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11. 发明申请

US20130004963A1 Tyrosine, serine and threonine phosphorylation sites 有权
标题翻译：酪氨酸，丝氨酸和苏氨酸磷酸化位点
公开(公告)号：US20130004963A1
公开(公告)日：2013-01-03
申请号：US12310852
申请日：2007-09-08
申请人： Peter Hornbeck , Judit Villen , Albrecht Moritz , John Rush , Steven Gygi , Sean Beausoleil , Scott Gerber
发明人： Peter Hornbeck , Judit Villen , Albrecht Moritz , John Rush , Steven Gygi , Sean Beausoleil , Scott Gerber
IPC分类号： G01N33/566 , C07K16/18 , G01N33/573
CPC分类号： G01N33/6842 , C07K16/44 , G01N2440/14
摘要： The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和白血病中鉴定的155个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

12. 发明申请

US20130002449A1 SYSTEMS, METHODS, AND APPARATUS FOR UTILITY METER CONFIGURATION 审中-公开
标题翻译：系统，方法和实用程序配置的设备
公开(公告)号：US20130002449A1
公开(公告)日：2013-01-03
申请号：US13170515
申请日：2011-06-28
申请人： Hyoung Jhang , Bradley Richard Ree , Timothy John Rush
发明人： Hyoung Jhang , Bradley Richard Ree , Timothy John Rush
IPC分类号： H04Q9/00
CPC分类号： H04Q9/00 , H04Q2209/60
摘要： Systems, methods, and apparatus for configuring utility meters are provided. A utility meter may receive, via one or more networks, a command for accessing a configuration table associated with the utility meter. The command may be formatted in accordance with an Internet-based protocol. The utility meter may process the received command in order to access the configuration table, and the configuration table may be in conformance with an American National Standards Institute (ANSI) C12.19 standard.
摘要翻译：提供了配置电表的系统，方法和设备。公用事业计量器可以经由一个或多个网络接收用于访问与公用事业计量表相关联的配置表的命令。该命令可以根据基于因特网的协议进行格式化。公用事业计量器可以处理接收到的命令以访问配置表，并且配置表可以符合美国国家标准协会（ANSI）C12.19标准。

13. 发明授权

US08326360B2 Method and system for the configuration of a mobile station baseband circuit for an acoustic accessory 有权
标题翻译：配置用于声学附件的移动台基带电路的方法和系统
公开(公告)号：US08326360B2
公开(公告)日：2012-12-04
申请号：US13050564
申请日：2011-03-17
申请人： Barry Steven Hazell , Kevin John Rush
发明人： Barry Steven Hazell , Kevin John Rush
IPC分类号： H04B7/00 , H04B1/38 , H04M1/00 , H04R5/02
CPC分类号： H04W4/008 , H04M1/6025 , H04M1/6041 , H04M1/72525 , H04M1/7253 , H04W4/80 , H04W88/02
摘要： A method and system for the configuration of a mobile station baseband circuit for an acoustic accessory having an identifier, the method comprising the steps of: determining whether the mobile device recognizes the identifier of the acoustic device; and configuring the baseband circuit with a DSP filter response and CODEC acoustic gain parameters for the acoustic device if the mobile device recognizes the identifier of the acoustic device. The system comprising: an identifier for each of the plurality of acoustic devices; a local memory in the mobile station storing a frequency (filter) response and gain parameters for at least one of the plurality of acoustic devices and for mapping them to the identifier; and a digital signal processor to re-shape an acoustic frequency response and adjust an audio gain of a baseband circuit for the mobile station based on the stored frequency response and gain parameters.
摘要翻译：一种用于配置具有标识符的声学附件的移动台基带电路的方法和系统，所述方法包括以下步骤：确定移动设备是否识别声学设备的标识符; 以及如果所述移动设备识别所述声学设备的标识符，则使用所述声学设备的DSP滤波器响应和CODEC声增益参数来配置所述基带电路。该系统包括：用于多个声学装置中的每一个的标识符; 移动站中的本地存储器存储用于多个声学装置中的至少一个的频率（滤波器）响应和增益参数，并将它们映射到标识符; 以及数字信号处理器，用于基于所存储的频率响应和增益参数来重新形成声频响应并调整用于移动台的基带电路的音频增益。

