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11. 发明授权

US5962680A Processes for producing epsilon caprolactams 失效
标题翻译：生产ε己内酰胺的方法
公开(公告)号：US5962680A
公开(公告)日：1999-10-05
申请号：US839576
申请日：1997-04-15
申请人： Thomas Carl Eisenschmid , John Robert Briggs , Diane Lee Packett , Kurt Damar Olson , John Michael Maher
发明人： Thomas Carl Eisenschmid , John Robert Briggs , Diane Lee Packett , Kurt Damar Olson , John Michael Maher
IPC分类号： B01J31/24 , C07B61/00 , C07D201/02 , C07D201/08 , C07D223/10 , C08G69/02 , C08G69/14 , C08G69/36
CPC分类号： C07D201/02 , C07D201/08 , C08G69/02 , C08G69/14 , C08G69/36 , Y02P20/582
摘要： This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactams, e.g., epsilon caprolactam, which comprises: (a) subjecting one or more substituted or unsubstituted alkadienes to hydroxycarbonylation in the presence of a hydroxycarbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and neutralization with a base to produce one or more substituted or unsubstituted pentenoic acid salts; (b) subjecting said one or more substituted or unsubstituted pentenoic acid salts to hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce one or more substituted or unsubstituted formylvaleric acid salts and/or one or more substituted or unsubstituted epsilon caprolactam precursors; and (c) subjecting said one or more substituted or unsubstituted formylvaleric acid salts and/or said one or more substituted or unsubstituted epsilon caprolactam precursors to reductive amination in the presence of a reductive amination catalyst and cyclization optionally in the presence of a cyclization catalyst to produce said one or more substituted or unsubstituted epsilon caprolactams. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactams as the principal product(s) of reaction.
摘要翻译：本发明部分地涉及用于制备一种或多种取代或未取代的ε-己内酰胺（例如ε-己内酰胺）的方法，其包括：（a）在羟基羰基化催化剂存在下使一种或多种取代或未取代的烷撑二醇进行羟基羰基化，金属有机磷配体络合物催化剂，并用碱中和以产生一种或多种取代或未取代的戊烯酸盐; （b）使所述一种或多种取代或未取代的戊烯酸盐在加氢甲酰化催化剂（例如金属 - 有机磷配体配合物催化剂）存在下进行加氢甲酰化，以产生一种或多种取代或未取代的甲酰基戊酸盐和/或一种或多种更多取代或未取代的ε己内酰胺前体; 和（c）在还原胺化催化剂存在下使所述一种或多种取代或未取代的甲酰基戊酸盐和/或所述一种或多种取代或未取代的己内酰胺前体进行还原胺化，任选地在环化催化剂存在下进行环化，产生所述一种或多种取代或未取代的ε己内酰胺。本发明还部分涉及含有一种或多种取代或未取代的ε-己内酰胺作为反应主要产物的反应混合物。

12. 发明授权

US5892119A Metal-ligand complex catalyzed processes 失效
标题翻译：金属 - 配体络合物催化方法
公开(公告)号：US5892119A
公开(公告)日：1999-04-06
申请号：US815476
申请日：1997-03-11
申请人： David Robert Bryant , James Clair Nicholson , Ernst Billig , John Robert Briggs , Diane Lee Packett , John Michael Maher
发明人： David Robert Bryant , James Clair Nicholson , Ernst Billig , John Robert Briggs , Diane Lee Packett , John Michael Maher
IPC分类号： C07C45/50 , C07F9/02
CPC分类号： C07C45/50 , C07F9/025 , Y02P20/582
摘要： This invention relates to a process for separating one or more phosphorus acidic compounds from a reaction product fluid containing said one or more phosphorus acidic compounds, a metal-organophosphorus ligand complex catalyst and optionally free organophosphorus ligand which process comprises (a) treating said reaction product fluid with water sufficient to remove at least some amount of said one or more phosphorus acidic compounds from said reaction product fluid and (b) treating the water which contains phosphorus acidic compounds removed from said reaction product fluid with an ion exchange resin sufficient to remove at least some amount of said one or more phosphorus acidic compounds from said water.
摘要翻译：本发明涉及从含有一种或多种磷酸性化合物，金属 - 有机磷配位体配合物催化剂和任选的游离有机磷配体的反应产物流体中分离一种或多种磷酸性化合物的方法，该方法包括（a）处理所述反应产物流体，其具有足以从所述反应产物流体中除去至少一定量的所述一种或多种磷酸性化合物的水，和（b）用足以在所述反应产物流体中除去的离子交换树脂处理从所述反应产物流体中除去的含磷酸性化合物的水从所述水中至少一些量的所述一种或多种磷酸性化合物。

