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11. 发明授权

US07708996B2 DR3 antibodies 失效
标题翻译： DR3抗体
公开(公告)号：US07708996B2
公开(公告)日：2010-05-04
申请号：US12046107
申请日：2008-03-11
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C12N2799/026
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了结合本发明多肽的抗体及其片段。本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

12. 发明申请

US20090104189A1 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：US20090104189A1
公开(公告)日：2009-04-23
申请号：US12210134
申请日：2008-09-12
申请人： GUO-LIANG YU , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich
发明人： GUO-LIANG YU , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich
IPC分类号： A61K39/395 , C12Q1/00 , A61P35/00 , A61K39/00 , G01N33/536 , A61K31/519
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

13. 发明授权

US07476384B2 Death domain containing receptor 4 antibody and methods 有权
标题翻译：含有受体4抗体的死亡域和方法
公开(公告)号：US07476384B2
公开(公告)日：2009-01-13
申请号：US11076187
申请日：2005-03-10
申请人： Jian Ni , Craig A. Rosen , James Pan , Reiner L. Gentz , Vishva M. Dixit
发明人： Jian Ni , Craig A. Rosen , James Pan , Reiner L. Gentz , Vishva M. Dixit
IPC分类号： A61K39/395 , A61K38/21 , C07K14/56 , C07K14/705
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。特别地，提供编码人DR4蛋白的分离的核酸分子。还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

14. 发明申请

US20080241155A1 Death domain containing receptor 4 有权
标题翻译：死亡域含受体4
公开(公告)号：US20080241155A1
公开(公告)日：2008-10-02
申请号：US12010108
申请日：2008-01-18
申请人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
发明人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
IPC分类号： A61K39/395 , C12N5/06 , A61P35/00 , A61P31/12
CPC分类号： C07K14/70578 , A01K2267/035 , C07K16/2878 , C07K2319/30
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。特别地，提供编码人DR4蛋白的分离的核酸分子。还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

15. 发明申请

US20080183891A1 TWO-LEVEL STRUCTURED OVERLAY DESIGN FOR CLUSTER MANAGEMENT IN A PEER-TO-PEER NETWORK 有权
标题翻译：同层对等网络中集群管理的两级结构化覆盖设计
公开(公告)号：US20080183891A1
公开(公告)日：2008-07-31
申请号：US12017534
申请日：2008-01-22
申请人： Jian Ni , Jie Lin , Steven J. Harrington , Naveen Sharma
发明人： Jian Ni , Jie Lin , Steven J. Harrington , Naveen Sharma
IPC分类号： G06F15/173
CPC分类号： H04L12/4625 , H04L45/64 , H04L67/104 , H04L67/1053 , H04L67/1059 , H04L67/1065
摘要： A method and system for designing file replication schemes in file sharing systems consider node storage constraints and node up/down statistics, file storage costs, and file transfer costs among the nodes, user request rates for the files, and user specified file availability requirements. Based on these considerations, a systematic method for designing file replication schemes can be implemented. The method first determines the number of copies of the files to be stored in the system to achieve the desired goal (e.g., to satisfy file availability requirements, or to maximize the system hit rate), and then selects the nodes at which to store the file copies to minimize the total expected cost. The file replication scheme for a peer-to-peer file sharing system in a distributed and adaptive manner can scale to a large number of nodes and files and can handle changes in the user request pattern over time.
摘要翻译：在文件共享系统中设计文件复制方案的方法和系统考虑节点之间的节点存储约束和节点上/下统计，文件存储成本和节点之间的文件传输成本，文件的用户请求速率和用户指定的文件可用性要求。基于这些考虑，可以实现用于设计文件复制方案的系统方法。该方法首先确定要存储在系统中的文件的副本数以实现所需目标（例如，满足文件可用性要求或最大化系统命中率），然后选择要存储的节点文件副本以最小化总预期成本。用于分布式和自适应方式的对等文件共享系统的文件复制方案可以扩展到大量的节点和文件，并且可以随着时间处理用户请求模式的变化。

