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11. 发明申请

WO1998007031A1 CONTAINERS AND KITS FOR THE DETERMINATION OF CELL FUNCTIONS, AND METHOD FOR THE DETERMINATION THEREOF 审中-公开
标题翻译：用于确定细胞功能的容器和试剂盒及其测定方法
公开(公告)号：WO1998007031A1
公开(公告)日：1998-02-19
申请号：PCT/JP1997002776
申请日：1997-08-08
申请人： SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA , KOBAYASHI, Koji , SETOGUCHI, Yuji , KURIYAMA, Kiyoshi
发明人： SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , G01N33/96 , Y10S435/809 , Y10S435/81 , Y10S435/969 , Y10S435/97 , Y10S435/971 , Y10S435/973 , Y10S435/974 , Y10S436/81
摘要： Containers for the determination of cell functions which are easy of operation and less dangerous and enable the determination with high accuracy. Specifically, a container for the determination of cell functions to be used in analyzing physiologically active substances produced by hemocytes, which is constituted in such a way that the amount of materials inducing the production of the physiologically active substances is lowered to such a level as not to cause hemocytes to produce the substances, as determined by extracting the container with water in an amount equal to that of a blood sample to be analyzed; and another container therefor, wherein materials which induce the production of the substances when brought into contact with blood are placed in a state capable of coming into contact with blood, and the amount of the materials in the container is lowered so as not to affect the analysis of the substances.
摘要翻译：用于确定电池功能的容器，其易于操作且危险性较小并且能够以高精度进行测定。具体而言，是用于测定细胞功能的容器，用于分析由血细胞产生的生理活性物质，其以使得诱导生理活性物质的生成的材料的量降低到不高于水平的水平使血细胞产生物质，如通过用与待分析血液样品相同的水提取容器而确定的; 和另一个容器，其中当与血液接触时诱导物质生产的物质被置于能够与血液接触的状态，并且容器中的物质的量降低，从而不影响分析物质。

12. 发明申请

WO1993011121A1 BENZOXAZINONE DERIVATIVE 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：WO1993011121A1
公开(公告)日：1993-06-10
申请号：PCT/JP1992001550
申请日：1992-11-27
申请人： JAPAN TOBACCO INC. , KOBAYASHI, Koji; , MANABE, Shunichi; , WATANABE, Yoshihiro; , HAYAKAWA, Kazuhide; , UCHIDA, Itsuo;
发明人： JAPAN TOBACCO INC.
IPC分类号： C07D265/22
CPC分类号： C07D265/22 , C07D413/10 , C07D413/14
摘要： A benzoxazinone derivative represented by general formula (I) or a pharmaceutically acceptable acid addition salt thereof, and an anti-inflammatory, a neutrophil infiltration inhibitor and a serine protease inhibitor each containing the derivative as an active ingredient, wherein R, R?1, R2 and R3¿ may be the same or different from one another and each represents hydrogen or lower alkyl; A represents optionally halogenated phenyl, heterocycle or adamantyl; B represents hydrogen or optionally halogenated phenyl or heterocycle; U represents =CH-, =C= or =N-; V represents -O-, -CH¿2?-, =N-, -NH-, -CH= or a single bond; X represents -O-, =CH-, -CH2- or a single bond; Y represents -CH2-, -NH-, -O- or a single bond; Z represents -CO- or -CH2-; and l represents an integer of 0 to 3. This compound has excellent activities of inhibiting serine protease, neutrotaxis, and infiltration of neutrophils into carragheenin-induced pneumocephalus.