14. 发明申请

US20100120055A1 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20100120055A1
公开(公告)日：2010-05-13
申请号：US12311464
申请日：2007-09-28
申请人： Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
发明人： Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要： The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的318个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

15. 发明申请

US20080130014A1 Displacement Measurement Sensor Using the Confocal Principle with an Optical Fiber 审中-公开
标题翻译：使用共焦原理与光纤的位移测量传感器
公开(公告)号：US20080130014A1
公开(公告)日：2008-06-05
申请号：US11949895
申请日：2007-12-04
申请人： Christopher John Rush
发明人： Christopher John Rush
IPC分类号： G01B11/00
CPC分类号： G01B11/0608
摘要： A displacement measurement sensor using the confocal principle with an optical fiber for measuring small changes in distance to a specular target surface comprises a monochromatic light source such as a laser diode 12 coupled to a multimode optical fiber. The fiber 32 functions as both a transmitter, receiver of light ray angle information. An objective lens 40 possessing spherical aberration separates the monochromatic light at different focal distances according to the magnitude of angular deviation from the optical axis. Each distance of the target surface from the objective lens will select specific angular rays able to retrace the path through the objective lens and fiber. Each angle then will correspond to specific distance. Angular information is preserved as the light path is traced back through the fiber 32 and the angle measurement is determined by registering the light impinging on a light sensitive electronic detector array 36.
摘要翻译：使用具有用于测量与镜面目标表面的距离的小变化的光纤的共焦原理的位移测量传感器包括耦合到多模光纤的单色光源，例如激光二极管12。光纤32用作光线角度信息的发射器，接收器。具有球面像差的物镜40根据与光轴的角度偏差的大小分离不同焦距的单色光。来自物镜的目标表面的每个距离将选择能够回溯通过物镜和光纤的路径的特定角射线。每个角度将对应于特定的距离。当通过光纤32跟踪光路时，保留角度信息，并且通过对入射在光敏电子检测器阵列36上的光进行登记来确定角度测量。

16. 发明申请

US20050003450A1 Immunoaffinity isolation of modified peptides from complex mixtures 有权
标题翻译：来自复杂混合物的修饰肽的免疫亲和分离
公开(公告)号：US20050003450A1
公开(公告)日：2005-01-06
申请号：US10777893
申请日：2004-02-12
申请人： John Rush , Hui Zhang , Xiangming Zha , Michael Comb , Yi Tan
发明人： John Rush , Hui Zhang , Xiangming Zha , Michael Comb , Yi Tan
IPC分类号： C12P21/06 , C07K1/22 , C07K14/47 , C07K16/18 , C07K16/44 , C12P21/08 , C12Q1/25 , C12Q1/48 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6872 , C07K14/47 , C07K16/44 , C12Q1/25 , C12Q1/485 , G01N33/6842
摘要： The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.
摘要翻译：本发明提供了从复杂的肽混合物中分离修饰的肽的方法，所述方法包括以下步骤：（a）从生物体获得蛋白质制剂，其中所述制剂包含来自两种或更多种不同蛋白质的修饰肽; （b）使制剂与至少一种固定的修饰特异性抗体接触; 和（c）在步骤（b）中分离至少一种由固定的修饰特异性抗体特异性结合的修饰的肽。该方法还可以包括以下步骤：（d）通过质谱（MS），串联质谱（MS-MS）和/或MS 3分析表征步骤（c）中分离的修饰肽，或步骤（e）使用搜索程序将在步骤（d）表征期间获得的修饰肽的光谱与已知肽序列的光谱基本上匹配，从而鉴定修饰肽的亲本蛋白。还提供了包含修饰特异性抗体和针对新型UFD1和PTN6磷酸化位点的抗体的免疫亲和分离装置。