13. 发明授权

US5874640A Metal-ligand complex catalyzed processes 失效
标题翻译：金属 - 配体络合物催化方法
公开(公告)号：US5874640A
公开(公告)日：1999-02-23
申请号：US818781
申请日：1997-03-11
申请人： David Robert Bryant , Tak Wai Leung , Ernst Billig , Thomas Carl Eisenschmid , James Clair Nicholson , John Robert Briggs , Diane Lee Packett , John Michael Maher
发明人： David Robert Bryant , Tak Wai Leung , Ernst Billig , Thomas Carl Eisenschmid , James Clair Nicholson , John Robert Briggs , Diane Lee Packett , John Michael Maher
IPC分类号： B01J31/18 , B01J31/24 , C07F9/02 , C07C45/50
CPC分类号： C07F9/025 , B01J31/185 , B01J31/1855 , B01J31/1865 , B01J31/187 , B01J31/2495 , B01J2231/321 , B01J2231/323 , B01J2231/52 , B01J2231/645 , B01J2531/80 , B01J2531/822 , Y02P20/582
摘要： This invention relates to a process for separating one or more phosphorus acidic compounds from a reaction product fluid containing said one or more phosphorus acidic compounds, a metal-organophosphorus ligand complex catalyst and optionally free organophosphorus ligand which process comprises treating said reaction product fluid with an aqueous buffer solution sufficient to neutralize and remove at least some amount of said one or more phosphorus acidic compounds from said reaction product fluid.
摘要翻译：本发明涉及从含有一种或多种磷酸性化合物，金属 - 有机磷配位体配合物催化剂和任选的游离有机磷配体的反应产物流体中分离一种或多种磷酸性化合物的方法，该方法包括用水溶液，足以中和并从所述反应产物流体中除去至少一些量的所述一种或多种磷酸性化合物。

14. 发明授权

US06307065B1 Processes for producing epsilon caprolactones and/or hydrates and/or esters thereof 失效
公开(公告)号：US06307065B1
公开(公告)日：2001-10-23
申请号：US09729408
申请日：2000-12-04
申请人： Erik Bruce Tjaden , John Robert Briggs , Anil Sakharam Guram , John Michael Maher
发明人： Erik Bruce Tjaden , John Robert Briggs , Anil Sakharam Guram , John Michael Maher
IPC分类号： C07D31304
CPC分类号： C07D315/00 , C07C67/38 , Y02P20/582 , C07C69/675
摘要： This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof which comprise subjecting one or more substituted or unsubstituted penten-1-ols to carbonylation in the presence of a carbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce said one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof. The substituted and unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., epsilon caprolactam. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof as principal product(s) of reaction.

15. 发明授权

US5883265A Processes for producing epsilon caprolactones and/or hydrates and/or esters thereof 失效
标题翻译：用于制备ε-己内酯和/或其水合物和/或其酯的方法
公开(公告)号：US5883265A
公开(公告)日：1999-03-16
申请号：US834271
申请日：1997-04-15
申请人： Erik Bruce Tjaden , John Robert Briggs , Anil Sakharam Guram , John Michael Maher
发明人： Erik Bruce Tjaden , John Robert Briggs , Anil Sakharam Guram , John Michael Maher
IPC分类号： C07C67/38 , C07D313/04
CPC分类号： C07D313/04 , C07C67/38 , Y02P20/582
摘要： This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof which comprise subjecting one or more substituted or unsubstituted penten-1-ols to carbonylation in the presence of a carbonylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce said one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof. The substituted and unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., epsilon caprolactam. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactones and/or hydrates and/or esters thereof as principal product(s) of reaction.
摘要翻译：本发明部分涉及制备一种或多种取代或未取代的ε-己内酯和/或其水合物和/或其酯的方法，其包括在羰基化催化剂存在下使一种或多种取代或未取代的戊烯-1-醇进行羰基化，例如金属 - 有机磷配体络合物催化剂，以产生所述一种或多种取代或未取代的ε己内酯和/或其水合物和/或其酯。通过本发明方法制备的取代和未取代的ε-己内酯和/或其水合物和/或酯可进一步反应以提供其所需的衍生物，例如ε己内酰胺。本发明还部分涉及含有一种或多种取代或未取代的ε-己内酯和/或其水合物和/或其酯作为主要反应产物的反应混合物。