13. 发明申请

WO1994012474A1 COMPOUND WITH PROLYL ENDOPEPTIDASE INHIBITOR ACTIVITY AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译：具有内切肽酶抑制剂活性的化合物及其药物用途
公开(公告)号：WO1994012474A1
公开(公告)日：1994-06-09
申请号：PCT/JP1993001687
申请日：1993-11-17
申请人： JAPAN TOBACCO INC. , YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. , KOBAYASHI, Koji; , AKAMATSU, Minoru; , YATA, Shinji; , ABE, Hiroyuki; , TOIDE, Katsuo; , KOGAYU, Motohiro; , UCHIDA, Itsuo;
发明人： JAPAN TOBACCO INC. , YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.
IPC分类号： C07D207/16
CPC分类号： C07D417/06 , C07D207/16 , C07D277/06
摘要： A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, wherein: R represents hydrogen or acyl; U represents -O-, -CHR - or -NR -, wherein R represents hydrogen or heterocycle, and R represents hydrogen or lower alkyl substituted by lower alkoxycarbonyl; V represents -O-, -S-, -CHR - or -NR -, wherein R represents hydrogen or lower alkoxycarbonyl, and R represents hydrogen, lower alkyl or acyl; W represents methyl, heterocycle or optionally substituted phenyl; X and Y, which may be the same or different from each other, represent each -CH2- or -S-; m represents an integer of 0 to 6; and n represents an integer of 1 to 4. The compound has a specifically potent inhibitory activity against prolyl endopeptidase and suppresses the decomposition and deactivation of TRH, substance P, neurotensin, vasopressin, and so forth. Hence it can be used for preventing and/or treating dementia and amnesia including Alzheimer's disease.
摘要翻译：由通式（I）表示的化合物或其药学上可接受的盐，其中：R表示氢或酰基; U表示-O-，-CHR 1 - 或-NR 2 - ，其中R 1表示氢或杂环，R 2表示氢或被低级烷氧基羰基取代的低级烷基; V表示-O - ， - S - ， - CH 3 - 或-NR 4 - ，其中R 3表示氢或低级烷氧基羰基，R 4表示氢，低级烷基或酰基。 W代表甲基，杂环或任选取代的苯基; X和Y可以相同或不同，表示每个-CH 2 - 或-S-; m表示0〜6的整数， n表示1〜4的整数。该化合物对脯氨酰内肽酶具有特异的抑制活性，抑制TRH，物质P，神经降压素，加压素等的分解和失活。因此，它可用于预防和/或治疗包括阿尔茨海默氏病在内的痴呆和遗忘。

14. 发明申请

WO1992018488A1 NOVEL OXAZINONE DERIVATIVE 审中-公开
标题翻译：新奥西汀酮衍生物
公开(公告)号：WO1992018488A1
公开(公告)日：1992-10-29
申请号：PCT/JP1992000444
申请日：1992-04-09
申请人： JAPAN TOBACCO INC. , KOBAYASHI, Koji; , MANABE, Shunichi; , WATANABE, Yoshihiro; , HAYAKAWA, Kazuhide; , UCHIDA, Itsuo;
发明人： JAPAN TOBACCO INC.
IPC分类号： C07D265/22
CPC分类号： C07D265/22 , C07D413/10 , C07D417/12 , C07D471/04
摘要： A novel oxazinone derivative represented by general formula (I), which is useful as an antiinflammatory agent, a neutrophile infiltration inhibitor and a serine protease inhibitor, and a pharmaceutically acceptable acid addition salt thereof. In formula (I) A represents the group (a) (wherein W represents a single bond, -O-, -S-, -CH=CH- or -NR -; V represents =CR - or =N-; and D represents a 5-to 7-membered carbocyclic or heterocyclic ring); X represents a single bond, -O-, -S-, -CO- or -NR -; Y represents a single bond, -O-, -CH=CH- or -NR -; Z represents -CH2- or -CO-; I represents an integer of 0 to 4; and R, R to R represent each hydrogen, lower alkyl, etc.
摘要翻译：由通式（I）表示的可用作抗炎剂，嗜中性粒细胞浸润抑制剂和丝氨酸蛋白酶抑制剂的恶嗪酮衍生物及其药学上可接受的酸加成盐。在式（I）中，A表示基团（a）（其中W表示单键，-O - ， - S-，-CH = CH-或-NR 9 - ; V 2表示= CR 12 > - 或= N-; D表示5至7元碳环或杂环）; X表示单键，-O - ， - S-，-CO-或-NR 15 - 。 Y表示单键，-O - ， - CH = CH-或-NR 16 - 。 Z表示-CH 2 - 或-CO-; I表示0〜4的整数， R 1，R 1〜R 16各自表示氢，低级烷基等。