17. 发明申请

US20120244594A9 Immunoaffinity isolation of modified peptides from complex mixtures 审中-公开
标题翻译：来自复杂混合物的修饰肽的免疫亲和分离
公开(公告)号：US20120244594A9
公开(公告)日：2012-09-27
申请号：US11823775
申请日：2007-06-28
申请人： John Rush , Hui Zhang , Xiangming Zha , Michael J. Comb , Yi Tan
发明人： John Rush , Hui Zhang , Xiangming Zha , Michael J. Comb , Yi Tan
IPC分类号： C12N11/00 , G01N33/566 , C07K1/14 , C07K16/18 , B01D11/02 , C07K16/40 , C07K1/22 , H01J49/26 , G01N30/72 , C12S3/14 , C07K16/00
CPC分类号： C07K16/18 , B01D15/3809 , B01D15/3828 , C07K1/22 , C07K16/44 , G01N30/7233 , G01N33/6842 , G01N33/6848 , G01N33/6854 , G01N2030/8831 , G01N2440/14
摘要： The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.
摘要翻译：本发明提供了从复杂的肽混合物中分离修饰的肽的方法，所述方法包括以下步骤：（a）从生物体获得蛋白质制剂，其中所述制剂包含来自两种或更多种不同蛋白质的修饰肽; （b）使制剂与至少一种固定的修饰特异性抗体接触; 和（c）在步骤（b）中分离至少一种由固定的修饰特异性抗体特异性结合的修饰的肽。该方法还可以包括以下步骤：（d）通过质谱（MS），串联质谱（MS-MS）和/或MS3分析表征步骤（c）中分离的修饰肽，或（e）利用搜索程序将在步骤（d）表征期间获得的修饰肽的光谱与已知肽序列的光谱基本上匹配，从而鉴定修饰肽的亲本蛋白。还提供了包含修饰特异性抗体和针对新型UFD1和PTN6磷酸化位点的抗体的免疫亲和分离装置。

18. 发明授权

US07977462B2 Tyrosine phosphorylation sites 有权
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US07977462B2
公开(公告)日：2011-07-12
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

19. 发明申请

US20100197532A1 METHOD OF MAKING PROPPANT USED IN GAS OR OIL EXTRACTION 有权
标题翻译：制备用于气体或油中提取物的方法
公开(公告)号：US20100197532A1
公开(公告)日：2010-08-05
申请号：US12622900
申请日：2009-11-20
申请人： David John Rush , Juan Leal Gonzalez
发明人： David John Rush , Juan Leal Gonzalez
IPC分类号： C09K8/80 , B02C13/26 , B02C23/08 , B02C23/18
CPC分类号： B03B9/00 , B02C17/002 , C09K8/80
摘要： Method and system for making a spherical proppant having a selected grade from a naturally occurring mined mineral having a hardness of over 6.0 Mohs. The method and system involves preprocessing the mineral mechanically into a semi-dry feedstock comprising a mass of particles with initial sphericity values generally less than 0.60; subjecting the semi-dry feedstock to an aggressive abrasive attrition operation for a process time; and, controlling the process time to a value wherein the particles of the feedstock are converted to final processed particles having a sphericity greater than 0.60 by increasing the sphericity of the feedstock particles by at least 0.10. In addition, the processed particles are screened to obtain a proppant having a selected grade.
摘要翻译：制备具有硬度超过6.0莫氏的天然矿物的具有选定等级的球形支撑剂的方法和系统。该方法和系统包括将矿物机械地预处理成半干原料，其包含一批具有通常小于0.60的初始球形度的颗粒; 对半干原料进行侵蚀性磨料磨耗操作以处理工艺时间; 并且通过将原料颗粒的球形度增加至少0.10，将处理时间控制到其中原料颗粒转化为球形度大于0.60的最终处理颗粒的值。另外，对经处理的颗粒进行筛选以获得具有所选等级的支撑剂。

20. 发明申请

US20090081659A1 Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
标题翻译：用于检测癌症信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20090081659A1
公开(公告)日：2009-03-26
申请号：US12075065
申请日：2008-03-07
申请人： Peter Hornbeck , Ailan Guo , Albrecht Moritz , John Rush , Charles Farnsworth , Matthew Stokes , Anthony Passemato
发明人： Peter Hornbeck , Ailan Guo , Albrecht Moritz , John Rush , Charles Farnsworth , Matthew Stokes , Anthony Passemato
IPC分类号： G01N33/574 , C07K16/18 , C12Q1/68
CPC分类号： C07K16/18 , C07K16/22 , C07K16/30 , C07K16/40 , C07K2317/34
摘要： The invention discloses 364 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的364个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

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