16. 发明授权

US5756855A Stabilization of phosphite ligands in hydroformylation process 失效
公开(公告)号：US5756855A
公开(公告)日：1998-05-26
申请号：US293028
申请日：1994-08-19
申请人： Anthony George Abatjoglou , David Robert Bryant , John Michael Maher
发明人： Anthony George Abatjoglou , David Robert Bryant , John Michael Maher
IPC分类号： B01J31/18 , C07C45/50
CPC分类号： C07C45/50 , B01J31/185 , B01J2231/321 , B01J2531/0288 , B01J2531/80 , B01J2531/821 , B01J2531/824 , B01J2531/845
摘要： The present invention provides a hydroformylation process comprising: (1) forming a reaction mixture containing: (a) an olefinic compound, (b) hydrogen, (c) carbon monoxide, (d) a phosphite in which each phosphorus atom is bonded to three oxygen atoms and at least one such oxygen atom is bonded to a carbon atom of an aromatic ring that is adjacent to another carbon atom of said ring having a pendant monovalent group having a steric hindrance at least as great as the steric hindrance of the isopropyl group, (e) a catalytic amount of rhodium, and (f) a Group VIII metal (other than a rhodium) in an amount sufficient to reduce the rhodium-catalyzed decomposition of the phosphite during the hydroformylation process; and (2) maintaining the reaction mixture under conditions at which the olefinic compound reacts with the hydrogen and carbon monoxide to form an aldehyde.

17. 发明授权

US06310260B1 Separation processes 有权
标题翻译：分离过程
公开(公告)号：US06310260B1
公开(公告)日：2001-10-30
申请号：US09526191
申请日：2000-03-15
申请人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher
发明人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher
IPC分类号： C07C4550
CPC分类号： C07C45/50 , C07B63/00 , Y02P20/582 , C07C47/02
摘要： This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more products from a continuously generated reaction product fluid comprising one or more unreacted reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, one or more polar solvents and one or more nonpolar solvents by phase separation wherein (i) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1 which is a value greater than about 2.5, (ii) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more organophosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.
摘要翻译：本发明涉及从连续生成的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种产物，所述反应产物流体包含一种或多种未反应的反应物，金属 - 有机磷配体络合物催化剂，有机磷配体，所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，一种或多种极性溶剂和一种或多种非极性溶剂通过相分离，其中（i）极性相的选择性为相对于一种或多种产物的有机磷配体由分配系数比Ef1表示，分配系数比Ef1大于约2.5，（ii）有机磷配体的极性相对于一种或多种有机磷配体的选择性降解产物由分配系数比Ef2表示，该分配系数比Ef2是大于th的值约为2.5，和（iii）极性相对于一种或多种反应副产物的有机磷配体的选择性由分配系数比Ef3表示，该分配系数比Ef3是大于约2.5的值。

18. 发明授权

US06307110B1 Separation processes 有权
标题翻译：分离过程
公开(公告)号：US06307110B1
公开(公告)日：2001-10-23
申请号：US09526337
申请日：2000-03-15
申请人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher
发明人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher
IPC分类号： C07C4550
CPC分类号： C07C45/50 , C07B63/00 , Y02P20/582 , C07C47/02
摘要： This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more products from a continuously generated reaction product fluid comprising one or more unreacted reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, one or more nonpolar solvents and one or more polar solvents by phase separation wherein (i) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1which is a value greater than about 2.5, (ii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more organophosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the nonpolar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.
摘要翻译：本发明涉及从连续生成的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种产物，所述反应产物流体包含一种或多种未反应的反应物，金属 - 有机磷配体络合物催化剂，有机磷配体，所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，一种或多种非极性溶剂和一种或多种极性溶剂通过相分离，其中（i）非极性相的选择性为相对于一种或多种产物的有机磷配体由分配系数比Ef1表示，分配系数比Ef1大于约2.5，（ii）非极性相对于有机磷配体相对于一种或多种有机磷配体降解的选择性产品由分配系数比Ef2表示，该分配系数比Ef2是一个很大的值（iii）非极性相对于一种或多种反应副产物对有机磷配体的选择性由分配系数比Ef3表示，该分配系数比Ef3是大于约2.5的值。