15. 发明申请

WO1991015487A1 NOVEL 4H-3,1-BENZOXAZIN-4-ONE DERIVATIVE 审中-公开
标题翻译：新的4H-3,1-苯并恶嗪-4-酮衍生物
公开(公告)号：WO1991015487A1
公开(公告)日：1991-10-17
申请号：PCT/JP1991000386
申请日：1991-03-26
申请人： JAPAN TOBACCO INC. , KOBAYASHI, Koji; , OZAWA, Koichi; , SASABUCHI, Masashi; , UCHIDA, Itsuo;
发明人： JAPAN TOBACCO INC.
IPC分类号： C07D413/12
CPC分类号： C07D413/10 , A61K38/00 , C07D207/16 , C07K5/06052 , C07K5/06078 , C07K5/06165 , C07K5/0806 , C07K5/0812
摘要： A 4H-3,1-benzoxazin-4-one derivative of general formula (I), which has a potent serine protease inhibitory action and is useful as the active ingredient of drugs for preventing and treating pneumonia, pulmonary emphysema, pulmonary fibrosis, bronchitis, arthritis, pancreatitis, nephritis, shock, sepsis, arteriosclerosis, etc.; wherein R1 represents lower alkyl; R2 represents lower alkyl, lower alkylthioalkyl or lower alkanesulfinylalkyl; R3 represents hydrogen, hydroxyl, lower alkoxy or lower acyloxy; X represents a residue of an amino acid selected from the group consisting of alanine, valine and phenyl-alanine; n is an integer of 0, 1 or 2; and Y represents a substituent selected from the group consisting of C¿2? to C6 alkanoyl optionally substituted with phenyl, benzyloxycarbonyl, lower alkoxycarbonyl, cinnamoyl and methoxysuccinoyl.

16. 发明专利

JP2006346404A DRAINING TOOL FOR COOKING 审中-公开
公开(公告)号：JP2006346404A
公开(公告)日：2006-12-28
申请号：JP2005206167
申请日：2005-06-18
申请人： KOBAYASHI KOJI
发明人： KOBAYASHI KOJI
IPC分类号： A47J47/00 , A47J47/16 , A47L19/02
摘要： PROBLEM TO BE SOLVED: To provide a draining tool for scraping off moisture staying on a chopping board or a top plate during cooking work, which can be easily stored without becoming an obstacle and be excellent in handleability. SOLUTION: On a position slightly shifted to an end part from the center of a planar spatula 1, an upper side hooking projection 2a and a lower side hooking projection 2b are provided such that an optional interval is provided vertically. The length of the lower side hooking projection 2b is made less than the length of the upper side hooking projection 2a, and a slip preventing coating film 3 is provided on the surface of the upper side hooking projection 2a. COPYRIGHT: (C)2007,JPO&INPIT

17. 发明专利

JP2002229729A ITEM SELECTION SYSTEM, CHARACTER SELECTION SYSTEM THEREBY, AND PROGRAM 失效
公开(公告)号：JP2002229729A
公开(公告)日：2002-08-16
申请号：JP2001062667
申请日：2001-01-30
申请人： KOBAYASHI KOJI
发明人： KOBAYASHI KOJI
IPC分类号： H03M11/04 , G06F3/023 , G06F3/03 , G06F3/033 , G06F3/041 , G06F3/14
摘要： PROBLEM TO BE SOLVED: To provide an item selection system/character selection system capable of achieving both of easy input at the initial time of learning and improvement in input efficiency at the time of learning using an item selection system having a recovery input part in a unique condition if no input is made. SOLUTION: If an input is made to the recovery input part, a currently selected item is changed to an item related to the input. If no input is made, on the other hand, a currently selected item is determined.