16. 发明申请

US20080177767A1 TWO-LEVEL STRUCTURED OVERLAY DESIGN FOR CLUSTER MANAGEMENT IN A PEER-TO-PEER NETWORK 有权
公开(公告)号：US20080177767A1
公开(公告)日：2008-07-24
申请号：US12017530
申请日：2008-01-22
申请人： Jie Lin , Jian Ni , Andres Quiroz Hernandez
发明人： Jie Lin , Jian Ni , Andres Quiroz Hernandez
IPC分类号： G06F17/30 , G06F15/16
CPC分类号： H04L12/4625 , H04L45/64 , H04L67/104 , H04L67/1053 , H04L67/1059 , H04L67/1065
摘要： A method and system for designing file replication schemes in file sharing systems consider node storage constraints and node up/down statistics, file storage costs, and file transfer costs among the nodes, user request rates for the files, and user specified file availability requirements. Based on these considerations, a systematic method for designing file replication schemes can be implemented. The method first determines the number of copies of the files to be stored in the system to achieve the desired goal (e.g., to satisfy file availability requirements, or to maximize the system hit rate), and then selects the nodes at which to store the file copies to minimize the total expected cost. The file replication scheme for a peer-to-peer file sharing system in a distributed and adaptive manner can scale to a large number of nodes and files and can handle changes in the user request pattern over time.

17. 发明授权

US07357927B2 Death domain containing receptors 有权
标题翻译：含有受体的死亡域
公开(公告)号：US07357927B2
公开(公告)日：2008-04-15
申请号：US10189189
申请日：2002-07-05
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： A61K39/395 , A61K39/00 , C07K16/18 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C12N2799/026
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了结合本发明多肽的抗体及其片段。本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

18. 发明申请

US20080051338A1 98 Human Secreted Proteins 审中-公开
标题翻译： 98人分泌蛋白
公开(公告)号：US20080051338A1
公开(公告)日：2008-02-28
申请号：US11777133
申请日：2007-07-12
申请人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
发明人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
IPC分类号： A61K31/70 , A61K38/00 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/11 , C12N15/87 , C12N5/06 , C12P21/04 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

19. 发明授权

US07335489B2 Polynucleotides encoding a protein kinase C inhibitor protein and methods of using these polynucleotides 失效
标题翻译：编码蛋白激酶C抑制蛋白的多核苷酸和使用这些多核苷酸的方法
公开(公告)号：US07335489B2
公开(公告)日：2008-02-26
申请号：US10453478
申请日：2003-06-04
申请人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
发明人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
IPC分类号： C07K14/35 , C12N15/00 , C12N5/00 , C12N1/20 , C07H21/04 , C07H21/02 , C07K14/435
CPC分类号： C07K14/47 , A61K38/00
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译：公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了将这些多肽用于治疗目的的方法。还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。还公开了用于检测利用序列和多肽的疾病的诊断方法。

20. 发明申请

US20070280903A1 T1 Receptor-Like Ligand II and Uses Thereof 审中-公开
标题翻译： T1受体样配体II及其用途
公开(公告)号：US20070280903A1
公开(公告)日：2007-12-06
申请号：US11554432
申请日：2006-10-30
申请人： Jian Ni , Reiner Gentz , Steven Ruben
发明人： Jian Ni , Reiner Gentz , Steven Ruben
IPC分类号： A61K38/19 , A61K38/17 , C12Q1/68 , A61K38/18
CPC分类号： G01N33/564 , A61K38/1709 , A61K38/20 , A61K45/06 , A61K48/00 , C07K14/54 , C12N2799/026 , G01N33/57407 , G01N33/57426 , G01N33/6893 , G01N33/6896 , G01N2800/24 , G01N2800/2821 , G01N2800/368
摘要： The present invention relates to a novel T1 Receptor (T1R)-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same. This invention further relates to pharmaceutical compositions and formulations comprising T1R-like ligand II. Also provided are methods of using T1R-like ligand II polynucleotides, polypeptides, antibodies or agonists/antagonists for therapeutic and diagnostic purposes. Diagnostic kits are further provided.
摘要翻译：本发明涉及一种新颖的T1受体（T1R）样配体II蛋白。特别地，提供编码T1R样配体II蛋白质的分离的核酸分子。还提供了T1R样配体II多肽，重组载体和用于表达它们的宿主细胞也是如此。本发明还涉及包含T1R样配体II的药物组合物和制剂。还提供了用于治疗和诊断目的的T1R样配体II多核苷酸，多肽，抗体或激动剂/拮抗剂的方法。还提供诊断试剂盒。

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