19. 发明授权

US06303829B1 Separation processes 有权
标题翻译：分离过程
公开(公告)号：US06303829B1
公开(公告)日：2001-10-16
申请号：US09526434
申请日：2000-03-15
申请人： Jeffrey Scott Kanel , John Nicholas Argyropoulos , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher , David Robert Bryant
发明人： Jeffrey Scott Kanel , John Nicholas Argyropoulos , Ailene Gardner Phillips , Brian Michael Roesch , John Robert Briggs , Max Min Lee , John Michael Maher , David Robert Bryant
IPC分类号： C07C4550
CPC分类号： C07C45/50 , C07B63/00 , Y02P20/582 , C07C47/02
摘要： This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more products, one or more nonpolar reaction solvents and one or more polar reaction solvents, wherein said process comprises (1) subjecting said reaction product fluid to fractional countercurrent extraction with at least two immiscible extraction solvents, said at least two immiscible extraction solvents comprising at least one nonpolar extraction solvent and at least one polar extraction solvent, to obtain a nonpolar phase comprising said metal-organophosphorus ligand complex catalyst, said optionally free organophosphorus ligand, said one or more nonpolar reaction solvents and said at least one nonpolar extraction solvent and a polar phase comprising said one or more products, said one or more polar reaction solvents and said at least one polar extraction solvent, and (2) recovering said polar phase from said nonpolar phase; wherein (i) the organophosphorus ligand has a partition coefficient Kp1 defined herein between the nonpolar phase and the polar phase of greater than about 5, and (ii) the one or more products have a partition coefficient Kp2 defined herein between the nonpolar phase and the polar phase of less than about 2.0.
摘要翻译：本发明涉及从反应产物流体中分离一种或多种产物的方法，其包括金属 - 有机磷配体配合物催化剂，任选的游离有机磷配体，所述一种或多种产物，一种或多种非极性反应溶剂和一种或多种极性反应溶剂其中所述方法包括（1）使所述反应产物流体用至少两种不混溶的萃取溶剂进行分数逆流萃取，所述至少两种不混溶的萃取溶剂包含至少一种非极性萃取溶剂和至少一种极性提取溶剂，以获得所述非极性相包含所述金属 - 有机磷配体配合物催化剂，所述任选游离的有机磷配体，所述一种或多种非极性反应溶剂和所述至少一种非极性萃取溶剂和包含所述一种或多种产物的极性相，所述一种或多种极性反应溶剂并表示至少一种极性提取溶剂，和（ 2）从所述非极性相中回收所述极性相; 其中（i）有机磷配体具有在非极性相和极性相之间定义的分配系数Kp1大于约5，和（ii）一种或多种产物在非极性相和非极性相之间具有本文定义的分配系数Kp2 极性相小于约2.0。

20. 发明授权

US5942611A Process for natamycin recovery 失效
标题翻译：游霉素回收方法
公开(公告)号：US5942611A
公开(公告)日：1999-08-24
申请号：US696841
申请日：1996-08-28
申请人： George Wayne Borden , John Michael Maher , Constantine Sklavounos
发明人： George Wayne Borden , John Michael Maher , Constantine Sklavounos
IPC分类号： C07H1/08 , C07H17/08 , C07H1/00
CPC分类号： C07H17/08 , C07H1/08
摘要： A new process for recovering high purity natamycin from fermentation broth containing natamycin comprises the steps of adjusting the pH of the broth to above about 10 and adding an amount of a water-miscible solvent, such as isopropanol, sufficient to dissolve the natamycin in the broth, followed by removing insoluble solids from the pH-adjusted broth, followed by lowering the pH of the broth to a level sufficient to precipitate the natamycin, and removing the natamycin from the broth.
摘要翻译： PCT No.PCT / IB95 / 00040 Sec。 371日期：1996年8月28日 102（e）日期1996年8月28日PCT提交1995年1月19日PCT公布。公开号WO95 / 27073 日期1995年10月12日从含有游霉素的发酵液中回收高纯度纳他霉素的新方法包括以下步骤：将培养液的pH调节至约10以上，并加入足量溶解的量的水混溶性溶剂如异丙醇培养基中的那他霉素，然后从pH调节的肉汤中除去不溶性固体，然后将肉汤的pH降低到足以沉淀那他霉素的水平，并从肉汤中除去那他霉素。

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