18. 发明专利

JP2000322440A SYSTEM AND METHOD FOR MANAGING PERSONAL INFORMATION AND STORAGE MEDIUM RECORDING PERSONAL INFORMATION MANAGEMENT PROGRAM 失效
公开(公告)号：JP2000322440A
公开(公告)日：2000-11-24
申请号：JP13305899
申请日：1999-05-13
申请人： KOBAYASHI KOJI , MITSUYA TATSUHIKO , FUJIMOTO MASASUKE , OGIWARA TAKUYA
发明人： KOBAYASHI KOJI , MITSUYA TATSUHIKO , FUJIMOTO MASASUKE , OGIWARA TAKUYA
IPC分类号： G06F15/00 , G06F17/30 , G06F21/31 , G06F21/60 , G06Q50/00 , G06Q50/10 , H04L9/32
摘要： PROBLEM TO BE SOLVED: To easily transmit personal information while holding the secrecy thereof on the side of an individual, to provide effective personal information at all the time on the side of a third person or enterprise and to improve efficiency in the mutual transmission or collection of personal information. SOLUTION: When the registration of personal information is requested from a terminal 2a, a certifying means 10 of an information managing device 1 issues and sends certification information by individuals to the terminal 2a. When the acquisition of personal information is requested from terminals 2b and 2c acquiring this certification information, the sent certification information is collated and access is permitted only to a certified person. An input/update means 11 respectively store the personal information sent from the terminal 2a in a PULL box 5a and a PUSH box 5b by individuals so as to enable updating. The personal information in the PULL box 5a is for disclosing and is stored in a data box 5c corresponding to acquisition requests from the terminals 2b and 2c. The personal information in the PUSH box 5b is for non-disclosing and can be acquired only for the terminals 2b and 2c specified by the transmission request from the terminal 2a.

19. 发明专利

JP2000062380A PORTABLE ROLLED WRITING INSTRUMENT AND METHOD FOR USING ROLLED WRITING INSTRUMENT 失效
公开(公告)号：JP2000062380A
公开(公告)日：2000-02-29
申请号：JP27244998
申请日：1998-08-20
申请人： KOBAYASHI KOJI
发明人： KOBAYASHI KOJI
IPC分类号： B43K19/02 , B43K3/00
摘要： PROBLEM TO BE SOLVED: To realize handling operability equivalent to that of a conventional writing instrument at the time of using by constituting of a plate-like part or component having flexibility of the degree for at least winding and a part or component for writing, thereby eliminating a disturbance at the time of carrying a portable rolled writing instrument. SOLUTION: One writing unit 3 and one sheet 2 are attached to a lead 1. The sheet 2 is not particularly limited in a material, size, number and shape except a flexible property in the degree of rolling on the lead 1. At the time of using, the sheet 2 is rolled on the lead 1. As a result, the writing instrument is changed from a plate-like shape to a rod-like shape to be easily handled. At the time of carrying, the sheet 2 is unrolled from the lead 1, and hence changed from the rod-like shape to the plate-like shape. Since the lead 1 is more slender than the sheet 2, even if the lead 1 is inserted into a notebook, the notebook is not partly thickened like that a rolled pen is inserted, but can be easily carried, and a breakage of the notebook is reduced.

20. 发明专利

JP2000014938A REPLACEABLE BLADE TYPE CUTTER KNIFE WITH COVER GUIDE 失效
公开(公告)号：JP2000014938A
公开(公告)日：2000-01-18
申请号：JP22737698
申请日：1998-07-06
申请人： KOBAYASHI KOJI
发明人： KOBAYASHI KOJI
IPC分类号： B26B1/08
摘要： PROBLEM TO BE SOLVED: To prevent the blade of a cutter from being unpreparedly broken, make easy to add a force, and improve the workability by fitting a cover guide to the part of the exposed blade of a cutter knife so as to cover the back side of the blade of the cutter knife. SOLUTION: This replaceable blade type cutter knife 1 has a cover guide 10 about on the straight line passing the working point of the cutter. In use, a cutter blade 2 is set so as not to protrude from the cover guide 10. By forming the cover guide 10 in this way, the cutter blade 2 can be held and stabilized. Accordingly, the cutter blade 2 is strong to a horizontal force and hardly broken. Even if a force is added from above the straight line passing the working point of the cutter, the back part of the exposed replaceable blade is never directly pressed, and the damage of a finger can be thus prevented. The material of the cover guide 10 is not particularly limited, and the form or size thereof can be also optionally selected. The fixing method is not particularly limited except its fixing to the horizontal direction of the cutter blade 2.

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