD REZA , RAFIEE-TEHRANI MORTEZA , JADHAV PANDHARINATH , KULKARNI RAJESH , KULKARNI SHIRISHKUMAR
发明人： JUNGINGER HANS E , SADEGHI ASSAL M M , DORKOOSH FARID , AVADI MOHAMMAD REZA , RAFIEE-TEHRANI MORTEZA , JADHAV PANDHARINATH , KULKARNI RAJESH , KULKARNI SHIRISHKUMAR
IPC分类号： A61K9/22 , A61K9/28
CPC分类号： A61K9/0007 , A61K9/0065 , A61K9/2009 , A61K9/2031 , A61K9/205 , A61K9/2846
摘要： An expandable drug delivery system comprising of one or more actives, force generating components, optionally containing one or more absorption modifiers and optionally containing one or more bioadhesive polymers. The active ingredient is entrapped into the nano/microsized particles of a mucoadhesive polymer matrix. The single unit dosage form is optionally coated with a degradable separating and/or enteric coating layer. An expandable drug delivery system for oral delivery consisting of a protein or peptide drug(s), force-generating components, with/with out absorption modifiers, wherein the composition is formulated to increase the residence time drug containing sub-units of the delivery system in the GIT, optionally coated with enteric polymers. An expandable drug delivery system consisting of a peptide drug, expandable polymer matrix, expanding force-generating component, which delivers drug to the absorbing membrane after a lag time followed by a burst release or sustained release.
摘要翻译：一种可膨胀药物递送系统，其包含一种或多种活性物质，产生力的组分，任选地含有一种或多种吸收改性剂和任选地含有一种或多种生物粘附性聚合物。将活性成分包埋在粘膜粘附聚合物基质的纳米/微粒化颗粒中。单一单位剂型任选地涂覆有可降解的分离和/或肠溶衣层。用于口服递送的可扩展药物递送系统，其由蛋白质或肽药物，具有/具有吸收改性剂的产生力的组分组成，其中配制组合物以增加包含递送系统的子单元的停留时间在GIT中，任选地涂覆有肠溶聚合物。一种由肽药物，可膨胀聚合物基质，膨胀力产生组分组成的可扩展药物递送系统，其在滞后时间之后将药物递送至吸收膜，随后是爆发释放或持续释放。

15. 发明申请

WO2009047802A3 NOVEL COLON TARGETED MODIFIED RELEASE BIOADHESIVE FORMULATION OF 5-AMINO SALICYLIC ACID OR ITS SALTS AND METABOLITES THEREOF 审中-公开
公开(公告)号：WO2009047802A3
公开(公告)日：2009-04-16
申请号：PCT/IN2008/000654
申请日：2008-10-08
申请人： LUPIN LIMITED , KULKARNI, Shirish, Kumar , KULKARNI, Rajesh , JADHAV, Pandarinath , BADHE, Umesh , GUPTA, Sushma
发明人： KULKARNI, Shirish, Kumar , KULKARNI, Rajesh , JADHAV, Pandarinath , BADHE, Umesh , GUPTA, Sushma
IPC分类号： A61K9/20 , A61K9/28 , A61K31/606 , A61P29/00
摘要： The present invention relates to a colon targeted modified release bioadhesive pharmaceutical composition of 5-amino salicylic acid or a pharmaceutically acceptable salt or enantiomer or polymorph or metabolites thereof, one or more hydrophilic or hydrophobic release controlling agent (s) and pharmaceutical acceptable excipient (s), and the process of preparing it.

16. 发明申请

WO2010010568A1 ORAL COMPOSITIONS OF CLINDAMYCIN 审中-公开
标题翻译： CLINDAMYCIN口服组合物
公开(公告)号：WO2010010568A1
公开(公告)日：2010-01-28
申请号：PCT/IN2008/000579
申请日：2008-09-10
申请人： LUPIN LIMITED , WALZADE, Kalpana , KULKARNI, Rajesh , KULKARNI, Shirishkumar
发明人： WALZADE, Kalpana , KULKARNI, Rajesh , KULKARNI, Shirishkumar
IPC分类号： A61K9/00
CPC分类号： A61K9/0095 , A61K9/1623 , A61K9/1641 , A61K9/5026 , Y02A50/411
摘要： A taste masked pharmaceutical composition of clindamycin, or a pharmaceutically acceptable salt(s), hydrate(s), solvate(s) and physiologically functional derivative(s) and precursors thereof, which includes all polymorphic forms, whether crystalline or amorphous comprising polyhydric alcohol(s); and one or more other pharmaceutically acceptable excipient(s). A process for preparation of a taste masked pharmaceutical composition of clindamycin or a pharmaceutically acceptable salt(s) thereof the said process comprising the steps of a) dry mixing clindamycin, polyhydric alcohol and other pharmaceutically acceptable excipient(s) to get a dry mixture; b) granulating the dry mixture above with a granulating liquid prepared by mixing the suitable pharmaceutically acceptable excipient(s) with aqueous /non-aqueous fluid to obtain a wet mass; c) drying the wet mass to obtain the discrete particles; d) lubricating the discrete particles obtained with a suitable lubricating agent and/or flavour(s).
摘要翻译：克林霉素或其药学上可接受的盐，水合物，溶剂合物和生理功能衍生物及其前体的掩味药物组合物，其包括所有多晶型物，无论是多晶型还是含有多元醇的无定形物质（一个或多个）; 和一种或多种其它药学上可接受的赋形剂。制备克林霉素或其药学上可接受的盐的掩味药物组合物的方法，所述方法包括以下步骤：a）将克林霉素，多元醇和其它药学上可接受的赋形剂干混以得到干混合物; b）将上述干混合物用通过将合适的药学上可接受的赋形剂与水/非水性流体混合而制备的造粒液体制粒得到湿物质; c）干燥湿物质以获得离散颗粒; d）润滑用合适的润滑剂和/或风味获得的离散颗粒。

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